Pub Date : 2002-05-01DOI: 10.1185/146300902322125091
G. Anabwani
{"title":"Drug Development: a Perspective from Africa","authors":"G. Anabwani","doi":"10.1185/146300902322125091","DOIUrl":"https://doi.org/10.1185/146300902322125091","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1185/146300902322125082
A. Smyth, I. Choonara
{"title":"Drug Development for Children","authors":"A. Smyth, I. Choonara","doi":"10.1185/146300902322125082","DOIUrl":"https://doi.org/10.1185/146300902322125082","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1185/146300902322125136
E. Webster, J. McIntyre, I. Choonara, T. Preston
The caffeine breath test is a non-invasive method of studying CYP1A2 activity that is suitable for children from the ages of 3 years upwards. It involves the oral administration of a stable isotope and the collection of breath samples for a period of 2 hours. Breath samples are analysed by continuous flow isotope ratio mass spectrometry. It has been used to study both drug interactions and the effect of disease on drug metabolism.
{"title":"The Caffeine Breath Test and CYP1A2 Activity in Children","authors":"E. Webster, J. McIntyre, I. Choonara, T. Preston","doi":"10.1185/146300902322125136","DOIUrl":"https://doi.org/10.1185/146300902322125136","url":null,"abstract":"The caffeine breath test is a non-invasive method of studying CYP1A2 activity that is suitable for children from the ages of 3 years upwards. It involves the oral administration of a stable isotope and the collection of breath samples for a period of 2 hours. Breath samples are analysed by continuous flow isotope ratio mass spectrometry. It has been used to study both drug interactions and the effect of disease on drug metabolism.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.1185/146300902322125929
Geert W. ‘t Jong, I. Eland, M. de Hoog, M.C.J.M. Sturkenboom, J. N. van den Anker, Bruno C. Stricker
{"title":"Unlicensed and off-label prescription of systemic anti-infective agents to children","authors":"Geert W. ‘t Jong, I. Eland, M. de Hoog, M.C.J.M. Sturkenboom, J. N. van den Anker, Bruno C. Stricker","doi":"10.1185/146300902322125929","DOIUrl":"https://doi.org/10.1185/146300902322125929","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505259
S. Conroy, R. Morton, H. Dixon, A. Porter, I. Choonara
Objective: To evaluate the use and safety of intranasal midazolam when used as first-line treatment for children with acute seizures. Study design: Prospective study of 20 children over the age of six months presenting with an acute seizure to the emergency department of a 70-bed children’s hospital in the UK. All children were treated with intranasal midazolam in a dose of 200 micrograms/kg. Efficacy and toxicity were assessed. Results: Midazolam controlled the seizure within 15 minutes in 10 patients (50%). A further five patients (25%) showed a partial response. Five children showed no response to midazolam. No adverse reactions were seen. Conclusion: This efficacy rate is lower than that shown in other studies. All studies to date have been small. It is suggested that larger, controlled studies are required to establish the place of midazolam, and alternative routes of administration, such as the intranasal route, in the treatment of children with acute seizures.
{"title":"A Prospective Study of Intranasal Midazolam for Children with Acute Seizures","authors":"S. Conroy, R. Morton, H. Dixon, A. Porter, I. Choonara","doi":"10.1185/1463009001505259","DOIUrl":"https://doi.org/10.1185/1463009001505259","url":null,"abstract":"Objective: To evaluate the use and safety of intranasal midazolam when used as first-line treatment for children with acute seizures. Study design: Prospective study of 20 children over the age of six months presenting with an acute seizure to the emergency department of a 70-bed children’s hospital in the UK. All children were treated with intranasal midazolam in a dose of 200 micrograms/kg. Efficacy and toxicity were assessed. Results: Midazolam controlled the seizure within 15 minutes in 10 patients (50%). A further five patients (25%) showed a partial response. Five children showed no response to midazolam. No adverse reactions were seen. Conclusion: This efficacy rate is lower than that shown in other studies. All studies to date have been small. It is suggested that larger, controlled studies are required to establish the place of midazolam, and alternative routes of administration, such as the intranasal route, in the treatment of children with acute seizures.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"52-57"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505295
I. Choonara, A. Nunn
{"title":"Two Major Advances for our Journal","authors":"I. Choonara, A. Nunn","doi":"10.1185/1463009001505295","DOIUrl":"https://doi.org/10.1185/1463009001505295","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"34-34"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505231
R. Damoiseaux
{"title":"Antibiotics for Acute Otitis Media in Infancy: Based on Fear or on Facts?","authors":"R. Damoiseaux","doi":"10.1185/1463009001505231","DOIUrl":"https://doi.org/10.1185/1463009001505231","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505312
S. Spielberg
{"title":"Paediatric Therapeutics in the USA and Internationally: An Unparalleled Opportunity","authors":"S. Spielberg","doi":"10.1185/1463009001505312","DOIUrl":"https://doi.org/10.1185/1463009001505312","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"71-74"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505277
M. Vater, Debra Hessell
{"title":"Nitrous Oxide and Oxygen Mixture (Entonox®), and Acute Procedural Pain","authors":"M. Vater, Debra Hessell","doi":"10.1185/1463009001505277","DOIUrl":"https://doi.org/10.1185/1463009001505277","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-12-01DOI: 10.1185/1463009001505268
G. Pons, R. Gorodischer
{"title":"The European Society for Developmental Pharmacology (ESDP)","authors":"G. Pons, R. Gorodischer","doi":"10.1185/1463009001505268","DOIUrl":"https://doi.org/10.1185/1463009001505268","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"4 1","pages":"62-66"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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