Pub Date : 1998-10-01DOI: 10.1191/096813098673417837
M. Kranjnik, I. Finlay, Z. Żylicz
Neurogenic inflammation, with its associated hyperalgesia, is linked to release of neuropeptide mediators including substance P, calcitonin gene-related peptide and corticotrophin-releasing factor. The release of substance P may be modified by opioid receptors on afferent nerve terminals. It is known to be a major mediator of neurogenic inflammation in synovia and is implicated in lymphocyte proliferation and arthritic bone changes. However, opioids may inhibit plasma extravasation and appear to decrease substance P r e l e a s e . Opioid peptides are found in inflamed tissues, released early by interleukin-1 and later by a corticotrophin-releasing factor effect. Opioids appear to interact with interleukins and may act as signalling molecules between immunologically active cells. Endogenous opioids tend to stimulate and exogenous opioids tend to suppress the immune system; information from infections in opioid addicts suggests that this has clinical signific a n c e . Thus, the effect of opioids in modifying the peripheral inflammatory response indicates an analgesic potential at peripheral afferent receptors.
{"title":"Opioids affect inflammation and the immune system","authors":"M. Kranjnik, I. Finlay, Z. Żylicz","doi":"10.1191/096813098673417837","DOIUrl":"https://doi.org/10.1191/096813098673417837","url":null,"abstract":"Neurogenic inflammation, with its associated hyperalgesia, is linked to release of neuropeptide mediators including substance P, calcitonin gene-related peptide and corticotrophin-releasing factor. The release of substance P may be modified by opioid receptors on afferent nerve terminals. It is known to be a major mediator of neurogenic inflammation in synovia and is implicated in lymphocyte proliferation and arthritic bone changes. However, opioids may inhibit plasma extravasation and appear to decrease substance P r e l e a s e . Opioid peptides are found in inflamed tissues, released early by interleukin-1 and later by a corticotrophin-releasing factor effect. Opioids appear to interact with interleukins and may act as signalling molecules between immunologically active cells. Endogenous opioids tend to stimulate and exogenous opioids tend to suppress the immune system; information from infections in opioid addicts suggests that this has clinical signific a n c e . Thus, the effect of opioids in modifying the peripheral inflammatory response indicates an analgesic potential at peripheral afferent receptors.","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"90 1","pages":"147-154"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84363599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-10-01DOI: 10.1191/096813098675014878
H. Fischer
{"title":"Peripheral nerve blockade in the treatment of pain","authors":"H. Fischer","doi":"10.1191/096813098675014878","DOIUrl":"https://doi.org/10.1191/096813098675014878","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"47 1","pages":"183-202"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80357588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-10-01DOI: 10.1191/096813098668122984
T. Bamigbade, R. Langford
{"title":"The clinical use of tramadol hydrochloride","authors":"T. Bamigbade, R. Langford","doi":"10.1191/096813098668122984","DOIUrl":"https://doi.org/10.1191/096813098668122984","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"18 1","pages":"155-182"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78924075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-10-01DOI: 10.1191/096813098666525736
K. Judkins
{"title":"Pain management in the burned patient","authors":"K. Judkins","doi":"10.1191/096813098666525736","DOIUrl":"https://doi.org/10.1191/096813098666525736","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"111 1","pages":"133-146"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76370633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-07-01DOI: 10.1191/096813098667425213
P. Siddall, M. Cousins
{"title":"Clinical aspects of present models of neuropathic pain","authors":"P. Siddall, M. Cousins","doi":"10.1191/096813098667425213","DOIUrl":"https://doi.org/10.1191/096813098667425213","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"67 1","pages":"101-123"},"PeriodicalIF":0.0,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77118032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-07-01DOI: 10.1191/096813098678013353
K. Mizumura
{"title":"Natural history of nociceptor sensitization: the search for a peripheral mechanism of hyperalgesia","authors":"K. Mizumura","doi":"10.1191/096813098678013353","DOIUrl":"https://doi.org/10.1191/096813098678013353","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"2 1","pages":"59-82"},"PeriodicalIF":0.0,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75655306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-07-01DOI: 10.1191/096813098674315767
B. Simpson
{"title":"Neuromodulation in Europe: regulation, variation and trends","authors":"B. Simpson","doi":"10.1191/096813098674315767","DOIUrl":"https://doi.org/10.1191/096813098674315767","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"27 1","pages":"124-131"},"PeriodicalIF":0.0,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82156382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-07-01DOI: 10.1191/096813098672721191
D. Ralston
{"title":"Present models of neuropathic pain","authors":"D. Ralston","doi":"10.1191/096813098672721191","DOIUrl":"https://doi.org/10.1191/096813098672721191","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"43 1","pages":"83-100"},"PeriodicalIF":0.0,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74013561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-04-01DOI: 10.1191/096813098677316312
N. Morton
{"title":"Prevention and control of pain in children","authors":"N. Morton","doi":"10.1191/096813098677316312","DOIUrl":"https://doi.org/10.1191/096813098677316312","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"3 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74320247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-04-01DOI: 10.1191/096813098666727985
J. Sykes, G. Hanks
{"title":"Nonopioid analgesics in the treatment of pain due to malignant disease","authors":"J. Sykes, G. Hanks","doi":"10.1191/096813098666727985","DOIUrl":"https://doi.org/10.1191/096813098666727985","url":null,"abstract":"","PeriodicalId":90719,"journal":{"name":"Reviews in pain","volume":"1 1","pages":"32-50"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90068985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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