Tamara Maksimovic, A. Mandić, S. Maksimovic, Ivan Kuhajda, Milorad Bijelović, N. Stevanovic
Introduction. Ovarian cancer is the most lethal gynecological cancer. The most common manifestation of thoracic metastasis is pleural effusion. Pleural effusion with positive cytology is regarded as stage IVa of the International Federation of Gynecology and Obstetrics classification, and the overall five-year survival in these patients is less than 20%. We analyzed the data of patients with ovarian cancer who were treated at the Oncology Institue of Vojvodina, in order to establish the incidence of malignant pleural effusions, laterality of pleural effusions, and clinical manifestations. Material and Methods. The study included 731 patients with ovarian cancer who were treated at the Oncology Institue of Vojvodina from January 2012 to May 2020. The obtained data were compared with data found in the literature in the same period. Results. The incidence of malignant pleural effusion in our study was 5.75%; right-sided pleural effusion was found in 57.15% of patients, 33.33% of patients had effusion on the left side, and 9.52% had bilateral effusions. Thus, unilateral effusion was found in 90.48% of cases, and bilateral in only 9.52%. The most common symptom was dyspnea, reported in 33 patients (78.6%). Conclusion. The incidence of malignant pleural effusion in our study was most similar to data found by Zamboni et al. published in 2015; the right side was the dominant side of pleural effusions. The most common symptoms were dyspnea, shortnes of breath and chest pain.
介绍。卵巢癌是最致命的妇科癌症。胸部转移最常见的表现是胸腔积液。细胞学阳性的胸腔积液被国际妇产联合会(International Federation of Gynecology and Obstetrics)分类为IVa期，这类患者的总5年生存率低于20%。我们分析了在伏伊伏丁那肿瘤研究所接受治疗的卵巢癌患者的资料，以确定恶性胸腔积液的发生率、胸腔积液的侧边性和临床表现。材料和方法。该研究包括2012年1月至2020年5月期间在伏伊伏丁那肿瘤研究所接受治疗的731名卵巢癌患者。将获得的数据与同期文献中的数据进行比较。结果。恶性胸腔积液的发生率为5.75%;右侧胸腔积液占57.15%，左侧胸腔积液占33.33%，双侧胸腔积液占9.52%。单侧积液占90.48%，双侧仅占9.52%。最常见的症状是呼吸困难，33例(78.6%)。结论。我们研究中恶性胸腔积液的发生率与Zamboni等人在2015年发表的数据最为相似;胸腔积液以右侧为主。最常见的症状是呼吸困难、呼吸短促和胸痛。
{"title":"Malignant pleural effusion in patients with ovarian cancer","authors":"Tamara Maksimovic, A. Mandić, S. Maksimovic, Ivan Kuhajda, Milorad Bijelović, N. Stevanovic","doi":"10.2298/mpns2202045m","DOIUrl":"https://doi.org/10.2298/mpns2202045m","url":null,"abstract":"Introduction. Ovarian cancer is the most lethal gynecological cancer. The most common manifestation of thoracic metastasis is pleural effusion. Pleural effusion with positive cytology is regarded as stage IVa of the International Federation of Gynecology and Obstetrics classification, and the overall five-year survival in these patients is less than 20%. We analyzed the data of patients with ovarian cancer who were treated at the Oncology Institue of Vojvodina, in order to establish the incidence of malignant pleural effusions, laterality of pleural effusions, and clinical manifestations. Material and Methods. The study included 731 patients with ovarian cancer who were treated at the Oncology Institue of Vojvodina from January 2012 to May 2020. The obtained data were compared with data found in the literature in the same period. Results. The incidence of malignant pleural effusion in our study was 5.75%; right-sided pleural effusion was found in 57.15% of patients, 33.33% of patients had effusion on the left side, and 9.52% had bilateral effusions. Thus, unilateral effusion was found in 90.48% of cases, and bilateral in only 9.52%. The most common symptom was dyspnea, reported in 33 patients (78.6%). Conclusion. The incidence of malignant pleural effusion in our study was most similar to data found by Zamboni et al. published in 2015; the right side was the dominant side of pleural effusions. The most common symptoms were dyspnea, shortnes of breath and chest pain.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73711853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bojana Markić, Milka Mavija, Sasa Smoljanovic-Skocic, S. Burgic
Introduction. Cataract surgery results in a reduction of intraocular pressure, but it has not been sufficiently investigated how it affects short-term intraocular pressure fluctuations. The aim of this study was to evaluate the effects of cataract surgery on short-term intraocular pressure fluctuations in patients with primary angle-closure, with or without glaucoma. Material and Methods. A prospective interventional clinical study included 31 patients (eyes) with primary angle-closure/primary angle-closure glaucoma (study group) and 31 patients (eyes) with cataract only (control group). All subjects underwent cataract surgery. Preoperatively, and at the first, third and sixth postoperative months, diurnal tension curves for the assessment of intraocular pressure was performed and the mean intraocular pressure and short-term intraocular pressure fluctuations were evaluated. Results. Postoperatively, the mean intraocular pressure and short-term intraocular pressure fluctuations were significantly reduced in both groups. In the study group, the highest mean intraocular pressure reduction was - 4.14 ? 2.50 mmHg, and in the control group it was - 2.44 ? 1.76 mmHg. The highest reduction of short-term fluctuations was - 1.61 ? 3.55 mmHg in the study group, and - 0.55 ? 1.72 mmHg in the control group. In both groups, a significant negative correlation was found between the preoperative and postoperative mean intraocular pressure and short-term intraocular pressure fluctuations. At the end of the research, the number of medications was reduced by 18.4% compared to the preoperative period. Conclusion. Cataract surgery in patients with primary angle-closure/primary angle-closure glaucoma results in a significant reduction of intraocular pressure, short-term intraocular pressure fluctuations, and a reduction in the number of medications.
{"title":"Effects of cataract surgery on short-term intraocular pressure fluctuations in patients with primary angle-closure and primary angle-closure glaucoma","authors":"Bojana Markić, Milka Mavija, Sasa Smoljanovic-Skocic, S. Burgic","doi":"10.2298/mpns2208217m","DOIUrl":"https://doi.org/10.2298/mpns2208217m","url":null,"abstract":"Introduction. Cataract surgery results in a reduction of intraocular pressure, but it has not been sufficiently investigated how it affects short-term intraocular pressure fluctuations. The aim of this study was to evaluate the effects of cataract surgery on short-term intraocular pressure fluctuations in patients with primary angle-closure, with or without glaucoma. Material and Methods. A prospective interventional clinical study included 31 patients (eyes) with primary angle-closure/primary angle-closure glaucoma (study group) and 31 patients (eyes) with cataract only (control group). All subjects underwent cataract surgery. Preoperatively, and at the first, third and sixth postoperative months, diurnal tension curves for the assessment of intraocular pressure was performed and the mean intraocular pressure and short-term intraocular pressure fluctuations were evaluated. Results. Postoperatively, the mean intraocular pressure and short-term intraocular pressure fluctuations were significantly reduced in both groups. In the study group, the highest mean intraocular pressure reduction was - 4.14 ? 2.50 mmHg, and in the control group it was - 2.44 ? 1.76 mmHg. The highest reduction of short-term fluctuations was - 1.61 ? 3.55 mmHg in the study group, and - 0.55 ? 1.72 mmHg in the control group. In both groups, a significant negative correlation was found between the preoperative and postoperative mean intraocular pressure and short-term intraocular pressure fluctuations. At the end of the research, the number of medications was reduced by 18.4% compared to the preoperative period. Conclusion. Cataract surgery in patients with primary angle-closure/primary angle-closure glaucoma results in a significant reduction of intraocular pressure, short-term intraocular pressure fluctuations, and a reduction in the number of medications.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81352654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrej Preveden, Mirna Usorac, M. Todić, M. Preveden, M. Golubović, L. Velicki
Introduction. Hypertrophic cardiomyopathy is a disorder of the myocardium characterized by asymmetric or symmetric left ventricular hypertrophy. It is often an inherited disorder with an autosomal dominant pattern. The aim of this study was to evaluate the electrocardiographic characteristics of patients with hypertrophic cardiomyopathy, as well as to assess the accuracy of current electrocardiographic criteria for left ventricular hypertrophy used as indicators of hypertrophic cardiomyopathy. Material and Methods. This retrospective study was conducted using hospital medical records of 42 patients with the diagnosis of hypertrophic cardiomyopathy. Detailed electrocardiography analysis, apart from all the usual parameters, included the calculation of indices used to diagnose left ventricular hypertrophy including Sokolow augmented vector left, Cornell voltage, Cornell product, and Sokolow-Lyon index. Results. Sinus rhythm was present in 95.2% of patients, while atrial fibrillation was found in 4.8%. The majority of patients presented with left axis deviation. A slight positive correlation was found between the Sokolow augmented vector left index and posterolateral wall thickness (r = 0.475; p < 0.05), and also between the Cornell voltage index and posterolateral wall thickness (r = 0.368; p < 0.05). A borderline positive correlation was found between the Cornell product index and posterolateral wall thickness (r = 0.290; p = 0.063). Interventricular septum thickness showed no significant correlation with any of the electrocardiographic indices of left ventricular hypertrophy. Conclusion. In patients with hypertrophic cardiomyopathy, the Sokolow augmented vector left and Cornell voltage indices were the best indicators of posterolateral wall hypertrophy, whereas none of the examined indices correlated well with the interventricular septum thickness.
{"title":"Electrocardiographic features of patients with hypertrophic cardiomyopathy","authors":"Andrej Preveden, Mirna Usorac, M. Todić, M. Preveden, M. Golubović, L. Velicki","doi":"10.2298/mpns2202056p","DOIUrl":"https://doi.org/10.2298/mpns2202056p","url":null,"abstract":"Introduction. Hypertrophic cardiomyopathy is a disorder of the myocardium characterized by asymmetric or symmetric left ventricular hypertrophy. It is often an inherited disorder with an autosomal dominant pattern. The aim of this study was to evaluate the electrocardiographic characteristics of patients with hypertrophic cardiomyopathy, as well as to assess the accuracy of current electrocardiographic criteria for left ventricular hypertrophy used as indicators of hypertrophic cardiomyopathy. Material and Methods. This retrospective study was conducted using hospital medical records of 42 patients with the diagnosis of hypertrophic cardiomyopathy. Detailed electrocardiography analysis, apart from all the usual parameters, included the calculation of indices used to diagnose left ventricular hypertrophy including Sokolow augmented vector left, Cornell voltage, Cornell product, and Sokolow-Lyon index. Results. Sinus rhythm was present in 95.2% of patients, while atrial fibrillation was found in 4.8%. The majority of patients presented with left axis deviation. A slight positive correlation was found between the Sokolow augmented vector left index and posterolateral wall thickness (r = 0.475; p < 0.05), and also between the Cornell voltage index and posterolateral wall thickness (r = 0.368; p < 0.05). A borderline positive correlation was found between the Cornell product index and posterolateral wall thickness (r = 0.290; p = 0.063). Interventricular septum thickness showed no significant correlation with any of the electrocardiographic indices of left ventricular hypertrophy. Conclusion. In patients with hypertrophic cardiomyopathy, the Sokolow augmented vector left and Cornell voltage indices were the best indicators of posterolateral wall hypertrophy, whereas none of the examined indices correlated well with the interventricular septum thickness.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90595892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Bulovic, Jelena Djurica, Milos Nisavic, Vanja Andric
Introduction. Sexually transmitted diseases can be prevented, but it is necessary to know how the infection is transmitted and be aware of the possibility of infection that will lead to change in behavior. Regular testing for sexually transmitted infections is also of crucial importance to prevent its further spread and the development of complications of the infection. The aim of this study was to examine the incidence of risky behaviors in the population of men who have sex with men, their self-assessment of the risk of sexually transmitted diseases, as well as the incidence of testing for these infections. Material and Methods. The study was conducted in the territory of the City of Novi Sad in the population of 185 men who have sex with men. The research method was an anonymous online survey that respondents filled out on a voluntary basis, with previously provided information about the research. Results. Of the total number of respondents, 39% claimed that they had unprotected sex with at least one partner in the previous year. Among the respondents who had unprotected sex in the past year, only 12% believe that they are at high risk of sexually transmitted diseases, and 42% of them have not been tested for sexually transmitted diseases in the past year. Conclusion. In conclusion, a large number of untested people practice risky sex and have a poor perception of the risk of sexually transmitted diseases. The common reason for not getting tested is fear or lack of information about testing.
{"title":"Self-assessment of the risk of sexually transmitted diseases","authors":"Aleksandra Bulovic, Jelena Djurica, Milos Nisavic, Vanja Andric","doi":"10.2298/mpns2206171b","DOIUrl":"https://doi.org/10.2298/mpns2206171b","url":null,"abstract":"Introduction. Sexually transmitted diseases can be prevented, but it is necessary to know how the infection is transmitted and be aware of the possibility of infection that will lead to change in behavior. Regular testing for sexually transmitted infections is also of crucial importance to prevent its further spread and the development of complications of the infection. The aim of this study was to examine the incidence of risky behaviors in the population of men who have sex with men, their self-assessment of the risk of sexually transmitted diseases, as well as the incidence of testing for these infections. Material and Methods. The study was conducted in the territory of the City of Novi Sad in the population of 185 men who have sex with men. The research method was an anonymous online survey that respondents filled out on a voluntary basis, with previously provided information about the research. Results. Of the total number of respondents, 39% claimed that they had unprotected sex with at least one partner in the previous year. Among the respondents who had unprotected sex in the past year, only 12% believe that they are at high risk of sexually transmitted diseases, and 42% of them have not been tested for sexually transmitted diseases in the past year. Conclusion. In conclusion, a large number of untested people practice risky sex and have a poor perception of the risk of sexually transmitted diseases. The common reason for not getting tested is fear or lack of information about testing.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90790504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Vasic, Valentina Isakovic, M. Sekulić, D. Ivanov
Introduction. Over 100 different surgical procedures for the treatment of rectal prolapse have been described. Since these patients commonly have associated comorbidities, methods of choice include surgical techniques with a perineal approach, such as perineal stapled rectal resection. Case Report. A 77-year-old female patient presented with a complete rectal prolapse measuring 12 cm in length. Considering the associated comorbidities and the patient?s age, perineal stapled rectal resection was chosen as the surgical modality. She underwent surgery under general anesthesia in the dorsal decubitus and slightly reverse-Trendelenburg position. The surgery lasted 35 minutes. The surgery and the immediate postoperative course were uneventful. At the follow-up examination, six months after surgery, the findings were normal, without local recurrence. There was a slight deterioration of fecal incontinence, with a Vaizey score 10/20, but the patient tolerated it well. Discussion. The perineal stapled rectal resection technique has fewer intraoperative complications and 6.3% fewer postoperative complications compared to classic perineal procedures (staple line bleeding, anastomotic stenosis, pelvic hematoma, sigmoid colon perforation, perirectal abscesses and rectovaginal fistulas), which were reported in many studies. However, patients with longer postoperative followup demonstrated a higher recurrence rate compared to patients who underwent other surgical techniques with an abdominal approach. Conclusion. The perineal stapled rectal resection procedure is easy to perform and acceptable for the elderly patients with associated comorbidities, who are not candidates for other surgical techniques with abdominal approach.
{"title":"Perineal stapled prolapse resection: A csse report","authors":"D. Vasic, Valentina Isakovic, M. Sekulić, D. Ivanov","doi":"10.2298/mpns2210317v","DOIUrl":"https://doi.org/10.2298/mpns2210317v","url":null,"abstract":"Introduction. Over 100 different surgical procedures for the treatment of rectal prolapse have been described. Since these patients commonly have associated comorbidities, methods of choice include surgical techniques with a perineal approach, such as perineal stapled rectal resection. Case Report. A 77-year-old female patient presented with a complete rectal prolapse measuring 12 cm in length. Considering the associated comorbidities and the patient?s age, perineal stapled rectal resection was chosen as the surgical modality. She underwent surgery under general anesthesia in the dorsal decubitus and slightly reverse-Trendelenburg position. The surgery lasted 35 minutes. The surgery and the immediate postoperative course were uneventful. At the follow-up examination, six months after surgery, the findings were normal, without local recurrence. There was a slight deterioration of fecal incontinence, with a Vaizey score 10/20, but the patient tolerated it well. Discussion. The perineal stapled rectal resection technique has fewer intraoperative complications and 6.3% fewer postoperative complications compared to classic perineal procedures (staple line bleeding, anastomotic stenosis, pelvic hematoma, sigmoid colon perforation, perirectal abscesses and rectovaginal fistulas), which were reported in many studies. However, patients with longer postoperative followup demonstrated a higher recurrence rate compared to patients who underwent other surgical techniques with an abdominal approach. Conclusion. The perineal stapled rectal resection procedure is easy to perform and acceptable for the elderly patients with associated comorbidities, who are not candidates for other surgical techniques with abdominal approach.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87128412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. ?Grey zone Lymphoma?? is associated with various entities. The last published classification of lymphoproliferative neoplasms includes mediastinal grey zone lymphoma. Precise diagnostic criteria are insufficient and establishing a diagnosis is as complex as deciding on treatment options. In this article pathologist and hematologist discuss issues on this topic through case presentation and literature review. Clinical characteristics. It presents in the younger population usually with a mediastinal mass, sometimes large, with compressive symptoms. Pathologic characteristics. Some cases can?t be classified neither as Hodgkin nor Primary mediastinal B-cell lymphoma. Morphology resembles Hodgkin, but with a positive immunophenotype for primary mediastinal or diffuse large B-cell lymphoma, and vice versa. Case report. We presented a case of a 33-year-old male with cervical lymphadenomegaly, B symptoms and clinical deterioration during the diagnostic period. After the first biopsy, differential diagnosis was Epstein-Barr virus-associated lymphoproliferative disorder or classical Hodgkin lymphoma. The second biopsy confirms Epstein-Barr virus-positive diffuse large B-cell lymphoma. The World Health Organization Classification of lymphoproliferative neoplasms - clinical perspective. The term ?grey zone lymphoma? is associated with overlapping diagnosis or uncertainty in diagnosis in more clinical settings than the ones provided in the 5th World Health Organization Classification. Discussion. For now, chemotherapeutic regimen (rituximab-cyclophos phamide, doxorubicin, vincristine, prednisone) stays the standard first line therapy for diffuse large B-cell lymphoma regardless of the Epstein- Barr virus status. Mediastinal grey zone lymphoma treatment varies: chemotherapeutic regimen (rituximab-cyclophos phamide, doxorubicin, vincristine, prednisone) was linked with better outcomes than chemotherapeutic regimen (adriablastin, bleomycin, vinblastine, dacarbazine) +/-R, but for some patients chemotherapeutic regimen (dose adjusted-etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) might be beneficial. Conclusion. Grey zone lymphoma is a rare hematologic malignancy that needs extensive sampling for correct diagnosis and is still subject to inter-observer variability.
{"title":"Grey zone lymphoma - diagnostic and therapeutic challenge","authors":"Danijela Agić, Tanja Lakic, Z. Nikin","doi":"10.2298/mpns22s1101a","DOIUrl":"https://doi.org/10.2298/mpns22s1101a","url":null,"abstract":"Introduction. ?Grey zone Lymphoma?? is associated with various entities. The last published classification of lymphoproliferative neoplasms includes mediastinal grey zone lymphoma. Precise diagnostic criteria are insufficient and establishing a diagnosis is as complex as deciding on treatment options. In this article pathologist and hematologist discuss issues on this topic through case presentation and literature review. Clinical characteristics. It presents in the younger population usually with a mediastinal mass, sometimes large, with compressive symptoms. Pathologic characteristics. Some cases can?t be classified neither as Hodgkin nor Primary mediastinal B-cell lymphoma. Morphology resembles Hodgkin, but with a positive immunophenotype for primary mediastinal or diffuse large B-cell lymphoma, and vice versa. Case report. We presented a case of a 33-year-old male with cervical lymphadenomegaly, B symptoms and clinical deterioration during the diagnostic period. After the first biopsy, differential diagnosis was Epstein-Barr virus-associated lymphoproliferative disorder or classical Hodgkin lymphoma. The second biopsy confirms Epstein-Barr virus-positive diffuse large B-cell lymphoma. The World Health Organization Classification of lymphoproliferative neoplasms - clinical perspective. The term ?grey zone lymphoma? is associated with overlapping diagnosis or uncertainty in diagnosis in more clinical settings than the ones provided in the 5th World Health Organization Classification. Discussion. For now, chemotherapeutic regimen (rituximab-cyclophos phamide, doxorubicin, vincristine, prednisone) stays the standard first line therapy for diffuse large B-cell lymphoma regardless of the Epstein- Barr virus status. Mediastinal grey zone lymphoma treatment varies: chemotherapeutic regimen (rituximab-cyclophos phamide, doxorubicin, vincristine, prednisone) was linked with better outcomes than chemotherapeutic regimen (adriablastin, bleomycin, vinblastine, dacarbazine) +/-R, but for some patients chemotherapeutic regimen (dose adjusted-etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) might be beneficial. Conclusion. Grey zone lymphoma is a rare hematologic malignancy that needs extensive sampling for correct diagnosis and is still subject to inter-observer variability.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"299 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86760825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tijana Aleksandric, Ivana Radicevic, V. Pejcic, A. Savić, Dajana Dedic, A. Knežević
Introduction. Pain perception varies due to many factors. Quantitative sensory testing is a panel of diagnostic tests used to assess somatosensory function. The aim of the study was to determine how psychophysical variables are related to the perceived pain intensity in patients with chronic pain. Material and Methods. The cross-sectional study included 88 subjects (average age 51.3 ? 9.4 years, 76 (86.4%) women) diagnosed with chronic pain syndrome and fibromyalgia or chronic neuropathic pain associated with lumbosacral radiculopathy. Current and average pain intensities in the past 4 weeks were rated on a numerical rating scale. Quantitative sensory testing included pressure pain thresholds, heat pain thresholds, and cold pain thresholds. Patients filled out the Fear Avoidance Component Scale, a questionnaire that examines the fear avoidance phenomenon. Results. The highest correlations were found between the Fear Avoidance Component Scale scores and current and average pain intensity (r = 0.438 and r = 0.253, respectively); between pain duration and current and average pain intensity in the past 4 weeks (r = 0.340 and r = 0.308, respectively). Moderate and negative correlations were found between pressure pain thresholds and current and average pain intensity (r = - 0.233 and r = -0.300, respectively). Conclusion. Low to moderate, significant positive correlations were found between fear-avoidance and pain intensity. Significant but low negative correlations were found between pressure pain threshold and current pain intensity, as well as between pressure pain threshold and average pain intensity.
{"title":"Correlation between the perceived pain intensity and psychophysical tests in patients with chronic pain","authors":"Tijana Aleksandric, Ivana Radicevic, V. Pejcic, A. Savić, Dajana Dedic, A. Knežević","doi":"10.2298/mpns2212356a","DOIUrl":"https://doi.org/10.2298/mpns2212356a","url":null,"abstract":"Introduction. Pain perception varies due to many factors. Quantitative sensory testing is a panel of diagnostic tests used to assess somatosensory function. The aim of the study was to determine how psychophysical variables are related to the perceived pain intensity in patients with chronic pain. Material and Methods. The cross-sectional study included 88 subjects (average age 51.3 ? 9.4 years, 76 (86.4%) women) diagnosed with chronic pain syndrome and fibromyalgia or chronic neuropathic pain associated with lumbosacral radiculopathy. Current and average pain intensities in the past 4 weeks were rated on a numerical rating scale. Quantitative sensory testing included pressure pain thresholds, heat pain thresholds, and cold pain thresholds. Patients filled out the Fear Avoidance Component Scale, a questionnaire that examines the fear avoidance phenomenon. Results. The highest correlations were found between the Fear Avoidance Component Scale scores and current and average pain intensity (r = 0.438 and r = 0.253, respectively); between pain duration and current and average pain intensity in the past 4 weeks (r = 0.340 and r = 0.308, respectively). Moderate and negative correlations were found between pressure pain thresholds and current and average pain intensity (r = - 0.233 and r = -0.300, respectively). Conclusion. Low to moderate, significant positive correlations were found between fear-avoidance and pain intensity. Significant but low negative correlations were found between pressure pain threshold and current pain intensity, as well as between pressure pain threshold and average pain intensity.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84798553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Nikolic, N. Manojlovic, Z. Andrić, D. Radosavljević, M. Ristic, V. Kovcin
Introduction. Patients with colorectal cancer with metastases in the liver parenchyma may benefit from perioperative chemotherapy with biological agents and operative liver resection. Material and Methods. This prospective, multicenter, non-interventional study included 191 previously untreated patients with metastatic colorectal cancer and potentially resectable or initially unresectable liver metastases who received bevacizumab plus chemotherapy. The safety profile, as well as progression-free-survival, response rate and conversion rate of initially unresectable metastases to resectable were assessed. Results. A total of 40 adverse events were reported in 29/191 patients (15.2%), of which 31 were serious adverse events. Among the serious adverse events, 14 were related to the use of bevacizumab therapy, of which 4 were fatal due to serious adverse events, but only one could be related to bevacizumab therapy. The median progression-free period was 9 months (1 - 28). A high rate of response to the applied therapy, 34.5% and 49%, was recorded in both groups of patients: with initially unresectable and potentially resectable metastases in the liver parenchyma. A significant part of patients with metastatic colorectal cancer and metastases only in the liver parenchyma had a clinical benefit from intensive chemotherapy with bevacizumab (disease control rate of 70%). Conclusion. This study confirmed a favourable safety profile and tolerability in terms of the incidence and severity of adverse and serious adverse events. High rates of resectability in both groups of patients, initially unresectable and potentially resectable, reflect the heterogeneity of criteria in decision making about liver resection and emphasize the need for establishing multisciplinary oncology teams and following the generally accepted criteria.
{"title":"Perioperative bevacizumab in the treatment of colorectal cancer in patients with liver metastases","authors":"I. Nikolic, N. Manojlovic, Z. Andrić, D. Radosavljević, M. Ristic, V. Kovcin","doi":"10.2298/mpns2202012n","DOIUrl":"https://doi.org/10.2298/mpns2202012n","url":null,"abstract":"Introduction. Patients with colorectal cancer with metastases in the liver parenchyma may benefit from perioperative chemotherapy with biological agents and operative liver resection. Material and Methods. This prospective, multicenter, non-interventional study included 191 previously untreated patients with metastatic colorectal cancer and potentially resectable or initially unresectable liver metastases who received bevacizumab plus chemotherapy. The safety profile, as well as progression-free-survival, response rate and conversion rate of initially unresectable metastases to resectable were assessed. Results. A total of 40 adverse events were reported in 29/191 patients (15.2%), of which 31 were serious adverse events. Among the serious adverse events, 14 were related to the use of bevacizumab therapy, of which 4 were fatal due to serious adverse events, but only one could be related to bevacizumab therapy. The median progression-free period was 9 months (1 - 28). A high rate of response to the applied therapy, 34.5% and 49%, was recorded in both groups of patients: with initially unresectable and potentially resectable metastases in the liver parenchyma. A significant part of patients with metastatic colorectal cancer and metastases only in the liver parenchyma had a clinical benefit from intensive chemotherapy with bevacizumab (disease control rate of 70%). Conclusion. This study confirmed a favourable safety profile and tolerability in terms of the incidence and severity of adverse and serious adverse events. High rates of resectability in both groups of patients, initially unresectable and potentially resectable, reflect the heterogeneity of criteria in decision making about liver resection and emphasize the need for establishing multisciplinary oncology teams and following the generally accepted criteria.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76599758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Minipuberty occurs during the first months of life after the activation of the hypothalamic-pituitary-gonadal axis which causes an increase in gonadotropic and sex hormones. Usually, it does not induce clinically evident physical changes. Studies have shown that minipuberty in extremely premature infants is more pronounced and lasts longer, leading to higher levels of sex hormones induce climically evident in physical changes. Case Report. We present two extremely premature female infants, born at 25 weeks of gestation, with clinically evident physical changes during minipuberty. The first infant presented with vaginal bleeding at the age of 4 months, corrected age of 2 weeks. The vaginal bleeding lasted for two days and stopped spontaneously. The infant also had small glandular breast buds of 1 cm bilaterally, swelling in the pubic region, swollen vulva and clitoris. The second infant presented with swelling in the genital region, suprapubic area and the anterior part of thighs, at the age of 4 months, corrected age of 2 weeks. Both infants had ovarian cysts. In both cases, laboratory tests were consistent with minipuberty. The described changes disappeared gradually and spontaneously. Conclusion. In order to avoid unnecessary testing, clinicians should be aware of possible physical changes during minipuberty in extremely premature infants. Clinical monitoring of these infants is recommended until regression of newly developed physical characteristics.
{"title":"Minipuberty in extremely premature female infants: A report of two cases","authors":"Djurdjina Stankovic, Ivana Vorgučin","doi":"10.2298/mpns2202067s","DOIUrl":"https://doi.org/10.2298/mpns2202067s","url":null,"abstract":"Introduction. Minipuberty occurs during the first months of life after the activation of the hypothalamic-pituitary-gonadal axis which causes an increase in gonadotropic and sex hormones. Usually, it does not induce clinically evident physical changes. Studies have shown that minipuberty in extremely premature infants is more pronounced and lasts longer, leading to higher levels of sex hormones induce climically evident in physical changes. Case Report. We present two extremely premature female infants, born at 25 weeks of gestation, with clinically evident physical changes during minipuberty. The first infant presented with vaginal bleeding at the age of 4 months, corrected age of 2 weeks. The vaginal bleeding lasted for two days and stopped spontaneously. The infant also had small glandular breast buds of 1 cm bilaterally, swelling in the pubic region, swollen vulva and clitoris. The second infant presented with swelling in the genital region, suprapubic area and the anterior part of thighs, at the age of 4 months, corrected age of 2 weeks. Both infants had ovarian cysts. In both cases, laboratory tests were consistent with minipuberty. The described changes disappeared gradually and spontaneously. Conclusion. In order to avoid unnecessary testing, clinicians should be aware of possible physical changes during minipuberty in extremely premature infants. Clinical monitoring of these infants is recommended until regression of newly developed physical characteristics.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76787944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Suvajdžić-Vuković, M. Mitrović, M. Virijević, A. Vidović, Z. Cvetković
Introduction. Acute myeloid leukemia is a rare malignancy with an average age of 70 years at diagnosis. Until recently, five-year survival of younger patients with this disease, despite being treated with allogenic hematopoietic stem cell transplantation, was < 30%, while in patients older than 60 years it was < 10%. Treatment overview. Due to the heterogeneity of acute myeloid leukemia no new drugs for treating this disease have been introduced for decades. The introduction of new drugs began from 2017: midostaurin, gilteritinib, CPX351, enasidenib, ivosidenib, venetoclax, glasdegib, while gemtuzumab ozogamicin has been reintroduced. Modern treatment strategies require an individual approach, based on prognostic parameters such as cytogenetical and molecular profile of acute myeloid leukemia at diagnosis and the assessment of minimal residual disease evaluated after two cycles of chemotherapy. Moreover, determining the eligibility of patients for ??intensive?? treatment, based on functional status, comorbidities and geriatric assessment of older patients, is necessary. Regarding the treatment of acute promyelocytic leukemia, the combination of arsenic trioxide and all-trans retinoic acid is universally accepted as the standard of care for non-high risk patients (WBC < 10x109/L), while standard chemotherapy combined with all-trans retinoic acid is still used for high-risk patients (WBC >10x109/L). Conclusion. Novel therapeutic modalities, along with allo-HSCT have changed the outcome of AML patients. However, treating patients unfit for intensive chemotherapy, as well as patients with relapse/refractory disease, is still challenging.
{"title":"Current strategies for the treatment of acute myeloid leukemia","authors":"N. Suvajdžić-Vuković, M. Mitrović, M. Virijević, A. Vidović, Z. Cvetković","doi":"10.2298/mpns22s1011s","DOIUrl":"https://doi.org/10.2298/mpns22s1011s","url":null,"abstract":"Introduction. Acute myeloid leukemia is a rare malignancy with an average age of 70 years at diagnosis. Until recently, five-year survival of younger patients with this disease, despite being treated with allogenic hematopoietic stem cell transplantation, was < 30%, while in patients older than 60 years it was < 10%. Treatment overview. Due to the heterogeneity of acute myeloid leukemia no new drugs for treating this disease have been introduced for decades. The introduction of new drugs began from 2017: midostaurin, gilteritinib, CPX351, enasidenib, ivosidenib, venetoclax, glasdegib, while gemtuzumab ozogamicin has been reintroduced. Modern treatment strategies require an individual approach, based on prognostic parameters such as cytogenetical and molecular profile of acute myeloid leukemia at diagnosis and the assessment of minimal residual disease evaluated after two cycles of chemotherapy. Moreover, determining the eligibility of patients for ??intensive?? treatment, based on functional status, comorbidities and geriatric assessment of older patients, is necessary. Regarding the treatment of acute promyelocytic leukemia, the combination of arsenic trioxide and all-trans retinoic acid is universally accepted as the standard of care for non-high risk patients (WBC < 10x109/L), while standard chemotherapy combined with all-trans retinoic acid is still used for high-risk patients (WBC >10x109/L). Conclusion. Novel therapeutic modalities, along with allo-HSCT have changed the outcome of AML patients. However, treating patients unfit for intensive chemotherapy, as well as patients with relapse/refractory disease, is still challenging.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82668883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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