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NMDA antagonists use in bipolar depression: A case report NMDA 拮抗剂用于双相抑郁症:病例报告。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-01 DOI: 10.1111/bdi.13496
Kirolos Ibrahim, Sara Abell, Rif El-Mallakh
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引用次数: 0
Conceptualizing the relationship between synthetic cannabinoid use and neuroleptic malignant syndrome. 合成大麻素的使用与神经性恶性综合征之间关系的概念化。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-01 DOI: 10.1111/bdi.13503
Vincent Zhang, Alexis June Wirtz, Anmol Dhingra, Ashar Zahid, Najeeb Hussain
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引用次数: 0
Utilizing long-acting injectables to address noncompliance among adolescents diagnosed with bipolar disorder 利用长效注射剂解决被诊断出患有躁郁症的青少年不遵医嘱的问题。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-09-01 DOI: 10.1111/bdi.13493
Kanuja Sood, Mahiya Buddhavarapu, Lajpat Rai Bansal, Daniel Schaefer, Parinda Parikh
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引用次数: 0
Treatment resistant but not irremediable. 有治疗耐药性,但并非不可救药。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-31 DOI: 10.1111/bdi.13490
Gin S Malhi, Erica Bell, Uyen Le, Philip Boyce, Michael Berk
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引用次数: 0
Towards development of reliable criteria for at-risk states for bipolar disorders 制定双相情感障碍高危状态的可靠标准。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-31 DOI: 10.1111/bdi.13497
Michael Berk, Aswin Ratheesh, Jan Scott
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引用次数: 0
Lithium and the American dream 锂与美国梦
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-29 DOI: 10.1111/bdi.13492
Gin S. Malhi, Erica Bell
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引用次数: 0
Mapping review of register-based cohort studies of bipolar disorder 以登记为基础的躁郁症队列研究图谱回顾。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-26 DOI: 10.1111/bdi.13491
Matthew Tennant, Richard Porter, Ben Beaglehole

Objectives

Register-based cohorts allow us to better understand bipolar disorder over a life course. They are inclusive and their long-term data collection provides a longer scope than most clinical trials. This mapping review provides an overview of register-based cohort studies of bipolar disorder to inform researchers of the strengths and limitations to this body of research and identify gaps for future research.

Methods

A systematic search was performed of Medline, EMBASE, and PsycINFO databases. Cohort studies were included if they focused on bipolar disorder and had a minimum of 1 year of longitudinal data. Studies needed to be from databases that monitor the whole state or national population. A descriptive analysis of the studies' populations and methodology provides an overview of this field of study and identifies evidence gaps.

Results

A hundred and forty-six studies were included. The majority were from databases in Taiwan (n = 63), Denmark (n = 38), Sweden (n = 23), and Finland (n = 11). Forty-eight studies focused on aetiological questions. Sixty prognostic studies identified cohorts with bipolar disorder and described the impact of the illness by considering comorbidity, prescribing patterns, social functioning, and mortality. Thirty-six treatment studies focused on the efficacy and adverse effects of pharmaceuticals and ECT. No studies focused on psychological treatments.

Conclusion

Bipolar disorder research should include register-based cohorts with greater geopolitical and cultural diversity. Custodians of health registers should consider how non-pharmaceutical interventions such as psychotherapy are captured. Register-based cohorts investigating treatments of bipolar disorder should consider long-term social outcomes alongside the usual clinical outcomes.

目的:以登记簿为基础的队列可以让我们更好地了解躁郁症的整个生命过程。与大多数临床试验相比,它们具有包容性和长期数据收集的优势。本图谱综述概述了以登记为基础的双相情感障碍队列研究,让研究人员了解这一研究机构的优势和局限性,并找出未来研究的差距:对 Medline、EMBASE 和 PsycINFO 数据库进行了系统检索。如果队列研究的重点是双相情感障碍,且至少有一年的纵向数据,则纳入研究。研究必须来自监测整个州或全国人口的数据库。通过对研究对象和研究方法的描述性分析,可以了解这一研究领域的概况,并找出证据差距:结果:共纳入 146 项研究。大部分研究来自台湾(63 项)、丹麦(38 项)、瑞典(23 项)和芬兰(11 项)的数据库。有 48 项研究侧重于病因问题。60项预后研究确定了患有双相情感障碍的群体,并通过考虑合并症、处方模式、社会功能和死亡率来描述疾病的影响。36项治疗研究侧重于药物和电痉挛疗法的疗效和不良反应。没有研究关注心理治疗:躁郁症的研究应包括以登记簿为基础的队列,并具有更大的地缘政治和文化多样性。健康登记册的保管人应考虑如何记录心理治疗等非药物干预措施。对躁狂症治疗方法进行调查的登记队列在考虑常规临床结果的同时,还应考虑长期社会结果。
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引用次数: 0
Active components and mechanisms of action of psychological interventions in bipolar disorder: A systematic literature review 双相情感障碍心理干预的活性成分和作用机制:系统性文献综述。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-26 DOI: 10.1111/bdi.13464
Duygu Serbetci, Zhao Hui Koh, Greg Murray, Hailey Tremain

Objective

The efficacy of psychological interventions for bipolar disorder (BD) is well established, but much remains unknown about how change occurs. The primary objective of this exploratory study was to audit what is known about active components and mechanisms of action of psychological interventions for BD.

Method

We conducted a systematic review (PROSPERO CRD42022323276). Two independent reviewers screened references from four databases and extracted data from eligible studies.

Results

We included four component studies, six studies with mediation analyses and 26 studies presenting subjective experiences of how psychological interventions bring change. Ten mediators were examined across six studies, with only one putative mediator, medication adherence, tested in more than one study. Some initial support for mediation of varied outcomes by control over thoughts, positive non-verbal behaviour, self-esteem, post-trauma growth and medication adherence. Some preliminary support was found in two components, human support and IPT. Studies exploring participant experiences of therapeutic change enumerated a range of potential active components, mechanisms of action and contextual factors potentially warranting investigation in future research. However, the evidence base for active components and mechanisms of action in psychological interventions for BD is unsatisfactory. Findings were inconsistent, studies homogenous with significant methodological limitations and statistical approaches failed to meet quality criteria.

Conclusions

Preliminary identification of potential components and mechanisms via qualitative analyses and the insights emerging from this review will inform future research aimed at investigating how psychological interventions work in BD.

目的:心理干预对双相情感障碍(BD)的疗效已得到公认,但关于改变是如何发生的仍有许多未知数。这项探索性研究的主要目的是对躁狂症心理干预的有效成分和作用机制进行审核:我们进行了一项系统性综述(PROSPERO CRD42022323276)。两名独立评审员筛选了四个数据库中的参考文献,并从符合条件的研究中提取了数据:我们纳入了四项成分研究、六项中介分析研究以及 26 项介绍心理干预如何带来改变的主观体验的研究。六项研究对十个中介因素进行了研究,只有一个假定中介因素(坚持用药)在多项研究中进行了测试。初步支持通过控制思想、积极的非语言行为、自尊、创伤后成长和坚持服药来调节不同的结果。人类支持和综合治疗法这两个组成部分也得到了一些初步支持。探索参与者治疗变化经验的研究列举了一系列潜在的有效成分、作用机制和背景因素,这些都可能值得在未来的研究中进行调查。然而,有关 BD 心理干预的活性成分和作用机制的证据基础并不令人满意。研究结果不一致,研究同质化严重,研究方法存在重大局限性,统计方法不符合质量标准:通过定性分析初步确定潜在的成分和机制,以及从本综述中获得的启示,将为今后旨在调查心理干预如何对 BD 起作用的研究提供参考。
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引用次数: 0
CoDesign of a digital intervention for parents with bipolar disorder informed by integrated knowledge translation principles 根据综合知识转化原则,共同设计针对双相情感障碍家长的数字化干预措施。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-22 DOI: 10.1111/bdi.13468
Steven H. Jones, Stephanie Fortier, Christopher Lodge, Cathy Creswell, Fiona Lobban, Richard Morriss, Jasper Palmier Claus, Anne Duffy, Brian Green, Abigail Wells, Lucy Cryle

Objectives

To provide detailed information on the codesign of a digital intervention to support parents with bipolar disorder (BD) who have young children. Each step of this process is reported, as well as a detailed description of the final version of the intervention in line with the TIDieR framework.

Methods

Clinical experience and lived experience experts participated in online workshops, meetings, and remote feedback requests, informed by Integrated Knowledge Translation (IKT) principles. The IKT research group responded to each phase of recommendations from the knowledge users.

Results

Five clinical experience experts and six lived experience experts engaged with the codesign process. Their recommendations for principles, content, look, and feel, and functionality of the digital intervention were structured over five iterative phases. This led to a final implemented design that was identified by the clinical and lived experience experts (referred to together as the knowledge users group) as genuinely reflecting their input.

Conclusions

The IKT principles offer an accessible structure for engaging with clinical and lived experience experts throughout a codesign process, in this case for a digital intervention for parents with BD. The resulting intervention is described in detail for transparency to aid further evaluation and development and to help other teams planning codesign approaches to intervention development.

目的提供有关数字干预的编码设计的详细信息,以支持有年幼子女的双相情感障碍(BD)父母。报告了这一过程的每一个步骤,以及根据 TIDieR 框架对干预措施最终版本的详细描述:方法:临床经验和生活经验专家根据综合知识转化(IKT)原则参与了在线研讨会、会议和远程反馈请求。IKT研究小组对知识使用者提出的每一阶段的建议都做出了回应:结果:五位临床经验专家和六位生活经验专家参与了编码设计过程。他们就数字干预的原则、内容、外观、感觉和功能提出的建议分为五个迭代阶段。最终,临床和生活经验专家(统称为知识用户组)认为最终实施的设计真正反映了他们的意见:IKT原则为临床和生活经验专家在整个代码设计过程中的参与提供了一个易于理解的结构,在本案例中,IKT原则是针对患有BD的父母的数字化干预措施。为了提高透明度,我们对最终干预措施进行了详细描述,以帮助进一步评估和开发,并帮助其他团队规划干预措施开发的代码设计方法。
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引用次数: 0
Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes 用于治疗妊娠期双相情感障碍的情绪稳定剂及其对新生儿预后的影响。
IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-08-22 DOI: 10.1111/bdi.13481
Nalinoë Kernizan, Alicia Forinash, Abigail Yancey, Samuel Kruger, Niraj R. Chavan, Katherine Mathews

Introduction

Untreated bipolar disorder in pregnancy is associated with adverse maternal and neonatal outcomes. Despite advances in clinical management, there is concern among obstetric providers and patients about the safety of pharmacological agents for the treatment of bipolar disorder in pregnancy. Recent studies have shown atypical antipsychotics and lamotrigine to have a favorable safety profile; however, little information is published on lurasidone.

Objectives

The objective of this retrospective chart review was to evaluate pregnancy and neonatal outcomes in obstetric patients with bipolar disorder who are untreated, compared to those treated with lurasidone, other atypical antipsychotics, and lamotrigine at a tertiary teaching institution.

Methods

This retrospective cohort study included neonates whose mothers had a diagnosis of bipolar disorder and were referred to the Maternal & Fetal Care Clinic with two documented visits after January 1, 2014, with delivery by October 31, 2017, within an SSM health-system hospital.

Results

In this study, women with untreated bipolar disorder (not on any mood stabilizer) in pregnancy had significantly higher rates of premature delivery and low birth weight compared to women on mood stabilizers of lamotrigine, lurasidone, and other atypical antipsychotics. No difference was observed for pregnancy or neonatal outcomes between patients taking any of the mood stabilizers.

Conclusions

This study suggests that the use of lurasidone, other atypical antipsychotics, and lamotrigine have better neonatal outcomes than untreated bipolar disorder in pregnancy.

导言:未经治疗的妊娠期双相情感障碍会对产妇和新生儿造成不良后果。尽管临床治疗取得了进展,但产科医生和患者对治疗妊娠期双相情感障碍的药物的安全性仍存在担忧。最近的研究表明,非典型抗精神病药物和拉莫三嗪具有良好的安全性,但有关鲁拉西酮的资料却很少:这项回顾性病历审查旨在评估一家三级教学机构中未经治疗的双相情感障碍产科患者与接受鲁拉西酮、其他非典型抗精神病药物和拉莫三嗪治疗的患者的妊娠和新生儿结局:这项回顾性队列研究纳入了母亲被诊断患有双相情感障碍、2014年1月1日后被转诊至母胎护理门诊并有两次就诊记录、2017年10月31日前在SSM医疗系统医院分娩的新生儿:在这项研究中,与服用拉莫三嗪、鲁拉西酮和其他非典型抗精神病药物等情绪稳定剂的妇女相比,未经治疗的妊娠期双相情感障碍妇女(未服用任何情绪稳定剂)的早产率和低出生体重率明显更高。在妊娠或新生儿结局方面,没有观察到服用任何一种情绪稳定剂的患者之间存在差异:这项研究表明,使用鲁拉西酮、其他非典型抗精神病药物和拉莫三嗪对新生儿的影响要优于未经治疗的妊娠期双相情感障碍患者。
{"title":"Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes","authors":"Nalinoë Kernizan,&nbsp;Alicia Forinash,&nbsp;Abigail Yancey,&nbsp;Samuel Kruger,&nbsp;Niraj R. Chavan,&nbsp;Katherine Mathews","doi":"10.1111/bdi.13481","DOIUrl":"10.1111/bdi.13481","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Untreated bipolar disorder in pregnancy is associated with adverse maternal and neonatal outcomes. Despite advances in clinical management, there is concern among obstetric providers and patients about the safety of pharmacological agents for the treatment of bipolar disorder in pregnancy. Recent studies have shown atypical antipsychotics and lamotrigine to have a favorable safety profile; however, little information is published on lurasidone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objective of this retrospective chart review was to evaluate pregnancy and neonatal outcomes in obstetric patients with bipolar disorder who are untreated, compared to those treated with lurasidone, other atypical antipsychotics, and lamotrigine at a tertiary teaching institution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included neonates whose mothers had a diagnosis of bipolar disorder and were referred to the Maternal &amp; Fetal Care Clinic with two documented visits after January 1, 2014, with delivery by October 31, 2017, within an SSM health-system hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, women with untreated bipolar disorder (not on any mood stabilizer) in pregnancy had significantly higher rates of premature delivery and low birth weight compared to women on mood stabilizers of lamotrigine, lurasidone, and other atypical antipsychotics. No difference was observed for pregnancy or neonatal outcomes between patients taking any of the mood stabilizers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests that the use of lurasidone, other atypical antipsychotics, and lamotrigine have better neonatal outcomes than untreated bipolar disorder in pregnancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"779-784"},"PeriodicalIF":5.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Bipolar Disorders
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