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End Stage Dementia and Entropy Definition of Suffering 终末期痴呆和痛苦的熵定义
Pub Date : 2009-02-27 DOI: 10.2174/1874827900902010005
B. Z. Aminoff
Objectives: A new definition of human suffering and satisfaction according to the entropy hypothesis may fa- cilitate comprehension of health, disease and the aging process. Methods: A cohort study of 71 patients (28 females, 43 males), with very advanced dementia, who died in our ward dur- ing the study period. The intense suffering level of end-stage dementia patients was evaluated by the Mini-Suffering State Examination (MSSE) scale. Results: Suffering level in end-stage dementia has a significant correlation with short survival, advancing age, more se- vere illness, malnutrition, the existence of decubitus ulcers, and the administration of medications. Established correla- tions could be explained by the enhanced level of the patients' body entropy. Discussion: Suffering and satisfaction are functional levels of human entropy. An elevated level of human entropy is a measure of disorder, a process of aging and torment of the patient. a perceived threat to the integrity of the self, perceived help- lessness in the face of that threat, and exhaustion of psycho- social and personal resources of coping. The model proposed by Cherny, Coyle, Foley (10) described suffering as an aver- sive experience, characterized by the perception of personal distress which is generated by adverse factors that undermine quality-of-life. Cherny (11) proposed the triangular model of suffering and taxonomy of factors, prevalence of distress experienced by patients, their families, and their attending health care professionals.
目的:根据熵假设对人类的痛苦和满足作出新的定义,有助于理解健康、疾病和衰老过程。方法:队列研究71例(女性28例,男性43例)在研究期间在我病房死亡的晚期痴呆患者。采用Mini-Suffering State Examination (MSSE)量表评估终末期痴呆患者的强烈痛苦程度。结果:终末期痴呆患者的痛苦程度与生存时间短、年龄增长、病情严重、营养不良、是否存在卧疮、是否服用药物等因素有显著相关性。已建立的相关性可以用患者身体熵水平的提高来解释。讨论:痛苦和满足是人类熵的功能层次。人体熵的升高是一种紊乱的度量,是病人衰老和折磨的过程。感知到对自我完整性的威胁,感知到面对威胁的无助,以及心理社会和个人应对资源的枯竭。Cherny, Coyle, Foley(10)提出的模型将痛苦描述为一种痛苦的经历,其特征是对个人痛苦的感知,这种痛苦是由破坏生活质量的不利因素产生的。Cherny(11)提出了痛苦和因素分类的三角模型,患者、其家人和其主治卫生保健专业人员所经历的痛苦的普遍性。
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引用次数: 0
Customer Satisfaction as a Quality Factor in Geriatric Rehabilitation 顾客满意度作为老年康复的质量因素
Pub Date : 2009-01-27 DOI: 10.2174/1874827900902010001
M. Colombo, A. Guaita, Albert Cottino, M. Cairati, Danila Ferrari, Giorgio Previderè, G. Procino, M. Gandolfi, Rosaria Tararà, Angela Mercanti
Customer satisfaction is relevant for geriatric rehabilitation, besides objective outcomes. We aimed at measur- ing customer satisfaction at discharge from our rehabilitative wards, and at singling out its predictive factors. We studied 506 elderly patients, aged 78 ± 8 years. Satisfaction at discharge scored high in all 4-levels graded items of a questionnaire surveying perception of patient improvement, quality of rehabilitative treatment, physicians' and nurses' intervention, personal care, lodging quality, goodness of information got. Mean overall rating (scoring 0 to 10) of the rehabilitative stay was 9.2 ± 2.1, median and mode were 10. Rating correlated with: relative functional gain (r = 0.23, p < .000), absolute Barthel Index total score at discharge (r = 0.18, p < .000), net gain in Barthel Index total score at discharge (r = 0.1, p = 0.021), and improvement in CIRS Severity Index (r = 0.9, p = 0.043). Relative functional gain was the only variable pre- dictive of rating that was retained by stepwise multiple regressions (p < .000).
除了客观结果外,顾客满意度与老年康复有关。我们的目标是在我们的康复病房出院时测量客户满意度,并挑出其预测因素。我们研究了506例老年患者,年龄78±8岁。出院满意度在患者改善感知、康复治疗质量、医护人员干预、个人护理、住宿质量、信息获取良好度4个分级项目中均得分较高。康复住院时间的平均总评分(0 ~ 10分)为9.2±2.1分,中位数和满分均为10分。评分与:相对功能增益(r = 0.23, p < .000)、出院时绝对Barthel指数总分(r = 0.18, p < .000)、出院时Barthel指数总分净增益(r = 0.1, p = 0.021)和CIRS严重性指数改善(r = 0.9, p = 0.043)相关。相对功能增益是通过逐步多元回归保留的唯一预测评分的变量(p < .000)。
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引用次数: 6
Skeletal Status Assessed by Quantitative Ultrasound in Elderly Women Compared with Early Postmenopausal Women 定量超声评估老年妇女与早期绝经后妇女的骨骼状况
Pub Date : 2009-01-02 DOI: 10.2174/1874827900801010056
B. Drozdzowska, W. Pluskiewicz, P. Adamczyk, W. Munzer
Background: The aim of the retrospective study was to reveal the pattern of bone loss in elderly women com- pared with early postmenopausal women. Material: The group of 254 women was studied, among them were 40 elderly women (mean age 74.7+/-4.0 y.) and 214 early postmenopausal women (mean age 53.4+/-3.7 y.). Skeletal status was evaluated using quantitative ultrasound (QUS) at the calcaneus (Achilles, Lunar, USA). Parameters measured were: Speed of Sound (SOS (m/s)), Broadband Ultrasound Attenuation (BUA (dB/MHz)) and Stiffness Index (SI (%)). Results: In elderly women age, years since menopause (YSM) and body size did not influence significantly ultrasound values, only positive influence of weight and body mass index on BUA was observed (p<0.05). In early postmenopausal women YSM negatively affected SOS (p<0.05), BUA (p=0.05) and SI (p<0.05), body size had generally a positive impact on all QUS parameters, and the percentage of life with menstruation positively affected SOS (p<0.05). In multiple step- wise regression analyses in elderly women only weight had a positive effect on BUA, and in early postmenopausal women, weight was a protective factor for all parameters, age negatively influenced BUA and SI, and YSM negatively in- fluenced SOS. Multiple stepwise regression analysis in the whole group showed that weight was a protective factor and age was a negative factor for all QUS parameters. Conclusion: The pattern of bone loss in the elderly differs in comparison to younger postmenopausal women, and the weight among factors assessed was the only protective one in postmenopausal women. Maintaince of body weight seems to be the most important in osteoporosis prevention.
背景:回顾性研究的目的是揭示老年妇女与早期绝经后妇女骨质流失的模式。材料:研究了254名妇女,其中40名老年妇女(平均年龄74.7+/-4.0岁)和214名早期绝经后妇女(平均年龄53.4+/-3.7岁)。使用定量超声(QUS)对跟骨(阿基里斯,Lunar, USA)进行骨骼状态评估。测量参数为:声速(SOS (m/s))、宽带超声衰减(BUA (dB/MHz))、刚度指数(SI(%))。结果:老年妇女年龄、绝经年数(YSM)、体型对超声值无显著影响,体重、体质指数对BUA有显著影响(p<0.05)。绝经早期妇女YSM负向影响SOS (p<0.05)、BUA负向影响(p=0.05)、SI负向影响(p<0.05),体型对所有QUS参数普遍呈正向影响,有月经的寿命百分比正向影响SOS (p<0.05)。在多步回归分析中,在老年妇女中,只有体重对BUA有积极影响,在早期绝经后妇女中,体重是所有参数的保护因素,年龄对BUA和SI有负向影响,YSM对SOS有负向影响。全组多元逐步回归分析显示,体重为保护因素,年龄为负向因素。结论:老年绝经后妇女骨质流失的模式与年轻绝经后妇女不同,在评估的因素中,体重是绝经后妇女唯一的保护因素。保持体重似乎是预防骨质疏松症最重要的。
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引用次数: 0
Domiciliary vs Centre-Based Rehabilitation of Older Community Dwellers: Randomised Trial with Economic Evaluation 老年社区居民住家康复与以中心为基础的康复:经济评价的随机试验
Pub Date : 2009-01-02 DOI: 10.2174/1874827900801010062
T. Comans, S. Brauer, T. Haines
Background: Community rehabilitation services for older adults aim to address factors that lead to physical de- cline and falls and return people to their normal activities in the community. While community rehabilitation has been proven effective in reducing falls in the elderly, previous studies have not specified whether delivering services at home or in a centre-based format is the more appropriate method of service delivery. Aim: This study aims to compare a centre-based group program with a home-based program. The purpose of this study is to identify the most clinically effective way of delivering community rehabilitation services to older fallers and determine which service delivery setting is more economically efficient. Methods/Design: This paper describes the study design and methods of a randomised clinical trial. One group of partici- pants will receive a centre-based community rehabilitation service, the other group a domiciliary (home-based) commu- nity rehabilitation service of near identical content. Participants in this study are those clients over 60 years of age referred to a community rehabilitation service. Patients referred to this service typically have had recent falls, poor or declining mobility, functional dependency, cognitive decline, and / or physical deconditioning. Clinical effectiveness will be primarily determined by comparison of health-related quality of life and rates of accidental falls. Secondary outcomes include the levels of participation in functional activities, and physical capacity between the two groups. Economic efficiency will be determined through conduct of a cost-benefit analysis. Discussion: Results from this study will guide clinicians and policy makers to identify the more effective and efficient falls prevention community rehabilitation program service delivery model for older adults living in the community. Trial Registration: Australian New Zealand Clinical Trials Register: ACTRN12605000056695.
背景:老年人社区康复服务旨在解决导致身体衰退和跌倒的因素,使人们恢复正常的社区活动。虽然社区康复已被证明在减少老年人跌倒方面是有效的,但以前的研究并没有具体说明在家中提供服务还是以中心为基础的形式提供服务是更合适的服务提供方法。目的:本研究旨在比较以中心为基础的团体课程与以家庭为基础的课程。本研究的目的是确定临床最有效的方式提供社区康复服务的老年跌倒,并确定哪种服务提供设置更经济有效。方法/设计:本文描述了一项随机临床试验的研究设计和方法。一组参与者将接受以中心为基础的社区康复服务,另一组将接受内容几乎相同的居家社区康复服务。本研究的参与者是那些60岁以上转介到社区康复服务的客户。该服务的患者通常有近期跌倒、活动能力差或下降、功能依赖、认知能力下降和/或身体状况下降。临床效果将主要通过与健康相关的生活质量和意外跌倒率的比较来确定。次要结果包括两组患者参与功能性活动的水平和身体能力。经济效率将通过进行成本效益分析来确定。讨论:本研究的结果将指导临床医生和政策制定者为生活在社区中的老年人确定更有效和高效的预防跌倒社区康复项目服务交付模式。试验注册:澳大利亚新西兰临床试验注册号:ACTRN12605000056695。
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引用次数: 9
Are Pictures Worth a Thousand Words: A Pilot Randomized Trial of Visual Cues to Improve Speed of Completion and Comprehension of Three Surveys for Older Adults 图片胜过千言万语:视觉提示提高老年人完成和理解三份调查的速度的随机试验
Pub Date : 2009-01-02 DOI: 10.2174/1874827900801010050
S. McPhail, E. Beller, T. Haines
Background and Aims: When conducting surveys with older adults, it is important that participants have clear comprehension of the questions being asked. It is also important that survey items can be administered efficiently. This paper investigates the effect of providing visual cues to aid participant understanding and speed of completion of three types of health surveys. Methods: Design - Pilot randomized controlled trial (n=12) of participants assigned to a visual cues (intervention) or no visual cues (control) group with unblinded outcome assessment using time taken to complete survey and question com- prehension as outcome measures. Results: Although participants from both groups did not report difficulty in understanding or remembering each question, the visual cues group were able to complete the surveys in significantly less time and with significantly fewer errors in comprehension than the no cues group. Conclusions: The results of this study indicate that visual cues improved speed of survey completion and patient compre- hension of survey items. This investigation suggests the use of visual cues may enhance efficiency and reduce labor costs in survey related research with the elderly and potentially reduce burden on participants. Furthermore, this may result in higher validity of questionnaires due to improved comprehension. The findings of this pilot study were unexpectedly de- finitive on their own merit such that a larger investigation was deemed to be unwarranted for the purpose of addressing the research aims.
背景和目的:在对老年人进行调查时,重要的是参与者对所问问题有清晰的理解。有效地管理调查项目也很重要。本文研究了提供视觉线索,以帮助参与者理解和完成三种类型的健康调查的速度的影响。方法:设计-试点随机对照试验(n=12),将参与者分配到视觉提示(干预)组或无视觉提示(对照组)组,以完成调查所需的时间和问题理解作为结果衡量标准进行非盲法结果评估。结果:尽管两组参与者都没有报告在理解或记忆每个问题上的困难,但视觉提示组能够在更短的时间内完成调查,并且在理解上的错误明显少于无提示组。结论:本研究结果表明,视觉提示提高了患者完成调查的速度和对调查项目的理解。本研究提示,在老年人调查相关研究中,使用视觉线索可以提高效率,减少人工成本,并可能减轻参与者的负担。此外,这可能会导致更高的效度问卷,因为提高理解。这项初步研究的结果出人意料地确定了其自身的优点,因此,为了解决研究目的,更大的调查被认为是没有根据的。
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引用次数: 3
Assessing Physical Activity in Older People: Findings from the Hertfordshire Cohort Study 评估老年人的身体活动:来自赫特福德郡队列研究的发现
Pub Date : 2009-01-02 DOI: 10.2174/1874827900801010043
H. Martin, H. Syddall, E. Dennison, V. Cox, C. Cooper, A. Sayer
Background: Physical activity (PA) is difficult to assess and few instruments are relevant to older people. We have developed a self-administered PA questionnaire (HPAQ) for the Hertfordshire Cohort Study; we report its feasibility and validity and describe PA participation in older people. Methods: 525 participants completed the HPAQ; 15 women also completed the EPAQ-2 for validation. Activity participa- tion was described using percentage participation, estimated energy expenditure and cluster analysis. Results: Most participants found the HPAQ simple to complete. Agreement between the HPAQ and EPAQ-2 was good. Activities with highest participation rates and energy expenditures were walking (99.6%, 149.8 MET.h/mth) for men and home activities (100%, 287.1 MET.h/mth) for women. Clustering identified three patterns of activity participation for men ("Keep Fit", "Indoors" & "Less active"), and two for women ("Keep Fit" & "Indoors"). Conclusions: The HPAQ is a feasible and valid PA questionnaire for older people. Clustering identified different patterns of PA participation.
背景:身体活动(PA)很难评估,很少有工具与老年人相关。我们为赫特福德郡队列研究开发了一份自我管理的PA问卷(HPAQ);我们报告了其可行性和有效性,并描述了老年人参与PA的情况。方法:525名参与者完成HPAQ;15名女性还完成了EPAQ-2验证。活动参与用参与率、估计能量消耗和聚类分析来描述。结果:大多数参与者认为HPAQ易于完成。HPAQ与EPAQ-2的一致性较好。参与率和能量消耗最高的活动是男性步行(99.6%,149.8 MET.h/月)和女性家庭活动(100%,287.1 MET.h/月)。聚类确定了男性的三种活动参与模式(“保持健康”,“室内”和“较少活动”),女性的两种模式(“保持健康”和“室内”)。结论:HPAQ是一份适用于老年人的有效问卷。聚类识别出PA参与的不同模式。
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引用次数: 3
New Perspectives for the Treatment of Alzheimer’s Disease~!2008-10-07~!2008-10-30~!2008-11-26~! 阿尔茨海默病治疗的新视角
Pub Date : 2008-12-01 DOI: 10.2174/1874827900801010033
D. Galimberti, E. Scarpini
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引用次数: 0
End-Stage Dementia: Aminoff Suffering Syndrome and Relief of Suffering Units~!2008-10-06~!2008-10-23~!2008-11-12~! 终末期痴呆:阿米诺夫综合征与解除痛苦单位~!
Pub Date : 2008-12-01 DOI: 10.2174/1874827900801010029
B. Z. Aminoff
Aminoff suffering syndrome (ASS) in advanced dementia is the new proposed term for a pathological symptoma- tology and entity that is characterized by a high Mini Suffering State Examination (MSSE) scale score, <6 months survival, irreversible and intractable aggravation of suffering and medical condition until demise. This paper proffers a new, alternative approach and setting for end-stage dementia (ESD) patients with ASS that could pertain to the Israeli setting, and could possibly also be applicable in other countries. Short hospitalization periods of approximately 1 month, and treatment in Relief of Suffering Units may be a new, palliative approach and present a possible solution for cop- ing with the horrendous burden of the anguish of end-of-life dementia patients, their families, and the medical and nursing staff.
晚期痴呆患者的阿米诺夫痛苦综合征(Aminoff suffering syndrome, ASS)是一种病理症状和实体的新术语,其特征是具有较高的迷你痛苦状态检查(MSSE)评分,生存时间<6个月,不可逆转且难治性的痛苦和医疗状况恶化直至死亡。本文为终末期痴呆(ESD)合并ASS患者提供了一种新的、可选择的方法和设置,这种方法和设置可能适用于以色列的设置,也可能适用于其他国家。大约1个月的短期住院治疗和在痛苦救济单位的治疗可能是一种新的、缓和的方法,并为应对临终痴呆患者、他们的家人以及医疗和护理人员的可怕负担提供了一种可能的解决方案。
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引用次数: 9
Sarcopenia: Current Clinical and Research Issues 肌少症:当前的临床和研究问题
Pub Date : 2008-07-24 DOI: 10.2174/1874827900801010014
M. Cesari, A. Ferrini, V. Zamboni, M. Pahor
Sarcopenia is the age-related progressive decline of muscle mass, strength and function. It is not due to dis- eases, but a normal part of the aging process, and multiple physiological and psychological factors seem to contribute to it. Sarcopenia has been associated with a higher risk of falls, incident disability and all-cause mortality in the elderly. De- spite this phenomenon has major clinical, social and economic consequences in older persons, its study is still limited and/or partial. The major issues making difficult the design of clinical trials on sarcopenia are: the multidimensional physiological mechanisms determining it, the lack of standardized definitions, the difficulties in operatively defining this dynamic mechanism, and the different methodologies able to estimate the muscle mass and function. The present review will 1) overview the current clinical and research issues related to the study of sarcopenia in the elderly, and 2) discuss the possible solutions on the basis of evidence on the topic.
肌肉减少症是与年龄相关的肌肉质量、力量和功能的进行性下降。它不是由疾病引起的,而是衰老过程的正常部分,多种生理和心理因素似乎都有助于衰老。骨骼肌减少症与老年人跌倒、意外残疾和全因死亡率的较高风险有关。尽管这一现象对老年人具有重大的临床、社会和经济后果,但其研究仍然有限和/或部分。造成肌肉减少症临床试验设计困难的主要问题是:决定它的多维生理机制,缺乏标准化的定义,在手术中定义这种动态机制的困难,以及能够估计肌肉质量和功能的不同方法。本文将1)综述当前与老年人肌肉减少症研究相关的临床和研究问题,2)在证据的基础上讨论可能的解决方案。
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引用次数: 12
Psychiatric Diagnoses in a Sample of Outpatient Psycho-Geriatric New Referrals with Suspected Mild Cognitive Impairment 疑似轻度认知障碍的老年精神科门诊新转诊患者的精神病学诊断
Pub Date : 2008-05-19 DOI: 10.2174/1874827900801010010
J. Heinik, P. Werner, G. Kavé
Psychiatric symptoms/syndromes are frequent in Mild Cognitive Impairment (MCI). However, only a few stud- ies reported full psychiatric diagnoses in MCI. We describe the nosology and prevalence of psychiatric diagnoses in a group of 102 consecutive patients evaluated for suspected MCI and finally re-classified into dementia, MCI and No Cog- nitive Impairment. Psychiatric diagnoses were frequent in MCI and the other groups as well, however they were qualita- tively different in each group.
精神症状/综合征在轻度认知障碍(MCI)中很常见。然而,只有少数研究报告了轻度认知障碍的完全精神诊断。我们描述了102名连续评估为疑似轻度认知损伤的患者的分科学和精神病学诊断的患病率,并最终重新分类为痴呆、轻度认知损伤和无认知损伤。精神病学诊断在轻度认知障碍患者和其他组中也很常见,但在每组中有质的不同。
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引用次数: 3
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The open geriatric medicine journal
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