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Role of surgery in isolated concha bullosa. 手术治疗孤立性甲壳大疱的作用。
Pub Date : 2011-03-14 eCollection Date: 2011-01-01 DOI: 10.4137/CMENT.S6769
Hatem Soliman Badran

Objective: To study the benefit of surgery in different types of isolated concha bullosa.

Design: Prospective case series.

Setting: Academic Medical Center.

Patients: Forty seven symptomatic patients complaining of nasal congestion and block, headache and facial pain having concha bullosa without any other sinonasal finding. Their conchae bullosa were classified as lamellar, bulbous and extensive concha bullosa. They were subjected to endoscopic operation.

Main outcome measures: Subjective evaluation of postoperative improvement of sinonasal symptoms and objective pre- and postoperative measurement of total nasal resistance by rhinomanometry.

Results: Two patients (25%) of lamellar type showed complete improvement, 5 patients (62.5%) showed partial improvement and 1 patient (12.5%) showed no improvement. Regarding bulbous type, 16 patients (72.72%) showed complete improvement, 6 patients (27.28%) showed partial improvement and no patient (0%) showed no improvement. Regarding extensive type, 15 (88.24%) patients showed complete improvement, 2 patients (11.76%) showed partial improvement and no patient (0%) showed no improvement. The total nasal resistance was 0.25 Pa/cm(3) per second postoperatively compared with 0.37 Pa/cm(3) per second preoperatively in patients having lamellar type; 0.28 Pa/cm(3) per second postoperatively compared with 0.71 Pa/cm(3) per second preoperatively in patients having bulbous type; and 0.27 Pa/cm(3) per second postoperatively compared with 0.67 Pa/cm(3) per second preoperatively in patients having extensive type.

Conclusions: With proper patient selection, the operative management is of great value in relieving the sinonasal symptoms in patients having isolated Concha bullosa. This will be more obvious in certain types as bulbous and extensive types especially of large sizes.

目的:探讨不同类型分离性甲壳大疱的手术治疗效果。设计:前瞻性病例系列。环境:学术医疗中心。患者:47例有症状的患者,主诉鼻塞和鼻塞,头痛和面部疼痛,伴有鼻甲大疱,无其他鼻窦症状。它们的甲壳大疱分为板状、球茎状和广泛的甲壳大疱。他们接受了内窥镜手术。主要观察指标:主观评价术后鼻窦症状的改善情况,客观评价术前和术后鼻部总阻力。结果:板层型完全改善2例(25%),部分改善5例(62.5%),无改善1例(12.5%)。球茎型完全好转16例(72.72%),部分好转6例(27.28%),无好转(0%)。广泛型完全改善15例(88.24%),部分改善2例(11.76%),无改善(0%)。术后总鼻阻力为0.25 Pa/cm(3) / s,而板层型患者术前为0.37 Pa/cm(3) / s;术后0.28 Pa/cm(3) / s,而球根型患者术前为0.71 Pa/cm(3) / s;术后0.27 Pa/cm(3) / s,而术前为0.67 Pa/cm(3) / s。结论:通过合理的患者选择,手术治疗对缓解孤立性大耳甲患者的鼻窦症状具有重要价值。这将在某些类型中更为明显,如球茎和广泛类型,特别是大尺寸。
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引用次数: 11
Management of the facial nerve in lateral skull base surgery analytic retrospective study. 侧颅底手术面神经处理的回顾性分析研究。
Pub Date : 2011-03-10 eCollection Date: 2011-01-01 DOI: 10.4137/CMENT.S6570
Mohamed A El Shazly, Mahmoud A M Mokbel, Amr A Elbadry, Hatem S Badran

Background: Surgical approaches to the jugular foramen are often complex and lengthy procedures associated with significant morbidity based on the anatomic and tumor characteristics. In addition to the risk of intra-operative hemorrhage from vascular tumors, lower cranial nerves deficits are frequently increased after intra-operative manipulation. Accordingly, modifications in the surgical techniques have been developed to minimize these risks. Preoperative embolization and intra-operative ligation of the external carotid artery have decreased the intraoperative blood loss. Accurate identification and exposure of the cranial nerves extracranially allows for their preservation during tumor resection. The modification of facial nerve mobilization provides widened infratemporal exposure with less postoperative facial weakness. The ideal approach should enable complete, one stage tumor resection with excellent infratemporal and posterior fossa exposure and would not aggravate or cause neurologic deficit. The aim of this study is to present our experience in handling jugular foramen lesions (mainly glomus jugulare) without the need for anterior facial nerve transposition.

Methods: In this series we present our experience in Kasr ElEini University hospital (Cairo-Egypt) in handling 36 patients with jugular foramen lesions over a period of 20 years where the previously mentioned preoperative and operative rules were followed. The clinical status, operative technique and postoperative care and outcome are detailed and analyzed in relation to the outcome.

Results: Complete cure without complications was achieved in four cases of congenital cholesteatoma and four cases with class B glomus. In advanced cases of glomus jugulare (28 patients) (C and D stages) complete cure was achieved in 21 of them (75%). The operative complications were also related to this group of 28 patients, in the form of facial paralysis in 20 of them (55.6%) and symptomatic vagal paralysis in 18 of them (50%).

Conclusions: Total anterior rerouting of the facial nerve carries a high risk of facial paralysis. So it should be reserved for cases where the lesion extends beyond the vertical ICA. Otherwise, for less extensive lesions and less aggressive pathologies, less aggressive approaches could be adopted with less hazards.

背景:颈静脉孔的手术入路通常是复杂和漫长的过程,根据解剖和肿瘤特征,伴有显著的发病率。除了术中血管肿瘤出血的风险外,术中操作后经常增加下颅神经缺损。因此,手术技术的改进已经发展到最小化这些风险。术前栓塞和术中结扎颈外动脉减少了术中出血量。准确识别和暴露颅外神经可以在肿瘤切除时保留它们。面神经活动的改变扩大了颞下暴露,减少了术后面部无力。理想的入路应能完成一期肿瘤切除,并有良好的颞下和后窝暴露,且不会加重或引起神经功能缺损。本研究的目的是介绍我们处理颈静脉孔病变(主要是颈静脉球囊)而不需要面神经前移位的经验。方法:在这个系列中,我们介绍了我们在Kasr ElEini大学医院(埃及开罗)处理36例颈静脉孔病变患者的经验,在过去的20年里,我们遵循了前面提到的术前和手术规则。详细分析了与预后相关的临床情况、手术技术、术后护理及预后。结果:4例先天性胆脂瘤和4例B类肾小球完全治愈,无并发症。晚期颈静脉球28例(C期和D期),其中21例(75%)完全治愈。本组28例患者均出现手术并发症,其中面瘫20例(55.6%),症状性迷走神经麻痹18例(50%)。结论:面神经完全前路改道有发生面神经麻痹的高风险。因此,它应该保留在病变超出垂直ICA的情况下。否则,对于不太广泛的病变和不太严重的病理,可以采用危害较小的不太严重的方法。
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引用次数: 3
Nasopharyngeal cancer in Sudan: epidemiology, clinical and histological characteristics. 苏丹鼻咽癌:流行病学、临床和组织学特征。
Pub Date : 2011-02-22 eCollection Date: 2011-01-01 DOI: 10.4137/CMENT.S5825
Nazik E Abdullah, Ameera A M Adam, Eman H Khalifa, Lamyaa A M El Hassan, M E Ibrahim, K M Hamad, A M El Hassan

Objectives: To study the epidemiology, clinical features, staging, etiology and pathology of nasopharyngeal cancer in Sudan.

Study design: This is a retrospective study.

Setting: Ear, Nose and Throat Department Khartoum Teaching Hospital, Khartoum City, Sudan.

Subjects and methods: Patients suspected to have nasopharyngeal cancer were assessed during the period March 2004 to May 2010. Data from confirmed cases was obtained; it included clinical and epidemiological information.

Results: Three hundred and eighty five cases were studied. Bimodal age distribution of the disease was noted with two peaks, one at 15-19 years and one at 50-54 years. The male to female ratio was 2.6:1 and a distinct geographical distribution of the disease was noted, with clustering of cases in the towns of Dilling, Kadogli and the surrounding rural area of the Nuba Mountains. These areas in the Western States were reported to be of high background radiation due to naturally produced radioactive uranium. The Nuba tribe headed the list among other tribes, demonstrating a clear ethnic predilection. Sixty-eight cases presented at stage IV. There was a predominance of Type II (15.58%) and Type III (65.97%). Patients were treated by neoadjuvant chemoradiotherapy.

Conclusions: NPC is an important form of cancer in Sudan. Some tribes are significantly more affected than others. Patients present with advanced disease. Environmental and genetic factors need further studies. Screening at risk populations that aim at early diagnosis and management of patients is recommended.

目的:了解苏丹地区鼻咽癌的流行病学、临床特征、分期、病因及病理。研究设计:这是一项回顾性研究。单位:苏丹喀土穆市喀土穆教学医院耳鼻喉科。对象和方法:对2004年3月至2010年5月期间疑似鼻咽癌患者进行评估。获得了来自确诊病例的数据;它包括临床和流行病学信息。结果:共研究病例385例。疾病的双峰年龄分布有两个高峰,一个在15-19岁,一个在50-54岁。男女比例为2.6:1,疾病的地理分布明显,病例集中在迪林镇、卡多格利镇和努巴山区的周边农村地区。据报道,西部各州的这些地区由于自然产生的放射性铀而具有高本底辐射。努巴部落在其他部落中名列前茅,表现出明显的种族偏好。68例出现在IV期,以II型(15.58%)和III型(65.97%)为主。患者接受新辅助放化疗。结论:鼻咽癌是苏丹重要的肿瘤类型。一些部落比其他部落受影响更大。患者表现为疾病晚期。环境和遗传因素需要进一步研究。建议在危险人群中进行筛查,以便对患者进行早期诊断和管理。
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引用次数: 17
Alternative agents to prevent fogging in head and neck endoscopy. 防止头颈部内窥镜雾化的替代药剂。
Pub Date : 2011-01-10 eCollection Date: 2011-01-01 DOI: 10.4137/CMENT.S6597
Patorn Piromchai, Pornthep Kasemsiri, Sanguansak Thanaviratananich

Background: The essential factor for diagnosis and treatment of diseases in head and neck endoscopy is the visibility of the image. An anti-fogging agent can reduce this problem by minimizing surface tension to prevent the condensation of water in the form of small droplets on a surface. There is no report on the use of hibiscrub(®) or baby shampoo to reduce fogging in the literature. The objective of this study was to compare the efficacy between commercial anti-fogging agent, hibiscrub(®) and baby shampoo to reduce fogging for the use in head and neck endoscopy.

Methods: The study was conducted at the Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University in August 2010. Commercial anti-fogging agent, baby shampoo and hibiscrub(®) were applied on rigid endoscope lens before putting them into a mist generator. The images were taken at baseline, 15 seconds, 30 seconds and 1 minute. The images' identifiers were removed before they were sent to two evaluators. A visual analogue scale (VAS) was used to rate the image quality from 0 to 10.

Results: The difference in mean VAS score between anti-fogging agent, baby shampoo and hibiscrub(®) versus no agent were 5.46, 4.45 and 2.1 respectively. The commercial anti-fogging agent and baby shampoo had most protective benefit and performed significantly better than no agent (P = 0.05).

Conclusions: Baby shampoo is an effective agent to prevent fogging during head and neck endoscopy and compares favourably with commercial anti-fogging agent.

背景:头颈部内窥镜疾病诊断和治疗的关键因素是图像的可见性。防雾剂可以通过最小化表面张力来防止水以小水滴的形式凝结在表面上,从而减少这个问题。文献中没有关于使用木槿花(®)或婴儿洗发水来减少起雾的报道。本研究的目的是比较商用防雾剂、芙蓉浴(®)和婴儿洗发水在头颈部内窥镜检查中减少雾霭的效果。方法:研究于2010年8月在孔庆大学医学院耳鼻咽喉科进行。将商业防雾剂、婴儿洗发水和芙蓉(®)涂抹在刚性内窥镜镜片上,然后将其放入雾发生器中。图像分别在基线、15秒、30秒和1分钟拍摄。这些图像的标识符在被发送给两名评估者之前被删除。采用视觉模拟量表(VAS)对图像质量进行0 - 10级评分。结果:抗雾剂、婴儿洗发香波和麻洗剂(®)与无防雾剂的VAS平均评分差异分别为5.46、4.45和2.1。市售防雾剂和婴儿洗发香波的防护效果最好,显著优于无防雾剂(P = 0.05)。结论:婴儿洗发香波是头颈部内镜检查时有效的防起雾剂,与市售防起雾剂效果相当。
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引用次数: 18
Article Commentary: Fas and Cancer 文章评论:Fas和癌症
Pub Date : 2010-01-01 DOI: 10.4137/CMENT.S3147
K. A. Abou-Elhamd
Apoptosis is an active process of programmed cell death. Fas is a cell-surface protein which is expressed on activated lymphocytes and known as CD95, TNFRSF6 or APO-1. Fas-L is ligand of Fas and known as CD95 LG or TNFSF6. Apoptosis or cell death is a result of binding of Fas-L to Fas which is expressed on the surfaces of these cells. Cancer cells escape this binding by overexpression of Fas-L or down expression of Fas. Fas and Fas-L exist in membrane bound and soluble forms. The serum level of sFas and sFas-L can be evaluated by immunostaining, immunohistochemical methods, immunofluorescence, flow cytometry and Western blotting. Head and neck squamous cell carcinoma diagnosis, staging and prognosis can be evaluated early and accurately by sFas and sFas-L expression levels detection.
细胞凋亡是细胞程序性死亡的一个活跃过程。Fas是一种在活化淋巴细胞上表达的细胞表面蛋白,被称为CD95、TNFRSF6或APO-1。Fas- l是Fas的配体,被称为CD95 LG或TNFSF6。细胞凋亡或细胞死亡是Fas- l与这些细胞表面表达的Fas结合的结果。癌细胞通过过度表达Fas- l或下调Fas表达来逃避这种结合。Fas和Fas- l以膜结合和可溶形式存在。免疫染色、免疫组织化学、免疫荧光、流式细胞术和Western blotting检测血清中sFas和sFas- l的水平。通过检测sFas和sFas- l表达水平,可以早期、准确地评估头颈部鳞状细胞癌的诊断、分期和预后。
{"title":"Article Commentary: Fas and Cancer","authors":"K. A. Abou-Elhamd","doi":"10.4137/CMENT.S3147","DOIUrl":"https://doi.org/10.4137/CMENT.S3147","url":null,"abstract":"Apoptosis is an active process of programmed cell death. Fas is a cell-surface protein which is expressed on activated lymphocytes and known as CD95, TNFRSF6 or APO-1. Fas-L is ligand of Fas and known as CD95 LG or TNFSF6. Apoptosis or cell death is a result of binding of Fas-L to Fas which is expressed on the surfaces of these cells. Cancer cells escape this binding by overexpression of Fas-L or down expression of Fas. Fas and Fas-L exist in membrane bound and soluble forms. The serum level of sFas and sFas-L can be evaluated by immunostaining, immunohistochemical methods, immunofluorescence, flow cytometry and Western blotting. Head and neck squamous cell carcinoma diagnosis, staging and prognosis can be evaluated early and accurately by sFas and sFas-L expression levels detection.","PeriodicalId":89906,"journal":{"name":"Clinical medicine insights. Ear, nose and throat","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMENT.S3147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70695217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Co-phenylcaine Spray or Lidocaine/Epinephrine Nasal Packing for Flexible Laryngoscopy 共苯基卡因喷雾剂与利多卡因/肾上腺素鼻填充物用于软性喉镜检查的比较
Pub Date : 2010-01-01 DOI: 10.4137/CMENT.S4533
R. P. D. de Freitas, B. Hanna, S. Hall
Background Nasal preparation prior to flexible laryngoscopy is a common ENT practice. Co-phenylcaine is increasingly used because it is safe and has both anaesthetic and vasoconstrictive properties. Lidocaine 4% and epinephrine 1:1000 nasal packing is another method used in our department. Methods A prospective case series was performed on eighty-one patients requiring flexible laryngoscopy. Patients were enrolled into either a co-phenylcaine or a lidocaine/epinephrine packing group. Visual analogue scales (VAS) were used to record unpleasantness of nasal preparation and flexible laryngoscopy. Decongestion and ease of endoscope passage were recorded by the doctors. Results Bad taste was statistically significantly worse when using cophenylcaine for nasal preparation (P = 0.001). However, there was no statistically significant difference in overall unpleasantness from nasal preparation or from subsequent flexible laryngoscopy between the two groups. There was no statistically significant difference in degree of decongestion or ease of endoscope passage between the two groups. Conclusion There is no statistically significant advantage of using cophenylcaine spray over non-proprietary lidocaine 4% and epinephrine 1:1000 nasal packing. However cost and bad taste is less with nasal packing.
背景:在柔性喉镜检查前进行鼻腔准备是一种常见的耳鼻喉科手术。共苯基卡因的使用越来越多,因为它是安全的,具有麻醉和血管收缩的特性。利多卡因4%加肾上腺素1:1000鼻塞是我科采用的另一种方法。方法对81例需要柔性喉镜检查的患者进行前瞻性病例分析。患者被纳入共苯基卡因组或利多卡因/肾上腺素包装组。采用视觉模拟量表(VAS)记录鼻部准备和柔性喉镜检查的不愉快程度。医生记录鼻塞缓解情况和内镜通过情况。结果使用苯基卡因鼻腔制剂时,不良味觉明显加重(P = 0.001)。然而,两组之间鼻腔准备或随后的柔性喉镜检查的总体不愉快没有统计学上的显著差异。两组患者在缓解充血程度和内镜通过难易程度上无统计学差异。结论与非专利利多卡因4%和肾上腺素1:1000鼻腔填充物相比,使用苯基卡因喷雾剂无统计学意义。然而,成本和不良口味较少与鼻包装。
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引用次数: 4
Nanobacteria: An Infectious Cause for Salivary Stone Formation and Recurrence 纳米细菌:唾液结石形成和复发的感染性原因
Pub Date : 2010-01-01 DOI: 10.4137/CMENT.S5147
A. Badry, M. Mokbel, Ismail El Mofty, A. Mohamed
Nanobacteria (NB) contribute to pathological calcification in the human and animal body. It has been isolated from salivary stones and suggested that it may act as a nucleus for the initiation of these stones. In the present study, we examined its role in the recurrent salivary gland stones using immunodetection with NB-specific monoclonal antibodies and scanning electron microscopy (SEM) hoping to provide a method for preventing the recurrence of these stones in the patient that has suffered from salivary stones. Our study comprised 30 patients with recurrent salivary gland stones (group I) and 30 patients with salivary gland stones for the first time (group II), in addition to 30 normal controls (group III). We could detect 100–500 nm nanoparticles in 24/30 (80%) cases in group I with significant difference <0.05 and <0.01 when compared with group II and group III in which they were detected in 19/30 (63.3%) and 6/30 (20%) respectively. Also there was a significant difference <0.05 between group II and group III. We proposed that salivary stone formation is a nanobacterial disease initiated by bacterial infection. This bacteria may play an important role in the recurrence of salivary stone. So the use of calcium chelator, ethylene diamine tetra acetic acid (EDTA), before or in combination with the suitable antibiotic that is given in an amount effective to inhibit or prevent the growth and development of nanobacteria may eradicate these stones and prevent their recurrence.
纳米细菌(NB)有助于人类和动物体内的病理性钙化。它已从唾液结石中分离出来,并提示它可能作为这些结石形成的细胞核。在本研究中,我们使用nb特异性单克隆抗体和扫描电镜(SEM)进行免疫检测,研究其在复发性唾液腺结石中的作用,希望为患有唾液腺结石的患者提供预防这些结石复发的方法。我们的研究包括30例复发性唾液腺结石患者(I组)和30例首次唾液腺结石患者(II组),以及30例正常对照(III组)。在1组中,100-500 nm纳米颗粒的检出率为24/30(80%),与II组和III组相比,前者的检出率分别为19/30(63.3%)和6/30(20%),差异有统计学意义<0.05和<0.01。II组与III组比较差异有统计学意义<0.05。我们提出唾液结石形成是一种由细菌感染引发的纳米细菌疾病。这种细菌可能在唾液结石的复发中起重要作用。因此,使用钙螯合剂乙二胺四乙酸(EDTA),在适当的抗生素之前或与抗生素联合使用,有效抑制或阻止纳米细菌的生长和发育,可能会根除这些结石并防止其复发。
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引用次数: 5
The Role of sFas in the Immune Escape Mechanism and Progression of Cancer Larynx sFas在喉癌免疫逃逸机制和进展中的作用
Pub Date : 2009-01-01 DOI: 10.4137/CMENT.S2565
A. Badry, Ismail Elmofty, A. Helmy
This work assess serum levels of soluble Fas form (sFas) in patients with different stages of laryngeal squamous cell carcinoma(LSCC) to investigate its prognostic significance. We correlate its levels with the morphological changes of peripheral blood cells via buffy coat examinatin. The study population included 70 patients clinically diagnosed and pathohistologically confirmed LSCC in addition to 20 healthy controls. According to TNM classification 33(47.1%) patients were in stage I (group I) and 24(34.3%) in stage II (group II), 13(18.5%) in stage III (group III). The results revealed that the mean serum level of sFas (pg/ml) in the control group was 51.2, in group I was 66.33, in group II was 81.33 and in group III was 112.45. Statistical analysis of the mean of sFas by ELISA test in the patients' groups in comparison to the control revealed a significant increase of both group II and III in comparison to the control group (P < 0.01) but there was no significant difference (P > 0.05) between group I in comparison to either the control or group II. There was a significant difference (P < 0.05) between group I in comparison to group III. LM examination revealed massive extent of the apoptotic cells in group III when compared to both group I and group II. EM examination of the buffy coat revealed apoptotic changes, mainly in the peripheral blood mononuclear cells (PBMNCs), represented by surface membrane ruffles and blebs with clumped nuclear chromatin and vacuolated cytoplasm. In conclusion, this study may help us to better understand one of the escape mechanisms in cancer larynx. This mechanism is represented by the significant increase in both the serum level of sFas and the morphological apoptotic changes that detected in PBMNCs. Soluble Fas may contribute to the progression of laryngeal cancer. It can be used as an attractive target for anticancer therapy and may be considered as a marker of disease progression and poor prognosis in laryngeal cancer.
本研究评估了不同分期喉鳞癌(LSCC)患者血清可溶性Fas形态(sFas)水平,探讨其预后意义。我们通过黄皮检查将其水平与外周血细胞的形态变化联系起来。研究人群包括70名临床诊断和病理组织学证实的LSCC患者以及20名健康对照。根据TNM分型,ⅰ期33例(47.1%),ⅱ期24例(34.3%),ⅲ期13例(18.5%)。结果显示,对照组血清sFas平均水平(pg/ml)为51.2,ⅰ组为66.33,ⅱ组为81.33,ⅲ组为112.45。用ELISA法对两组患者sFas均值进行统计分析,结果显示,II组和III组患者sFas均值均较对照组显著升高(P < 0.01),而I组患者sFas均值与对照组和II组患者sFas均值比较,差异均无统计学意义(P < 0.05)。I组与III组比较,差异有统计学意义(P < 0.05)。LM检查显示,与I组和II组相比,III组细胞凋亡程度较大。灰白色被膜的电镜检查显示凋亡改变,主要发生在外周血单个核细胞(pbmnc),表现为表面膜皱褶和泡,核染色质团块,细胞质空泡化。总之,本研究有助于我们更好地了解喉癌的逃逸机制之一。这一机制体现在pbmnc血清sFas水平的显著升高和形态学上的凋亡改变。可溶性Fas可能促进喉癌的发展。它可以作为抗癌治疗的一个有吸引力的靶点,并可能被认为是喉癌疾病进展和预后不良的标志。
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引用次数: 0
Hemangioma of the Thyroid 甲状腺血管瘤
Pub Date : 2009-01-01 DOI: 10.4137/CMENT.S3170
A. Sakai, I. Sugitani, N. Yamamoto, K. Kawabata
Introduction Thyroid hemangioma is very rare, and only a few cases have previously been reported. We encountered a patient with thyroid hemangioma diagnosed after surgery. Case Report A 71-year-old woman visited our hospital with a mass in the left thyroid region. A 5-cm, elastic mass of the thyroid was palpable in the left anterior neck. On cytology by fine-needle aspiration (FNA), the specimen mainly contained blood components without apparent atypical cells. A tumor with abundant blood flow was suspected based on Doppler ultrasonography. Adenomatous goiter was suspected, and subtotal thyroidectomy was performed. A blood clot was present in the tumor, and hemangioma was diagnosed on postoperative histopathological examination. Discussion Preoperative diagnosis of thyroid hemangioma is difficult. However, Doppler ultrasonography and FNA are useful for diagnosis. A differential diagnosis of hemangioma should be considered when blood flow is abundant and only blood components are collected.
甲状腺血管瘤是一种非常罕见的疾病,以往仅有少数病例报道。我们遇到了一个手术后诊断为甲状腺血管瘤的病人。病例报告一名71岁妇女因左侧甲状腺肿物就诊。左前颈部可见一5厘米的甲状腺弹性肿块。细针穿刺细胞学检查,标本以血液成分为主,未见明显非典型细胞。经多普勒超声检查,怀疑为血流丰富的肿瘤。怀疑为腺瘤性甲状腺肿,行甲状腺次全切除术。肿瘤内有血凝块,术后病理检查诊断为血管瘤。甲状腺血管瘤术前诊断困难。然而,多普勒超声和FNA对诊断是有用的。当血流充足且仅采集血液成分时,应考虑对血管瘤的鉴别诊断。
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引用次数: 4
Biomarkers for Cancers of the Head and Neck 头颈部癌症的生物标志物
Pub Date : 2008-01-01 DOI: 10.4137/CMENT.S1051
V. Lutzky, D. Moss, D. Chin, W. Coman, P. Parsons, G. Boyle
Head and neck cancer is a broad term used to describe malignancies that arise in the nasal and oral cavities, pharynx and larynx, as well as the paranasal sinuses. Head and neck squamous cell carcinoma (HNSCC) affects the squamous epithelium of the oral cavity, tongue and oropharynx, excluding the nasopharynx. Recent advances in molecular technology, including gene expression and proteomic profiling appear to offer the potential for the development of specific biomarkers including diagnostic tools which may act as an aid to guide therapy for this malignancy. The other human head and neck cancer included in this review, nasopharyngeal carcinoma (NPC) is a malignancy derived from the undifferentiated epithelium of the nasopharyngeal cavity, and is considered here as a separate entity because its strong association with Epstein-Barr virus (EBV) presents the opportunity for the development of virus related and unrelated biomarkers. In particular, IgA antibodies to EBV and high levels of EBV DNA in serum samples of NPC patients have been recorded. This review aims to summarize some current and also potential new biomarkers that could be used for screening, diagnosis, monitoring and prognostic prediction for cancers of the head and neck, including NPC and HNSCC.
头颈癌是一个广义的术语,用来描述出现在鼻腔、口腔、咽、喉以及鼻窦的恶性肿瘤。头颈部鳞状细胞癌(HNSCC)影响口腔、舌头和口咽部的鳞状上皮,鼻咽部除外。分子技术的最新进展,包括基因表达和蛋白质组学分析,似乎为开发特定的生物标志物提供了潜力,包括诊断工具,这可能有助于指导这种恶性肿瘤的治疗。这篇综述中包括的另一种人类头颈部癌症,鼻咽癌(NPC)是一种源自鼻咽腔未分化上皮的恶性肿瘤,在这里被视为一个单独的实体,因为它与eb病毒(Epstein-Barr virus, EBV)有很强的相关性,为开发病毒相关和不相关的生物标志物提供了机会。特别是,在鼻咽癌患者的血清样本中记录了EBV的IgA抗体和高水平的EBV DNA。本文旨在总结一些现有的和潜在的新的生物标志物,可用于筛查、诊断、监测和预后预测头颈部癌症,包括NPC和HNSCC。
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引用次数: 16
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Clinical medicine insights. Ear, nose and throat
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