Pub Date : 2016-03-10DOI: 10.1186/s12860-016-0085-9
S. Boggild, S. Mølgaard, S. Glerup, J. Nyengaard
{"title":"Spatiotemporal patterns of sortilin and SorCS2 localization during organ development","authors":"S. Boggild, S. Mølgaard, S. Glerup, J. Nyengaard","doi":"10.1186/s12860-016-0085-9","DOIUrl":"https://doi.org/10.1186/s12860-016-0085-9","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0085-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1186/s12860-016-0084-x
Zhaoxing Dong, W. Tai, Wen Lei, Yin Wang, Zhen-kun Li, Tao Zhang
{"title":"IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells","authors":"Zhaoxing Dong, W. Tai, Wen Lei, Yin Wang, Zhen-kun Li, Tao Zhang","doi":"10.1186/s12860-016-0084-x","DOIUrl":"https://doi.org/10.1186/s12860-016-0084-x","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0084-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-12DOI: 10.1186/s12860-016-0082-z
Timothy R. Sands
{"title":"Annual Acknowledgement of Reviewers","authors":"Timothy R. Sands","doi":"10.1186/s12860-016-0082-z","DOIUrl":"https://doi.org/10.1186/s12860-016-0082-z","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0082-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-02DOI: 10.1186/s12860-016-0081-0
Hande Aypek, V. Bay, Gulistan Mese
{"title":"Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations","authors":"Hande Aypek, V. Bay, Gulistan Mese","doi":"10.1186/s12860-016-0081-0","DOIUrl":"https://doi.org/10.1186/s12860-016-0081-0","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0081-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The intestinal cells of Caenorhabditis elegans are filled with heterogeneous granular organelles that are associated with specific organ functions. The best studied of these organelles are lipid droplets and acidified gut granules associated with GLO-1, a homolog of the small GTPase Rab38. In this study, we characterized a subset of the intestinal granules in which HAF-4 and HAF-9 localize on the membrane. HAF-4 and HAF-9 are ATP-binding cassette (ABC) transporter proteins that are homologous to the mammalian lysosomal peptide transporter TAPL (transporter associated with antigen processing-like, ABCB9).
Results: Using transgenic worms expressing fluorescent protein-tagged marker proteins, we demonstrated that the HAF-4- and HAF-9-localizing organelles are not lipid droplets and do not participate in yolk protein transport. They were also ruled out as GLO-1-positive acidified gut granules. Furthermore, we clarified that the late endosomal protein RAB-7 localizes to the HAF-4- and HAF-9-localizing organelles and is required for their biogenesis.
Conclusions: Our results indicate that the HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway.
{"title":"Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells.","authors":"Takahiro Tanji, Kenji Nishikori, Syoko Haga, Yuki Kanno, Yusuke Kobayashi, Mai Takaya, Keiko Gengyo-Ando, Shohei Mitani, Hirohisa Shiraishi, Ayako Ohashi-Kobayashi","doi":"10.1186/s12860-015-0076-2","DOIUrl":"10.1186/s12860-015-0076-2","url":null,"abstract":"<p><strong>Background: </strong>The intestinal cells of Caenorhabditis elegans are filled with heterogeneous granular organelles that are associated with specific organ functions. The best studied of these organelles are lipid droplets and acidified gut granules associated with GLO-1, a homolog of the small GTPase Rab38. In this study, we characterized a subset of the intestinal granules in which HAF-4 and HAF-9 localize on the membrane. HAF-4 and HAF-9 are ATP-binding cassette (ABC) transporter proteins that are homologous to the mammalian lysosomal peptide transporter TAPL (transporter associated with antigen processing-like, ABCB9).</p><p><strong>Results: </strong>Using transgenic worms expressing fluorescent protein-tagged marker proteins, we demonstrated that the HAF-4- and HAF-9-localizing organelles are not lipid droplets and do not participate in yolk protein transport. They were also ruled out as GLO-1-positive acidified gut granules. Furthermore, we clarified that the late endosomal protein RAB-7 localizes to the HAF-4- and HAF-9-localizing organelles and is required for their biogenesis.</p><p><strong>Conclusions: </strong>Our results indicate that the HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway.</p>","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2016-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65672762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-13DOI: 10.1186/s12860-016-0080-1
Lina Rimkute, Vaidas Jotautis, Alina Marandykina, Renata Sveikatienė, Ieva Antanavičiūtė, V. A. Skeberdis
{"title":"The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes","authors":"Lina Rimkute, Vaidas Jotautis, Alina Marandykina, Renata Sveikatienė, Ieva Antanavičiūtė, V. A. Skeberdis","doi":"10.1186/s12860-016-0080-1","DOIUrl":"https://doi.org/10.1186/s12860-016-0080-1","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-016-0080-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-12DOI: 10.1186/s12860-015-0079-z
J. D. Robinson, Jennifer R. Powell
{"title":"Long-term recovery from acute cold shock in Caenorhabditis elegans","authors":"J. D. Robinson, Jennifer R. Powell","doi":"10.1186/s12860-015-0079-z","DOIUrl":"https://doi.org/10.1186/s12860-015-0079-z","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-015-0079-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-07DOI: 10.1186/s12860-015-0078-0
Katarzyna Plak, Henderikus Pots, P. V. van Haastert, A. Kortholt
{"title":"Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells","authors":"Katarzyna Plak, Henderikus Pots, P. V. van Haastert, A. Kortholt","doi":"10.1186/s12860-015-0078-0","DOIUrl":"https://doi.org/10.1186/s12860-015-0078-0","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-015-0078-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65673154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.1186/s12860-015-0077-1
E. Ghanem, M. Al-Balushi
{"title":"Adopting the rapamycin trapping assay to track the trafficking of murine MHC class I alleles, H-2Kb","authors":"E. Ghanem, M. Al-Balushi","doi":"10.1186/s12860-015-0077-1","DOIUrl":"https://doi.org/10.1186/s12860-015-0077-1","url":null,"abstract":"","PeriodicalId":9051,"journal":{"name":"BMC Cell Biology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12860-015-0077-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65672828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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