Pub Date : 2024-08-09DOI: 10.25135/acg.oc.2405.32434
Sule Gursoy, Dilara Ergun, Mehmet Abdullah Alagöz
{"title":"Synthesis and antifungal activities of bisbenzazole derivatives","authors":"Sule Gursoy, Dilara Ergun, Mehmet Abdullah Alagöz","doi":"10.25135/acg.oc.2405.32434","DOIUrl":"https://doi.org/10.25135/acg.oc.2405.32434","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"82 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.25135/bmcr.31.23.01.2775
R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem
{"title":"Impact of COVID-19 on the thyroid gland in Iraqi females","authors":"R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem","doi":"10.25135/bmcr.31.23.01.2775","DOIUrl":"https://doi.org/10.25135/bmcr.31.23.01.2775","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"35 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139777550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.25135/bmcr.31.23.01.2775
R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem
{"title":"Impact of COVID-19 on the thyroid gland in Iraqi females","authors":"R. Ersan, Kajeen H. Jasim, Noor Adnan Naeem, Lana Ziyad Sulayman, Rayan Sadiq, Nechervan Waheed, Jihan Hasan Jasim, Azheen Qasem","doi":"10.25135/bmcr.31.23.01.2775","DOIUrl":"https://doi.org/10.25135/bmcr.31.23.01.2775","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139837256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.25135/bmcr.27.2204.2418
Y. Kadioglu, Alptug Atila
{"title":"Determination of Lidocaine HCl in commercially cream and injection forms by GC-FID method","authors":"Y. Kadioglu, Alptug Atila","doi":"10.25135/bmcr.27.2204.2418","DOIUrl":"https://doi.org/10.25135/bmcr.27.2204.2418","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82314407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-28DOI: 10.25135/acg.bmcr.26.2111.2255
Merve Saylam, Ayse H. Tarikogullari, S. Yılmaz, P. Ballar Kirmizibayrak
{"title":"Neuroprotective activity studies of some phenylacetamide derivatives bearing 1H-pyrazole or 1H-1,2,4-triazole","authors":"Merve Saylam, Ayse H. Tarikogullari, S. Yılmaz, P. Ballar Kirmizibayrak","doi":"10.25135/acg.bmcr.26.2111.2255","DOIUrl":"https://doi.org/10.25135/acg.bmcr.26.2111.2255","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-12DOI: 10.25135/acg.bmcr.22.20.07.1706
Nebih Lolak, Muhammed Tuneğ, Asli E Dogan, M. Boğa, Suleyman Akocak
A series of twenty 1,3,5-triazine-substituted ureido benzenesulfonamides 2 (a-e) and 3 (a-o) were re-synthesized and assayed for antioxidant properties by using several different methods including 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation radical decolarization assay, metal chelating and cupric reducing antioxidant capacity (CUPRAC) methods. The inhibitory effects of compounds on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes have been also demonstrated. All compounds showed a greater antioxidant capacity against ABTS assay by having a more potent activity than the standards BHT, BHA and α-TOC. In general, all compounds were non susceptible to against AChE enzyme. On the other hand, several lead compounds were obtained from the current series against BChE enzyme. More specifically, compound 3m showed great inhibition profile against BChE with % inhibition value of 93.77, which is better than the standard drug galantamine (% inhibition value of 87.86).
重新合成了20种1,3,5-三嗪取代的脲基苯磺酰胺2 (A -e)和3 (A -o)，并采用1,1-二苯基-2-吡啶酰肼(DPPH)自由基清除法、2,2 ' -氮基-双-(3-乙基苯并噻唑-6-磺酸)(ABTS)阳离子自由基脱色法、金属螯合法和铜还原抗氧化能力(CUPRAC)法测定了它们的抗氧化性能。化合物对乙酰胆碱酯酶(AChE)和丁基胆碱酯酶(BChE)也有抑制作用。所有化合物均比BHT、BHA和α-TOC具有更强的抗氧化能力。总的来说，所有化合物对乙酰胆碱酯酶均不敏感。另一方面，从目前的系列中获得了几个针对BChE酶的先导化合物。其中，化合物3m对BChE的抑制率为93.77 %，优于标准药物加兰他明(87.86 %)。
{"title":"Synthesis and biological evaluation of 1,3,5-triazine-substituted ureido benzenesulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors","authors":"Nebih Lolak, Muhammed Tuneğ, Asli E Dogan, M. Boğa, Suleyman Akocak","doi":"10.25135/acg.bmcr.22.20.07.1706","DOIUrl":"https://doi.org/10.25135/acg.bmcr.22.20.07.1706","url":null,"abstract":"A series of twenty 1,3,5-triazine-substituted ureido benzenesulfonamides 2 (a-e) and 3 (a-o) were re-synthesized and assayed for antioxidant properties by using several different methods including 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation radical decolarization assay, metal chelating and cupric reducing antioxidant capacity (CUPRAC) methods. The inhibitory effects of compounds on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes have been also demonstrated. All compounds showed a greater antioxidant capacity against ABTS assay by having a more potent activity than the standards BHT, BHA and α-TOC. In general, all compounds were non susceptible to against AChE enzyme. On the other hand, several lead compounds were obtained from the current series against BChE enzyme. More specifically, compound 3m showed great inhibition profile against BChE with % inhibition value of 93.77, which is better than the standard drug galantamine (% inhibition value of 87.86).","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81472521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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