Pub Date : 2011-03-24DOI: 10.2174/1874827901104010001
A. Gonçalves, Yara Regina Bianchini Ávalos, E. Chen, Bianca Borsatto-Galera, R. D. Lábio, S. Payão, M. Arruda, T. Sandoval
Objective: We aimed to investigate whether rRNA 28S/18S levels decrease with aging in Down Syndrome (DS) individuals and whether these decreased levels are tissue-specific. Methods: We investigated mature rRNA 28S/18S levels by Northern Blotting in blood cells from 21 younger and 21 older DS individuals in comparison to 42 age-sex-matched controls. We also investigated these levels in oral mucosa and in blood cells from the same DS individuals. Results: All DS subjects showed no clinical signs of dementia at the time of the study. We did not detect differences in rRNA 28S/18S levels among DS and control groups concerning either aging process or cell types. Conclusions: Aging process in DS individuals was not characterized by reduced rDNA transcriptional activity and did not indicate a preclinical marker of AD in older DS subjects.
{"title":"Ribosomal Genes Activity in Aged Down Syndrome Subjects","authors":"A. Gonçalves, Yara Regina Bianchini Ávalos, E. Chen, Bianca Borsatto-Galera, R. D. Lábio, S. Payão, M. Arruda, T. Sandoval","doi":"10.2174/1874827901104010001","DOIUrl":"https://doi.org/10.2174/1874827901104010001","url":null,"abstract":"Objective: We aimed to investigate whether rRNA 28S/18S levels decrease with aging in Down Syndrome (DS) individuals and whether these decreased levels are tissue-specific. Methods: We investigated mature rRNA 28S/18S levels by Northern Blotting in blood cells from 21 younger and 21 older DS individuals in comparison to 42 age-sex-matched controls. We also investigated these levels in oral mucosa and in blood cells from the same DS individuals. Results: All DS subjects showed no clinical signs of dementia at the time of the study. We did not detect differences in rRNA 28S/18S levels among DS and control groups concerning either aging process or cell types. Conclusions: Aging process in DS individuals was not characterized by reduced rDNA transcriptional activity and did not indicate a preclinical marker of AD in older DS subjects.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"65 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2011-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68091979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-06DOI: 10.2174/1874827901003010017
N. Nishio, S. Ito, Haruhiko Suzuki, Y. Okawa, K. Isobe
Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITC- labeled anti-IgG1 in C57BL/6 mice. These bands were highest in 4 months old C57BL/6 mice. The sera taken from 2 months and 20 months old mice also bound to wounded tissues, although the bands were weaker than those of 4 months old mice. We also examined the autoreactive IgM binding to wounded tissues. We could detect relatively strong bands even in 2 M old mice. The pattern of these bands was changed by advancing age. Intensity of IgM bands was not decreased by advancing age. The splenectomy reduced the intensity of IgG1 bands especially in 4 months old mice. Although we observed the slight delay of wound repair by splenectomy in 2 M and 20 M old mice, we observed that wound repair was strongly delayed in 4 M old mice. Serum from any age of mice enhanced the macrophage phagocytosis by opsonization. Serum taken from splenectomized mice decreased the opsonizing capacity only at 4 M.
{"title":"Effect of Aging on Auto-Antibodies to Wounded Tissues~!2010-03-17~!2010-04-30~!2010-06-17~!","authors":"N. Nishio, S. Ito, Haruhiko Suzuki, Y. Okawa, K. Isobe","doi":"10.2174/1874827901003010017","DOIUrl":"https://doi.org/10.2174/1874827901003010017","url":null,"abstract":"Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITC- labeled anti-IgG1 in C57BL/6 mice. These bands were highest in 4 months old C57BL/6 mice. The sera taken from 2 months and 20 months old mice also bound to wounded tissues, although the bands were weaker than those of 4 months old mice. We also examined the autoreactive IgM binding to wounded tissues. We could detect relatively strong bands even in 2 M old mice. The pattern of these bands was changed by advancing age. Intensity of IgM bands was not decreased by advancing age. The splenectomy reduced the intensity of IgG1 bands especially in 4 months old mice. Although we observed the slight delay of wound repair by splenectomy in 2 M and 20 M old mice, we observed that wound repair was strongly delayed in 4 M old mice. Serum from any age of mice enhanced the macrophage phagocytosis by opsonization. Serum taken from splenectomized mice decreased the opsonizing capacity only at 4 M.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"3 1","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2010-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68091937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-28DOI: 10.2174/1874827901003010001
Robert M Chapman, Mark Mapstone, John W McCrary, Margaret N Gardner, Laura E Bachus, Elizabeth Degrush, Lindsey A Reilly, Tiffany C Sandoval, Maria D Guillily
The aim of this research was to assess similarity in cognitive factor structures underlying neuropsychological test performance of elders belonging to three clinical groups: Alzheimer's disease (AD), Mild Cognitive Impairment (MCI), and normal elderly. We administered a battery of neuropsychological tests to 214 elderly participants in the groups. First, the underlying cognitive structure of a Combined-Set of AD, MCI, and Control subjects was determined by Principal Components Analysis (PCA), including quantitative relationships (loadings) between the test measures and the factors. The PCA resolved 17 neuropsychological test measures into 6 interpretable factors, accounting for 78% of the variance. This cognitive structure was compared with separate cognitive structures from an AD-Set, an MCI-Set, and a Control-Set (different individuals in each set) in additional PCA using Procrustes factor rotation. Analysis of congruence coefficients between each set and the Combined-Set by a bootstrapping statistical procedure supported the factor invariance hypothesis. These close similarities across groups in their underlying neuropsychological dimensions support the use of a common metric system (the factor structure of a Combined-Set) for measuring neuropsychological factors in all these elderly individuals.
{"title":"Cognitive Dimensions in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Elderly: Developing a Common Metric.","authors":"Robert M Chapman, Mark Mapstone, John W McCrary, Margaret N Gardner, Laura E Bachus, Elizabeth Degrush, Lindsey A Reilly, Tiffany C Sandoval, Maria D Guillily","doi":"10.2174/1874827901003010001","DOIUrl":"10.2174/1874827901003010001","url":null,"abstract":"<p><p>The aim of this research was to assess similarity in cognitive factor structures underlying neuropsychological test performance of elders belonging to three clinical groups: Alzheimer's disease (AD), Mild Cognitive Impairment (MCI), and normal elderly. We administered a battery of neuropsychological tests to 214 elderly participants in the groups. First, the underlying cognitive structure of a Combined-Set of AD, MCI, and Control subjects was determined by Principal Components Analysis (PCA), including quantitative relationships (loadings) between the test measures and the factors. The PCA resolved 17 neuropsychological test measures into 6 interpretable factors, accounting for 78% of the variance. This cognitive structure was compared with separate cognitive structures from an AD-Set, an MCI-Set, and a Control-Set (different individuals in each set) in additional PCA using Procrustes factor rotation. Analysis of congruence coefficients between each set and the Combined-Set by a bootstrapping statistical procedure supported the factor invariance hypothesis. These close similarities across groups in their underlying neuropsychological dimensions support the use of a common metric system (the factor structure of a Combined-Set) for measuring neuropsychological factors in all these elderly individuals.</p>","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"3 10","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2010-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922059/pdf/nihms188339.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29193380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-07-06DOI: 10.2174/1874827900902010034
P. Bourne, D. McGrowder, Tazhmoye V. Crawford
Population ageing in Jamaica follows a global trend where the number of persons aged 60 and over is increasing. This study investigated age-specific death rates, mortality sex ratio and health status of the elderly in Jamaica aged 55 years and over. The study utilized secondary data published by the Statistical Institute of Jamaica on mortality and secondary cross-sectional probability survey data were used to model poor health status in elderly residents. The findings revealed that there is increased life expectancy. In 2005, the age-specific mortality rate for elderly 75 years and older was 4.4 times more than that of the crude death rate for the population; 9.4 times more than that of age-specific death rate at ages 55 to 59 years and that disparity narrows at the elderly gets older. The mortality sex ratio revealed that between 115 to 120 males die for every 100 females. More men die between the ages of 55 and 75, than men 75 years and older. As Jamaicans become older than 55 years their poor health status significantly increased. Poor health status was accounted for significantly by hypertension, diabetes mellitus, and arthritis. Eight factors determine poor health status of elderly Jamaicans. Some of these factors are retirement income (OR = 1.461, 95%CI:1.001, 2.131); cost of medical care (OR = 1.144, 95%CI = 1.073, 1.220); area of residence (other towns - OR = 0.754, 95%CI = 0.597, 0.953); marital status (separated - OR = 1.901, 95%CI = 1.479, 2.445; married - OR = 1.406, 95%CI = 1.103, 1.792); education (secondary - OR = 1.206, 95%CI = 1.001, 1.451; tertiary level education - OR = 0.492, 95%CI = 0.281, 0.861), and number of men in household (OR = 0.987, 95%CI = 0.806, 0.998). This study provides valuable information about the mortality rates and health status of elderly residents in Jamaica. High mortality rates for avoidable and preventable diseases and potential years of life lost are major public health concerns, especially for regional healthcare providers.
{"title":"Decomposing Mortality Rates and Examining Health Status of the Elderly in Jamaica","authors":"P. Bourne, D. McGrowder, Tazhmoye V. Crawford","doi":"10.2174/1874827900902010034","DOIUrl":"https://doi.org/10.2174/1874827900902010034","url":null,"abstract":"Population ageing in Jamaica follows a global trend where the number of persons aged 60 and over is increasing. This study investigated age-specific death rates, mortality sex ratio and health status of the elderly in Jamaica aged 55 years and over. The study utilized secondary data published by the Statistical Institute of Jamaica on mortality and secondary cross-sectional probability survey data were used to model poor health status in elderly residents. The findings revealed that there is increased life expectancy. In 2005, the age-specific mortality rate for elderly 75 years and older was 4.4 times more than that of the crude death rate for the population; 9.4 times more than that of age-specific death rate at ages 55 to 59 years and that disparity narrows at the elderly gets older. The mortality sex ratio revealed that between 115 to 120 males die for every 100 females. More men die between the ages of 55 and 75, than men 75 years and older. As Jamaicans become older than 55 years their poor health status significantly increased. Poor health status was accounted for significantly by hypertension, diabetes mellitus, and arthritis. Eight factors determine poor health status of elderly Jamaicans. Some of these factors are retirement income (OR = 1.461, 95%CI:1.001, 2.131); cost of medical care (OR = 1.144, 95%CI = 1.073, 1.220); area of residence (other towns - OR = 0.754, 95%CI = 0.597, 0.953); marital status (separated - OR = 1.901, 95%CI = 1.479, 2.445; married - OR = 1.406, 95%CI = 1.103, 1.792); education (secondary - OR = 1.206, 95%CI = 1.001, 1.451; tertiary level education - OR = 0.492, 95%CI = 0.281, 0.861), and number of men in household (OR = 0.987, 95%CI = 0.806, 0.998). This study provides valuable information about the mortality rates and health status of elderly residents in Jamaica. High mortality rates for avoidable and preventable diseases and potential years of life lost are major public health concerns, especially for regional healthcare providers.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"2 1","pages":"34-43"},"PeriodicalIF":0.0,"publicationDate":"2009-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68091910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-06-18DOI: 10.2174/1874827900902010028
M. Innamorati, Antonino Tamburello, D. Lester, S. Rigucci, M. Amore, C. D. Vittorio, P. Girardi, R. Tatarelli, M. Pompili
Suicide among the elderly is a critical public health problem. Large socioeconomic inequalities are present in suicide mortality cases, but the association is complex and may be different for elderly men and women. Reducing these differences could significantly reduce the burden of excess mortality, at least in elderly men. The aim of the present paper is to review research concerning the socioeconomic risk factors associated with suicide in the elderly. It is noted that the association between suicide risk and socioeconomic factors is likely to be overestimated when the effect of psychiatric status is not considered.
{"title":"Socioeconomic Risk Factors in the Precipitation of Suicide in the Elderly","authors":"M. Innamorati, Antonino Tamburello, D. Lester, S. Rigucci, M. Amore, C. D. Vittorio, P. Girardi, R. Tatarelli, M. Pompili","doi":"10.2174/1874827900902010028","DOIUrl":"https://doi.org/10.2174/1874827900902010028","url":null,"abstract":"Suicide among the elderly is a critical public health problem. Large socioeconomic inequalities are present in suicide mortality cases, but the association is complex and may be different for elderly men and women. Reducing these differences could significantly reduce the burden of excess mortality, at least in elderly men. The aim of the present paper is to review research concerning the socioeconomic risk factors associated with suicide in the elderly. It is noted that the association between suicide risk and socioeconomic factors is likely to be overestimated when the effect of psychiatric status is not considered.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"2 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2009-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68091898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-03-19DOI: 10.2174/1874827900902010009
N. D. Morton, J. Keating
The aim of this study was to illustrate the potential for confounding when interpreting group mean data from systematic reviews for a heterogeneous participant population. A case report comparing the results obtained from a Coch- rane review and meta-analysis compared to an individual patient data (IPD) meta-analysis was conducted. Participants were 396 older patients admitted to a general medical ward at two acute public hospitals. For the intervention group, an exercise program was provided for 20-30 minutes twice per day in addition to usual care. The control group received usual hospital care. The primary outcome measure was changed in Barthel Index scores between hospital admission and discharge. Meta-analysis of group mean data provided evidence that additional exercise for older medical patients does not significantly improve Barthel Index scores at hospital discharge (fixed effects model, 0.17 (-0.06 to 0.40) I 2 = 0%). Re- sults of IPD meta-analysis indicated that additional exercise significantly improved discharge Barthel Index scores for pa- tients who required assistance to ambulate at hospital admission (coefficient for group 5.4 (1.38 to 9.40), p=0.01) but not for those who were non ambulant or independently ambulant at hospital admission. This case report provides an example where performing meta-analysis using group mean data for heterogeneous populations can result in effective interventions being discarded.
{"title":"Different Meta-Analysis Methods, Different Answers: The Case of Exercise for Older Acute Medical Patients","authors":"N. D. Morton, J. Keating","doi":"10.2174/1874827900902010009","DOIUrl":"https://doi.org/10.2174/1874827900902010009","url":null,"abstract":"The aim of this study was to illustrate the potential for confounding when interpreting group mean data from systematic reviews for a heterogeneous participant population. A case report comparing the results obtained from a Coch- rane review and meta-analysis compared to an individual patient data (IPD) meta-analysis was conducted. Participants were 396 older patients admitted to a general medical ward at two acute public hospitals. For the intervention group, an exercise program was provided for 20-30 minutes twice per day in addition to usual care. The control group received usual hospital care. The primary outcome measure was changed in Barthel Index scores between hospital admission and discharge. Meta-analysis of group mean data provided evidence that additional exercise for older medical patients does not significantly improve Barthel Index scores at hospital discharge (fixed effects model, 0.17 (-0.06 to 0.40) I 2 = 0%). Re- sults of IPD meta-analysis indicated that additional exercise significantly improved discharge Barthel Index scores for pa- tients who required assistance to ambulate at hospital admission (coefficient for group 5.4 (1.38 to 9.40), p=0.01) but not for those who were non ambulant or independently ambulant at hospital admission. This case report provides an example where performing meta-analysis using group mean data for heterogeneous populations can result in effective interventions being discarded.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"2 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2009-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68092338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-02-27DOI: 10.2174/1874827900902010005
B. Z. Aminoff
Objectives: A new definition of human suffering and satisfaction according to the entropy hypothesis may fa- cilitate comprehension of health, disease and the aging process. Methods: A cohort study of 71 patients (28 females, 43 males), with very advanced dementia, who died in our ward dur- ing the study period. The intense suffering level of end-stage dementia patients was evaluated by the Mini-Suffering State Examination (MSSE) scale. Results: Suffering level in end-stage dementia has a significant correlation with short survival, advancing age, more se- vere illness, malnutrition, the existence of decubitus ulcers, and the administration of medications. Established correla- tions could be explained by the enhanced level of the patients' body entropy. Discussion: Suffering and satisfaction are functional levels of human entropy. An elevated level of human entropy is a measure of disorder, a process of aging and torment of the patient. a perceived threat to the integrity of the self, perceived help- lessness in the face of that threat, and exhaustion of psycho- social and personal resources of coping. The model proposed by Cherny, Coyle, Foley (10) described suffering as an aver- sive experience, characterized by the perception of personal distress which is generated by adverse factors that undermine quality-of-life. Cherny (11) proposed the triangular model of suffering and taxonomy of factors, prevalence of distress experienced by patients, their families, and their attending health care professionals.
目的:根据熵假设对人类的痛苦和满足作出新的定义，有助于理解健康、疾病和衰老过程。方法:队列研究71例(女性28例，男性43例)在研究期间在我病房死亡的晚期痴呆患者。采用Mini-Suffering State Examination (MSSE)量表评估终末期痴呆患者的强烈痛苦程度。结果:终末期痴呆患者的痛苦程度与生存时间短、年龄增长、病情严重、营养不良、是否存在卧疮、是否服用药物等因素有显著相关性。已建立的相关性可以用患者身体熵水平的提高来解释。讨论:痛苦和满足是人类熵的功能层次。人体熵的升高是一种紊乱的度量，是病人衰老和折磨的过程。感知到对自我完整性的威胁，感知到面对威胁的无助，以及心理社会和个人应对资源的枯竭。Cherny, Coyle, Foley(10)提出的模型将痛苦描述为一种痛苦的经历，其特征是对个人痛苦的感知，这种痛苦是由破坏生活质量的不利因素产生的。Cherny(11)提出了痛苦和因素分类的三角模型，患者、其家人和其主治卫生保健专业人员所经历的痛苦的普遍性。
{"title":"End Stage Dementia and Entropy Definition of Suffering","authors":"B. Z. Aminoff","doi":"10.2174/1874827900902010005","DOIUrl":"https://doi.org/10.2174/1874827900902010005","url":null,"abstract":"Objectives: A new definition of human suffering and satisfaction according to the entropy hypothesis may fa- cilitate comprehension of health, disease and the aging process. Methods: A cohort study of 71 patients (28 females, 43 males), with very advanced dementia, who died in our ward dur- ing the study period. The intense suffering level of end-stage dementia patients was evaluated by the Mini-Suffering State Examination (MSSE) scale. Results: Suffering level in end-stage dementia has a significant correlation with short survival, advancing age, more se- vere illness, malnutrition, the existence of decubitus ulcers, and the administration of medications. Established correla- tions could be explained by the enhanced level of the patients' body entropy. Discussion: Suffering and satisfaction are functional levels of human entropy. An elevated level of human entropy is a measure of disorder, a process of aging and torment of the patient. a perceived threat to the integrity of the self, perceived help- lessness in the face of that threat, and exhaustion of psycho- social and personal resources of coping. The model proposed by Cherny, Coyle, Foley (10) described suffering as an aver- sive experience, characterized by the perception of personal distress which is generated by adverse factors that undermine quality-of-life. Cherny (11) proposed the triangular model of suffering and taxonomy of factors, prevalence of distress experienced by patients, their families, and their attending health care professionals.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"2 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2009-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68092327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-27DOI: 10.2174/1874827900902010001
M. Colombo, A. Guaita, Albert Cottino, M. Cairati, Danila Ferrari, Giorgio Previderè, G. Procino, M. Gandolfi, Rosaria Tararà, Angela Mercanti
Customer satisfaction is relevant for geriatric rehabilitation, besides objective outcomes. We aimed at measur- ing customer satisfaction at discharge from our rehabilitative wards, and at singling out its predictive factors. We studied 506 elderly patients, aged 78 ± 8 years. Satisfaction at discharge scored high in all 4-levels graded items of a questionnaire surveying perception of patient improvement, quality of rehabilitative treatment, physicians' and nurses' intervention, personal care, lodging quality, goodness of information got. Mean overall rating (scoring 0 to 10) of the rehabilitative stay was 9.2 ± 2.1, median and mode were 10. Rating correlated with: relative functional gain (r = 0.23, p < .000), absolute Barthel Index total score at discharge (r = 0.18, p < .000), net gain in Barthel Index total score at discharge (r = 0.1, p = 0.021), and improvement in CIRS Severity Index (r = 0.9, p = 0.043). Relative functional gain was the only variable pre- dictive of rating that was retained by stepwise multiple regressions (p < .000).
除了客观结果外，顾客满意度与老年康复有关。我们的目标是在我们的康复病房出院时测量客户满意度，并挑出其预测因素。我们研究了506例老年患者，年龄78±8岁。出院满意度在患者改善感知、康复治疗质量、医护人员干预、个人护理、住宿质量、信息获取良好度4个分级项目中均得分较高。康复住院时间的平均总评分(0 ~ 10分)为9.2±2.1分，中位数和满分均为10分。评分与:相对功能增益(r = 0.23, p < .000)、出院时绝对Barthel指数总分(r = 0.18, p < .000)、出院时Barthel指数总分净增益(r = 0.1, p = 0.021)和CIRS严重性指数改善(r = 0.9, p = 0.043)相关。相对功能增益是通过逐步多元回归保留的唯一预测评分的变量(p < .000)。
{"title":"Customer Satisfaction as a Quality Factor in Geriatric Rehabilitation","authors":"M. Colombo, A. Guaita, Albert Cottino, M. Cairati, Danila Ferrari, Giorgio Previderè, G. Procino, M. Gandolfi, Rosaria Tararà, Angela Mercanti","doi":"10.2174/1874827900902010001","DOIUrl":"https://doi.org/10.2174/1874827900902010001","url":null,"abstract":"Customer satisfaction is relevant for geriatric rehabilitation, besides objective outcomes. We aimed at measur- ing customer satisfaction at discharge from our rehabilitative wards, and at singling out its predictive factors. We studied 506 elderly patients, aged 78 ± 8 years. Satisfaction at discharge scored high in all 4-levels graded items of a questionnaire surveying perception of patient improvement, quality of rehabilitative treatment, physicians' and nurses' intervention, personal care, lodging quality, goodness of information got. Mean overall rating (scoring 0 to 10) of the rehabilitative stay was 9.2 ± 2.1, median and mode were 10. Rating correlated with: relative functional gain (r = 0.23, p < .000), absolute Barthel Index total score at discharge (r = 0.18, p < .000), net gain in Barthel Index total score at discharge (r = 0.1, p = 0.021), and improvement in CIRS Severity Index (r = 0.9, p = 0.043). Relative functional gain was the only variable pre- dictive of rating that was retained by stepwise multiple regressions (p < .000).","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"32 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68092243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-02DOI: 10.2174/1874827900801010056
B. Drozdzowska, W. Pluskiewicz, P. Adamczyk, W. Munzer
Background: The aim of the retrospective study was to reveal the pattern of bone loss in elderly women com- pared with early postmenopausal women. Material: The group of 254 women was studied, among them were 40 elderly women (mean age 74.7+/-4.0 y.) and 214 early postmenopausal women (mean age 53.4+/-3.7 y.). Skeletal status was evaluated using quantitative ultrasound (QUS) at the calcaneus (Achilles, Lunar, USA). Parameters measured were: Speed of Sound (SOS (m/s)), Broadband Ultrasound Attenuation (BUA (dB/MHz)) and Stiffness Index (SI (%)). Results: In elderly women age, years since menopause (YSM) and body size did not influence significantly ultrasound values, only positive influence of weight and body mass index on BUA was observed (p<0.05). In early postmenopausal women YSM negatively affected SOS (p<0.05), BUA (p=0.05) and SI (p<0.05), body size had generally a positive impact on all QUS parameters, and the percentage of life with menstruation positively affected SOS (p<0.05). In multiple step- wise regression analyses in elderly women only weight had a positive effect on BUA, and in early postmenopausal women, weight was a protective factor for all parameters, age negatively influenced BUA and SI, and YSM negatively in- fluenced SOS. Multiple stepwise regression analysis in the whole group showed that weight was a protective factor and age was a negative factor for all QUS parameters. Conclusion: The pattern of bone loss in the elderly differs in comparison to younger postmenopausal women, and the weight among factors assessed was the only protective one in postmenopausal women. Maintaince of body weight seems to be the most important in osteoporosis prevention.
{"title":"Skeletal Status Assessed by Quantitative Ultrasound in Elderly Women Compared with Early Postmenopausal Women","authors":"B. Drozdzowska, W. Pluskiewicz, P. Adamczyk, W. Munzer","doi":"10.2174/1874827900801010056","DOIUrl":"https://doi.org/10.2174/1874827900801010056","url":null,"abstract":"Background: The aim of the retrospective study was to reveal the pattern of bone loss in elderly women com- pared with early postmenopausal women. Material: The group of 254 women was studied, among them were 40 elderly women (mean age 74.7+/-4.0 y.) and 214 early postmenopausal women (mean age 53.4+/-3.7 y.). Skeletal status was evaluated using quantitative ultrasound (QUS) at the calcaneus (Achilles, Lunar, USA). Parameters measured were: Speed of Sound (SOS (m/s)), Broadband Ultrasound Attenuation (BUA (dB/MHz)) and Stiffness Index (SI (%)). Results: In elderly women age, years since menopause (YSM) and body size did not influence significantly ultrasound values, only positive influence of weight and body mass index on BUA was observed (p<0.05). In early postmenopausal women YSM negatively affected SOS (p<0.05), BUA (p=0.05) and SI (p<0.05), body size had generally a positive impact on all QUS parameters, and the percentage of life with menstruation positively affected SOS (p<0.05). In multiple step- wise regression analyses in elderly women only weight had a positive effect on BUA, and in early postmenopausal women, weight was a protective factor for all parameters, age negatively influenced BUA and SI, and YSM negatively in- fluenced SOS. Multiple stepwise regression analysis in the whole group showed that weight was a protective factor and age was a negative factor for all QUS parameters. Conclusion: The pattern of bone loss in the elderly differs in comparison to younger postmenopausal women, and the weight among factors assessed was the only protective one in postmenopausal women. Maintaince of body weight seems to be the most important in osteoporosis prevention.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"1 1","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2009-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68092202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-02DOI: 10.2174/1874827900801010062
T. Comans, S. Brauer, T. Haines
Background: Community rehabilitation services for older adults aim to address factors that lead to physical de- cline and falls and return people to their normal activities in the community. While community rehabilitation has been proven effective in reducing falls in the elderly, previous studies have not specified whether delivering services at home or in a centre-based format is the more appropriate method of service delivery. Aim: This study aims to compare a centre-based group program with a home-based program. The purpose of this study is to identify the most clinically effective way of delivering community rehabilitation services to older fallers and determine which service delivery setting is more economically efficient. Methods/Design: This paper describes the study design and methods of a randomised clinical trial. One group of partici- pants will receive a centre-based community rehabilitation service, the other group a domiciliary (home-based) commu- nity rehabilitation service of near identical content. Participants in this study are those clients over 60 years of age referred to a community rehabilitation service. Patients referred to this service typically have had recent falls, poor or declining mobility, functional dependency, cognitive decline, and / or physical deconditioning. Clinical effectiveness will be primarily determined by comparison of health-related quality of life and rates of accidental falls. Secondary outcomes include the levels of participation in functional activities, and physical capacity between the two groups. Economic efficiency will be determined through conduct of a cost-benefit analysis. Discussion: Results from this study will guide clinicians and policy makers to identify the more effective and efficient falls prevention community rehabilitation program service delivery model for older adults living in the community. Trial Registration: Australian New Zealand Clinical Trials Register: ACTRN12605000056695.
{"title":"Domiciliary vs Centre-Based Rehabilitation of Older Community Dwellers: Randomised Trial with Economic Evaluation","authors":"T. Comans, S. Brauer, T. Haines","doi":"10.2174/1874827900801010062","DOIUrl":"https://doi.org/10.2174/1874827900801010062","url":null,"abstract":"Background: Community rehabilitation services for older adults aim to address factors that lead to physical de- cline and falls and return people to their normal activities in the community. While community rehabilitation has been proven effective in reducing falls in the elderly, previous studies have not specified whether delivering services at home or in a centre-based format is the more appropriate method of service delivery. Aim: This study aims to compare a centre-based group program with a home-based program. The purpose of this study is to identify the most clinically effective way of delivering community rehabilitation services to older fallers and determine which service delivery setting is more economically efficient. Methods/Design: This paper describes the study design and methods of a randomised clinical trial. One group of partici- pants will receive a centre-based community rehabilitation service, the other group a domiciliary (home-based) commu- nity rehabilitation service of near identical content. Participants in this study are those clients over 60 years of age referred to a community rehabilitation service. Patients referred to this service typically have had recent falls, poor or declining mobility, functional dependency, cognitive decline, and / or physical deconditioning. Clinical effectiveness will be primarily determined by comparison of health-related quality of life and rates of accidental falls. Secondary outcomes include the levels of participation in functional activities, and physical capacity between the two groups. Economic efficiency will be determined through conduct of a cost-benefit analysis. Discussion: Results from this study will guide clinicians and policy makers to identify the more effective and efficient falls prevention community rehabilitation program service delivery model for older adults living in the community. Trial Registration: Australian New Zealand Clinical Trials Register: ACTRN12605000056695.","PeriodicalId":89035,"journal":{"name":"The open geriatric medicine journal","volume":"1 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2009-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68092230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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