Pub Date : 2020-12-12DOI: 10.25135/acg.bmcr.23.20.08.1773
M. Alagöz
Intensive studies are being conducted to develop effective prevention and treatment strategies for the Covid-19 pandemic. During a pandemic, it is vital to act quickly to develop a defense strategy. It usually takes a long time to develop a preventive vaccine, and immediate drug development is needed to reduce the impact of the rapidly increasing Covid-19 pandemic. This study aimed to design an effective and potent drug by selecting remdesivir, a nucleotide analog prodrug that inhibits viral RNA polymerases and is known to be active against Covid-19. Remdesivir is metabolized into active nucleoside triphosphate (NTP) by the host; this metabolite competes with adenosine triphosphate (ATP) for incorporation into the nascent RNA strand. Therefore, molecular docking studies have been conducted based on NTP (the active form of remdesivir), and a target molecule that could be effective against Covid-19 has been designed.
{"title":"New molecule design with in-silico methods for Covid-19 treatment","authors":"M. Alagöz","doi":"10.25135/acg.bmcr.23.20.08.1773","DOIUrl":"https://doi.org/10.25135/acg.bmcr.23.20.08.1773","url":null,"abstract":"Intensive studies are being conducted to develop effective prevention and treatment strategies for the Covid-19 pandemic. During a pandemic, it is vital to act quickly to develop a defense strategy. It usually takes a long time to develop a preventive vaccine, and immediate drug development is needed to reduce the impact of the rapidly increasing Covid-19 pandemic. This study aimed to design an effective and potent drug by selecting remdesivir, a nucleotide analog prodrug that inhibits viral RNA polymerases and is known to be active against Covid-19. Remdesivir is metabolized into active nucleoside triphosphate (NTP) by the host; this metabolite competes with adenosine triphosphate (ATP) for incorporation into the nascent RNA strand. Therefore, molecular docking studies have been conducted based on NTP (the active form of remdesivir), and a target molecule that could be effective against Covid-19 has been designed.","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75328352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/bmcr.10.18.12.1104
B. Kuzu, Nurettin Menges
{"title":"Analyzing of Some Drugable Properties of Hydrazono-pyridazinones","authors":"B. Kuzu, Nurettin Menges","doi":"10.25135/bmcr.10.18.12.1104","DOIUrl":"https://doi.org/10.25135/bmcr.10.18.12.1104","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86303702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/BMCR.15.18.12.1124
B. Dur, R. Ozen, Furkan Ayaz
{"title":"Citric acid synthesis efficiency of Aspergillus niger in carob molasses based media","authors":"B. Dur, R. Ozen, Furkan Ayaz","doi":"10.25135/BMCR.15.18.12.1124","DOIUrl":"https://doi.org/10.25135/BMCR.15.18.12.1124","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84201309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/bmcr.09.18.01.001
Oztekin Algul
{"title":"Welcome to the first issue of BioorgMedChemRep for 2018!","authors":"Oztekin Algul","doi":"10.25135/bmcr.09.18.01.001","DOIUrl":"https://doi.org/10.25135/bmcr.09.18.01.001","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77216628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/BMCR.12.18.11.1035
Esen Yıldız Bekfelavi, Pınar Çevik, Ö. Yılmaz, N. S. Kus, G. Coral, A. Çelik
{"title":"The synthesis of two novel bicyclic haloketones and measurement of their biological activity","authors":"Esen Yıldız Bekfelavi, Pınar Çevik, Ö. Yılmaz, N. S. Kus, G. Coral, A. Çelik","doi":"10.25135/BMCR.12.18.11.1035","DOIUrl":"https://doi.org/10.25135/BMCR.12.18.11.1035","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81460197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/BMCR.11.18.09.899
Furkan Ayaz
Especially in elderly women osteoporosis leads to decline in the strength of the bone tissue by erosion of its mass. Weakened bone tissue is more prone to breaks. Patients mostly realize this situation after having a bone breakage especially with the wrist and hip fractures. There has not been an effective way of improving this debilitating condition. A new approach aiming to regulate the activities of the immune system cells in order to reverse osteoporosis and push the tissue for the formation of the bone structure gained attention due to its promising potential. In this review, I will be focusing on this approach by regulation of the macrophage activity, the major immune cell type that is involved in the bone formation. Immunomodulation of the macrophages enable formation and healing of the bone tissue in the patients and conducting more studies in this area would certainly improve the quality of the applicable medicines.
{"title":"Immunomodulation of macrophages for bone formation","authors":"Furkan Ayaz","doi":"10.25135/BMCR.11.18.09.899","DOIUrl":"https://doi.org/10.25135/BMCR.11.18.09.899","url":null,"abstract":"Especially in elderly women osteoporosis leads to decline in the strength of the bone tissue by erosion of its mass. Weakened bone tissue is more prone to breaks. Patients mostly realize this situation after having a bone breakage especially with the wrist and hip fractures. There has not been an effective way of improving this debilitating condition. A new approach aiming to regulate the activities of the immune system cells in order to reverse osteoporosis and push the tissue for the formation of the bone structure gained attention due to its promising potential. In this review, I will be focusing on this approach by regulation of the macrophage activity, the major immune cell type that is involved in the bone formation. Immunomodulation of the macrophages enable formation and healing of the bone tissue in the patients and conducting more studies in this area would certainly improve the quality of the applicable medicines.","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"67 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83075341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.25135/BMCR.10.18.12.110486
Z. Kudaş
{"title":"Electrochemical studies of regorafenib in non-aqueous media","authors":"Z. Kudaş","doi":"10.25135/BMCR.10.18.12.110486","DOIUrl":"https://doi.org/10.25135/BMCR.10.18.12.110486","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84232870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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