{"title":"Research of the eradication of Helicobacter pylori to prevent gastric cancer","authors":"Zhao-chun Chi","doi":"10.53388/ghr2023-03-065","DOIUrl":"https://doi.org/10.53388/ghr2023-03-065","url":null,"abstract":"","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85987775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andong Zhao, L. Xiao, Hong-yue Niu, Lian Liu, Xiao-Yu Dai
Objective: To explore the main acupoint prescription and mechanism of acupuncture in treating Functional dyspepsia (FD) by analyzing the clinical randomized controlled trial literature on acupoints and targets of acupuncture in the treatment of FD combined with association rule mining and bioinformatics/network pharmacology methods. Methods: Search relevant clinical randomized controlled trial literature on acupoints and therapeutic targets of acupuncture in the treatment of FD from eight databases from their inception to June 18th, 2022. We obtained acupuncture selection points, meridian, and therapeutic targets and established acupoints database for acupuncture treatment of FD. FD-related targets were collected from GeneCards, DisGeNET, OMIM, and DrugBank databases. We obtained the potential targets of acupuncture on FD by taking the intersection of acupuncture for FD therapeutic targets and FD-related targets. We performed the protein-protein interaction network, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: In this study, 26 Randomized Controlled Trials related to acupuncture treatment of FD were retrieved. We obtained 29 acupoints, 17 acupuncture for FD therapeutic targets, and 10 intersection targets. Tumor necrosis factor (TNF), Interleukin (IL)-1, and Neuropeptide Y (NPY) are key targets of acupuncture in the treatment of FD. Conclusion: ST36-CV12-PC6-LR3 is the main acupoint prescription for FD. Acupuncture may affect Neuroactive ligand-receptor interaction, Gastric acid secretion, and IL-17, TNF signaling pathways by regulating related key targets, and play a synergistic role in the treatment of FD by inhibiting gastric acid secretion, alleviating inflammatory response, regulating the brain-gut axis, improving mood and other aspects.
{"title":"Study of the potential mechanism of acupuncture treatment for functional dyspepsia based on association rule mining and bioinformatics/network pharmacology approach","authors":"Andong Zhao, L. Xiao, Hong-yue Niu, Lian Liu, Xiao-Yu Dai","doi":"10.53388/ghr2023-03-071","DOIUrl":"https://doi.org/10.53388/ghr2023-03-071","url":null,"abstract":"Objective: To explore the main acupoint prescription and mechanism of acupuncture in treating Functional dyspepsia (FD) by analyzing the clinical randomized controlled trial literature on acupoints and targets of acupuncture in the treatment of FD combined with association rule mining and bioinformatics/network pharmacology methods. Methods: Search relevant clinical randomized controlled trial literature on acupoints and therapeutic targets of acupuncture in the treatment of FD from eight databases from their inception to June 18th, 2022. We obtained acupuncture selection points, meridian, and therapeutic targets and established acupoints database for acupuncture treatment of FD. FD-related targets were collected from GeneCards, DisGeNET, OMIM, and DrugBank databases. We obtained the potential targets of acupuncture on FD by taking the intersection of acupuncture for FD therapeutic targets and FD-related targets. We performed the protein-protein interaction network, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: In this study, 26 Randomized Controlled Trials related to acupuncture treatment of FD were retrieved. We obtained 29 acupoints, 17 acupuncture for FD therapeutic targets, and 10 intersection targets. Tumor necrosis factor (TNF), Interleukin (IL)-1, and Neuropeptide Y (NPY) are key targets of acupuncture in the treatment of FD. Conclusion: ST36-CV12-PC6-LR3 is the main acupoint prescription for FD. Acupuncture may affect Neuroactive ligand-receptor interaction, Gastric acid secretion, and IL-17, TNF signaling pathways by regulating related key targets, and play a synergistic role in the treatment of FD by inhibiting gastric acid secretion, alleviating inflammatory response, regulating the brain-gut axis, improving mood and other aspects.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90227062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Zheng, Yang Zheng, Jianlong He, Can Xu, Wenqing He, Rui Xu, Jiahui Wang, Tiejian Zhao
{"title":"Network meta-analysis of the compensatory effect of different Chinese herbal compounds combined with Entecavir in the treatment of hepatitis B cirrhosis","authors":"Hui Zheng, Yang Zheng, Jianlong He, Can Xu, Wenqing He, Rui Xu, Jiahui Wang, Tiejian Zhao","doi":"10.53388/ghr2023-03-069","DOIUrl":"https://doi.org/10.53388/ghr2023-03-069","url":null,"abstract":"","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87681494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peptic ulcer, a common digestive ailment, has been considered as an inflammatory response and necrotic lesions of the gastric mucosa. Peptic ulcer reaches intensely to the mucosal muscle layer in the stomach and duodenum. Various factors have been documented to be involved in the pathogenesis of peptic ulcers like Helicobacter pylori , nonsteroidal anti-inflammatory drugs (NSAIDs), acid and pepsin, genetics, and smoking. The conventional use of drugs like proton pump inhibitors (PPIs), histamine (H 2 ) receptor antagonists, antacids, potassium competitive acid blockers, and antibiotics has shown antiulcer effects. However, various researches have shown that herbal drugs can successfully treat peptic ulcers in preclinical and clinical models by different mechanisms. Many herbal drugs and their extracts from different parts like root, stem, leaf, flower, and seed showed potent ulcerprotective effects in the experimental setup. This review critically discusses the factors involved in the pathogenesis of peptic ulcers. In addition, the potential of herbal drug extracts has been highlighted in the present review.
{"title":"A review on conventional and herbal drug approach to peptic ulcer","authors":"D. Kiran, A. Rohilla, Naresh Kalra","doi":"10.53388/ghr2023-03-074","DOIUrl":"https://doi.org/10.53388/ghr2023-03-074","url":null,"abstract":"Peptic ulcer, a common digestive ailment, has been considered as an inflammatory response and necrotic lesions of the gastric mucosa. Peptic ulcer reaches intensely to the mucosal muscle layer in the stomach and duodenum. Various factors have been documented to be involved in the pathogenesis of peptic ulcers like Helicobacter pylori , nonsteroidal anti-inflammatory drugs (NSAIDs), acid and pepsin, genetics, and smoking. The conventional use of drugs like proton pump inhibitors (PPIs), histamine (H 2 ) receptor antagonists, antacids, potassium competitive acid blockers, and antibiotics has shown antiulcer effects. However, various researches have shown that herbal drugs can successfully treat peptic ulcers in preclinical and clinical models by different mechanisms. Many herbal drugs and their extracts from different parts like root, stem, leaf, flower, and seed showed potent ulcerprotective effects in the experimental setup. This review critically discusses the factors involved in the pathogenesis of peptic ulcers. In addition, the potential of herbal drug extracts has been highlighted in the present review.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82535162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhengxin Li, Tingting Zhu, Zhimin Zhao, Li Shen, Gaofeng Chen, Hongtu Gu, Cheng-hai Liu
{"title":"Changing liver stiffness predict regression in advanced fibrosis patients with chronic hepatitis B, but not in moderate fibrosis patients","authors":"Zhengxin Li, Tingting Zhu, Zhimin Zhao, Li Shen, Gaofeng Chen, Hongtu Gu, Cheng-hai Liu","doi":"10.53388/ghr2023-03-067","DOIUrl":"https://doi.org/10.53388/ghr2023-03-067","url":null,"abstract":"","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73195693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Ge, Hongling Cheng, Wei-Fang Liu, Yan-Mei Cai, Qiao-yan Zhang, Shuang Dai, Bo Jia
{"title":"Mechanism of Zuojin Pill in the treatment of anxiety disorder and Major depressive disorder based on network pharmacology and molecular docking validation","authors":"P. Ge, Hongling Cheng, Wei-Fang Liu, Yan-Mei Cai, Qiao-yan Zhang, Shuang Dai, Bo Jia","doi":"10.53388/2023-03-068","DOIUrl":"https://doi.org/10.53388/2023-03-068","url":null,"abstract":"","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83662751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Banxia XieXin Decoction (BXD) is a traditional Chinese medicine decoction commonly used in the Chinese clinical treatment of gastric ulcer (GU). Although some people believe that it may have some advantages in this regard,There is no reliable evidence-based study demonstrating its effectiveness. This study aims to systematically evaluate the healing effect and security of BXD in the treatment of GU. Methods: PubMed, Cochrane Library, EMBASE, ScienceNet, China National Knowledge Infrastructure (CNKI), Wanfang database, Weipu database, and China biomedical literature service (CBM) database were systematically searched to obtain all randomized controlled trials (RCTs) evaluating the treatment GU of BXD published as of April 2022. Two researchers independently screened and extracted all research data, finally evaluated the bias risk of inclusion in the study using revman 5.4. Results: This meta-analysis included 27 randomized controlled trials and 1411 patients. The clinical effective rate, recurrence rate, HP eradication rate, adverse reaction rate, and visual analog score (VAS) of BXD combined treatment and standard treatment alone were compared. The results of the meta-analysis showed that BXD combined treatment improve the symptoms related to the gastric ulcers and reduce drug-related adverse reactions. Due to the low quality of the research included in this analysis, in-depth high-quality research is crucial for verifying these results.
{"title":"Efficacy and safety of Banxia Xiexin Decoction in the treatment of gastric ulcer: a systematic review and meta-analysis of twenty-seven randomized controlled trials","authors":"Boran Gong, Zhehao Xu, Ying Wang, Zitong Feng, Zhao Li, Guodan Yu, Hui-fang Zhou, Yu-Hong Bian","doi":"10.53388/ghr2023-03-073","DOIUrl":"https://doi.org/10.53388/ghr2023-03-073","url":null,"abstract":"Background: Banxia XieXin Decoction (BXD) is a traditional Chinese medicine decoction commonly used in the Chinese clinical treatment of gastric ulcer (GU). Although some people believe that it may have some advantages in this regard,There is no reliable evidence-based study demonstrating its effectiveness. This study aims to systematically evaluate the healing effect and security of BXD in the treatment of GU. Methods: PubMed, Cochrane Library, EMBASE, ScienceNet, China National Knowledge Infrastructure (CNKI), Wanfang database, Weipu database, and China biomedical literature service (CBM) database were systematically searched to obtain all randomized controlled trials (RCTs) evaluating the treatment GU of BXD published as of April 2022. Two researchers independently screened and extracted all research data, finally evaluated the bias risk of inclusion in the study using revman 5.4. Results: This meta-analysis included 27 randomized controlled trials and 1411 patients. The clinical effective rate, recurrence rate, HP eradication rate, adverse reaction rate, and visual analog score (VAS) of BXD combined treatment and standard treatment alone were compared. The results of the meta-analysis showed that BXD combined treatment improve the symptoms related to the gastric ulcers and reduce drug-related adverse reactions. Due to the low quality of the research included in this analysis, in-depth high-quality research is crucial for verifying these results.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83330837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-na Zhang, Naiwei Zhang, Libao An, Bao-Tuan Zhao, Weifang Liu, Bo Jia, Hongling Cheng
Introduction: Functional Constipation (FC) is a type of functional bowel disease that is in Clinically characterized by dysportia, decreased frequency of bowel movements, or incomplete bowel movements in the absence of irritable bowel syndrome syndrome, at least 6 months before diagnosis, and symptoms within the last 3 months. At present, commonly used drugs include enema and suppositories, laxatives, microecological preparations, gastrointestinal motility drugs and other treatments. However, the effect is limited. Traditional Chinese medicine (TCM) treatment of FC has advantages. Methods: In this randomized controlled study, 244 eligible patients were randomly assigned in a 1:1 ratio to a treatment group (Zangfu ointment and massage therapy + Lactulose Oral Liquid) and a control group (Lactulose Oral Liquid) for 14 days. Number of spontaneous defecation per week and First defecation time will be used as primary outcomes, and Traditional Chinese Medicine (TCM) syndrome scores and syndrome scores,PAC-QOL form will be used as secondary outcomes. Blood routine, liver function, and renal function will be used as safety outcomes. The primary and secondary outcomes will be performed at 0th, 7th, and 14th day, and the safety outcomes will be performed at 0th and 14th day. Ethics and dissemination: Ethical approval has been obtained from the Committee on Health Research Ethics of the Fangshan Hospital,
{"title":"Effect of Zangfu ointment and massage therapy on functional constipation: a protocol for a randomised controlled trial","authors":"Xiao-na Zhang, Naiwei Zhang, Libao An, Bao-Tuan Zhao, Weifang Liu, Bo Jia, Hongling Cheng","doi":"10.53388/ghr2023-03-072","DOIUrl":"https://doi.org/10.53388/ghr2023-03-072","url":null,"abstract":"Introduction: Functional Constipation (FC) is a type of functional bowel disease that is in Clinically characterized by dysportia, decreased frequency of bowel movements, or incomplete bowel movements in the absence of irritable bowel syndrome syndrome, at least 6 months before diagnosis, and symptoms within the last 3 months. At present, commonly used drugs include enema and suppositories, laxatives, microecological preparations, gastrointestinal motility drugs and other treatments. However, the effect is limited. Traditional Chinese medicine (TCM) treatment of FC has advantages. Methods: In this randomized controlled study, 244 eligible patients were randomly assigned in a 1:1 ratio to a treatment group (Zangfu ointment and massage therapy + Lactulose Oral Liquid) and a control group (Lactulose Oral Liquid) for 14 days. Number of spontaneous defecation per week and First defecation time will be used as primary outcomes, and Traditional Chinese Medicine (TCM) syndrome scores and syndrome scores,PAC-QOL form will be used as secondary outcomes. Blood routine, liver function, and renal function will be used as safety outcomes. The primary and secondary outcomes will be performed at 0th, 7th, and 14th day, and the safety outcomes will be performed at 0th and 14th day. Ethics and dissemination: Ethical approval has been obtained from the Committee on Health Research Ethics of the Fangshan Hospital,","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"26 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77098493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Chang, Ling Liu, Qianfeng Wang, Xiang-Qing Cui
Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage, which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases. In the management plan of non-alcoholic fatty liver disease and type 2 diabetes, there is no drug with significant efficacy or both. The dialectical idea of traditional Chinese medicine has a good curative effect and significant advantages in treating metabolic disorders. The author now reviewed a case of non-alcoholic steatohepatitis combined with type 2 diabetes. In this case, the method of invigorating the spleen and eliminating turbidity was effective, which effectively prevented the progression of liver disease in the patient, and T2DM was alleviated by maintaining within the standard range after the use of insulin was stopped. It can be said that “killing two birds with one stone”, more fully reflects the advantages of traditional Chinese medicine in the integrated treatment of metabolic-related diseases.
{"title":"Treatment for non-alcoholic steatohepatitis with type 2 diabetes by traditional Chinese medicine: a case report and experience","authors":"Jing Chang, Ling Liu, Qianfeng Wang, Xiang-Qing Cui","doi":"10.53388/ghr2023-03-070","DOIUrl":"https://doi.org/10.53388/ghr2023-03-070","url":null,"abstract":"Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage, which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases. In the management plan of non-alcoholic fatty liver disease and type 2 diabetes, there is no drug with significant efficacy or both. The dialectical idea of traditional Chinese medicine has a good curative effect and significant advantages in treating metabolic disorders. The author now reviewed a case of non-alcoholic steatohepatitis combined with type 2 diabetes. In this case, the method of invigorating the spleen and eliminating turbidity was effective, which effectively prevented the progression of liver disease in the patient, and T2DM was alleviated by maintaining within the standard range after the use of insulin was stopped. It can be said that “killing two birds with one stone”, more fully reflects the advantages of traditional Chinese medicine in the integrated treatment of metabolic-related diseases.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88774431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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