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Microfluidic and impedance analysis of rosemary essential oil: implications for dental health. 迷迭香精油的微流体和阻抗分析:对牙齿健康的影响。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-11-04 DOI: 10.1186/s12938-024-01301-4
Karunan Joseph, Bojan Petrović, Syarifah Aisyah Syed Ibrahim, Aung Thiha, Lazar Milić, Mohd Yazed Ahmad, Nebojša Pavlović, Sanja Kojić, Fatimah Ibrahim, Goran M Stojanović

Background: Oral health is closely linked to systemic conditions, particularly non-communicable diseases (NCDs), which can exacerbate oral issues. Essential oils (EOs) have emerged as potential alternatives for oral health due to their antibacterial, anti-inflammatory, and antioxidant properties. Among these, rosemary essential oil (REO) shows promise due to its various biological activities. This study investigates the potential of REO in dental applications using microfluidic devices and electrochemical impedance spectroscopy (EIS) to analyze the electrical properties of REO in artificial saliva (AS) mixtures.

Results: The study demonstrated significant variations in impedance across different REO concentrations and their mixtures with AS. Higher impedance was observed in REO mixtures, particularly at lower frequencies, indicating distinct electrical properties compared to pure AS. The impedance of REO was influenced by its concentration, with a 1% REO solution showing higher impedance than a 4% solution, possibly due to micelle formation and changes in dielectric properties. Additionally, microfluidic devices enabled precise control over fluid interactions and real-time monitoring, offering valuable insights into REO's behavior in a simulated oral environment. The impedance data demonstrated significant differences in REO-AS mixtures, highlighting potential interactions critical for oral care applications.

Conclusions: Rosemary essential oil exhibits unique electrical properties, making it a promising candidate for dental applications, particularly in preventing and treating oral diseases. Microfluidic devices enhance the accuracy and reliability of studying REO's interactions with AS, providing a robust platform for future dental research. The findings suggest that REO could be effectively incorporated into oral care products, offering a natural alternative for combating oral pathogens, reducing inflammation, and protecting against oxidative stress. Future research should focus on clinical trials to validate these findings and explore the synergistic effects of REO with other essential oils.

背景:口腔健康与全身状况密切相关,尤其是非传染性疾病(NCDs),这些疾病会加剧口腔问题。精油因其抗菌、消炎和抗氧化特性,已成为口腔健康的潜在替代品。其中,迷迭香精油(REO)因其多种生物活性而大有可为。本研究利用微流体设备和电化学阻抗谱(EIS)分析了 REO 在人工唾液(AS)混合物中的电特性,从而研究了 REO 在牙科应用中的潜力:研究表明,不同浓度的 REO 及其与 AS 的混合物在阻抗方面存在明显差异。在 REO 混合物中观察到了较高的阻抗,尤其是在较低频率下,这表明与纯 AS 相比,REO 具有独特的电特性。REO 的阻抗受其浓度的影响,1% 的 REO 溶液比 4% 的溶液显示出更高的阻抗,这可能是由于胶束的形成和介电性质的变化。此外,微流控装置还能精确控制液体的相互作用并进行实时监测,为了解 REO 在模拟口腔环境中的行为提供了宝贵的信息。阻抗数据显示了 REO-AS 混合物的显著差异,突出了对口腔护理应用至关重要的潜在相互作用:迷迭香精油具有独特的电学特性,使其成为牙科应用的理想候选物质,尤其是在预防和治疗口腔疾病方面。微流控装置提高了研究 REO 与 AS 相互作用的准确性和可靠性,为未来的牙科研究提供了一个强大的平台。研究结果表明,REO 可以有效地融入口腔护理产品中,为对抗口腔病原体、减少炎症和防止氧化应激提供一种天然的替代品。未来的研究应侧重于临床试验,以验证这些发现,并探索 REO 与其他精油的协同作用。
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引用次数: 0
A modified deep learning method for Alzheimer's disease detection based on the facial submicroscopic features in mice. 基于小鼠面部亚显微特征的阿尔茨海默病检测改进型深度学习方法。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-31 DOI: 10.1186/s12938-024-01305-0
Guosheng Shen, Fei Ye, Wei Cheng, Qiang Li

Alzheimer's disease (AD) is a chronic disease among people aged 65 and older. As the aging population continues to grow at a rapid pace, AD has emerged as a pressing public health issue globally. Early detection of the disease is important, because increasing evidence has illustrated that early diagnosis holds the key to effective treatment of AD. In this work, we developed and refined a multi-layer cyclic Residual convolutional neural network model, specifically tailored to identify AD-related submicroscopic characteristics in the facial images of mice. Our experiments involved classifying the mice into two distinct groups: a normal control group and an AD group. Compared with the other deep learning models, the proposed model achieved a better detection performance in the dataset of the mouse experiment. The accuracy, sensitivity, specificity and precision for AD identification with our proposed model were as high as 99.78%, 100%, 99.65% and 99.44%, respectively. Moreover, the heat maps of AD correlation in the facial images of the mice were acquired with the class activation mapping algorithm. It was proven that the facial images contained AD-related submicroscopic features. Consequently, through our mouse experiments, we validated the feasibility and accuracy of utilizing a facial image-based deep learning model for AD identification. Therefore, the present study suggests the potential of using facial images for AD detection in humans through deep learning-based methods.

阿尔茨海默病(AD)是 65 岁及以上人群中的一种慢性疾病。随着老龄化人口的持续快速增长,阿兹海默症已成为全球亟待解决的公共卫生问题。早期发现这种疾病非常重要,因为越来越多的证据表明,早期诊断是有效治疗老年痴呆症的关键。在这项工作中,我们开发并改进了一种多层循环残差卷积神经网络模型,专门用于识别小鼠面部图像中与注意力缺失症相关的亚显微特征。我们的实验将小鼠分为两组:正常对照组和注意力缺失症组。与其他深度学习模型相比,所提出的模型在小鼠实验数据集中取得了更好的检测性能。我们提出的模型对AD的识别准确率、灵敏度、特异性和精确度分别高达99.78%、100%、99.65%和99.44%。此外,我们还利用类激活图谱算法获得了小鼠面部图像中的AD相关性热图。结果证明,面部图像中包含了与AD相关的亚显微特征。因此,通过小鼠实验,我们验证了利用基于面部图像的深度学习模型进行AD识别的可行性和准确性。因此,本研究表明,通过基于深度学习的方法,利用面部图像检测人类多动症是有潜力的。
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引用次数: 0
Advances in the development and application of non-contact intraoperative image access systems. 非接触式术中图像存取系统的开发和应用进展。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-30 DOI: 10.1186/s12938-024-01304-1
Zhengnan Liu, Chengrun Li, Jixing Lin, Hengliang Xu, Yan Xu, Haoning Nan, Wei Cheng, Jie Li, Bin Wang

This article provides an overview of recent progress in the achievement of non-contact intraoperative image control through the use of vision and sensor technologies in operating room (OR) environments. A discussion of approaches to improving and optimizing associated technologies is also provided, together with a survey of important challenges and directions for future development aimed at improving the use of non-contact intraoperative image access systems.

本文概述了通过在手术室(OR)环境中使用视觉和传感器技术实现非接触式术中图像控制的最新进展。文章还讨论了改进和优化相关技术的方法,以及旨在改进非接触式术中图像存取系统使用的重要挑战和未来发展方向。
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引用次数: 0
Self-supervised learning framework application for medical image analysis: a review and summary. 自监督学习框架在医学图像分析中的应用:回顾与总结。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-27 DOI: 10.1186/s12938-024-01299-9
Xiangrui Zeng, Nibras Abdullah, Putra Sumari

Manual annotation of medical image datasets is labor-intensive and prone to biases. Moreover, the rate at which image data accumulates significantly outpaces the speed of manual annotation, posing a challenge to the advancement of machine learning, particularly in the realm of supervised learning. Self-supervised learning is an emerging field that capitalizes on unlabeled data for training, thereby circumventing the need for extensive manual labeling. This learning paradigm generates synthetic pseudo-labels through pretext tasks, compelling the network to acquire image representations in a pseudo-supervised manner and subsequently fine-tuning with a limited set of annotated data to achieve enhanced performance. This review begins with an overview of prevalent types and advancements in self-supervised learning, followed by an exhaustive and systematic examination of methodologies within the medical imaging domain from 2018 to September 2024. The review encompasses a range of medical image modalities, including CT, MRI, X-ray, Histology, and Ultrasound. It addresses specific tasks, such as Classification, Localization, Segmentation, Reduction of False Positives, Improvement of Model Performance, and Enhancement of Image Quality. The analysis reveals a descending order in the volume of related studies, with CT and MRI leading the list, followed by X-ray, Histology, and Ultrasound. Except for CT and MRI, there is a greater prevalence of studies focusing on contrastive learning methods over generative learning approaches. The performance of MRI/Ultrasound classification and all image types segmentation still has room for further exploration. Generally, this review can provide conceptual guidance for medical professionals to combine self-supervised learning with their research.

医学影像数据集的人工标注耗费大量人力,而且容易产生偏差。此外,图像数据的积累速度大大超过了人工标注的速度,这对机器学习的进步,尤其是监督学习领域的进步提出了挑战。自我监督学习是一个新兴领域,它利用未标注数据进行训练,从而避免了大量人工标注的需要。这种学习模式通过借口任务生成合成伪标签,迫使网络以一种伪监督的方式获取图像表征,然后利用有限的注释数据集进行微调,以提高性能。本综述首先概述了自监督学习的普遍类型和进展,然后对 2018 年至 2024 年 9 月期间医学影像领域的方法进行了详尽、系统的研究。综述涵盖一系列医学影像模式,包括 CT、MRI、X 射线、组织学和超声波。它涉及分类、定位、分割、减少误判、提高模型性能和增强图像质量等具体任务。分析表明,相关研究的数量从高到低依次为 CT 和 MRI,其次是 X 射线、组织学和超声波。除 CT 和 MRI 外,更多的研究侧重于对比学习方法,而不是生成学习方法。MRI/Ultrasound 分类和所有图像类型分割的性能仍有进一步探索的空间。总体而言,本综述可为医学专业人员提供概念指导,帮助他们将自我监督学习与研究相结合。
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引用次数: 0
The probability density function of the surface electromyogram and its dependence on contraction force in the vastus lateralis. 外侧肌表面肌电图的概率密度函数及其与收缩力的关系。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-26 DOI: 10.1186/s12938-024-01285-1
Javier Rodriguez-Falces, Armando Malanda, Cristina Mariscal, Silvia Recalde, Javier Navallas

Introduction: The probability density function (PDF) of the surface electromyogram (sEMG) depends on contraction force. This dependence, however, has so far been investigated by having the subject generate force at a few fixed percentages of MVC. Here, we examined how the shape of the sEMG PDF changes with contraction force when this force was gradually increased from zero.

Methods: Voluntary surface EMG signals were recorded from the vastus lateralis of healthy subjects as force was increased in a continuous manner vs. in a step-wise fashion. The sEMG filling process was examined by measuring the EMG filling factor, computed from the non-central moments of the rectified sEMG signal.

Results: (1) In 84% of the subjects, as contraction force increased from 0 to 10% MVC, the sEMG PDF shape oscillated back and forth between the semi-degenerate and the Gaussian distribution. (2) The PDF-force relation varied greatly among subjects for forces between 0 and ~ 10% MVC, but this variability was largely reduced for forces above 10% MVC. (3) The pooled analysis showed that, as contraction force gradually increased, the sEMG PDF evolved rapidly from the semi-degenerate towards the Laplacian distribution from 0 to 5% MVC, and then more slowly from the Laplacian towards the Gaussian distribution for higher forces.

Conclusions: The study demonstrated that the dependence of the sEMG PDF shape on contraction force can only be reliably assessed by gradually increasing force from zero, and not by performing a few constant-force contractions. The study also showed that the PDF-force relation differed greatly among individuals for contraction forces below 10% MVC, but this variability was largely reduced when force increased above 10% MVC.

简介表面肌电图(sEMG)的概率密度函数(PDF)取决于收缩力。然而,迄今为止,对这种依赖性的研究都是通过让受试者在几种固定的 MVC 百分比下产生力来进行的。在此,我们研究了当收缩力从零开始逐渐增加时,肌电图 PDF 的形状如何随收缩力而变化:方法:我们从健康受试者的外侧阔肌记录了持续增加力量与逐步增加力量时的自主表面肌电信号。结果:(1)在 84% 的受试者中,当收缩力从 0 增加到 10% MVC 时,肌电图 PDF 的形状在半退化分布和高斯分布之间来回摆动。(2)不同受试者的 PDF 与收缩力的关系在收缩力为 0 到 10% MVC 之间时变化很大,但当收缩力超过 10%MVC时,这种变化就大大减小了。(3) 汇总分析表明,随着收缩力的逐渐增加,从 0 到 5% MVC,sEMG PDF 迅速从半退化分布向拉普拉斯分布演化,然后在更大的收缩力下,从拉普拉斯分布向高斯分布演化的速度更慢:该研究表明,只有通过从零开始逐渐增加力量,而不是通过进行几次恒定力量的收缩,才能可靠地评估 sEMG PDF 形状对收缩力的依赖性。研究还表明,当收缩力低于 10% MVC 时,不同个体的 PDF 与收缩力的关系差异很大,但当收缩力增加到 10% MVC 以上时,这种差异就会大大减小。
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引用次数: 0
Evaluation of stiffness-matched, 3D-printed, NiTi mandibular graft fixation in an ovine model. 在绵羊模型中评估硬度匹配的 3D 打印镍钛下颌骨移植物固定。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-26 DOI: 10.1186/s12938-024-01289-x
Nada Raafat Khattab, Luis H Olivas-Alanis, Agnieszka Chmielewska-Wysocka, Hany Emam, Ryan Brune, Ahmadreza Jahadakbar, Sahil Khambhampati, Joseph Lozier, Keyvan Safaei, Roman Skoracki, Mohammad Elahinia, David Dean

Background: Manually bent, standard-of-care, Ti-6Al-4V, mandibular graft fixation devices are associated with a significant post-operative failure rate. These failures require the patient to endure stressful and expensive re-operation. The approach recommended in this report demonstrates the optimization of graft fixation device mechanical properties via "stiffness-matching" by varying the fixation device's location, shape, and material composition through simulation of the device's post-operative performance. This provides information during pre-operative planning that may avoid future device failure. Optimized performance may combine translation of all loading into compression of the bone graft with the adjacent bone segments and elimination or minimization of post-healing interruption of normal stress-strain (loading) trajectories.

Results: This study reports a sheep mandibular graft model where four animals received virtually optimized, experimental nickel-titanium (NiTi) fixation plates fabricated using laser beam powder bed fusion (LPBF) additive manufacturing (AM). The last animal, our control, received a standard-of-care, manually bent, Ti-6Al-4V (aka Ti64) fixation plate. A 17.5-mm mandibular graft healed completely in all four animals receiving the experimental device. Experimental NiTi-implanted sheep experienced mandibular bone healing and restoration. The Ti64 plate, in the control animal, fractured and dislocated shortly after being implanted.

Conclusion: The use of stiffness-matched implants, by means of plate material (NiTi) and geometry (porosity) enhanced bone healing and promoted better load transfer to the healed bone when compared to the bulk Ti64 found in the fixation plate that the Control animal received. The design technique and screw orientation and depth planning improved throughout the study leading to more rapid healing. The large animal model reported here provides data useful for a follow-on clinical trial.

背景:手动弯曲、标准护理、Ti-6Al-4V 下颌骨移植物固定装置的术后失败率很高。这些失败需要患者承受压力和昂贵的再次手术。本报告推荐的方法展示了通过 "刚度匹配 "优化移植物固定装置机械性能的方法,即通过模拟装置的术后性能来改变固定装置的位置、形状和材料成分。这为术前规划提供了信息,可避免未来的装置故障。优化性能可将所有加载转化为骨移植与邻近骨段的压缩,并消除或尽量减少愈合后正常应力-应变(加载)轨迹的中断:本研究报告了一个绵羊下颌骨移植模型,其中四只动物接受了利用激光束粉末床融合(LPBF)增材制造(AM)技术制作的经过实际优化的实验性镍钛(NiTi)固定板。最后一只动物,也就是我们的对照组,接受的是人工弯曲的标准钛-6Al-4V(又称 Ti64)固定板。接受实验装置的所有四只动物的 17.5 毫米下颌骨移植物均完全愈合。植入镍钛的实验绵羊下颌骨愈合并恢复。对照组的钛64钢板在植入后不久就发生了断裂和脱位:结论:与对照组动物使用的Ti64固定钢板相比,通过钢板材料(镍钛)和几何形状(多孔性)使用硬度匹配的植入体可促进骨愈合,并更好地将负荷传递到愈合的骨。在整个研究过程中,设计技术、螺钉方向和深度规划都得到了改进,从而加快了愈合速度。本文报告的大型动物模型为后续临床试验提供了有用的数据。
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引用次数: 0
Enhancing the estimation of PaCO2 from etCO2 during ventilation through non-invasive parameters in the ovine model. 在绵羊模型中,通过非侵入性参数加强通气过程中根据 etCO2 估算 PaCO2。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-24 DOI: 10.1186/s12938-024-01292-2
Mike Grüne, Lena Olivier, Valerie Pfannschmidt, Matthias Hütten, Thorsten Orlikowsky, Andre Stollenwerk, Mark Schoberer

Background: In mechanically ventilated neonates, the arterial partial pressure of CO 2 ( PaCO 2 ) is an important indicator for the adequacy of ventilation settings. Determining the PaCO 2 is commonly done using invasive blood gas analyses, which constitute risks for neonates and are typically only available infrequently. An accurate, reliable, and continuous estimation of PaCO 2 is of high interest for medical staff, giving the possibility of a closer monitoring and faster reactions to changes. We aim to present a non-invasive estimation method for PaCO 2 in neonates on the basis of end-tidal CO 2 ( etCO 2 ) with inclusion of different physiological and ventilation parameters. The estimation method should be more accurate than an estimation by unaltered etCO 2 measurements with regard to the mean absolute error and the standard deviation.

Methods: Secondary data from 51 preterm lambs are used, due to its high comparability to preterm human data. We utilize robust linear regression on 863 PaCO 2 measurements below or equal to 75 mmHg from the first day of life. etCO 2 along with a set of ventilation settings and measurements as well as vital parameters are included in the regression. Included independent variables are chosen iteratively by highest Pearson correlation to the remaining estimation deviation.

Results: The evaluation is carried out on 12 additional neonatal lambs with 246 PaCO 2 measurements below or equal to 75 mmHg from the first two days of life. The estimation method shows a mean absolute error of 3.80 mmHg with a 4.92 mmHg standard deviation of differences and a standard error of 0.31 mmHg in comparison to measured PaCO 2 by blood gas analysis.

Conclusions: The estimation of PaCO 2 by the proposed equation is less biased than unaltered etCO 2 . The usage of this method in clinical practice or in applications like the automation of ventilation needs further investigation.

背景:在机械通气的新生儿中,动脉二氧化碳分压(PaCO 2)是衡量通气设置是否充分的重要指标。确定 PaCO 2 通常采用有创血气分析法,但这种方法对新生儿有风险,而且通常不常使用。准确、可靠、持续地估算 PaCO 2 值是医务人员非常关心的问题,这样可以更密切地监测病情变化并做出更快的反应。我们的目标是在潮气末 CO 2 ( etCO 2 ) 的基础上,结合不同的生理和通气参数,提出一种无创的新生儿 PaCO 2 估算方法。就平均绝对误差和标准偏差而言,该估算方法应比未经改变的 etCO 2 测量值估算更为准确:方法:我们使用了 51 只早产羔羊的二手数据,因为这些数据与人类早产羔羊的数据具有很高的可比性。我们利用稳健线性回归法对出生第一天起低于或等于 75 mmHg 的 863 个 PaCO 2 测量值进行回归。根据与剩余估计偏差的最高皮尔逊相关性反复选择所包含的自变量:对另外 12 只新生羔羊进行了评估,这些羔羊在出生后头两天内有 246 次 PaCO 2 测量值低于或等于 75 mmHg。与通过血气分析测得的 PaCO 2 相比,该估算方法的平均绝对误差为 3.80 mmHg,差异标准偏差为 4.92 mmHg,标准误差为 0.31 mmHg:结论:与未经改变的等CO 2 相比,用提出的等式估计 PaCO 2 的偏差较小。这种方法在临床实践或通气自动化等应用中的使用还需进一步研究。
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引用次数: 0
Four-phase CT lesion recognition based on multi-phase information fusion framework and spatiotemporal prediction module. 基于多相信息融合框架和时空预测模块的四相 CT 病灶识别。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-21 DOI: 10.1186/s12938-024-01297-x
Shaohua Qiao, Mengfan Xue, Yan Zuo, Jiannan Zheng, Haodong Jiang, Xiangai Zeng, Dongliang Peng

Multiphase information fusion and spatiotemporal feature modeling play a crucial role in the task of four-phase CT lesion recognition. In this paper, we propose a four-phase CT lesion recognition algorithm based on multiphase information fusion framework and spatiotemporal prediction module. Specifically, the multiphase information fusion framework uses the interactive perception mechanism to realize the channel-spatial information interactive weighting between multiphase features. In the spatiotemporal prediction module, we design a 1D deep residual network to integrate multiphase feature vectors, and use the GRU architecture to model the temporal enhancement information between CT slices. In addition, we employ CT image pseudo-color processing for data augmentation and train the whole network based on a multi-task learning framework. We verify the proposed network on a four-phase CT dataset. The experimental results show that the proposed network can effectively fuse the multi-phase information and model the temporal enhancement information between CT slices, showing excellent performance in lesion recognition.

多相信息融合和时空特征建模在四相 CT 病灶识别任务中起着至关重要的作用。本文提出了一种基于多相信息融合框架和时空预测模块的四相 CT 病灶识别算法。具体来说,多相信息融合框架利用交互感知机制实现多相特征之间的信道空间信息交互加权。在时空预测模块中,我们设计了一维深度残差网络来整合多相特征向量,并使用 GRU 架构对 CT 切片之间的时间增强信息进行建模。此外,我们还利用 CT 图像伪彩色处理进行数据增强,并基于多任务学习框架训练整个网络。我们在四期 CT 数据集上验证了所提出的网络。实验结果表明,所提出的网络能有效融合多相信息,并对 CT 切片间的时间增强信息进行建模,在病变识别方面表现出色。
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引用次数: 0
A transcriptomic analysis of dental pulp stem cell senescence in vitro. 牙髓干细胞体外衰老的转录组分析。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-18 DOI: 10.1186/s12938-024-01298-w
Jidong Xu, Mingchang Hu, Longfei Liu, Xuecheng Xu, Linlin Xu, Yu Song

Background/purpose: The use of human dental pulp stem cells (hDPSCs) as autologous stem cells for tissue repair and regenerative techniques is a significant area of global research. The objective of this study was to investigate the effects of long-term in vitro culture on the multidifferentiation potential of hDPSCs and the potential molecular mechanisms involved.

Materials and methods: The tissue block method was used to extract hDPSCs from orthodontic-minus-extraction patients, which were then expanded and cultured in vitro for 12 generations. Stem cells from passages three, six, nine, and twelve were selected. Flow cytometry was used to detect the expression of stem cell surface markers, and CCK-8 was used to assess cell proliferation. β-Galactosidase staining was employed to detect cellular senescence, Alizarin Red S staining to assess osteogenic potential, and Oil Red O staining to evaluate lipogenic capacity. RNA sequencing (RNA-seq) was conducted to identify differentially expressed genes in DPSCs and investigate their potential mechanisms.

Results: With increasing passage numbers, pulp stem cells showed an increase in senescence and a decrease in proliferative capacity and osteogenic-lipogenic multidifferentiation potential. The expression of stem cell surface markers CD34 and CD45 was stable, whereas the expression of CD73, CD90, and CD105 decreased with increasing passages. According to the RNA-seq analysis, the differentially expressed genes CFH, WNT16, HSD17B2, IDI1, and COL5A3 may be associated with stem cell senescence.

Conclusion: Increased in vitro expansion induced cellular senescence in pulp stem cells, which resulted in a reduction in their proliferative capacity and osteogenic-lipogenic differentiation potential. The differential expression of genes such as CFH, WNT16, HSD17B2, IDI1, and COL5A3 may represent a potential mechanism for the induction of cellular senescence in pulp stem cells.

背景/目的:将人牙髓干细胞(hDPSCs)作为自体干细胞用于组织修复和再生技术是全球研究的一个重要领域。本研究旨在探讨长期体外培养对 hDPSCs 多分化潜能的影响以及潜在的分子机制:采用组织块法从正畸-拔牙患者体内提取 hDPSCs,然后在体外扩增培养 12 代。选取第 3、6、9 和 12 代的干细胞。流式细胞仪用于检测干细胞表面标记物的表达,CCK-8用于评估细胞增殖。β-半乳糖苷酶染色用于检测细胞衰老,茜素红 S 染色用于评估成骨潜能,油红 O 染色用于评估脂肪生成能力。进行了RNA测序(RNA-seq),以确定DPSCs中的差异表达基因,并研究其潜在机制:结果:随着通过数的增加,纸浆干细胞的衰老程度增加,增殖能力和成骨-成脂多分化潜能下降。干细胞表面标志物CD34和CD45的表达稳定,而CD73、CD90和CD105的表达则随着传代数的增加而减少。根据RNA-seq分析,差异表达基因CFH、WNT16、HSD17B2、IDI1和COL5A3可能与干细胞衰老有关:结论:体外扩增诱导了牙髓干细胞的细胞衰老,导致其增殖能力和成骨-成脂分化潜能下降。CFH、WNT16、HSD17B2、IDI1和COL5A3等基因的不同表达可能是诱导牙髓干细胞细胞衰老的潜在机制。
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引用次数: 0
Potential role of metal nanoparticles in treatment of peri-implant mucositis and peri-implantitis. 金属纳米粒子在治疗种植体周围粘膜炎和种植体周围炎中的潜在作用。
IF 2.9 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-10-12 DOI: 10.1186/s12938-024-01294-0
Mohammad Hosseini Hooshiar, Asieh Mozaffari, Mareb Hamed Ahmed, Radhwan Abdul Kareem, Athmar Jaber Zrzo, Aseel Salah Mansoor, Zainab H Athab, Zahra Parhizgar, Parisa Amini

Peri-implantitis (PI), a pathological condition associated with plaque, affects the tissues around dental implants. In addition, peri-implant mucositis (PIM) is a precursor to the destructive inflammatory PI and is an inflammation of the soft tissues surrounding the dental implant. It is challenging to eradicate and regulate the PI treatment due to its limited effectiveness. Currently, there is a significant interest in the development and research of additional biocompatible materials to prevent the failure of dental implants. Nanotechnology has the potential to address or develop solutions to the significant challenge of implant failure caused by cytotoxicity and biocompatibility in dentistry. Nanoparticles (NPs) may be used as carriers for the release of medicines, as well as to make implant coatings and supply appropriate materials for implant construction. Furthermore, the bioactivity and therapeutic efficacy of metal NPs in peri-implant diseases (PID) are substantiated by a plethora of in vitro and in vivo studies. Furthermore, the use of silver (Ag), gold (Au), zinc oxide, titanium oxide (TiO2), copper (Cu), and iron oxide NPs as a cure for dental implant infections brought on by bacteria that have become resistant to several medications is the subject of recent dentistry research. Because of their unique shape-dependent features, which enhance bio-physio-chemical functionalization, antibacterial activity, and biocompatibility, metal NPs are employed in dental implants. This study attempted to provide an overview of the application of metal and metal oxide NPs to control and increase the success rate of implants while focusing on the antimicrobial properties of these NPs in the treatment of PID, including PIM and PI. Additionally, the study reviewed the potential benefits and drawbacks of using metal NPs in clinical settings for managing PID, with the goal of advancing future treatment strategies for these conditions.

种植体周围炎(PI)是一种与牙菌斑有关的病理状态,会影响种植体周围的组织。此外,种植体周围粘膜炎(PIM)是破坏性炎症 PI 的前兆,是种植体周围软组织的炎症。由于 PIM 的疗效有限,根除和调节 PIM 的治疗具有挑战性。目前,人们对开发和研究更多的生物相容性材料以防止牙科植入物失效有着浓厚的兴趣。纳米技术有可能解决或开发出解决方案,以应对牙科领域因细胞毒性和生物相容性造成的种植失败这一重大挑战。纳米颗粒(NPs)可用作释放药物的载体,也可用于制造种植体涂层和提供适当的种植体制造材料。此外,大量的体外和体内研究证实了金属纳米粒子对种植体周围疾病(PID)的生物活性和治疗效果。此外,使用银(Ag)、金(Au)、氧化锌、氧化钛(TiO2)、铜(Cu)和氧化铁 NPs 治疗对多种药物产生抗药性的细菌引起的种植牙感染也是近期牙科研究的主题。由于金属 NPs 具有独特的形状特征,可增强生物-物理-化学功能化、抗菌活性和生物相容性,因此被广泛应用于牙科植入物中。本研究试图概述金属和金属氧化物 NPs 在控制和提高种植成功率方面的应用,同时重点研究这些 NPs 在治疗 PID(包括 PIM 和 PI)方面的抗菌特性。此外,该研究还回顾了在临床环境中使用金属 NPs 治疗 PID 的潜在好处和缺点,目的是推进这些病症的未来治疗策略。
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BioMedical Engineering OnLine
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