Immunology and infectious diseases最新文献

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Administration of an Autogenous Vaccine in Patients with Chronic Bacterial Osteomyelitis 慢性细菌性骨髓炎患者自体疫苗的应用

Immunology and infectious diseases

Pub Date : 2014-01-01 DOI: 10.13189/IID.2014.020103

D. Vito, E. Jirillo, A. Ballini, G. Mastrorillo

Since we face the problem of rapidly growing rates of antimicrobial resistance, autovaccination may provide a treatment alternative at least in those patients which suffer from treatment refractory infections. Interest is turning towards the therapy of infectious diseases by stimulation of the immune defence mechanisms. In fact there are reports of drug resistance in a wide range of bacterial diseases. In our experience, autovaccine immunization has the potential to treat chronic infections such as osteomyelitis unresponsive to antimicrobial therapy.

由于我们面临着抗菌素耐药性迅速增长的问题，自身疫苗接种至少可以为那些患有难治性感染的患者提供一种治疗选择。通过刺激免疫防御机制来治疗传染病的兴趣正在转向。事实上，在许多细菌性疾病中都有耐药性的报告。根据我们的经验，自身疫苗免疫有可能治疗慢性感染，如对抗菌药物治疗无反应的骨髓炎。

引用次数: 0

Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis. HLA-DRB1*1501和tnf - α在多发性硬化症人群病例对照研究中的相互作用

Immunology and infectious diseases

Pub Date : 2013-09-01 DOI: 10.13189/iid.2013.010102

Dhelia M Williamson, Ruth Ann Marrie, Allison Ashley-Koch, Glen A Satten

This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (HLA), T cell receptor beta (TCA receptor β), tumor necrosis factor α (TNF α), tumor necrosis factor β (TNF β), apolipoprotein E (APOE), interleukin 7 receptor alpha chain (IL7RA) interleukin 2 receptor alpha chain (IL2RA) myelin basic protein (MBP) and vitamin D receptor (VDR)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of HLA DRB1*1501. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. HLA DRB1*1501 risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the HLA DRB1*1501 risk allele identified significant associations with TNF α -1031 (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF α and HLA DRB1*1501 may influence the risk of developing MS.

本研究旨在确定与多发性硬化症(MS)相关的9个基因(人白细胞抗原(HLA)、T细胞受体β (TCA受体β)、肿瘤坏死因子α (TNF α)、肿瘤坏死因子β (TNF β)、载脂蛋白E (APOE)、白细胞介素7受体α链(IL7RA)、白细胞介素2受体α链(IL2RA)、髓鞘碱性蛋白(MBP)和维生素D受体(VDR))的单核苷酸多态性(snp)是否可以在人群样本中复制。并确定这些关联是否因HLA DRB1*1501的存在而改变。参与以人群为基础的病例对照研究的722名个体(223名多发性硬化症患者和499名对照组)可获得DNA。病例和对照组在血统、年龄、性别和地理区域上相匹配。HLA DRB1*1501风险等位基因(T)通过基因型检测在该人群中得到确认，控制多重比较。检测HLA DRB1*1501风险等位基因存在或不存在时每个SNP的影响，发现在没有HLA风险等位基因的人群中，TNF α -1031 (rs1799964)显著相关。在个案分析中，没有额外的相互作用是显著的。我们的研究结果表明，TNF α和HLA DRB1*1501的snp之间的相互作用可能影响发生MS的风险。

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引用次数: 2

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