{"title":"Proceedings of the 16th European Bioenergetics Conference, 17-22 July 2010, Warsaw, Poland.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1797 6-7","pages":"577-1341"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29585741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings of biomolecular dynamics and protein-water interactions-a neutron scattering workshop. September 2008. Feldafing, Germany.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"3-241"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28755353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Notch signaling is an evolutionarily conserved mechanism that determines cell fate in a variety of contexts during development. This is achieved through different modes of action that are context dependent. One mode involves boundary formation between two groups of cells. With this mode of action, Notch signaling is central to vertebrate evolution as it drives the segmentation of paraxial mesoderm in the formation of somites, which are the precursors of the vertebra. In this case, boundary formation facilitates a mesenchymal to epithelial transition, leading to the creation of a somite. In addition, the boundary establishes a signaling center that patterns the somite, a feature that directly impacts on vertebral column formation. Studies in Xenopus, zebrafish, chicken and mouse have established the importance of Notch signaling in somitogenesis, and indeed in mouse how perturbations in somitogenesis affect vertebral column formation. Spondylocostal dysostosis is a congenital disorder characterized by formation of abnormal vertebrae. Here, mutation in Notch pathway genes demonstrates that Notch signaling is also required for normal somite formation and vertebral column development in humans; of particular interest here is mutation of the LUNATIC FRINGE (LFNG) gene, which causes SCD type 3. LUNATIC FRINGE encodes for a fucose-specific beta1,3-N-acetylglucosaminyltransferase, which modifies Notch receptors and alters Notch signaling activity. This review will focus on Notch glycolsylation, and the role of LUNATIC FRINGE in somite formation and vertebral column development in mice and humans.
Notch信号是一种进化保守的机制，在发育过程中的各种情况下决定细胞的命运。这是通过依赖于上下文的不同动作模式来实现的。一种模式涉及两组细胞之间的边界形成。在这种作用模式下，Notch信号是脊椎动物进化的核心，因为它驱动体体形成的近轴中胚层的分割，体体是脊椎的前体。在这种情况下，边界的形成促进了间充质细胞向上皮细胞的转变，导致了体体的产生。此外，该边界还建立了一个信号中心，该信号中心对体体进行了标记，这是一个直接影响脊柱形成的特征。对非洲爪蟾、斑马鱼、鸡和小鼠的研究已经确定了Notch信号在躯体发生中的重要性，以及在小鼠体内，躯体发生的扰动如何影响脊柱的形成。脊椎骨发育不全是一种以异常椎骨形成为特征的先天性疾病。这里，Notch通路基因的突变表明Notch信号也是人类正常体形成和脊柱发育所必需的;这里特别令人感兴趣的是导致SCD 3型的LUNATIC FRINGE (LFNG)基因突变。LUNATIC FRINGE编码一种聚焦特异性β，3- n -乙酰氨基葡萄糖转移酶，该酶可修饰Notch受体并改变Notch信号活性。本文将重点讨论Notch糖基化，以及LUNATIC FRINGE在小鼠和人类体形成和脊柱发育中的作用。
{"title":"Reprint of mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine.","authors":"Sally L Dunwoodie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Notch signaling is an evolutionarily conserved mechanism that determines cell fate in a variety of contexts during development. This is achieved through different modes of action that are context dependent. One mode involves boundary formation between two groups of cells. With this mode of action, Notch signaling is central to vertebrate evolution as it drives the segmentation of paraxial mesoderm in the formation of somites, which are the precursors of the vertebra. In this case, boundary formation facilitates a mesenchymal to epithelial transition, leading to the creation of a somite. In addition, the boundary establishes a signaling center that patterns the somite, a feature that directly impacts on vertebral column formation. Studies in Xenopus, zebrafish, chicken and mouse have established the importance of Notch signaling in somitogenesis, and indeed in mouse how perturbations in somitogenesis affect vertebral column formation. Spondylocostal dysostosis is a congenital disorder characterized by formation of abnormal vertebrae. Here, mutation in Notch pathway genes demonstrates that Notch signaling is also required for normal somite formation and vertebral column development in humans; of particular interest here is mutation of the LUNATIC FRINGE (LFNG) gene, which causes SCD type 3. LUNATIC FRINGE encodes for a fucose-specific beta1,3-N-acetylglucosaminyltransferase, which modifies Notch receptors and alters Notch signaling activity. This review will focus on Notch glycolsylation, and the role of LUNATIC FRINGE in somite formation and vertebral column development in mice and humans.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1792 9","pages":"862-73"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28496037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-11-24DOI: 10.1016/j.bbagen.2008.11.003
S Prasanna Kumar, G Thippeswamy, Bharathi P Salimath
This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause.
{"title":"WITHDRAWN: Anti-tumor and proapoptotic effect of withaferin A is mediated by up-regulation of Bax and inhibition NF-kappaB in Ehrlich ascites tumor cells.","authors":"S Prasanna Kumar, G Thippeswamy, Bharathi P Salimath","doi":"10.1016/j.bbagen.2008.11.003","DOIUrl":"10.1016/j.bbagen.2008.11.003","url":null,"abstract":"<p><p>This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2008-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27900317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IPK'2007. Proceedings of the 5th International Conference Inhibitors of Protein Kinases and workshop session on novel molecular design and simulation methods, Warsaw, Poland, June 23-27, 2007.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1784 1","pages":"1-258"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27341858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-15DOI: 10.1016/j.bbagrm.2007.10.001
Zhi-Xin Qiao, Bo Huang, Jin-Yuan Liu
The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem.Biophys.Acta, doi:10.1016/j.bbagrm.2007.10.003. The duplicate article has therefore been withdrawn.
{"title":"WITHDRAWN: Molecular cloning and functional analysis of an ERFgene from cotton(Gossypiumhirsutum).","authors":"Zhi-Xin Qiao, Bo Huang, Jin-Yuan Liu","doi":"10.1016/j.bbagrm.2007.10.001","DOIUrl":"10.1016/j.bbagrm.2007.10.001","url":null,"abstract":"<p><p>The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem.Biophys.Acta, doi:10.1016/j.bbagrm.2007.10.003. The duplicate article has therefore been withdrawn.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2007-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27827066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-10-16DOI: 10.1016/j.bbaexp.2007.09.006
Satoko Asai, Akiko Yamaki, Jun Kudoh, Nobuyoshi Shimizu, Yoshiko Shimizu
The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem. Biophys. Acta, doi:10.1016/j.bbagrm.2007.09.005. The duplicate article has therefore been withdrawn.
{"title":"WITHDRAWN: Analysis of the promoter region of human placenta-specific DSCR4 gene.","authors":"Satoko Asai, Akiko Yamaki, Jun Kudoh, Nobuyoshi Shimizu, Yoshiko Shimizu","doi":"10.1016/j.bbaexp.2007.09.006","DOIUrl":"10.1016/j.bbaexp.2007.09.006","url":null,"abstract":"<p><p>The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem. Biophys. Acta, doi:10.1016/j.bbagrm.2007.09.005. The duplicate article has therefore been withdrawn.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2007-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41013696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-10-12DOI: 10.1016/j.bbabio.2004.03.002
Petr Paucek, Martin Jaburek
The publisher regrets that this article is an accidental duplication of an article that has already been published in Biochim. Biophys. Acta, 1659 (2004) 83-91, doi:10.1016/j.bbabio.2004.03.019. The duplicate article has therefore been withdrawn.
{"title":"WITHDRAWN: Kinetics and ion specificity of Na(+)/Ca(2+) exchange mediated by the reconstituted beef heart mitochondrial Na(+)/Ca(2+) antiporter.","authors":"Petr Paucek, Martin Jaburek","doi":"10.1016/j.bbabio.2004.03.002","DOIUrl":"10.1016/j.bbabio.2004.03.002","url":null,"abstract":"<p><p>The publisher regrets that this article is an accidental duplication of an article that has already been published in Biochim. Biophys. Acta, 1659 (2004) 83-91, doi:10.1016/j.bbabio.2004.03.019. The duplicate article has therefore been withdrawn.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2007-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27837540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-10-12DOI: 10.1016/j.bbaexp.2007.10.001
T Lukusa, J P Fryns
The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem. Biophys. Acta, doi:10.1016/j.bbagrm.2007.10.005. The duplicate article has therefore been withdrawn.
{"title":"WITHDRAWN: Human chromosome fragility.","authors":"T Lukusa, J P Fryns","doi":"10.1016/j.bbaexp.2007.10.001","DOIUrl":"10.1016/j.bbaexp.2007.10.001","url":null,"abstract":"<p><p>The Publisher regrets that this article is an accidental duplication of an article that has already been published in Biochem. Biophys. Acta, doi:10.1016/j.bbagrm.2007.10.005. The duplicate article has therefore been withdrawn.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2007-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41009474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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