Pub Date : 2018-09-01DOI: 10.1142/S179304801850008X
K. Zioutas, Edward Valachovic
We present signature for planetary correlations following an analysis of monthly melanoma rates in USA for the period 1973–2011. Apart from seasonal observations, to the best of our knowledge, a planetary relationship in medicine is observed for the first time. The statistical significance is well above 5[Formula: see text], while various crosschecks make systematics highly improbable as the cause. The observed planetary dependence in physics was suggestive for this investigation, which extends the otherwise unexpected planetary connection. Thus, streaming invisible matter from the dark sector, whose flux can be occasionally enhanced towards the Earth via planetary gravitational focusing, and, even much stronger by the Sun, it may be the explanation for 1–10% of melanoma diagnoses. The derived shortest melanoma periodicity of about 87.5 days points in its own right at a short latency period of about few months. Contrariwise, the present findings strengthen the previous physics claim of streams of invisible matter.
{"title":"Planetary Dependence of Melanoma","authors":"K. Zioutas, Edward Valachovic","doi":"10.1142/S179304801850008X","DOIUrl":"https://doi.org/10.1142/S179304801850008X","url":null,"abstract":"We present signature for planetary correlations following an analysis of monthly melanoma rates in USA for the period 1973–2011. Apart from seasonal observations, to the best of our knowledge, a planetary relationship in medicine is observed for the first time. The statistical significance is well above 5[Formula: see text], while various crosschecks make systematics highly improbable as the cause. The observed planetary dependence in physics was suggestive for this investigation, which extends the otherwise unexpected planetary connection. Thus, streaming invisible matter from the dark sector, whose flux can be occasionally enhanced towards the Earth via planetary gravitational focusing, and, even much stronger by the Sun, it may be the explanation for 1–10% of melanoma diagnoses. The derived shortest melanoma periodicity of about 87.5 days points in its own right at a short latency period of about few months. Contrariwise, the present findings strengthen the previous physics claim of streams of invisible matter.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S179304801850008X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48670730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-01DOI: 10.1142/S1793048018500078
V. Zhdanov
The author presents theoretical mean-field analysis of the initial phase of the kinetics of intracellular replication of plus-stranded RNA viruses, which are abundant and include, e.g., the hepatitis C virus (HCV). The treatment is based on the conventional concept that the replication process of such viruses takes place at the membrane complexes formed with participation of viral proteins, e.g., NS5A in the HCV case. The key novel prediction supported by Monte Carlo calculations is that this scheme may be insufficient in order to describe the very initial phase of the process, because the initial intracellular viral RNA and protein populations may in this case go extinct rather than overcome the kinetic barrier for transition to the full-scale infection of a host cell. Practically, this means that in such situations, the conventional replication scenario should be complemented by another pathway, e.g., by replication outside the membrane without viral proteins, which operates in the very beginning.
{"title":"Initial Phase of Replication of Plus-Stranded RNA Viruses","authors":"V. Zhdanov","doi":"10.1142/S1793048018500078","DOIUrl":"https://doi.org/10.1142/S1793048018500078","url":null,"abstract":"The author presents theoretical mean-field analysis of the initial phase of the kinetics of intracellular replication of plus-stranded RNA viruses, which are abundant and include, e.g., the hepatitis C virus (HCV). The treatment is based on the conventional concept that the replication process of such viruses takes place at the membrane complexes formed with participation of viral proteins, e.g., NS5A in the HCV case. The key novel prediction supported by Monte Carlo calculations is that this scheme may be insufficient in order to describe the very initial phase of the process, because the initial intracellular viral RNA and protein populations may in this case go extinct rather than overcome the kinetic barrier for transition to the full-scale infection of a host cell. Practically, this means that in such situations, the conventional replication scenario should be complemented by another pathway, e.g., by replication outside the membrane without viral proteins, which operates in the very beginning.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43789931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.1142/S1793048018500054
A. Ayadi, W. Sahtout, O. Balédent
Local wave speed plays an interesting role in investigating cardiovascular diseases and arterial wall stiffness. The aim of this study was to implement a novel method based on cepstral analysis for noninvasive determination of local wave speed in the carotid artery. To show the precision of the proposed method, we specially focused on the effect of age. In addition, we intended to compare the obtained results to those obtained by the foot-to-foot method. Our method consists in measuring the instantaneous blood velocity in the internal carotid by using phase-contrast magnetic resonance imaging in 20 healthy subjects distributed as follows: 10 young subjects aged between 22 and 41 years, and 10 old subjects aged between 50 and 86 years. The cepstral analysis was used to determine the arrival time of the reflection wave and the wave speed in the carotid artery. A statistical test analysis was conducted in order to establish the relation between the wave speed and the age in the sample under investigation. Our main finding was that there was a high significant difference between the two groups forming the studied sample ([Formula: see text]). In terms of the internal carotid arterial branch, our experimental results were in total agreement with reference values by the invasive method reported in the literature. Moreover, the wave speed detected using our method correlated with that detected using foot-to-foot analysis ([Formula: see text], [Formula: see text]). We can conclude that the new technique described in this paper offers a promising, convenient and efficient method to measure wave speed noninvasively.
{"title":"A New Noninvasive Method for Determining the Local (True) Wave Speed: Application to Internal Carotid Artery","authors":"A. Ayadi, W. Sahtout, O. Balédent","doi":"10.1142/S1793048018500054","DOIUrl":"https://doi.org/10.1142/S1793048018500054","url":null,"abstract":"Local wave speed plays an interesting role in investigating cardiovascular diseases and arterial wall stiffness. The aim of this study was to implement a novel method based on cepstral analysis for noninvasive determination of local wave speed in the carotid artery. To show the precision of the proposed method, we specially focused on the effect of age. In addition, we intended to compare the obtained results to those obtained by the foot-to-foot method. Our method consists in measuring the instantaneous blood velocity in the internal carotid by using phase-contrast magnetic resonance imaging in 20 healthy subjects distributed as follows: 10 young subjects aged between 22 and 41 years, and 10 old subjects aged between 50 and 86 years. The cepstral analysis was used to determine the arrival time of the reflection wave and the wave speed in the carotid artery. A statistical test analysis was conducted in order to establish the relation between the wave speed and the age in the sample under investigation. Our main finding was that there was a high significant difference between the two groups forming the studied sample ([Formula: see text]). In terms of the internal carotid arterial branch, our experimental results were in total agreement with reference values by the invasive method reported in the literature. Moreover, the wave speed detected using our method correlated with that detected using foot-to-foot analysis ([Formula: see text], [Formula: see text]). We can conclude that the new technique described in this paper offers a promising, convenient and efficient method to measure wave speed noninvasively.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44568590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-21DOI: 10.1142/S1793048018500042
Anjana P. Das, M. Pal
In this paper, we propose and analyze a Susceptible-Vaccinated-Exposed-Infected-Recovered (SVEIR) type infectious disease model with imprecise parameters. Introducing the interval numbers in functional form, the SVEIR model is proposed and formulated. The existence of possible equilibrium points with their feasibility criteria and an explicit value of basic reproduction number is obtained. The asymptotic stability of the system at different equilibrium points are also discussed. Next by considering treatment and vaccination as two control parameters, an optimal control problem is formulated and solved. Finally, some computer simulation works are given in support of our analytical results.
{"title":"Modeling and Analysis of an Imprecise Epidemic System with Optimal Treatment and Vaccination Control","authors":"Anjana P. Das, M. Pal","doi":"10.1142/S1793048018500042","DOIUrl":"https://doi.org/10.1142/S1793048018500042","url":null,"abstract":"In this paper, we propose and analyze a Susceptible-Vaccinated-Exposed-Infected-Recovered (SVEIR) type infectious disease model with imprecise parameters. Introducing the interval numbers in functional form, the SVEIR model is proposed and formulated. The existence of possible equilibrium points with their feasibility criteria and an explicit value of basic reproduction number is obtained. The asymptotic stability of the system at different equilibrium points are also discussed. Next by considering treatment and vaccination as two control parameters, an optimal control problem is formulated and solved. Finally, some computer simulation works are given in support of our analytical results.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46033916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-15DOI: 10.1142/S1793048018500030
M. Parsadanyan, A. Antonyan, P. O. Vardevanyan, Hakob Sngryan
The interaction of methylene blue (MB) with poly(dA)-poly(dT) has been studied. It was revealed that MB binds to this polynucleotide by strong and weak modes. It was shown that the strong binding m...
{"title":"Interaction of Methylene Blue with Synthetic Polynucleotide Poly(dA)-Poly(dT)","authors":"M. Parsadanyan, A. Antonyan, P. O. Vardevanyan, Hakob Sngryan","doi":"10.1142/S1793048018500030","DOIUrl":"https://doi.org/10.1142/S1793048018500030","url":null,"abstract":"The interaction of methylene blue (MB) with poly(dA)-poly(dT) has been studied. It was revealed that MB binds to this polynucleotide by strong and weak modes. It was shown that the strong binding m...","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"13 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2018-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48380727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-15DOI: 10.1142/S1793048018500017
S. Nandi, Soovoojeet Jana, Manotosh Mandal, T. K. Kar
In this paper, we proposed and analyzed a susceptible-infected-recovered (SIR) type epidemic model to investigate the effect of transport-related infectious diseases namely tuberculosis, measles, r...
{"title":"Mathematical Analysis of an Epidemic System in the Presence of Optimal Control and Population Dispersal","authors":"S. Nandi, Soovoojeet Jana, Manotosh Mandal, T. K. Kar","doi":"10.1142/S1793048018500017","DOIUrl":"https://doi.org/10.1142/S1793048018500017","url":null,"abstract":"In this paper, we proposed and analyzed a susceptible-infected-recovered (SIR) type epidemic model to investigate the effect of transport-related infectious diseases namely tuberculosis, measles, r...","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"13 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2018-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43575928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-27DOI: 10.1142/S1793048018500029
D. H. Margarit, L. Romanelli, A. Fendrik
A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell differentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells (DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken into account. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.
{"title":"A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity","authors":"D. H. Margarit, L. Romanelli, A. Fendrik","doi":"10.1142/S1793048018500029","DOIUrl":"https://doi.org/10.1142/S1793048018500029","url":null,"abstract":"A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell differentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells (DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken into account. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"13 1","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2018-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048018500029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43858819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-17DOI: 10.1142/S1793048017500114
S. Khajanchi
This paper describes the synergistic interaction between the growth of malignant gliomas and the immune system interactions using a system of coupled ordinary differential equations (ODEs). The pro...
本文用耦合常微分方程系统描述了恶性胶质瘤生长与免疫系统相互作用之间的协同作用。亲……
{"title":"Uniform Persistence and Global Stability for a Brain Tumor and Immune System Interaction","authors":"S. Khajanchi","doi":"10.1142/S1793048017500114","DOIUrl":"https://doi.org/10.1142/S1793048017500114","url":null,"abstract":"This paper describes the synergistic interaction between the growth of malignant gliomas and the immune system interactions using a system of coupled ordinary differential equations (ODEs). The pro...","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"187-208"},"PeriodicalIF":0.0,"publicationDate":"2017-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46130664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-01DOI: 10.1142/S1793048017500096
Y. Babayan, S. Hakobyan, R. S. Ghazaryan, M. Shahinyan
The interaction of antitumor drug mitoxantrone (MTX) with double-stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-Visible absorption, circular dichroism) technique...
{"title":"Interaction of Antitumor Agent Mitoxantrone with Double Helical Synthetic Polyribonucleotides Poly(G)⋅Poly(C) and Poly(I)⋅Poly(C)","authors":"Y. Babayan, S. Hakobyan, R. S. Ghazaryan, M. Shahinyan","doi":"10.1142/S1793048017500096","DOIUrl":"https://doi.org/10.1142/S1793048017500096","url":null,"abstract":"The interaction of antitumor drug mitoxantrone (MTX) with double-stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-Visible absorption, circular dichroism) technique...","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"165-176"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47233947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-01DOI: 10.1142/S1793048017500102
S. Masood
Effects of weak magnetic fields are observed on the growth of various bacterial strains. Different sources of a constant magnetic field are used to demonstrate that ion transport in the nutrient br...
观察了弱磁场对不同菌株生长的影响。恒定磁场的不同来源被用来证明离子在营养物中的传输。
{"title":"Effect of Weak Magnetic Field on Bacterial Growth","authors":"S. Masood","doi":"10.1142/S1793048017500102","DOIUrl":"https://doi.org/10.1142/S1793048017500102","url":null,"abstract":"Effects of weak magnetic fields are observed on the growth of various bacterial strains. Different sources of a constant magnetic field are used to demonstrate that ion transport in the nutrient br...","PeriodicalId":88835,"journal":{"name":"Biophysical reviews and letters","volume":"12 1","pages":"177-186"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793048017500102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43632066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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