Pub Date : 2003-06-01DOI: 10.1185/146300903322012068
Y. Velázquez-Armenta, A. Nava-Ocampo
{"title":"Is Pharmacy Dispensing Information Useful to Identify Problems with Analgesic Prescribing in Children","authors":"Y. Velázquez-Armenta, A. Nava-Ocampo","doi":"10.1185/146300903322012068","DOIUrl":"https://doi.org/10.1185/146300903322012068","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"135-138"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-01-01DOI: 10.1185/146300903322012004
C. Pandolfini, M. Bonati, H. Sammons, I. Choonara, É. Jacqz-Aigrain, I. Danés, I. Fuentes, J. Arnau
{"title":"A European clinical trials registry for children","authors":"C. Pandolfini, M. Bonati, H. Sammons, I. Choonara, É. Jacqz-Aigrain, I. Danés, I. Fuentes, J. Arnau","doi":"10.1185/146300903322012004","DOIUrl":"https://doi.org/10.1185/146300903322012004","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"98-100"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65624024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-10-01DOI: 10.1185/146300902322125839
A. Doloy, S. Roy, S. Djoussa-Kambou, F. Legrand, F. Brion, A. Rieutord
{"title":"The Use of Sodium Benzoate in a Ten-fold Overdose of Asparaginase","authors":"A. Doloy, S. Roy, S. Djoussa-Kambou, F. Legrand, F. Brion, A. Rieutord","doi":"10.1185/146300902322125839","DOIUrl":"https://doi.org/10.1185/146300902322125839","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-10-01DOI: 10.1185/146300902322125910
J. Drew, A. Watson, J. Evans, A. Smyth
{"title":"Antibiotics and Acute Renal Failure in Children with Cystic Fibrosis","authors":"J. Drew, A. Watson, J. Evans, A. Smyth","doi":"10.1185/146300902322125910","DOIUrl":"https://doi.org/10.1185/146300902322125910","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"65-67"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-10-01DOI: 10.1185/146300902322125884
Tony Nunn
{"title":"From Medication Errors to Safe Medication Practice","authors":"Tony Nunn","doi":"10.1185/146300902322125884","DOIUrl":"https://doi.org/10.1185/146300902322125884","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"50-51"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-10-01DOI: 10.1185/146300902322125866
T. Johnson
{"title":"Approaches to Studying the Development of Drug Metabolism in Children","authors":"T. Johnson","doi":"10.1185/146300902322125866","DOIUrl":"https://doi.org/10.1185/146300902322125866","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"75-92"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-10-01DOI: 10.1185/146300902322125893
D. Cousins, A. Clarkson, S. Conroy, I. Choonara
{"title":"Medication Errors in Children - an Eight Year Review Using Press Reports","authors":"D. Cousins, A. Clarkson, S. Conroy, I. Choonara","doi":"10.1185/146300902322125893","DOIUrl":"https://doi.org/10.1185/146300902322125893","url":null,"abstract":"","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1185/146300902322125109
I. Choonara, M. Rieder
AbstractDrug toxicity in association with adverse drug reactions is common in hospitalisedchildren. The toxicity of medicines in children is different to that seen in adults.There are also differences between different age groups of paediatric patientswith neonates being generally at greater risk for experiencing a drug-associatedadverse event. The major examples of drug toxicity that have occurred inpaediatric patients are reviewed ranging from percutaneous toxicity over 100years ago to formulation errors and toxicity associated with normal,developmental alterations in drug metabolism . The need to learn from previouscases of drug toxicity to prevent future cases is paramount. Paed Perinatal Drug Ther 2002; 5: 12– 18 Key words: Drug toxicity – drug metabolism – children Introduction Adverse drug reactions ( ADRs ) are commonclinical problems in both paediatric and adultmedicine. Over 9% of hospitalised children haveadverse reactions to therapy and up to 4% of allhospital admissions are the consequence of ADRs
{"title":"Drug Toxicity and Adverse Drug Reactions in Children - A Brief Historical Review","authors":"I. Choonara, M. Rieder","doi":"10.1185/146300902322125109","DOIUrl":"https://doi.org/10.1185/146300902322125109","url":null,"abstract":"AbstractDrug toxicity in association with adverse drug reactions is common in hospitalisedchildren. The toxicity of medicines in children is different to that seen in adults.There are also differences between different age groups of paediatric patientswith neonates being generally at greater risk for experiencing a drug-associatedadverse event. The major examples of drug toxicity that have occurred inpaediatric patients are reviewed ranging from percutaneous toxicity over 100years ago to formulation errors and toxicity associated with normal,developmental alterations in drug metabolism . The need to learn from previouscases of drug toxicity to prevent future cases is paramount. Paed Perinatal Drug Ther 2002; 5: 12– 18 Key words: Drug toxicity – drug metabolism – children Introduction Adverse drug reactions ( ADRs ) are commonclinical problems in both paediatric and adultmedicine. Over 9% of hospitalised children haveadverse reactions to therapy and up to 4% of allhospital admissions are the consequence of ADRs","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1185/146300902322125145
S. Playfor
Neuromuscular blockade is used in critically ill children for a variety of reasons. The physiology and pharmacology of neuromuscular blocking agents is reviewed. The effect of hypothermia on the pharmacodynamics of neuromuscular blockade is discussed. The ideal agent would have a rapid rate of onset with spontaneous reversal after discontinuation. Patients receiving neuromuscular blocking agents need to be assessed for the degree of blockade that is being sustained. The need to temporarily discontinue infusions of neuromuscular blocking agents to enable an assessment of the level of sedation or to allow an assessment of neuromuscular function is highlighted. Paed Perinatal Drug Ther 2002; 5: 35–46
{"title":"Neuromuscular Blocking Agents in Critically Ill Children","authors":"S. Playfor","doi":"10.1185/146300902322125145","DOIUrl":"https://doi.org/10.1185/146300902322125145","url":null,"abstract":"Neuromuscular blockade is used in critically ill children for a variety of reasons. The physiology and pharmacology of neuromuscular blocking agents is reviewed. The effect of hypothermia on the pharmacodynamics of neuromuscular blockade is discussed. The ideal agent would have a rapid rate of onset with spontaneous reversal after discontinuation. Patients receiving neuromuscular blocking agents need to be assessed for the degree of blockade that is being sustained. The need to temporarily discontinue infusions of neuromuscular blocking agents to enable an assessment of the level of sedation or to allow an assessment of neuromuscular function is highlighted. Paed Perinatal Drug Ther 2002; 5: 35–46","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"35-46"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-05-01DOI: 10.1185/146300902322125118
P. Impicciatore, A. Mohn, F. Chiarelli, C. Pandolfini, M. Bonati
Recently published studies examining the extent of off-label drug prescribing in various European paediatric wards have reported that off-label use is widespread and particularly high in Italy. So far, however, no studies have investigated the extent to which adverse drug reactions (ADRs) due to off-label drug use occur in Italy. To evaluate the risk associated with off-label drug use in paediatric inpatients, a prospective surveillance study was carried out in the paediatric ward of a teaching hospital over a 9 month period. Forty-one children (mean age: 7.2 years, 58% male ), out of a study population of 1619 patients, experienced ADRs. In 29 children the ADRs were due to in hospital drug therapies, while in 12 they were due to medicines administered in the community. Urticaria (11 cases), vomiting and rash (5 cases each ) and tremor (4 cases) were the most common ADRs. Eight ADRs (20%) were classified as severe. The drugs most frequently associated with ADRs were salbutamol (5 cases) and coamoxiclav (4 cases). Off-label drug prescriptions were responsible for 38% of inpatient ADRs and for 42% of the ADRs occurring in the community that led to hospitalisation. The use of drugs not licensed for paediatric use (8 cases) or for indications for which the drug was not licensed (6 cases) were the off-label categories most frequently associated with ADRs. Drugs used for diagnostic tests in endocrinology were responsible for one third of ADRs due to off-label uses. The results of this study suggest a high risk of ADRs associated with offlabel prescribing in children, both in the hospital and in the community. This pilot study also demonstrates the feasibility of an ADR monitoring system that could take into account important issues relating to rational drug prescribing in paediatric patients. In order to achieve a comprehensive risk assessment of off-label drug interventions in children, the study should be continued and expanded to involve the community setting as well.
{"title":"Adverse Drug Reactions to Off-label Drugs on a Paediatric Ward: an Italian Prospective Pilot Study","authors":"P. Impicciatore, A. Mohn, F. Chiarelli, C. Pandolfini, M. Bonati","doi":"10.1185/146300902322125118","DOIUrl":"https://doi.org/10.1185/146300902322125118","url":null,"abstract":"Recently published studies examining the extent of off-label drug prescribing in various European paediatric wards have reported that off-label use is widespread and particularly high in Italy. So far, however, no studies have investigated the extent to which adverse drug reactions (ADRs) due to off-label drug use occur in Italy. To evaluate the risk associated with off-label drug use in paediatric inpatients, a prospective surveillance study was carried out in the paediatric ward of a teaching hospital over a 9 month period. Forty-one children (mean age: 7.2 years, 58% male ), out of a study population of 1619 patients, experienced ADRs. In 29 children the ADRs were due to in hospital drug therapies, while in 12 they were due to medicines administered in the community. Urticaria (11 cases), vomiting and rash (5 cases each ) and tremor (4 cases) were the most common ADRs. Eight ADRs (20%) were classified as severe. The drugs most frequently associated with ADRs were salbutamol (5 cases) and coamoxiclav (4 cases). Off-label drug prescriptions were responsible for 38% of inpatient ADRs and for 42% of the ADRs occurring in the community that led to hospitalisation. The use of drugs not licensed for paediatric use (8 cases) or for indications for which the drug was not licensed (6 cases) were the off-label categories most frequently associated with ADRs. Drugs used for diagnostic tests in endocrinology were responsible for one third of ADRs due to off-label uses. The results of this study suggest a high risk of ADRs associated with offlabel prescribing in children, both in the hospital and in the community. This pilot study also demonstrates the feasibility of an ADR monitoring system that could take into account important issues relating to rational drug prescribing in paediatric patients. In order to achieve a comprehensive risk assessment of off-label drug interventions in children, the study should be continued and expanded to involve the community setting as well.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65623663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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