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Usefulness of Checking Sensitization Status in Adult Patients with Suspected Sleep Apnea 检查成人疑似睡眠呼吸暂停患者致敏状态的有用性
Pub Date : 2022-01-28 DOI: 10.5005/jp-journals-10069-0085
C. Gouder, S. Montefort, J. Bartra
Aim: An association between obstructive sleep apnea (OSA) and allergic rhinitis (AR), both common with increasing prevalence worldwide, has frequently been reported. The objective of this study was to assess acceptability, feasibility, and usefulness of routinely checking sensitization status in suspected sleep apnea. Materials and methods: All consecutive adult patients referred to an adult sleep clinic in Malta over a 10-week period were included. A medical history, physical examination, and skin testing for common aeroallergens were performed for all and rhinoconjunctivitis quality of life questionnaire (RQLQ), Total-4-nasal symptom score (T4NSS), and visual analogue scale (VAS) for AR patients. Uncontrolled AR was treated. The polysomnography report was reviewed. Results: Our cohort included 95 patients—34.7% were sensitized and diagnosed with AR. The most common perennial aeroallergens were Dermatophagoides pteronyssinus (86.1%), farina (75%), seasonal aeroallergens, tree (19%), and grass pollen (19%). When comparing allergic and nonallergic groups, the former were younger (p = 0.002), more likely female (p = 0.06) and asthmatic (p = 0.014), suffered rhinorrhea (p = 0.02), or other rhinoconjunctivitis symptoms (p <0.001). Patients with AR were less likely diagnosed with sleep apnea (60.6%) compared to those without (81.3%) (p = 0.014). A total of 54.2% of patients with normal polysomnography were diagnosed with AR compared to 30% of sleep apnea patients (p = 0.26). Conclusion: Skin prick testing (SPT) in this context is acceptable, safe, and feasible, mainly useful in younger females, asthmatics, and those with AR symptoms. Diagnosing AR in patients whose symptoms have been mistaken for sleep apnea and in patients with coexisting sleep apnea will improve morbidity and quality of life. Clinical significance: Checking sensitization status in patients with suspected sleep apnea will improve clinical outcomes.
目的:阻塞性睡眠呼吸暂停(OSA)和变应性鼻炎(AR)之间的关联经常被报道,两者都很常见,并且在世界范围内的患病率越来越高。本研究的目的是评估常规检查疑似睡眠呼吸暂停患者致敏状态的可接受性、可行性和实用性。材料和方法:纳入马耳他一家成人睡眠诊所连续10周的所有成年患者。对所有患者进行病史、体格检查和常见空气过敏原皮肤试验,对AR患者进行鼻结膜炎生活质量问卷(RQLQ)、总4-鼻症状评分(T4NSS)和视觉模拟评分(VAS)。治疗未控制的AR。复习多导睡眠图报告。结果:我们的队列包括95例患者(34.7%)致敏并诊断为AR。最常见的常年性气体过敏原是翼状螨(86.1%),farina(75%),季节性气体过敏原,树(19%)和草花粉(19%)。当比较过敏组和非过敏组时,前者更年轻(p = 0.002),更有可能是女性(p = 0.06)和哮喘(p = 0.014),有鼻漏(p = 0.02)或其他鼻结膜炎症状(p <0.001)。与没有AR的患者(81.3%)相比,AR患者被诊断为睡眠呼吸暂停的可能性较低(60.6%)(p = 0.014)。共有54.2%的多导睡眠图正常患者被诊断为AR,而30%的睡眠呼吸暂停患者被诊断为AR (p = 0.26)。结论:在这种情况下,皮肤点刺试验(SPT)是可接受、安全、可行的,主要适用于年轻女性、哮喘患者和有AR症状的患者。在症状被误认为睡眠呼吸暂停的患者和共存睡眠呼吸暂停的患者中诊断AR将改善发病率和生活质量。临床意义:检查疑似睡眠呼吸暂停患者的致敏状态可改善临床预后。
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引用次数: 0
Laurence–Moon–Bardet–Biedl Syndrome and Obstructive Sleep Apnea Laurence–Moon–Bardet–Biedl综合征与阻塞性睡眠呼吸暂停
Pub Date : 2022-01-28 DOI: 10.5005/jp-journals-10069-0090
Rohit Kumar, P. Ish, Nitesh Gupta, N. Malhotra, Harsha Jain, N. Gupta
Pediatric obstructive sleep apnea (OSA) often is underdiagnosed, particularly when associated with a syndrome when there are numerous and varied manifestations. However, a high index of suspicion and screening can help in early diagnosis and treatment for the same. We present a case of Laurence–Moon–Bardet–Biedl syndrome diagnosed since the age of 8 years presenting at the age of 16 years with severe OSA with good clinical recovery on therapeutic use of continuous positive airway pressure (CPAP).
儿童阻塞性睡眠呼吸暂停(OSA)经常被误诊,特别是当它伴有多种多样的症状时。然而,高度的怀疑和筛查有助于早期诊断和治疗。我们报告一例自8岁起诊断为Laurence-Moon-Bardet-Biedl综合征的病例,在16岁时出现严重的OSA,在持续气道正压通气(CPAP)治疗下临床恢复良好。
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引用次数: 0
Effect of Mandibular Advancement through Oral Appliance Therapy on Quality of Life in Obstructive Sleep Apnea: A Scoping Review 口腔矫治器治疗下颌前移对阻塞性睡眠呼吸暂停患者生活质量的影响:范围界定综述
Pub Date : 2022-01-28 DOI: 10.5005/jp-journals-10069-0088
Prashant Sharma, Pradeep Raghav, Nisha Kalonia, K. Amit
Ab s t r Ac t Purpose: The scoping review was conducted for the evaluation of effect of mandibular advancement through oral appliance therapy on quality of life in obstructive sleep apnea (OSA). Methods: Strategic and thorough literature search using free text and MESH terms in three major database systems PubMed, SCOPUS, and Web of Science was undertaken till October 30, 2020, followed by PRISMA for the identification of studies for data extraction. Results and conclusions: Summarization of evidence was done for study characteristics, and diagnostic methods for the evaluation of effect of mandibular advancement through oral appliance therapy on quality of life in OSA. The literature supports that patients using mandibular advancement appliances (MADs) showed better adherence and compliance in comparison with those using continuous positive airway pressure (CPAP); along with the patients’ compliance, the daytime sleepiness, state on waking, morning headache, oxygen saturation, frequency and intensity of snoring, and quality of sleep for both patients and their bed partners showed a marked improvement with MAD.
目的:评价口腔矫治器下颌前移对阻塞性睡眠呼吸暂停(OSA)患者生活质量的影响。方法:到2020年10月30日,在PubMed、SCOPUS和Web of Science三大数据库系统中使用自由文本和MESH术语进行战略性和全面的文献检索,随后使用PRISMA进行研究识别,进行数据提取。结果与结论:总结研究特点及诊断方法,评价口腔矫治器下颌前移对OSA患者生活质量的影响。文献支持使用下颌推进器(MADs)的患者比使用持续气道正压通气(CPAP)的患者表现出更好的依从性和依从性;随着患者的依从性,患者及其床伴的白天嗜睡、清醒状态、早晨头痛、血氧饱和度、打鼾的频率和强度以及睡眠质量在MAD的治疗下均有显著改善。
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引用次数: 2
Sleep Quality during COVID-19 Lockdown among Young Indian Adults: A Cross-sectional Study 新冠肺炎封锁期间印度年轻成年人的睡眠质量:一项跨部门研究
Pub Date : 2022-01-28 DOI: 10.5005/jp-journals-10069-0087
Priyanka Sharma, A. Das
Background: COVID-19 disrupted lives globally, and to combat it, various countries including India imposed lockdown and other restrictions. This study was conducted to estimate the prevalence of poor sleep quality among Indian adults in 18–30-year age-group and factors associated with it during lockdown. Methods: This was an online survey-based cross-sectional study conducted in May 2020 after 6 weeks of lockdown in India. Information regarding sociodemographic profile, screen time, physical activity, substance use, caffeine intake, and sleep habits during lockdown was collected. Pittsburgh sleep quality index was used to assess the sleep quality. Descriptive analysis was performed. Results: A total of 244 study participants were included in the study, out of which 59% (144) were males and mean age was 24.1 years. Physical activity was decreased among 138 (56.6%) and screen time of more than 4 hours among 152 (62.3%) study participants. Poor sleep quality was reported by 47.1% (115) and sleep duration was decreased among 24.6% (60) study participants. Younger age, living in a containment zone, optimal use of available time, and decreased sleep duration were found to be associated with poor sleep quality. Conclusion: Lockdown affected sleep quality of the study participants adversely, delaying sleeping and waking times. It is important to ensure minimum disruption of day-to-day schedule of people even during such restrictions. Living in a containment zone was found to be significantly associated with poor sleep quality. Authorities should see to it that people living in such zones should be given priority and counseled appropriately.
背景:COVID-19扰乱了全球的生活,为了对抗它,包括印度在内的许多国家实施了封锁和其他限制措施。本研究旨在估计18 - 30岁年龄组印度成年人在封锁期间睡眠质量差的普遍程度及其相关因素。方法:这是一项基于在线调查的横断面研究,于2020年5月在印度封锁6周后进行。收集了禁闭期间的社会人口统计资料、屏幕时间、身体活动、物质使用、咖啡因摄入量和睡眠习惯等信息。采用匹兹堡睡眠质量指数评价睡眠质量。进行描述性分析。结果:共纳入244例研究参与者,其中59%(144例)为男性,平均年龄24.1岁。138人(56.6%)的体力活动减少,152人(62.3%)的屏幕时间超过4小时。47.1%(115人)报告睡眠质量差,24.6%(60人)的研究参与者睡眠时间缩短。研究发现,年龄较小、生活在隔离区、最佳利用可用时间和睡眠时间缩短与睡眠质量差有关。结论:封锁对研究参与者的睡眠质量有不利影响,延迟了睡眠和清醒时间。重要的是,即使在这种限制期间,也要确保尽量减少对人们日常日程的干扰。研究发现,生活在隔离区与睡眠质量差显著相关。当局应确保生活在这些地区的人得到优先考虑,并得到适当的咨询。
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引用次数: 0
Association Between Suggestive Symptom of Restless Legs Syndrome and COVID-19 Vaccination: A Pilot Study 不宁腿综合征的暗示症状与COVID-19疫苗接种之间的关联:一项试点研究
Pub Date : 2022-01-26 DOI: 10.13078/jsm.210022
J. Seok, Eun Jin Na, Seul Gi Kim, Jongkyu Park, Eunkyeong Park, P. Song, Kwang Ik Yang
Jin Myoung Seok, Eun Jin Na, Seul Gi Kim, Jongkyu Park, Eunkyeong Park, Pamela Song, Kwang Ik Yang Sleep Disorders Center, Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, Cheonan, Infection Control Team, Soonchunhyang University Hospital Cheonan, Cheonan, Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
Seok Jin Myoung, Na Eun Jin, Kim Seul Gi, Park Jongkyu, Park Eunkyeong, Pamela Song, Kwang Ik Yang睡眠障碍中心,天安顺天香大学医院神经科,天安顺天香大学医学院,感染控制组,天安顺天香大学医院,天安,仁济大学医学院,白一山医院神经科,韩国高阳市
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引用次数: 1
Positional Therapy in a Patient With Refractory Treatment-Emergent Central Sleep Apnea 体位疗法治疗难治性中枢性睡眠呼吸暂停患者
Pub Date : 2021-12-31 DOI: 10.13078/jsm.210019
William Palmer, M. Jaziri, M. Tovar
Treatment-emergent central sleep apnea (TE-CSA) is commonly encountered during the treatment for obstructive sleep apnea (OSA) with positive airway pressure (PAP) and usually remains self-limited. Persistent TE-CSA is sporadically seen with PAP therapy and has only rarely been described with hypoglossal nerve stimulation (HGNS). We report the case of a 60-year-old female patient with moderate OSA that progressed to TE-CSA with PAP therapy. A prolonged trial with PAP therapy was limited because the patient experienced recurrent aerophagia and subsequently underwent HGNS implantation. HGNS titration led to improved control of the patient’s OSA, but TE-CSA recurred and demonstrated a strong positional component. Lateral positional therapy was implemented with adequate control of respiratory events. TE-CSA can persist throughout different treatment modalities, including HGNS. The patient’s successful lateral sleep therapy for persistent and positionally exacerbated TE-CSA demonstrates the benefit of a well-known sleep apnea treatment for this poorly understood condition.
治疗突发性中心性睡眠呼吸暂停(TE-CSA)是在气道正压(PAP)治疗阻塞性睡眠呼吸暂停(OSA)过程中常见的,通常保持自限性。持续性TE-CSA在PAP治疗中偶见,仅在舌下神经刺激(HGNS)中罕见。我们报告一例60岁的女性患者,患有中度OSA,通过PAP治疗进展为TE-CSA。PAP治疗的长期试验受到限制,因为患者经历了反复的噬气症,随后接受了HGNS植入。HGNS滴定改善了对患者OSA的控制,但TE-CSA复发并表现出强烈的体位成分。在充分控制呼吸事件的情况下实施侧位治疗。TE-CSA可以在不同的治疗方式中持续存在,包括HGNS。患者成功的侧卧睡眠治疗持续性和体位加重TE-CSA,证明了众所周知的睡眠呼吸暂停治疗对这种鲜为人知的疾病的益处。
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引用次数: 0
The “Sleep Well, Lincolnshire” Project: Evaluation of an Online Sleep Practitioner Clinic 林肯郡“睡眠好”项目:在线睡眠医生诊所的评估
Pub Date : 2021-12-31 DOI: 10.13078/jsm.210013
H. Elphick, Claire Earley, Karen Tyas, Lowri Thomas, Lisa Artis, V. Dawson
Objectives: Poor sleep is associated with adverse outcomes during childhood. Behavioral insomnia is the most common sleep difficulty experienced by children. The coronavirus disease 2019 (COVID-19) global pandemic in 2020 has profoundly affected children’s sleep patterns. This project aimed to evaluate a one-toone sleep service delivered via online clinics by community sleep practitioners in the UK.Methods: This was an observational pre- and post-evaluation study over a 12-month period. The intervention derived from aspects of cognitive-behavioral therapy for insomnia. The evaluation was questionnaire-based and assessed sleep parameters and well-being.Results: 104 parents returned completed questionnaires. The average time of sleep onset was 1 hour and 39 minutes pre-intervention and 20 minutes post-intervention. The average number of nights per week that children woke up was 3.9 pre-intervention and 0.9 post-intervention; the number of night awakenings fell from 1.9 to 0.5 and the time that children were awake after sleep onset fell from 66.8 minutes to 5.8 minutes. The average time that children were asleep was 8.0 hours per night pre-intervention and 10.2 hours post-intervention. The improvement in all sleep parameters was statistically significant (p<0.05). All parameters of parental and children’s well-being improved significantly (p<0.05), except for perceived ability to drive (p=0.07). All parents stated that they would recommend sleep support and 20% already had done so.Conclusions: The COVID-19 pandemic has accelerated the development of remote health care solutions, and in the case of children’s sleep clinics, the online mode of intervention delivery that is as effective, acceptable, and accessible as face-to-face delivery.
目的:儿童时期睡眠不良与不良后果有关。行为性失眠是儿童最常见的睡眠困难。2020年的2019冠状病毒病(COVID-19)全球大流行深刻影响了儿童的睡眠模式。该项目旨在评估英国社区睡眠从业者通过在线诊所提供的一对一睡眠服务。方法:这是一项为期12个月的观察性评估前和评估后研究。干预源自失眠的认知行为疗法的各个方面。该评估以问卷为基础,评估睡眠参数和健康状况。结果:104名家长完成问卷调查。干预前平均睡眠时间为1小时39分钟,干预后为20分钟。干预前儿童每周平均醒来的天数为3.9晚,干预后为0.9晚;夜间醒来的次数从1.9次降至0.5次,儿童入睡后醒来的时间从66.8分钟降至5.8分钟。干预前儿童每晚平均睡眠时间为8.0小时,干预后为10.2小时。各睡眠参数改善均有统计学意义(p<0.05)。除驾驶能力知觉外,父母和儿童的各项幸福感均有显著提高(p<0.05)。所有的父母都表示他们会推荐睡眠支持,20%的父母已经这样做了。结论:2019冠状病毒病大流行加速了远程医疗解决方案的发展,就儿童睡眠诊所而言,在线干预交付模式与面对面交付一样有效、可接受和可获取。
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引用次数: 0
Efficacy of Oxcarbazepine for Sleep-Related Leg Cramps: A Retrospective Study 奥卡西平治疗与睡眠有关的腿部痉挛的疗效:一项回顾性研究
Pub Date : 2021-12-31 DOI: 10.13078/jsm.210018
S. Ahn, Y. Shin, K. Jung
Objectives: Sleep-related leg cramps (SRLC) are common among older people. Severe clinical symptoms of SRLC usually cause great discomfort to patients. To date, many treatment drugs have been tried; however, there are currently no drugs approved for treating this condition. We aimed to assess the efficacy of a new drug, oxcarbazepine (OXC), in the treatment of SRLC.Methods: We retrospectively analyzed clinical outcomes following OXC administration. A daily dose of 150 mg OXC was prescribed to control nocturnal leg cramps. Clinical outcomes were measured using the Clinical Global Impression Scale to confirm the effectiveness of OXC.Results: A total of 88.9% (16/18) of patients clinically improved four weeks after OXC prescription, and 94% (15/16) of patients continued to improve at the last follow-up (3–6 months). None of the patients complained of side effects related to 150 mg OXC.Conclusions: OXC may be a new medical option for treatment of SRLC.
目的:睡眠相关性腿痉挛(SRLC)在老年人中很常见。严重的SRLC临床症状通常会给患者带来极大的不适。迄今为止,已经尝试了许多治疗药物;然而,目前还没有药物被批准用于治疗这种疾病。我们的目的是评估一种新药奥卡西平(OXC)治疗SRLC的疗效。方法:回顾性分析口服OXC后的临床结果。每天服用150毫克氧合碳来控制夜间腿部抽筋。使用临床总体印象量表测量临床结果,以确认OXC的有效性。结果:88.9%(16/18)患者处方后4周临床改善,94%(15/16)患者末次随访(3-6个月)持续改善。没有患者抱怨与150mg OXC相关的副作用。结论:OXC可能是治疗SRLC的一种新的医学选择。
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引用次数: 0
Sleep-Wake Pattern, Sleep Quality and Daytime Status in Fixed Day-Shift Hospital Workers 医院固定日班职工的睡眠-觉醒模式、睡眠质量与日间状态
Pub Date : 2021-12-31 DOI: 10.13078/jsm.210021
S. Choi, Hyunjin Jo, Dongyeop Kim, E. Joo
Objectives: Sleep issues are more prevalent in healthcare workers compared to workers in other industries. This study investigated sleep-wake pattern, sleep quality, and daytime status in hospital workers using a Galaxy Watch3 (GW3), a wrist-worn device that uses an accelerometer and heart rate sensor to distinguish sleep and wakefulness.Methods: Multiple sleep parameters including total sleep time (TST) were obtained using a GW3. The Epworth sleepiness scale (ESS), insomnia severity index (ISI), Pittsburgh sleep quality index (PSQI), and bedtime procrastination scale (BPS) were used to assess participants’ status.Results: A total of 70 daytime hospital workers (male, 45.7%; mean age, 35.66±7.79 yr) participated in the monitoring of their sleep-wake patterns for 30 consecutive days. Participants had a mean ESS of 8.14±3.62, ISI of 6.13±3.83, and PSQI of 4.86±2.14. The mean TST was 5.75±0.74 hr (range: 3.42–6.88) during workdays and 5.92±0.92 hr (range: 2.87–8.25) during free days. Chronotype (mid-sleep on freedays corrected for sleep debt accumulated over the work week) was 3.60±1.03 clock hr (range: 1.84–6.69). BPS was negatively correlated with age (rho=-0.27, p=0.022), TST of workdays (rho=-0.53, p<0.001), and TST of free days (rho=-0.43, p<0.001). A higher BPS was associated with larger social jetlag (rho=0.28, p=0.018) and later chronotype (rho=0.41, p<0.001).Conclusions: In this study, 91.5% of daytime hospital workers suffered from chronic sleep insufficiency (<7 hr during both workdays and free days) although their daytime sleepiness or subjective sleep were not poor. Individuals with a later chronotype had poorer sleep quality and worse sleep procrastination behavior.
目的:与其他行业的工人相比,卫生保健工作者的睡眠问题更为普遍。这项研究调查了医院工作人员使用Galaxy Watch3 (GW3)的睡眠-觉醒模式、睡眠质量和白天状态,这是一种腕戴设备,使用加速度计和心率传感器来区分睡眠和清醒。方法:采用GW3法获得包括总睡眠时间(TST)在内的多项睡眠参数。采用Epworth嗜睡量表(ESS)、失眠严重程度指数(ISI)、匹兹堡睡眠质量指数(PSQI)和就寝拖延量表(BPS)评估受试者的睡眠状态。结果:共70名日间医院工作人员(男性占45.7%;平均年龄(35.66±7.79岁)连续30天参与睡眠-觉醒模式监测。参与者的平均ESS为8.14±3.62,ISI为6.13±3.83,PSQI为4.86±2.14。工作日平均TST为5.75±0.74 hr(范围3.42 ~ 6.88),休息日平均TST为5.92±0.92 hr(范围2.87 ~ 8.25)。睡眠类型(工作日的睡眠中,修正了工作日累积的睡眠债务)为3.60±1.03小时(范围:1.84-6.69)。BPS与年龄(rho=-0.27, p=0.022)、工作日TST (rho=-0.53, p<0.001)、空闲日TST (rho=-0.43, p<0.001)呈负相关。较高的BPS与较大的社会时差(rho=0.28, p=0.018)和较晚的睡眠类型(rho=0.41, p<0.001)相关。结论:在本研究中,91.5%的日间医院工作人员存在慢性睡眠不足(工作日和休息日均<7小时),尽管他们的白天嗜睡或主观睡眠并不差。睡眠类型较晚的人睡眠质量较差,睡眠拖延行为也更严重。
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引用次数: 2
Bedtime Procrastination as a Mediator in the Relationship Between Active Emotion Regulation Strategies and Insomnia 睡前拖延在积极情绪调节策略与失眠的关系中起中介作用
Pub Date : 2021-12-31 DOI: 10.13078/jsm.210023
Goeun Kim, H. Jeon, S. Suh
Objectives: Bedtime procrastination (BP) is defined as the behavior of voluntarily postponing bedtime without having external reasons for doing so. According to previous studies, people with reduced use of active emotion regulation strategies may use BP to cope with negative emotions. However, research about the relationship among active emotional regulation strategies, BP, and insomnia is lacking. This study aimed to investigate the mediating effect of BP between active emotional regulation strategies and insomnia severity.Methods: In total, 597 adults (female, 81.9%; mean age, 23.18±2.80 years) completed the Emotional Regulation Strategies Checklist, Insomnia Severity Index, and Bedtime Procrastination Scale.Results: There was a significant association between active emotional regulation strategies and BP (r=-0.152, p<0.01), between BP and insomnia severity (r=0.259, p<0.01), and between active emotional regulation strategies and insomnia severity (r=-0.128, p<0.01). BP significantly mediated the relationship between active emotional regulation strategies and insomnia severity (B=-0.024; 95% confidence interval [CI], -0.04 to -0.01).Conclusions: BP may be considered in the relationship between active emotional regulation strategies and insomnia severity. Understanding the mediating role of BP may help prevent insomnia.
睡前拖延症(BP)被定义为在没有外部原因的情况下自愿推迟就寝时间的行为。根据以往的研究,积极情绪调节策略使用减少的人可能会使用BP来应对消极情绪。然而,关于积极情绪调节策略、血压与失眠之间关系的研究尚缺乏。本研究旨在探讨血压在积极情绪调节策略与失眠严重程度之间的中介作用。方法:成人597例,其中女性占81.9%;平均年龄(23.18±2.80岁)完成情绪调节策略检查表、失眠严重程度指数和就寝拖延量表。结果:积极情绪调节策略与血压(r=-0.152, p<0.01)、血压与失眠严重程度(r=0.259, p<0.01)、积极情绪调节策略与失眠严重程度(r=-0.128, p<0.01)有显著相关。血压显著介导积极情绪调节策略与失眠严重程度的关系(B=-0.024;95%置信区间[CI], -0.04 ~ -0.01)。结论:在积极情绪调节策略与失眠严重程度的关系中,血压可能被考虑。了解血压的调节作用可能有助于预防失眠。
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引用次数: 1
期刊
Indian journal of sleep medicine
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