Pub Date : 2020-12-11DOI: 10.33552/WJGWH.2020.04.000594
Yishan Dong
Objective: To discover the characteristics of trisomies 18 who were prenatal diagnosed or failed to be diagnosed, and to reduce the failed to be diagnosed. Method: In this multicenter study, we collected a total of 52 babies of 18-trisomy syndrome (34 cases were prenatally diagnosed and 18 failed to be diagnosed) and analyzed their characteristics. Results: In the past 13 years, according to the data from the prenatal diagnosis center in Jiangsu, the estimated detection rate was 65.4% for trisomies 18 in the second trimester. After analyzed the distribution of the groups according to T18-risk, there were two important cut-off values to be noted: 1/455 and 1/5050. It was worthwhile noting that the risk of 65.4% trisomy 18 cases was higher than 1/455, 90.4% higher than 1/5050. However, 96.1% cases in normal control group were lower than 1/5050. No case from normal control group would be higher than the value of risk in 1/450. Meanwhile, the T18-risk of 50% T18 failed to be diagnosed cases were 1/1001~1/5050. If we chose NIPT follow the standard of 1/5050, we could find 90.4 % T18 cases. It could increase 19.2% T18 babies be detected, but 3.2% normal mother would accept the NIPT examination which maybe unnecessary. Conclusions: The prediction mode of HCG MoM and AFP MoM might be able to help us reduce the failed to be diagnosed. It is also necessary to adjust more reasonable range of NIPT with further clinical researches.
{"title":"Clinical Characteristics of 18-Trisomy Syndrome Failed to Be Diagnosed After Prenatal Screening","authors":"Yishan Dong","doi":"10.33552/WJGWH.2020.04.000594","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000594","url":null,"abstract":"Objective: To discover the characteristics of trisomies 18 who were prenatal diagnosed or failed to be diagnosed, and to reduce the failed to be diagnosed. Method: In this multicenter study, we collected a total of 52 babies of 18-trisomy syndrome (34 cases were prenatally diagnosed and 18 failed to be diagnosed) and analyzed their characteristics. Results: In the past 13 years, according to the data from the prenatal diagnosis center in Jiangsu, the estimated detection rate was 65.4% for trisomies 18 in the second trimester. After analyzed the distribution of the groups according to T18-risk, there were two important cut-off values to be noted: 1/455 and 1/5050. It was worthwhile noting that the risk of 65.4% trisomy 18 cases was higher than 1/455, 90.4% higher than 1/5050. However, 96.1% cases in normal control group were lower than 1/5050. No case from normal control group would be higher than the value of risk in 1/450. Meanwhile, the T18-risk of 50% T18 failed to be diagnosed cases were 1/1001~1/5050. If we chose NIPT follow the standard of 1/5050, we could find 90.4 % T18 cases. It could increase 19.2% T18 babies be detected, but 3.2% normal mother would accept the NIPT examination which maybe unnecessary. Conclusions: The prediction mode of HCG MoM and AFP MoM might be able to help us reduce the failed to be diagnosed. It is also necessary to adjust more reasonable range of NIPT with further clinical researches.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49413159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-25DOI: 10.33552/WJGWH.2020.04.000593
P. Hollands
Leiomyoma are a significant source of morbidity in reproductive aged woman across the globe causing distressing symptoms and in infertility in some women. There does, however, appear to be an increased incidence of leiomyoma in women of black African ethnicity and especially those women in Nigeria. This review covers the incidence and possibly aetiology and treatment of leiomyoma in Nigeria.
{"title":"The Incidence, Aetiology And Treatment of Leiomyoma in Nigeria","authors":"P. Hollands","doi":"10.33552/WJGWH.2020.04.000593","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000593","url":null,"abstract":"Leiomyoma are a significant source of morbidity in reproductive aged woman across the globe causing distressing symptoms and in infertility in some women. There does, however, appear to be an increased incidence of leiomyoma in women of black African ethnicity and especially those women in Nigeria. This review covers the incidence and possibly aetiology and treatment of leiomyoma in Nigeria.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42333562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-23DOI: 10.33552/WJGWH.2020.04.000592
Álvaro Tejerizo García
Background: The inflammatory reaction after a surgical intervention could exacerbate the course of the COVID-19. We aim to determine the rate of COVID-19 and its complications among gynecological surgeries in the context of different measures taken during the pandemic period in our department. Methods: A retrospective longitudinal observational study was conducted. Clinical records of patients who underwent gynecological surgery from March 1st to April 10th, 2020 were reviewed. During this period, three different approaches were made: first phase, without any screening or surgical restrictions; second phase, with presurgical epidemiological screening using a specific questionnaire; and third phase, also with presurgical SARS-COV-19 RT-PCR. During the second and third phases the surgical activity and complexity were restricted, and different workflows were established for patient with suspected/confirmed infection. After hospital discharge, telephone follow-up was performed and screening for COVID-19 was carried out. Complications from the disease were analyzed. Results: Of the 118 patients that underwent gynecological surgeries, 10 (8.5%) were perioperatively diagnosed with COVID-19. Of these patients, 8 (80%) were not pre-surgical screened for SARS-CoV-2 infection, neither clinical nor with RT-PCR. The other 2 (20%) were preoperative screened with RT-PCR, one of them with a positive test result. Screening false negative rate was 0.8%. No postoperative complications derived from COVID-19 were observed. Conclusions: The establishment of different surgical workflows, the reduction of surgical complexity, and the use of a pre-surgical screening to detect patient at SARS-CoV-2 infection risk, could reduce the postoperative complications derived from that infection and improve surgical outcomes.
{"title":"Incidence and Clinical Profiles of COVID-19 In Patients with Gynecological Surgery. A Single Center Descriptive Study from Spain","authors":"Álvaro Tejerizo García","doi":"10.33552/WJGWH.2020.04.000592","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000592","url":null,"abstract":"Background: The inflammatory reaction after a surgical intervention could exacerbate the course of the COVID-19. We aim to determine the rate of COVID-19 and its complications among gynecological surgeries in the context of different measures taken during the pandemic period in our department. Methods: A retrospective longitudinal observational study was conducted. Clinical records of patients who underwent gynecological surgery from March 1st to April 10th, 2020 were reviewed. During this period, three different approaches were made: first phase, without any screening or surgical restrictions; second phase, with presurgical epidemiological screening using a specific questionnaire; and third phase, also with presurgical SARS-COV-19 RT-PCR. During the second and third phases the surgical activity and complexity were restricted, and different workflows were established for patient with suspected/confirmed infection. After hospital discharge, telephone follow-up was performed and screening for COVID-19 was carried out. Complications from the disease were analyzed. Results: Of the 118 patients that underwent gynecological surgeries, 10 (8.5%) were perioperatively diagnosed with COVID-19. Of these patients, 8 (80%) were not pre-surgical screened for SARS-CoV-2 infection, neither clinical nor with RT-PCR. The other 2 (20%) were preoperative screened with RT-PCR, one of them with a positive test result. Screening false negative rate was 0.8%. No postoperative complications derived from COVID-19 were observed. Conclusions: The establishment of different surgical workflows, the reduction of surgical complexity, and the use of a pre-surgical screening to detect patient at SARS-CoV-2 infection risk, could reduce the postoperative complications derived from that infection and improve surgical outcomes.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46309412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-23DOI: 10.33552/WJGWH.2020.04.000591
Ankudinov No
classification of MS Robson, medical decision support medical
医疗决策支持医学
{"title":"Regional Register of Cesarean Sections “С-Registеr”","authors":"Ankudinov No","doi":"10.33552/WJGWH.2020.04.000591","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000591","url":null,"abstract":"classification of MS Robson, medical decision support medical","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44796149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-10DOI: 10.33552/WJGWH.2020.04.000590
Tara Giacchino
Ultrasound is vital tool for imaging women and men with infertility as it is inexpensive, accessible and non-invasive, providing crucial information to allow quick diagnosis. It also helps to facilitate an interactive discussion with the patient where findings can instantly be seen and acted upon. Additionally, US is indispensable for assisting IVF and ICSI treatment especially with the introduction of 3D technology ensuring the best quality oocytes are used to strive for the best outcomes. The diagnosis and treatment of infertility can be extremely distressing for patients and we must ensure we provide the highest level of care with the use of US playing a key role in management. Furthermore, all contemporary trainees aspiring for a career in reproductive medicine should be trained and competent in advanced ultrasound.
{"title":"State-Of-The-Art Ultrasound in the Management of the Infertile Couple","authors":"Tara Giacchino","doi":"10.33552/WJGWH.2020.04.000590","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000590","url":null,"abstract":"Ultrasound is vital tool for imaging women and men with infertility as it is inexpensive, accessible and non-invasive, providing crucial information to allow quick diagnosis. It also helps to facilitate an interactive discussion with the patient where findings can instantly be seen and acted upon. Additionally, US is indispensable for assisting IVF and ICSI treatment especially with the introduction of 3D technology ensuring the best quality oocytes are used to strive for the best outcomes. The diagnosis and treatment of infertility can be extremely distressing for patients and we must ensure we provide the highest level of care with the use of US playing a key role in management. Furthermore, all contemporary trainees aspiring for a career in reproductive medicine should be trained and competent in advanced ultrasound.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42570354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-22DOI: 10.33552/WJGWH.2020.04.000589
Devon Smith
Objectives: The purpose of this study was to determine predictive factors of para-aortic lymph node (PALN) involvement in low-grade endometrial cancer of endometrioid type. These factors may influence treatment algorithms and determine the extent of lymph node dissection in patients with low grade endometrial cancer. Our hypothesis was that tumor size, location, and depth of myometrium invasion may be independent predictors of PALN involvement in low grade endometrial cancer. Methods: A retrospective chart review was performed on patients with grades 1 or 2 endometrial cancer of endometroid type who underwent hysterectomy with lymph node removal from January 1, 2004 to August 1, 2014. Data was evaluated using independent t-tests, Mann Whitney U test, and chi square tests. Sensitivity, specificity, positive and negative predictive values were calculated for tumor size, location, and myometrium invasion in association with PALN and pelvic lymph node (PLN) involvement. Results: A total of 259 patients met the inclusion criteria. Tumor size was not significantly different between positive and negative PALN samples (4.5cm vs 3.5cm, respectively; p=0.29). Location was not significantly different among positive and negative PALN groups, as the majority of patients in both groups had tumors in the fundal region (75% vs 70.5%, respectively; p=1.00). Myometrial invasion was not significantly different between positive and negative PALN groups (48% vs 28%, respectively; p=0.14). Myometrial invasion was significantly different among positive and negative PLN groups (71% vs 26%, respectively. p<0.001). Lymphovascular space invasion (LVSI) demonstrated a significant association with both positive PALN and PLN groups (100% vs 22.31%, and 81.25% vs 19.67%, respectively; p=0.003, <0.001). Conclusions: LVSI may be an independent predictor of both PALN and PLN involvement in low grade endometrial tumors. It remains unclear whether tumor size, location, and myometrial invasion can be used to predict para-aortic nodal involvement in these cases.
目的:本研究的目的是确定低级别子宫内膜样型子宫内膜癌中主动脉旁淋巴结(PALN)累及的预测因素。这些因素可能会影响治疗方法，并决定低级别子宫内膜癌患者淋巴结清扫的程度。我们的假设是肿瘤的大小、位置和肌层浸润的深度可能是低级别子宫内膜癌PALN累及的独立预测因素。方法:回顾性分析2004年1月1日至2014年8月1日1级或2级子宫内膜癌子宫内膜样型患者行子宫切除术并淋巴结清扫术的资料。使用独立t检验、Mann Whitney U检验和卡方检验对数据进行评估。计算肿瘤大小、位置、肌层浸润与PALN和盆腔淋巴结(PLN)累及的敏感性、特异性、阳性和阴性预测值。结果:259例患者符合纳入标准。PALN阳性和阴性样本的肿瘤大小差异无统计学意义(分别为4.5cm和3.5cm);p = 0.29)。PALN阳性组和阴性组的肿瘤位置无显著差异，因为两组中大多数患者的肿瘤位于基底区(分别为75%和70.5%);p = 1.00)。PALN阳性组和阴性组之间肌层侵犯无显著差异(分别为48%和28%;p = 0.14)。PLN阳性组和阴性组的肌层浸润率差异显著(分别为71%和26%)。p < 0.001)。淋巴血管腔浸润(LVSI)与PALN和PLN阳性组均有显著相关性(分别为100% vs 22.31%、81.25% vs 19.67%);p = 0.003 < 0.001)。结论:LVSI可能是低级别子宫内膜肿瘤PALN和PLN累及的独立预测因子。目前尚不清楚肿瘤的大小、位置和肌层浸润是否可以用于预测这些病例的主动脉旁淋巴结累及。
{"title":"Determining Predictive Factors of Para-aortic Lymph Node Involvement in Low-grade Endometrial Cancer","authors":"Devon Smith","doi":"10.33552/WJGWH.2020.04.000589","DOIUrl":"https://doi.org/10.33552/WJGWH.2020.04.000589","url":null,"abstract":"Objectives: The purpose of this study was to determine predictive factors of para-aortic lymph node (PALN) involvement in low-grade endometrial cancer of endometrioid type. These factors may influence treatment algorithms and determine the extent of lymph node dissection in patients with low grade endometrial cancer. Our hypothesis was that tumor size, location, and depth of myometrium invasion may be independent predictors of PALN involvement in low grade endometrial cancer. Methods: A retrospective chart review was performed on patients with grades 1 or 2 endometrial cancer of endometroid type who underwent hysterectomy with lymph node removal from January 1, 2004 to August 1, 2014. Data was evaluated using independent t-tests, Mann Whitney U test, and chi square tests. Sensitivity, specificity, positive and negative predictive values were calculated for tumor size, location, and myometrium invasion in association with PALN and pelvic lymph node (PLN) involvement. Results: A total of 259 patients met the inclusion criteria. Tumor size was not significantly different between positive and negative PALN samples (4.5cm vs 3.5cm, respectively; p=0.29). Location was not significantly different among positive and negative PALN groups, as the majority of patients in both groups had tumors in the fundal region (75% vs 70.5%, respectively; p=1.00). Myometrial invasion was not significantly different between positive and negative PALN groups (48% vs 28%, respectively; p=0.14). Myometrial invasion was significantly different among positive and negative PLN groups (71% vs 26%, respectively. p<0.001). Lymphovascular space invasion (LVSI) demonstrated a significant association with both positive PALN and PLN groups (100% vs 22.31%, and 81.25% vs 19.67%, respectively; p=0.003, <0.001). Conclusions: LVSI may be an independent predictor of both PALN and PLN involvement in low grade endometrial tumors. It remains unclear whether tumor size, location, and myometrial invasion can be used to predict para-aortic nodal involvement in these cases.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46984914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-26DOI: 10.33552/wjgwh.2020.04.000588
A. Abbas
COVID-19 is a pandemic disease caused by the SARS-CoV-2 which began to appear around in December 2019 in Wuhan, China and spread globally in the last few months. Currently, there is no specific treatment for SARS-CoV-2 which forced clinicians to use old drugs, chosen for their efficacy against similar viruses or their in vitro activity. The majority of information comes from small case series and single center reports which showed that COVID-19 infection in pregnant women can lead to intrauterine growth restriction, premature labor and spontaneous abortion. So, in the view of the urgency of COVID-19 pandemic and the uncertainties about its management during pregnancy, we aimed to provide a literature review on the effectiveness and safety of available medications for COVID-19 in pregnant women. Here, our overview may provide useful information for physicians to choose the best available medications for treatment a pregnant case with COVID-19. inflammatory protein1 alpha, monocyte chemoattractant protein1, granulocyte-colony stimulating factor, interferon gamma inducible
{"title":"A Scoping Review of the Effects of COVID-19 Medications on Pregnancy","authors":"A. Abbas","doi":"10.33552/wjgwh.2020.04.000588","DOIUrl":"https://doi.org/10.33552/wjgwh.2020.04.000588","url":null,"abstract":"COVID-19 is a pandemic disease caused by the SARS-CoV-2 which began to appear around in December 2019 in Wuhan, China and spread globally in the last few months. Currently, there is no specific treatment for SARS-CoV-2 which forced clinicians to use old drugs, chosen for their efficacy against similar viruses or their in vitro activity. The majority of information comes from small case series and single center reports which showed that COVID-19 infection in pregnant women can lead to intrauterine growth restriction, premature labor and spontaneous abortion. So, in the view of the urgency of COVID-19 pandemic and the uncertainties about its management during pregnancy, we aimed to provide a literature review on the effectiveness and safety of available medications for COVID-19 in pregnant women. Here, our overview may provide useful information for physicians to choose the best available medications for treatment a pregnant case with COVID-19. inflammatory protein1 alpha, monocyte chemoattractant protein1, granulocyte-colony stimulating factor, interferon gamma inducible","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42526868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-26DOI: 10.33552/wjgwh.2020.04.000587
A. Abbas
Objective: To evaluate the value of Atwal striae gravidarum (SG) score for prediction of occurrence of perineal tears (PT) during vaginal delivery. Methods: A cross-sectional study conducted between October 2016 and April 2018 included all multiparous women presented in the active phase of labor. Assessment of SG score was done using Atwal score in the abdomen, hips, breasts and buttocks. According to the total striae score (TSS) women were classified into two groups; group (I): mild SG (TSS ≤12) and group (II) moderate/severe SG (TSS >12). The primary study outcome was the rate of PT in both groups. Results: The study included 421 women; 188 in group I and 233 in group II. The rate of PT was significantly higher in group II than group I (56.2% vs. 3.2% respectively, p<0.001). Additionally, para-urethral, vaginal and cervical tears were more common in group II (p=0.029, 0.025 and 0.047 respectively). Additionally, we found significantly higher TSS among women with PT versus those without PT (17.07±3.56 vs. 7.93±6.94, p <0.001). Multivariate regression analysis revealed that the presence of abdominal striae and the TSS >12 were associated with increased risk of PT. Conclusion: Assessment of Atwal SG score could precisely predict the occurrence of PT in multiparous women during vaginal delivery.
{"title":"Atwal Striae Gravidarum Score for Prediction of Perineal Tears During Vaginal Delivery: A Cross- Sectional Study","authors":"A. Abbas","doi":"10.33552/wjgwh.2020.04.000587","DOIUrl":"https://doi.org/10.33552/wjgwh.2020.04.000587","url":null,"abstract":"Objective: To evaluate the value of Atwal striae gravidarum (SG) score for prediction of occurrence of perineal tears (PT) during vaginal delivery. Methods: A cross-sectional study conducted between October 2016 and April 2018 included all multiparous women presented in the active phase of labor. Assessment of SG score was done using Atwal score in the abdomen, hips, breasts and buttocks. According to the total striae score (TSS) women were classified into two groups; group (I): mild SG (TSS ≤12) and group (II) moderate/severe SG (TSS >12). The primary study outcome was the rate of PT in both groups. Results: The study included 421 women; 188 in group I and 233 in group II. The rate of PT was significantly higher in group II than group I (56.2% vs. 3.2% respectively, p<0.001). Additionally, para-urethral, vaginal and cervical tears were more common in group II (p=0.029, 0.025 and 0.047 respectively). Additionally, we found significantly higher TSS among women with PT versus those without PT (17.07±3.56 vs. 7.93±6.94, p <0.001). Multivariate regression analysis revealed that the presence of abdominal striae and the TSS >12 were associated with increased risk of PT. Conclusion: Assessment of Atwal SG score could precisely predict the occurrence of PT in multiparous women during vaginal delivery.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49467245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-20DOI: 10.33552/wjgwh.2020.04.000586
N. Ivonne
Cell-free circulating tumor DNA (ctDNA), shed into the blood stream by apoptotic or necrotic tumor cells of either primary or metastatic sites, became an extensively investigated and very promising analyte in oncology research. If passing through the kidney barrier, ctDNA is likely to occur in urine. Literature research revealed a lack of studies aiming at diagnostic use of urinary ctDNA. Most studies investigating urinary ctDNA were performed in the field of urological cancers emphasizing, however, that urinary liquid biopsies were suitable to draw conclusive real time pictures of ctDNA alterations coming from circulation and hence strengthen the hypothesis that genetic profiling of urinary ctDNA could be valuable to gain tumor-related information also in other solid tumors such as breast cancer. Usually, clinical treatment decisions are based on mutation profiles that were received from initial tissue biopsies. Though, during therapy the genetic tumor profile might change e.g. gain and loss of genetic alterations that might be relevant for targeted therapy options or treatment resistance. Particularly patients with advanced breast cancer may acquire mutations during treatment cycles and might benefit from serial ctDNA sequencing to find new targetable mutations and gain access to tailored therapy. Here, the use of urinary ctDNA might offer an opportunity for non-invasive longitudinal genotyping and testing for actionable mutations. In contrast to plasma-derived ctDNA, only a few studies were performed using urinary ctDNA from patients with breast cancer and revealed that targeted NGS appeared to be a sensitive method to detect tumor-specific genetic features. In this mini review we sought to illuminate the potential use of urinary ctDNA for longitudinal disease monitoring at frequent intervals and low effort for patients with breast cancer.
{"title":"The Potential Use of Urinary CtDNA Profiling in the Treatment of Breast Cancer","authors":"N. Ivonne","doi":"10.33552/wjgwh.2020.04.000586","DOIUrl":"https://doi.org/10.33552/wjgwh.2020.04.000586","url":null,"abstract":"Cell-free circulating tumor DNA (ctDNA), shed into the blood stream by apoptotic or necrotic tumor cells of either primary or metastatic sites, became an extensively investigated and very promising analyte in oncology research. If passing through the kidney barrier, ctDNA is likely to occur in urine. Literature research revealed a lack of studies aiming at diagnostic use of urinary ctDNA. Most studies investigating urinary ctDNA were performed in the field of urological cancers emphasizing, however, that urinary liquid biopsies were suitable to draw conclusive real time pictures of ctDNA alterations coming from circulation and hence strengthen the hypothesis that genetic profiling of urinary ctDNA could be valuable to gain tumor-related information also in other solid tumors such as breast cancer. Usually, clinical treatment decisions are based on mutation profiles that were received from initial tissue biopsies. Though, during therapy the genetic tumor profile might change e.g. gain and loss of genetic alterations that might be relevant for targeted therapy options or treatment resistance. Particularly patients with advanced breast cancer may acquire mutations during treatment cycles and might benefit from serial ctDNA sequencing to find new targetable mutations and gain access to tailored therapy. Here, the use of urinary ctDNA might offer an opportunity for non-invasive longitudinal genotyping and testing for actionable mutations. In contrast to plasma-derived ctDNA, only a few studies were performed using urinary ctDNA from patients with breast cancer and revealed that targeted NGS appeared to be a sensitive method to detect tumor-specific genetic features. In this mini review we sought to illuminate the potential use of urinary ctDNA for longitudinal disease monitoring at frequent intervals and low effort for patients with breast cancer.","PeriodicalId":87379,"journal":{"name":"World journal of gynecology & womens health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43723240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-10DOI: 10.33552/wjgwh.2020.04.000584
I. Ali
Purpose: To determine the incidence of post-partum depression among female patients as this form of mental illness is much more serious than the “baby blues” (relatively mild depressive and anxiety symptoms that typically clear within two weeks after delivery) that many women experience after giving birth. Women with PPD may experience full-blown major depression during pregnancy or after delivery. The feelings of extreme sadness, anxiety, and exhaustion that accompany PPD may make it difficult for these new mothers to complete daily care activities for themselves and/or for their newborns. Early diagnosis and management are essential for the prevention of serious complications. Materials and methods: This are a descriptive analytical hospital-based prospective study. Study included a total coverage of all women attending the outpatient clinic of Obstetrics and gynecology 4-6 weeks post-partum, which was a total of 40 women. Each woman answered the questionnaire in an interview method and the score of the Edinburgh Post Natal Depression Scale (EPDS) was recorded along with the factors included in the “added” questionnaire; marital status, partner support, employment and socioeconomic status. As for the EPDS scoring, any score of 10 or higher is considered suggestive of PPD. Results: The incidence of PPD among the taken sample was found to be was found to be 7.5% - only three women presented with a score of equal/more than 10. With regards to marital status; single, widowed and divorced women all had EPDS scores less than 10; so, no depression. Of married women, 8.8% had EPDS scores of equal to or greater than 10 suggesting PPD. However, the p value for the association between marital status and PPD was (0.903) which is considered insignificant. Significant EPDS scores for depression were also shown to present with women complaining of “rarely supportive” partners, as all three women presenting with PPD were in that category. The p value for this association was found to be (0.301), also insignificant. When it comes to socioeconomic status, all three women with PPD were of low socioeconomic status, that is 8.6% of all those with low socioeconomic status presented with EPDS scores of 10 or higher. The p value for this association was found to be (0.496), insignificant. 12.5% of women who are unemployed presented with PPD while all those employed had no significant EPDS scores. The p value for this association was (0.141) which is, once again, insignificant. Conclusion: According to the results obtained, the incidence of PPD is 7.5% and it appears that there is no significant association between PPD and any of the factors mentioned; marital status, employment, partner support and socioeconomic status. All P values were greater than 0.05.
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