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Induction of thrombotic thrombocytopenic purpura by dengue virus infection in a critical patient: Role of therapeutic plasma exchange. 一名危重病人因感染登革热病毒而诱发血栓性血小板减少性紫癜:治疗性血浆置换的作用。
IF 0.6 Pub Date : 2023-07-01 Epub Date: 2022-09-28 DOI: 10.4103/ajts.AJTS_56_22
Rathindra Nath Biswas, Sudipta Sekhar Das, Anupam Chakrapani, Subrata Sen

Thrombotic thrombocytopenic purpura (TTP) secondary to dengue fever is a very unusual occurrence. Both conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, we present a young lady who suffered dengue fever followed by microangiopathic anemia, thrombocytopenic purpura, and altered sensorium. Investigations revealed microangiopathic hemolysis; there was no evidence of disseminated intravascular coagulation. As soon as, we diagnosed the patient as having TTP, we treated her with serial plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized. Hence, timely diagnosis and starting appropriate treatment immediately are key factors for successful outcomes.

继发于登革热的血栓性血小板减少性紫癜(TTP)是一种非常罕见的疾病。这两种疾病都是致命的,如果不及时治疗,会导致严重的死亡率和发病率。在本病例中,我们介绍了一名年轻女性,她在登革热后出现微血管病性贫血、血小板减少性紫癜和感觉改变。检查发现她患有微血管病性溶血,但没有弥散性血管内凝血的迹象。我们一诊断出患者患有 TTP,就立即对她进行了连续血浆置换治疗、类固醇治疗和利妥昔单抗等单克隆抗体治疗。患者对治疗反应良好,神经症状完全恢复,实验室指标也恢复正常。因此,及时诊断和立即开始适当的治疗是取得成功的关键因素。
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引用次数: 0
Brief Alcohol Interventions 简短的酒精干预措施
S. Scott, E. Kaner
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引用次数: 9
Legalising assisted suicide: keeping sight of the fundamental issues: commentary on… crossing the rubicon? 协助自杀合法化:关注基本问题:关于跨越卢比孔河的评论?
R. Preston
Assisting another person’s suicide is a criminal offence in England and Wales, although the offence is rare and the law allows for charges not to be brought where there has been no criminal intent. Campaigners for ‘assisted dying’ want something else – a law licensing assisted suicide in advance for certain groups of people in certain circumstances. The present law has been challenged in the courts, hitherto unsuccessfully, as incompatible with article 8 of the European Convention on Human Rights. The Supreme Court has taken the view that, given its social policy implications, this is a matter that Parliament is better placed to consider than the courts.
在英格兰和威尔士,协助他人自杀是一种刑事犯罪,尽管这种犯罪很少见,而且法律允许在没有犯罪意图的情况下不提出指控。“协助死亡”的活动人士想要的是别的东西——一项法律允许在某些情况下,某些群体提前协助自杀。目前的法律在法庭上受到质疑,但迄今未获成功,因为它不符合《欧洲人权公约》第8条。最高法院认为,鉴于其所涉社会政策问题,议会比法院更有资格审议这一问题。
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引用次数: 0
Mindfulness-based training in residential settings: rationale, advantages and obstacles 以正念为基础的训练在住宅设置:理由,优势和障碍
F. Didonna, S. Bhattacherjee
The past few decades have witnessed the synthesis of Buddhist mindfulness practice with the Western psychological paradigm, leading to the development of a variety of mindfulness-based interventions. These are delivered to various populations to treat a wide range of physical and psychological disorders, and several protocols have been implemented and evaluated, mostly, if not exclusively, in open or out-patient treatment settings. Little attention has been given to the definition of criteria, guidelines and protocols for the use of mindfulness in residential settings such as in-patient psychiatric wards, secure and forensic services, prisons, nursing homes and hospices. In this article, we discuss the rationale, advantages and obstacles to delivering mindfulness-based interventions in residential treatment settings, with specific reference to forensic settings. We also discuss the problem of developing robust outcome data and recommendations for future research.
过去几十年见证了佛教正念练习与西方心理学范式的综合,导致了各种正念干预的发展。这些药物被提供给不同的人群,用于治疗各种各样的身体和心理障碍,并且已经实施和评估了几种方案,大多数(如果不是完全的话)是在开放或门诊治疗环境中实施的。很少注意定义在住院精神病病房、安全和法医服务、监狱、疗养院和临终关怀等居住环境中使用正念的标准、准则和规程。在这篇文章中,我们讨论了在住宅治疗环境中提供基于正念的干预措施的基本原理、优势和障碍,并特别提到了法医环境。我们还讨论了开发可靠的结果数据和对未来研究的建议的问题。
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引用次数: 3
Crossing the Rubicon? Legal developments in assisted suicide 渡过卢比孔河?协助自杀的法律发展
Susan F. Welsh
UK law on assisted suicide and euthanasia is very clear: it is unlawful. However, there have been successive proposals for changes to legislation in this area (in England and Scotland) and a series of individual challenges to current legislation in the courts. This article does not seek to debate the profound ethical arguments that surround this emotive subject, but instead to portray how the law, through court judgment and legislative proposals, has wrestled with opposing views, particularly over the past decade or so, as the impact of the Human Rights Act has presented unique challenges. Some of our closest European neighbours have diverse legislation that could influence our own legislature, and, from across the Atlantic, the Oregon Death with Dignity Act is being mirrored in proposals to change the law in the UK.
英国关于协助自杀和安乐死的法律非常明确:这是非法的。然而,在这一领域(在英格兰和苏格兰)不断有人提出修改立法的建议,并在法庭上对现行立法提出了一系列个人挑战。本文并不试图讨论围绕这一情感主题的深刻伦理争论,而是描述法律如何通过法院判决和立法提案与反对意见进行斗争,特别是在过去十年左右的时间里,因为《人权法案》的影响提出了独特的挑战。我们最近的一些欧洲邻国有各种各样的立法,可能会影响我们自己的立法机构,从大西洋彼岸,俄勒冈州尊严死亡法案正在反映在英国修改法律的建议中。
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引用次数: 0
Cognitive-friendly hospitals: a leap from Flat Earthers to Galileo: COMMENTARY ON… MANAGING DELIRIUM IN EVERYDAY PRACTICE 认知友好型医院:从地平论到伽利略的飞跃:评论……在日常实践中管理谵妄
D. Jolley
SUMMARY General hospitals and hospices see mostly older people, many of whom have dementia and multiple pathologies: delirium is common, costly and damaging. Informed and kindly care can reduce the incidence of delirium and hasten its resolution. O’Connell et al demand ownership of this phenomenon by the whole hospital. This will require a turnabout of philosophy, management and training for all professions.
综合医院和临终关怀医院接待的大多是老年人,其中许多人患有痴呆症和多种疾病:谵妄很常见,费用高昂且具有破坏性。知情和善意的护理可以减少谵妄的发生率,并加快其解决。O 'Connell等人要求整个医院对这一现象负责。这将要求对所有职业的理念、管理和培训进行转变。
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引用次数: 0
Balancing risk requires a balanced approach: COMMENTARY ON… SEVERE AND ENDURING EATING DISORDERS: RECOGNITION AND MANAGEMENT 平衡风险需要一个平衡的方法:评论……严重和持久的饮食失调:认识和管理
W. Jones, J. Morgan
SUMMARY Paul Robinson’s article provides an excellent summary of some of the challenges faced by clinicians working with patients with severe and enduring eating disorders (SEED) and outlines a robust approach to the recognition and management of this complex group of patients. This commentary expands on some of the points raised, adds some further views and suggests a tailored approach to establishing a therapeutic alliance with patients and carers.
Paul Robinson的文章很好地总结了临床医生在治疗严重和持久饮食失调(SEED)患者时所面临的一些挑战,并概述了一种识别和管理这一复杂患者群体的有效方法。本评论对提出的一些观点进行了扩展,增加了一些进一步的观点,并提出了一种与患者和护理人员建立治疗联盟的量身定制的方法。
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引用次数: 1
Evaluating malingering in cognitive and memory examinations: a guide for clinicians 评估认知和记忆检查中的装病:临床医生指南
D. Tracy
Cognitive and memory testing are a common part of clinical practice, but professional concerns are sometimes raised that the individual being tested might be feigning deficits. Most clinicians have limited experience and training in detecting malingering in such cognitive testing, and the very issue raises considerable ethical dilemmas. Nevertheless, psychiatric work faces ever greater potential for legal scrutiny, and failure to appropriately evaluate potential malingering risks professional embarrassment and distress. There is a need for clinicians to make themselves aware of the ways in which malingered behaviour might be evaluated through the clinical history, the use of routine psychometric testing and, particularly, the use of symptom validity (‘malingering’) tests. This article describes these factors and gives guidance on the appropriate reporting of findings.
认知和记忆测试是临床实践的一个常见部分,但专业人士有时会担心,被测试的个人可能是假装的缺陷。大多数临床医生在这种认知测试中检测装病方面的经验和培训都很有限,而且这个问题本身就引发了相当大的伦理困境。然而,精神病学工作面临着更大的法律审查的可能性,而不能恰当地评估潜在的装病风险会使专业人员感到尴尬和痛苦。临床医生有必要让自己意识到,通过临床病史、使用常规心理测试,特别是使用症状效度(“装病”)测试,可以评估装病行为的方式。本文描述了这些因素,并给出了适当报告发现的指导。
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引用次数: 6
Managing delirium in everyday practice: towards cognitive-friendly hospitals 在日常实践中管理谵妄:走向认知友好型医院
H. O’connell, S. Kennelly, W. Cullen, D. Meagher
Providing optimal healthcare for increasingly elderly hospital populations who have high rates of cognitive disorder is a great challenge. Using delirium as an example, we describe how improved management of acute cognitive problems through a multifaceted hospital-wide programme can promote cognitive-friendly hospital environments. A specific plan of action is described that spans interventions in day-to-day clinical care of individual patients all the way to wider organisational practices.
为越来越多的老年医院人口提供最佳的医疗保健是一个巨大的挑战,他们的认知障碍率很高。以谵妄为例,我们描述了如何通过一个多方面的全院范围的方案来改善急性认知问题的管理,从而促进认知友好的医院环境。一个具体的行动计划被描述,在日常的临床护理干预个体病人的所有方式更广泛的组织实践。
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引用次数: 31
Severe and enduring eating disorders: recognition and management 严重和持久的饮食失调:识别和管理
P. Robinson
Patients with severe and enduring eating disorders (SEED) may constitute a specific group. It is proposed that patients with anorexia nervosa (SEED-AN) or bulimia nervosa (SEED-BN) that requires the regular attention of a multidisciplinary team and is of a duration known to have a low recovery rate should be included in the SEED group. These patients present with a combination of severe symptoms and long-term illness, and may experience serious chronic physical sequelae (e.g. osteoporosis and renal failure), marked social isolation and stigma. Their carers suffer from the stress of caring for them over a prolonged period. Symptoms, treatment and crisis management of SEED-AN are discussed. SEED is a relatively recently described area of eating disorders psychiatry that requires research and service development so that patients and carers are helped to cope with very serious chronic, but not incurable, conditions.
患有严重和持久的饮食失调(SEED)的患者可能构成一个特定的群体。建议神经性厌食症(SEED- an)或神经性贪食症(SEED- bn)患者需要多学科团队的定期关注,并且持续时间已知恢复率低,应纳入SEED组。这些患者表现为严重症状和长期疾病的结合,并可能出现严重的慢性身体后遗症(如骨质疏松症和肾衰竭),明显的社会孤立和耻辱。他们的照顾者承受着长时间照顾他们的压力。讨论了SEED-AN的症状、治疗和危机管理。SEED是饮食失调精神病学的一个相对较新的研究领域,需要研究和服务开发,以便帮助患者和护理人员应对非常严重的慢性疾病,但不是无法治愈的疾病。
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引用次数: 20
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Advances in psychiatric treatment : the Royal College of Psychiatrists' journal of continuing professional development
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