Pub Date : 2025-11-24DOI: 10.1016/j.biopsych.2025.11.010
Robin Bonomi, Nakul Raval, Ansel Hillmer, Kelly P. Cosgrove
{"title":"Imaging Neuroimmune Dysfunction: From TSPO to Emerging PET Targets","authors":"Robin Bonomi, Nakul Raval, Ansel Hillmer, Kelly P. Cosgrove","doi":"10.1016/j.biopsych.2025.11.010","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.010","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"24 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1016/j.biopsych.2025.11.013
Nicholas R. Fontaine, Lauren Lepeak, Mahafuza Aktar, Aimee Mahler, William Black, Jens Hannibal, Margaret A. Vizzard, Victor May, Sayamwong E. Hammack
{"title":"BNST PACAP signaling in the dorsal medial habenula mediates depression- related behavioral responses after chronic stress","authors":"Nicholas R. Fontaine, Lauren Lepeak, Mahafuza Aktar, Aimee Mahler, William Black, Jens Hannibal, Margaret A. Vizzard, Victor May, Sayamwong E. Hammack","doi":"10.1016/j.biopsych.2025.11.013","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.013","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"2 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.biopsych.2025.11.011
Erica B. Baller, Elena C. Cooper, Matthew K. Schindler, Amit Bar-Or, Michael D. Fox, Russell T. Shinohara, Theodore D. Satterthwaite
{"title":"Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis","authors":"Erica B. Baller, Elena C. Cooper, Matthew K. Schindler, Amit Bar-Or, Michael D. Fox, Russell T. Shinohara, Theodore D. Satterthwaite","doi":"10.1016/j.biopsych.2025.11.011","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.011","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.biopsych.2025.11.009
Thomas Pak, Nabila Haque, Manish K. Jha
{"title":"Lessons from clinical trials of immunomodulatory drugs in psychiatric disorders","authors":"Thomas Pak, Nabila Haque, Manish K. Jha","doi":"10.1016/j.biopsych.2025.11.009","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.009","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"14 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.biopsych.2025.11.007
Sebastian Hachenberg, Scott J Russo, Flurin Cathomas
Chronic stress is a major risk factor for several psychiatric disorders, including major depressive disorder and posttraumatic stress disorder. This review synthesizes rodent-based findings showing that stress modifies immune function in the central nervous system (e.g., microglia), the neurovascular unit, and the peripheral circulation. Stress paradigms such as chronic social defeat stress or chronic variable stress induce morphological and transcriptomic changes in microglia, disrupt blood-brain barrier integrity, and mobilize immune cells (e.g., monocytes, neutrophils). These cells, in turn, secrete proinflammatory mediators, including interleukin 6 and matrix metalloproteinase 8, which can penetrate limbic brain regions and contribute to behavioral changes. Integrating next-generation molecular insights with refined behavioral models, particularly those that capture sex-related differences, holds promise for advancing personalized strategies to prevent and treat stress-related disorders.
{"title":"Immunity in Rodent Models of Stress.","authors":"Sebastian Hachenberg, Scott J Russo, Flurin Cathomas","doi":"10.1016/j.biopsych.2025.11.007","DOIUrl":"10.1016/j.biopsych.2025.11.007","url":null,"abstract":"<p><p>Chronic stress is a major risk factor for several psychiatric disorders, including major depressive disorder and posttraumatic stress disorder. This review synthesizes rodent-based findings showing that stress modifies immune function in the central nervous system (e.g., microglia), the neurovascular unit, and the peripheral circulation. Stress paradigms such as chronic social defeat stress or chronic variable stress induce morphological and transcriptomic changes in microglia, disrupt blood-brain barrier integrity, and mobilize immune cells (e.g., monocytes, neutrophils). These cells, in turn, secrete proinflammatory mediators, including interleukin 6 and matrix metalloproteinase 8, which can penetrate limbic brain regions and contribute to behavioral changes. Integrating next-generation molecular insights with refined behavioral models, particularly those that capture sex-related differences, holds promise for advancing personalized strategies to prevent and treat stress-related disorders.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.1016/j.biopsych.2025.10.038
Kristien van der Walt, Dan J. Stein, Anthony W. Zoghbi
{"title":"Genetic evidence for a neuro-immune model of schizophrenia","authors":"Kristien van der Walt, Dan J. Stein, Anthony W. Zoghbi","doi":"10.1016/j.biopsych.2025.10.038","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.10.038","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"56 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.1016/j.biopsych.2025.11.004
Jazmine D.W. Yaeger, Morgan H. James, Cliff H. Summers
Orexin/hypocretin (Orx) peptides critically contribute to stress and arousal circuits’ flexibility and equilibrium. New discoveries highlight plasticity of orexin neurons themselves, as well as plasticity-inducing properties of orexin peptides within projection circuits, as an integral part of this function. Specifically, orexin peptide release in response to stress alters the microcircuitry and gene expression profile of downstream stress regions. Here, we propose that orexin-mediated plasticity within stress circuitry is constructed across a lifetime in response to a myriad of variable challenges, ultimately enhancing neural flexibility and future adaptive behavioral responses. This provides a framework through which exposure to unusually salient stressors, either acutely or over extended periods, can result in altered engagement of stress circuitry and maladaptive affective behavioral outcomes (as in general anxiety disorder, post-traumatic stress disorder). We further posit that the diversity of plastic orexin functions is regulated, at least in part, by unique signaling roles for Orx 1 and 2 receptors in distinct brain regions. By extension, therapeutics with selective actions at these receptors might offer viable treatments designed to override pathological rewiring of stress circuits and restore adaptive stress responsivity.
{"title":"Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States","authors":"Jazmine D.W. Yaeger, Morgan H. James, Cliff H. Summers","doi":"10.1016/j.biopsych.2025.11.004","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.004","url":null,"abstract":"Orexin/hypocretin (Orx) peptides critically contribute to stress and arousal circuits’ flexibility and equilibrium. New discoveries highlight plasticity of orexin neurons themselves, as well as plasticity-inducing properties of orexin peptides within projection circuits, as an integral part of this function. Specifically, orexin peptide release in response to stress alters the microcircuitry and gene expression profile of downstream stress regions. Here, we propose that orexin-mediated plasticity within stress circuitry is constructed across a lifetime in response to a myriad of variable challenges, ultimately enhancing neural flexibility and future adaptive behavioral responses. This provides a framework through which exposure to unusually salient stressors, either acutely or over extended periods, can result in altered engagement of stress circuitry and maladaptive affective behavioral outcomes (as in general anxiety disorder, post-traumatic stress disorder). We further posit that the diversity of plastic orexin functions is regulated, at least in part, by unique signaling roles for Orx 1 and 2 receptors in distinct brain regions. By extension, therapeutics with selective actions at these receptors might offer viable treatments designed to override pathological rewiring of stress circuits and restore adaptive stress responsivity.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"1 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-15DOI: 10.1016/j.biopsych.2025.11.005
Halide Bilge Turkozer, Paulo Lizano, Carol A. Tamminga, Steven M. Silverstein
The visual system, as one of the most well-understood components of the central nervous system, offers a unique framework for understanding mechanistic aspects of psychosis. This review explores the clinical translational potential of visual system alterations in psychosis spectrum disorders, emphasizing their relevance across neurodevelopmental and neurodegenerative processes. The current evidence supporting the clinical significance of visual alterations is reviewed, covering aspects from the retina to low- and mid-level visual regions of the brain, emphasizing the feasibility, accessibility, and cost-effectiveness of vision science tools compared to more invasive, burdensome, and costly neuroimaging biomarkers. Additionally, this review discusses the therapeutic promise of visual system assessments for guiding personalized treatments, monitoring responses to novel pharmacological agents, and advancing approaches such as visual remediation and non-invasive brain stimulation to target vision-related symptoms in psychosis spectrum disorders. By addressing current gaps and proposing a roadmap for integrating these tools into psychiatric research and clinical care, this review underscores the significant potential of leveraging the visual system to enhance diagnostic precision and improve clinical outcomes in psychosis spectrum disorders.
{"title":"Vision and Psychosis: A Clinical Translational Perspective","authors":"Halide Bilge Turkozer, Paulo Lizano, Carol A. Tamminga, Steven M. Silverstein","doi":"10.1016/j.biopsych.2025.11.005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.11.005","url":null,"abstract":"The visual system, as one of the most well-understood components of the central nervous system, offers a unique framework for understanding mechanistic aspects of psychosis. This review explores the clinical translational potential of visual system alterations in psychosis spectrum disorders, emphasizing their relevance across neurodevelopmental and neurodegenerative processes. The current evidence supporting the clinical significance of visual alterations is reviewed, covering aspects from the retina to low- and mid-level visual regions of the brain, emphasizing the feasibility, accessibility, and cost-effectiveness of vision science tools compared to more invasive, burdensome, and costly neuroimaging biomarkers. Additionally, this review discusses the therapeutic promise of visual system assessments for guiding personalized treatments, monitoring responses to novel pharmacological agents, and advancing approaches such as visual remediation and non-invasive brain stimulation to target vision-related symptoms in psychosis spectrum disorders. By addressing current gaps and proposing a roadmap for integrating these tools into psychiatric research and clinical care, this review underscores the significant potential of leveraging the visual system to enhance diagnostic precision and improve clinical outcomes in psychosis spectrum disorders.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"108 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.biopsych.2025.10.037
Donald Huang, Yao-Ying Ma
{"title":"Downregulation of Small Conductance Potassium Channels in Cortical Pyramidal Neurons of the Supplementary Motor Cortex Underlies High Cocaine Seeking Behaviors","authors":"Donald Huang, Yao-Ying Ma","doi":"10.1016/j.biopsych.2025.10.037","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.10.037","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"118 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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