Pub Date : 2005-03-31DOI: 10.2174/1568013053586496
K. Hartil, R. Weldon, Y. Seki, M. J. Charron
{"title":"The GLUTs Family - Lessons from Transgenic Mice","authors":"K. Hartil, R. Weldon, Y. Seki, M. J. Charron","doi":"10.2174/1568013053586496","DOIUrl":"https://doi.org/10.2174/1568013053586496","url":null,"abstract":"","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"104 1","pages":"189-206"},"PeriodicalIF":0.0,"publicationDate":"2005-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053586496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67898966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-01-31DOI: 10.2174/1568013053005445
G. B. Gomez, F. Cappuccio
{"title":"Dietary Salt and Disease Prevention: A Global Perspective","authors":"G. B. Gomez, F. Cappuccio","doi":"10.2174/1568013053005445","DOIUrl":"https://doi.org/10.2174/1568013053005445","url":null,"abstract":"","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-01-31DOI: 10.2174/1568013053005409
R. Kharbanda, R. Macallister
Atherosclerosis remains a major cause of morbidity and mortality worldwide. Conventional risk factors do not completely account for the development of atherosclerosis and its complications. Accumulating data suggest that endothelial dysfunction has independent prognostic implications. It has been implicated in the initiation of atherosclerosis, the precipitation of acute ischaemia, and the determination of the extent of injury following such complications. Atherosclerosis develops as a consequence of lipid accumulation in the vessel wall, a co-existent inflammatory response and proliferation of smooth muscle cells; endothelial dysfunction can be added to this pathogenic triad. The endothelium regulates numerous blood vessel functions, including vascular tone, cell adhesiveness, and coagulation through the production of mediators. The best characterized of these are the vasodilators, nitric oxide (NO), prostacyclin, and endothelium derived hyperpolarising factor (EDHF), and the vasoconstrictors thromboxane and endothelin. Endothelial dysfunction may encourage the adhesion and transmigration of monocytes and platelets to initiate and promote atherosclerosis. In addition, endothelial dysfunction may precipitate the acute complications of atherosclerosis through vasospasm and thrombosis, and may be a determinant of the transition from stable chronic atherosclerosis, to the development of acute coronary syndromes. Understanding of the biology of the endothelium in atherosclerosis may lead to novel therapies that will retard its progression, and reduce the incidence or consequences of acute complications.
{"title":"The Atherosclerosis Time-Line and the Role of the Endothelium","authors":"R. Kharbanda, R. Macallister","doi":"10.2174/1568013053005409","DOIUrl":"https://doi.org/10.2174/1568013053005409","url":null,"abstract":"Atherosclerosis remains a major cause of morbidity and mortality worldwide. Conventional risk factors do not completely account for the development of atherosclerosis and its complications. Accumulating data suggest that endothelial dysfunction has independent prognostic implications. It has been implicated in the initiation of atherosclerosis, the precipitation of acute ischaemia, and the determination of the extent of injury following such complications. Atherosclerosis develops as a consequence of lipid accumulation in the vessel wall, a co-existent inflammatory response and proliferation of smooth muscle cells; endothelial dysfunction can be added to this pathogenic triad. The endothelium regulates numerous blood vessel functions, including vascular tone, cell adhesiveness, and coagulation through the production of mediators. The best characterized of these are the vasodilators, nitric oxide (NO), prostacyclin, and endothelium derived hyperpolarising factor (EDHF), and the vasoconstrictors thromboxane and endothelin. Endothelial dysfunction may encourage the adhesion and transmigration of monocytes and platelets to initiate and promote atherosclerosis. In addition, endothelial dysfunction may precipitate the acute complications of atherosclerosis through vasospasm and thrombosis, and may be a determinant of the transition from stable chronic atherosclerosis, to the development of acute coronary syndromes. Understanding of the biology of the endothelium in atherosclerosis may lead to novel therapies that will retard its progression, and reduce the incidence or consequences of acute complications.","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-01-31DOI: 10.2174/1568013053005508
E. Vasilopoulou, K. Georga, M. Joergensen, A. Naska, A. Trichopoulou
The Mediterranean diet is currently attracting interest because of its health benefits that may be due, in part, to the high content of this diet in antioxidant phytochemicals. The variety and amount of phytochemical s taken with the consumption of primary and composite foods of the Mediterranean diet may provide better antiatherogenic properties than single phytochemicals. Flavonoids are the most important group of plant antioxidants. The Mediterranean diet is characterized by high intake of olive oil, fruit, vegetables, cereals, and legumes, some of which are good sources of flavonoids. Flavonoids consist of six principal classes: flavones, flavonols, flavan-3-ols, flavanones, anthocyanidins and isoflavones. The flavonoid intake from a traditional Greek plant-based weekly menu was calculated and the daily average flavonoid intake was found 118.6 mg/d, of which flavanones contribute 32% (38.5 mg/d), catechins (the most important group of flavan-3-ols) contribute 28% (32.7 mg/d), flavonols 22% (26.4 mg/d), anthocyanidins 9% (11 mg/d), flavones 8% (8.7 mg/d) and isoflavones contribute 1% (1.3 mg/d). Herbs and spices, which are commonly used in the traditional Greek cuisine, although added in small quantities, significantly contribute to the flavonol and flavone intake due to frequent consumption. The Greek version of the Mediterranean diet with its high consumption of fruit and vegetables is characterized by high intake of flavonoids in comparison to diets in northern European countries.
{"title":"The Antioxidant Properties of Greek Foods and the Flavonoid Content of the Mediterranean Menu","authors":"E. Vasilopoulou, K. Georga, M. Joergensen, A. Naska, A. Trichopoulou","doi":"10.2174/1568013053005508","DOIUrl":"https://doi.org/10.2174/1568013053005508","url":null,"abstract":"The Mediterranean diet is currently attracting interest because of its health benefits that may be due, in part, to the high content of this diet in antioxidant phytochemicals. The variety and amount of phytochemical s taken with the consumption of primary and composite foods of the Mediterranean diet may provide better antiatherogenic properties than single phytochemicals. Flavonoids are the most important group of plant antioxidants. The Mediterranean diet is characterized by high intake of olive oil, fruit, vegetables, cereals, and legumes, some of which are good sources of flavonoids. Flavonoids consist of six principal classes: flavones, flavonols, flavan-3-ols, flavanones, anthocyanidins and isoflavones. The flavonoid intake from a traditional Greek plant-based weekly menu was calculated and the daily average flavonoid intake was found 118.6 mg/d, of which flavanones contribute 32% (38.5 mg/d), catechins (the most important group of flavan-3-ols) contribute 28% (32.7 mg/d), flavonols 22% (26.4 mg/d), anthocyanidins 9% (11 mg/d), flavones 8% (8.7 mg/d) and isoflavones contribute 1% (1.3 mg/d). Herbs and spices, which are commonly used in the traditional Greek cuisine, although added in small quantities, significantly contribute to the flavonol and flavone intake due to frequent consumption. The Greek version of the Mediterranean diet with its high consumption of fruit and vegetables is characterized by high intake of flavonoids in comparison to diets in northern European countries.","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-01-31DOI: 10.2174/1568013053005517
E. Giovannucci
{"title":"The Role of Insulin Resistance and Hyperinsulinemia in Cancer Causation","authors":"E. Giovannucci","doi":"10.2174/1568013053005517","DOIUrl":"https://doi.org/10.2174/1568013053005517","url":null,"abstract":"","PeriodicalId":88234,"journal":{"name":"Current medicinal chemistry. Immunology, endocrine & metabolic agents","volume":"5 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568013053005517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67897794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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