Pub Date : 2024-08-09DOI: 10.25135/acg.oc.2405.32434
Sule Gursoy, Dilara Ergun, Mehmet Abdullah Alagöz
{"title":"Synthesis and antifungal activities of bisbenzazole derivatives","authors":"Sule Gursoy, Dilara Ergun, Mehmet Abdullah Alagöz","doi":"10.25135/acg.oc.2405.32434","DOIUrl":"https://doi.org/10.25135/acg.oc.2405.32434","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"82 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.25135/bmcr.31.23.01.2775
R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem
{"title":"Impact of COVID-19 on the thyroid gland in Iraqi females","authors":"R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem","doi":"10.25135/bmcr.31.23.01.2775","DOIUrl":"https://doi.org/10.25135/bmcr.31.23.01.2775","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"35 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139777550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.25135/bmcr.31.23.01.2775
R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem
{"title":"Impact of COVID-19 on the thyroid gland in Iraqi females","authors":"R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem","doi":"10.25135/bmcr.31.23.01.2775","DOIUrl":"https://doi.org/10.25135/bmcr.31.23.01.2775","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139837256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.25135/bmcr.27.2204.2418
Y. Kadioglu, Alptug Atila
{"title":"Determination of Lidocaine HCl in commercially cream and injection forms by GC-FID method","authors":"Y. Kadioglu, Alptug Atila","doi":"10.25135/bmcr.27.2204.2418","DOIUrl":"https://doi.org/10.25135/bmcr.27.2204.2418","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82314407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-28DOI: 10.25135/acg.bmcr.26.2111.2255
Merve Saylam, Ayse H. Tarikogullari, S. Yılmaz, P. Ballar Kirmizibayrak
{"title":"Neuroprotective activity studies of some phenylacetamide derivatives bearing 1H-pyrazole or 1H-1,2,4-triazole","authors":"Merve Saylam, Ayse H. Tarikogullari, S. Yılmaz, P. Ballar Kirmizibayrak","doi":"10.25135/acg.bmcr.26.2111.2255","DOIUrl":"https://doi.org/10.25135/acg.bmcr.26.2111.2255","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-12DOI: 10.25135/acg.bmcr.23.20.08.1773
M. Alagöz
Intensive studies are being conducted to develop effective prevention and treatment strategies for the Covid-19 pandemic. During a pandemic, it is vital to act quickly to develop a defense strategy. It usually takes a long time to develop a preventive vaccine, and immediate drug development is needed to reduce the impact of the rapidly increasing Covid-19 pandemic. This study aimed to design an effective and potent drug by selecting remdesivir, a nucleotide analog prodrug that inhibits viral RNA polymerases and is known to be active against Covid-19. Remdesivir is metabolized into active nucleoside triphosphate (NTP) by the host; this metabolite competes with adenosine triphosphate (ATP) for incorporation into the nascent RNA strand. Therefore, molecular docking studies have been conducted based on NTP (the active form of remdesivir), and a target molecule that could be effective against Covid-19 has been designed.
{"title":"New molecule design with in-silico methods for Covid-19 treatment","authors":"M. Alagöz","doi":"10.25135/acg.bmcr.23.20.08.1773","DOIUrl":"https://doi.org/10.25135/acg.bmcr.23.20.08.1773","url":null,"abstract":"Intensive studies are being conducted to develop effective prevention and treatment strategies for the Covid-19 pandemic. During a pandemic, it is vital to act quickly to develop a defense strategy. It usually takes a long time to develop a preventive vaccine, and immediate drug development is needed to reduce the impact of the rapidly increasing Covid-19 pandemic. This study aimed to design an effective and potent drug by selecting remdesivir, a nucleotide analog prodrug that inhibits viral RNA polymerases and is known to be active against Covid-19. Remdesivir is metabolized into active nucleoside triphosphate (NTP) by the host; this metabolite competes with adenosine triphosphate (ATP) for incorporation into the nascent RNA strand. Therefore, molecular docking studies have been conducted based on NTP (the active form of remdesivir), and a target molecule that could be effective against Covid-19 has been designed.","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75328352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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