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Five-year Pan-European, longitudinal surveillance of Clostridium difficile ribotype prevalence and antimicrobial resistance: the extended ClosER study. 对艰难梭菌核型流行率和抗菌药耐药性进行为期五年的泛欧纵向监测:扩展的 ClosER 研究。
IF 3.7 Pub Date : 2020-01-01 Epub Date: 2019-12-07 DOI: 10.1007/s10096-019-03708-7
Jane Freeman, Jonathan Vernon, Sally Pilling, Kirsti Morris, Scott Nicolson, Sharie Shearman, Emma Clark, Jose Alejandro Palacios-Fabrega, Mark Wilcox

Clostridium difficile infection (CDI) has been primarily treated with metronidazole or vancomycin. High recurrence rates, the emergence of epidemic PCR ribotypes (RTs) and the introduction of fidaxomicin in Europe in 2011 necessitate surveillance of antimicrobial resistance and CDI epidemiology. The ClosER study monitored antimicrobial susceptibility and geographical distribution of C. difficile RTs pre- and post-fidaxomicin introduction. From 2011 to 2016, 28 European countries submitted isolates or faecal samples for determination of PCR ribotype, toxin status and minimal inhibitory concentrations (MICs) of metronidazole, vancomycin, rifampicin, fidaxomicin, moxifloxacin, clindamycin, imipenem, chloramphenicol and tigecycline. RT diversity scores for each country were calculated and mean MIC results used to generate cumulative resistant scores (CRSs) for each isolate and country. From 40 sites, 3499 isolates were analysed, of which 95% (3338/3499) were toxin positive. The most common of the 264 RTs isolated was RT027 (mean prevalence 11.4%); however, RT prevalence varied greatly between countries and between years. The fidaxomicin geometric mean MIC for years 1-5 was 0.04 mg/L; only one fidaxomicin-resistant isolate (RT344) was submitted (MIC ≥ 4 mg/L). Metronidazole and vancomycin geometric mean MICs were 0.46 mg/L and 0.70 mg/L, respectively. Of prevalent RTs, RT027, RT017 and RT012 demonstrated resistance or reduced susceptibility to multiple antimicrobials. RT diversity was inversely correlated with mean CRS for individual countries (Pearson coefficient r = - 0.57). Overall, C. difficile RT prevalence remained stable in 2011-2016. Fidaxomicin susceptibility, including in RT027, was maintained post-introduction. Reduced ribotype diversity in individual countries was associated with increased antimicrobial resistance.

艰难梭菌感染(CDI)主要采用甲硝唑或万古霉素治疗。高复发率、流行性 PCR 核型(RT)的出现以及 2011 年菲达霉素在欧洲的引入,使得有必要对抗菌药耐药性和 CDI 流行病学进行监测。ClosER研究对引入菲达霉素前后艰难梭菌RT的抗菌药敏感性和地理分布进行了监测。从2011年到2016年,28个欧洲国家提交了分离物或粪便样本,用于确定甲硝唑、万古霉素、利福平、非达霉素、莫西沙星、克林霉素、亚胺培南、氯霉素和替加环素的PCR核型、毒素状态和最小抑菌浓度(MICs)。计算每个国家的 RT 多样性得分,并使用 MIC 平均值结果生成每个分离物和国家的耐药性累积得分(CRS)。对来自 40 个地点的 3499 个分离物进行了分析,其中 95% (3338/3499)为毒素阳性。在分离出的264种RT中,最常见的是RT027(平均流行率为11.4%);然而,不同国家和不同年份的RT流行率差异很大。第 1-5 年的非达霉素几何平均 MIC 值为 0.04 mg/L;仅提交了一个耐非达霉素的分离物(RT344)(MIC 值≥ 4 mg/L)。甲硝唑和万古霉素的几何平均 MIC 分别为 0.46 mg/L 和 0.70 mg/L。在普遍存在的 RT 中,RT027、RT017 和 RT012 对多种抗菌药物具有耐药性或敏感性降低。RT 多样性与各个国家的平均 CRS 成反比(皮尔逊系数 r = - 0.57)。总体而言,艰难梭菌 RT 的流行率在 2011-2016 年间保持稳定。对菲达霉素(包括 RT027)的敏感性在引入后保持不变。个别国家核型多样性的减少与抗菌药耐药性的增加有关。
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引用次数: 0
Bringing television back to the bedroom: Transactions between a seventh grade struggling reader and her mathematics teacher 把电视带回到卧室:一个七年级吃力的读者和她的数学老师之间的对话
Pub Date : 2007-06-01 DOI: 10.1080/19388070709558473
L. Hall
Abstract This year long case study examined: (a) how a seventh‐grade struggling reader transacted with the reading task demands of her mathematics classroom and (b) how her teacher responded to her in regards to these reading task demands. The results suggest that struggling readers may engage in behaviors that are designed to help others construct specific beliefs about them as readers or students. Teachers may not be aware of the beliefs struggling readers are trying to promote about themselves. While content area teachers may draw on a number of strategies to help improve their students’ reading abilities, the results of this study suggest that such instruction, no mater how effective it is, may not be enough.
今年的案例研究考察了:(a)一位七年级的困难读者如何处理她的数学课堂的阅读任务要求,以及(b)她的老师如何回应她的这些阅读任务要求。研究结果表明,阅读困难的人可能会做出一些行为,旨在帮助他人建立对他们作为读者或学生的特定信念。老师们可能没有意识到苦苦挣扎的读者正在努力宣传自己的信念。虽然内容领域的教师可能会采用一些策略来帮助提高学生的阅读能力,但这项研究的结果表明,无论这种指导多么有效,都可能是不够的。
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引用次数: 5
“Kiss your brain”: A closer look at flourishing literacy gains in impoverished elementary schools “亲吻你的大脑”:近距离观察贫困小学蓬勃发展的识字率
Pub Date : 2007-06-01 DOI: 10.1080/19388070709558474
Keonya C. Booker, M. Invernizzi, Montana K. McCormick
Abstract This study uses a qualitative methodology to explore the instructional reading practices of high achieving/low‐income elementary schools. Extensive interviews and observations were conducted to examine the nature of literacy gains on a statewide reading assessment from fall to spring. Detailed cases studies of four exceptional schools are presented along with a discussion of implications for the field of reading instruction.
摘要本研究采用质性方法探讨高成就/低收入小学的教学阅读实践。通过广泛的访谈和观察,研究了从秋季到春季全州阅读评估中读写能力提高的性质。四所特殊学校的详细案例研究以及对阅读教学领域的影响的讨论。
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引用次数: 12
Becoming technologically literate through technology integration in PK‐12 preservice literacy courses: Three case studies 通过PK‐12职前扫盲课程中的技术整合来提高技术素养:三个案例研究
Pub Date : 2007-06-01 DOI: 10.1080/19388070709558476
Lois A. Groth, Kristy L. Dunlap, Julie K. Kidd
With an increased emphasis on incorporating technology-based instruction into K-12 classrooms and an expectation that teachers will use technology to support their teaching, teacher educators are continuously challenged to prepare K-12 teachers to use new and emerging technologies effectively for learning and teaching (Ross & Wiseman, 2001). Although some teacher educators are preparing teachers who have the knowledge and skills to integrate technology into their classrooms, research indicates that graduates are not adequately prepared to teach with technology (JohnsonGentile, Lonberger, Parana, & West, 2000; Strudler, Wetzel, Moursud, & Biefeldt, 1999). A study completed by the National Center for Education Statistics (2000) found that only one-third of the licensed classroom teachers who have computers or Internet access in their classrooms believed they were well prepared to use technology for instructional purposes. Ninetythree percent of those who felt well prepared attributed their confidence to independent learning. Lewis and Finders (2002) found that many new teachers, even those for whom the use of digital technologies was personally comfortable, found it difficult to assimilate classroom use of these tools into their conception of their role as teachers.
随着越来越强调将基于技术的教学纳入K-12课堂,以及教师将使用技术来支持他们的教学的期望,教师教育工作者不断面临挑战,使K-12教师能够有效地使用新兴技术进行学习和教学(Ross & Wiseman, 2001)。尽管一些教师教育工作者正在培养具有将技术融入课堂的知识和技能的教师,但研究表明,毕业生并没有为使用技术进行教学做好充分的准备(JohnsonGentile, Lonberger, Parana, & West, 2000;Strudler, Wetzel, Moursud, & Biefeldt, 1999)。一项由国家教育统计中心(2000)完成的研究发现,只有三分之一在教室里有电脑或互联网接入的有执照的课堂教师认为他们已经做好了充分的准备,可以将技术用于教学目的。百分之九十三觉得准备充分的学生将他们的自信归功于自主学习。Lewis和Finders(2002)发现,许多新教师,即使是那些对数字技术的使用个人来说很舒服的教师,也很难将这些工具的课堂使用融入到他们作为教师的角色概念中。
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引用次数: 40
“I talk them through it”: Teacher mediation of picturebooks with sparse verbal text during whole‐class readalouds “我把它讲完”:教师在课堂朗读中对绘本和稀疏的口头文本进行调解
Pub Date : 2007-06-01 DOI: 10.1080/19388070709558475
M. Ghiso, Caroline E. McGuire
Abstract Picturebook readalouds have been promoted as a rich resource for strengthening literacy development in young children and discussions of picturebooks have become a common ‐ if threatened — practice in the primary grades. One subset of the diverse body of children's literature teachers can draw from is picturebooks with sparse verbal text. Such picturebooks may place additional demands on both teacher and student during whole class readalouds, who in their responses must attend even more closely to the print that is there as well as to the illustrations and other visual features of the books. The present study explores the particular “affordances” (Gibson, 1950) of such texts and how one teacher maximizes these potentials as she orchestrates three readaloud experiences in an urban kindergarten classroom.
摘要:绘本朗读被认为是加强幼儿读写能力发展的丰富资源,对绘本的讨论在小学年级已经成为一种常见的——如果受到威胁的话——做法。在各种各样的儿童文学作品中,教师可以借鉴的一个子集是带有少量口头文本的绘本。这样的绘本可能会在整个课堂朗读中对教师和学生提出额外的要求,他们在回应时必须更加密切地关注书中的印刷、插图和其他视觉特征。本研究探讨了这些文本的特殊“启示”(Gibson, 1950),以及一位教师如何在城市幼儿园教室中编排三种朗读体验时最大限度地发挥这些潜力。
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引用次数: 13
Writing your first textbook 写你的第一本教科书
Pub Date : 2007-03-01 DOI: 10.1080/19388070709558470
N. Anderson
Abstract Writing and publishing a textbook for the first time is an arduous process. Potential authors are provided information on things they should, and should not, do to insure a more successful experience in writing their first textbook. Authors are provided information on decisions to be made and actions to be taken at the various stages of prewriting, developing a prospectus, selling the idea to a publisher, revising a prospectus, negotiating a contract, writing the first draft, revising the manuscript, final stages of production, promoting the book, and post‐publication efforts.
第一次编写和出版教科书是一个艰苦的过程。潜在的作者被告知他们应该做什么,不应该做什么,以确保他们在编写第一本教科书时获得更成功的经验。作者可以在写作前的各个阶段,制定招股说明书,向出版商出售想法,修改招股说明书,谈判合同,撰写初稿,修改手稿,制作的最后阶段,推广书籍和出版后的努力,做出决定和采取行动的信息。
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引用次数: 1
Preparing students for college‐level reading and writing: Implementing a rhetoric and writing class in the senior year 为学生准备大学水平的阅读和写作:在大四实施修辞和写作课程
Pub Date : 2007-03-01 DOI: 10.1080/19388070709558468
Barbara Moss, Suzanne Bordelon
Abstract This study investigated the instructional practices of three high school teachers perceived as successful in implementing a new rhetoric and writing course in an ethnically diverse high school district in the Southwest United States. Using qualitative research methods over a three‐month period, researchers examined teacher practices related to the yearlong course, teachers’ perceptions of the successes and challenges in applying the curriculum, and the impact of the curriculum on teachers and students. Through an analysis of field notes, structured interviews, a pilot survey, and course‐related documents, researchers found that the class provided important bridging opportunities aimed at preparing students for college‐level reading and writing. The curriculum also emphasized direct, explicit instruction, which several scholars contend benefits linguistically and culturally diverse students. In addition, course creators offered weekly staff‐development sessions that supported teachers in implementing the new curriculum. Areas of challenge that emerged included the course pacing, reading selections, and the focus on writing and revising.
摘要本研究调查了美国西南部一个多种族高中区的三名高中教师的教学实践,他们被认为是成功地实施了一门新的修辞和写作课程。在三个月的时间里,研究人员使用定性研究方法,调查了与一年课程相关的教师实践,教师对应用课程的成功和挑战的看法,以及课程对教师和学生的影响。通过对实地记录、结构化访谈、试点调查和课程相关文件的分析,研究人员发现,该课程为学生准备大学水平的阅读和写作提供了重要的桥梁机会。该课程还强调直接、明确的教学,一些学者认为这有利于语言和文化多样化的学生。此外,课程创建者每周提供员工发展会议,以支持教师实施新课程。出现的挑战领域包括课程节奏,阅读选择,以及对写作和修改的关注。
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引用次数: 23
Promise and Possibility ‐ Hope for Teacher Education: Pre‐service Literacy Instruction Can Have an Impact 教师教育的承诺和可能性-希望:职前扫盲教学可以产生影响
Pub Date : 2007-03-01 DOI: 10.1080/19388070709558469
D. Shaw, M. Dvorak, K. Bates
Abstract The purpose of this study was to identify the literacy knowledge, beliefs and self‐efficacy of 52 undergraduate elementary pre‐service teachers prior to and at the conclusion of a reading methods course. The teacher candidates completed the Theoretical Orientation to Reading Profile (TORP, DeFord, 1985), the Teacher Self Efficacy Literacy Scale (TSELS, Johnson & Tschannen‐Moran, 2003) and an instructor‐made questionnaire. Quantitative results indicated the change of beliefs (TORP) and self‐efficacy (TSELS) were significant. Qualitative results indicated the novice teachers’ knowledge aligned with their beliefs. This study is important because our findings contradict the belief that teacher education has not generally been viewed as powerful enough to affect pre‐service teachers’ beliefs and views. Our findings show the teacher education program can be effective in changing student views. Implications for this study are addressed.
摘要本研究旨在了解52名本科小学职前教师在阅读方法课程前和课程结束时的读写知识、信念和自我效能感。教师候选人完成了阅读理论取向量表(TORP, DeFord, 1985)、教师自我效能素养量表(TSELS, Johnson & Tschannen - Moran, 2003)和教师问卷调查。定量结果显示信念改变(TORP)和自我效能感(TSELS)显著。定性结果表明,新教师的知识与信念一致。这项研究很重要,因为我们的发现与教师教育通常被认为不足以影响职前教师的信仰和观点的观点相矛盾。我们的研究结果表明,教师教育计划可以有效地改变学生的观点。讨论了本研究的意义。
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引用次数: 52
Phonemic awareness: When and how much to teach? 音位意识:何时教,教多少?
Pub Date : 2007-03-01 DOI: 10.1080/19388070709558471
S. Reading, Dana Van Deuren
Abstract Literacy skills of 1st grade children were assessed; one group received instruction in phonemic awareness in kindergarten, while one group did not. Both groups received phonemic awareness instruction during 1st grade. At the beginning of 1st grade, the group with early phonemic awareness training scored higher on phoneme segmentation and had fewer children identified for reading difficulties. By middle of 1st grade, literacy skills of children without the early training were comparable to skills of children with such training in kindergarten. Results suggest that learning phonemic awareness skills during 1st grade supports grade level reading, learning phonemic awareness skills can occur within a short time period, and learning these skills beyond a sufficient level does not necessarily result in improved oral reading fluency.
摘要对小学一年级儿童的读写能力进行了评价;一组在幼儿园接受了音位意识方面的指导,而另一组没有。两组在一年级时均接受音素意识指导。在一年级开始的时候,接受过早期音素意识训练的那一组在音素分割方面得分更高,并且发现有阅读困难的孩子更少。到一年级中期,未接受过早期训练的儿童的读写能力与在幼儿园接受过早期训练的儿童相当。结果表明,在一年级时学习音位意识技能有助于年级水平的阅读,学习音位意识技能可以在短时间内发生,学习这些技能超过足够的水平并不一定会提高口语阅读的流畅性。
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引用次数: 38
Data‐driven professional development: The professional development plan for a reading excellence act school 数据驱动的专业发展:阅读卓越行为学校的专业发展计划
Pub Date : 2006-12-01 DOI: 10.1080/19388070709558463
Latisha Hayes, Valerie J. Robnolt
Abstract The purpose of this article is to describe the professional development plan for an elementary school receiving federal funding through the Reading Excellence Act (REA). The Reading Excellence Act provided the school with a two‐year plan for literacy improvement. During the first year of the grant, assessment‐driven instruction and flexible grouping for instruction were the focus of professional development. This article focuses on the professional development of the second year of the grant during which school‐based data provided the REA grant coordinator with instructional needs of the staff, and disaggregated data provided specific needs for each grade level. Based upon the analysis of student achievement data, professional development for kindergarten and first grade teachers focused on training in word study to improve phonics and spelling achievement. Professional development for second through fourth grade teachers focused on fluency instruction and comprehension instruction, including narrative and expository text structure.
摘要本文的目的是描述一所通过阅读卓越法案(REA)获得联邦资助的小学的专业发展计划。《优秀阅读法》为学校提供了一个提高读写能力的两年计划。在奖助金的第一年,评估导向的教学和灵活的教学分组是专业发展的重点。本文主要关注资助第二年的专业发展,在此期间,基于学校的数据为REA资助协调员提供了员工的教学需求,而分类数据则提供了每个年级的具体需求。基于对学生成绩数据的分析,幼儿园和一年级教师的专业发展重点放在单词学习训练上,以提高语音和拼写成绩。二至四年级教师的专业发展重点是流畅性教学和理解性教学,包括叙述和说明文的文本结构。
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引用次数: 24
期刊
Reading research and instruction : the journal of the College Reading Association
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