Pub Date : 2026-02-04DOI: 10.1016/j.biopsych.2025.12.006
Anne Rifkin-Graboi
{"title":"Taking Moderation in Moderation: Limitations, Possibilities, and Implications of Research Examining the Interaction Between Hippocampal Volume, Caregiving Quality, and Child Outcomes","authors":"Anne Rifkin-Graboi","doi":"10.1016/j.biopsych.2025.12.006","DOIUrl":"10.1016/j.biopsych.2025.12.006","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"99 5","pages":"Pages 353-354"},"PeriodicalIF":9.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drinking behavior, for most organisms, is essential for maintaining fluid homeostasis and fundamental to survival and normal physiological functions. Physiologically motivated drinking is typically triggered by thirst, which originates from the brain's perception and processing of signals reflecting changes in osmotic pressure, blood volume, and psychological factors. This behavior is mainly regulated by neural circuits centered on the lamina terminalis and hormonal signals such as angiotensin II and arginine vasopressin, collectively ensuring precise control of fluid homeostasis. In this review, we systematically discuss the multisystemic mechanisms underlying thirst generation, the integration from motivation initiation, execution to behavioral termination of drinking, and summarize the molecular mechanisms of thirst-related neuronal populations in several brain regions, along with the specific regulatory roles of their neural circuits. Additionally, we discuss the long-range communication between peripheral organs and the central nervous system in thirst modulation, as well as the fluctuations and impacts of fluid-regulating hormones under different homeostatic conditions. Finally, we highlight several unresolved research gaps in current knowledge, and discuss perspectives for future investigation and potential clinical translation.
{"title":"The thirsty brain: Integrating molecular signals, neural circuit and behavior.","authors":"Xiaolong Ma, Lingyu Xu, Lingyan Zheng, Qiujie Shi, Jiaxuan Li, Yuhao Sun, Chenyuan Huang, Yi Wang, Zhong Chen","doi":"10.1016/j.biopsych.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.01.017","url":null,"abstract":"<p><p>Drinking behavior, for most organisms, is essential for maintaining fluid homeostasis and fundamental to survival and normal physiological functions. Physiologically motivated drinking is typically triggered by thirst, which originates from the brain's perception and processing of signals reflecting changes in osmotic pressure, blood volume, and psychological factors. This behavior is mainly regulated by neural circuits centered on the lamina terminalis and hormonal signals such as angiotensin II and arginine vasopressin, collectively ensuring precise control of fluid homeostasis. In this review, we systematically discuss the multisystemic mechanisms underlying thirst generation, the integration from motivation initiation, execution to behavioral termination of drinking, and summarize the molecular mechanisms of thirst-related neuronal populations in several brain regions, along with the specific regulatory roles of their neural circuits. Additionally, we discuss the long-range communication between peripheral organs and the central nervous system in thirst modulation, as well as the fluctuations and impacts of fluid-regulating hormones under different homeostatic conditions. Finally, we highlight several unresolved research gaps in current knowledge, and discuss perspectives for future investigation and potential clinical translation.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.biopsych.2026.01.016
Mehmet Bostancıklıoğlu, Davut Sinan Kaplan, Ramazan Bal, Elif Yiğit, Hasan Ulusal, Ebru Temiz
{"title":"MDMA and psilocybin regulate oligodendrocyte-lineage cell numbers and anxiety-like behaviors in a rat model of fear","authors":"Mehmet Bostancıklıoğlu, Davut Sinan Kaplan, Ramazan Bal, Elif Yiğit, Hasan Ulusal, Ebru Temiz","doi":"10.1016/j.biopsych.2026.01.016","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.01.016","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"39 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.biopsych.2026.01.014
Rajan K C, Nehal R. Patel, Abbigail Thurmon, Belle L. Kantor, Maryann Grace Lorino, Alina S. Tiemroth, Vivianne Morrison, Mauren Akumuo, Anoushka Shenoy, Xabier Blanco-Fernandez, Victoria Baccini, Most Ayesha Siddika, Cong Gu, Stryder M. Meadows, Maria J. Galazo
De novo mutations in transcriptional regulators are emerging as key risk factors contributing to the etiology of neurodevelopmental disorders. Human genetic studies have recently identified ZMIZ1 and its de novo mutations as causal of a neurodevelopmental syndrome strongly associated with intellectual disability, autism, ADHD, microcephaly, and other developmental anomalies. However, the role of ZMIZ1 in brain development or how ZMIZ1 mutations cause neurological phenotypes is unknown.
{"title":"Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviors","authors":"Rajan K C, Nehal R. Patel, Abbigail Thurmon, Belle L. Kantor, Maryann Grace Lorino, Alina S. Tiemroth, Vivianne Morrison, Mauren Akumuo, Anoushka Shenoy, Xabier Blanco-Fernandez, Victoria Baccini, Most Ayesha Siddika, Cong Gu, Stryder M. Meadows, Maria J. Galazo","doi":"10.1016/j.biopsych.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.01.014","url":null,"abstract":"<ce:italic>De novo</ce:italic> mutations in transcriptional regulators are emerging as key risk factors contributing to the etiology of neurodevelopmental disorders. Human genetic studies have recently identified ZMIZ1 and its <ce:italic>de novo</ce:italic> mutations as causal of a neurodevelopmental syndrome strongly associated with intellectual disability, autism, ADHD, microcephaly, and other developmental anomalies. However, the role of ZMIZ1 in brain development or how ZMIZ1 mutations cause neurological phenotypes is unknown.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"80 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1016/j.biopsych.2026.01.013
Rachel Yehuda, Dennis S. Charney
{"title":"Can Psychedelics Help Us Reimagine Prevention of Post-Traumatic Stress Disorder?","authors":"Rachel Yehuda, Dennis S. Charney","doi":"10.1016/j.biopsych.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.01.013","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"100 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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