Pub Date : 2016-03-01DOI: 10.3923/IJCR.2016.152.161
H. Ragab, H. Shaaban, N. A. Maksoud, S. Radwan, Wafaa Abd Elaziz, N. Hafez
{"title":"Expression of Vascular Endothelial Growth Factor Protein in Both Serum Samples and Excised Tumor Tissues of Breast Carcinoma Patients","authors":"H. Ragab, H. Shaaban, N. A. Maksoud, S. Radwan, Wafaa Abd Elaziz, N. Hafez","doi":"10.3923/IJCR.2016.152.161","DOIUrl":"https://doi.org/10.3923/IJCR.2016.152.161","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"12 1","pages":"152-161"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77728327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.3923/IJCR.2016.176.187
G. Akunna, E. Obikili, G. Anyanwu, E. Esom
{"title":"Spermiographic, 2 and 3-dimensional Quantitative Analysis of Testicular Tissues of Rat Submitted to Citrus paradisi Waste Extract and Cisplatin-induced Cytotoxicity","authors":"G. Akunna, E. Obikili, G. Anyanwu, E. Esom","doi":"10.3923/IJCR.2016.176.187","DOIUrl":"https://doi.org/10.3923/IJCR.2016.176.187","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"32 1","pages":"176-187"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74436257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.3923/IJCR.2016.169.175
H. Mozaffari, B. Izadi, M. Sadeghi, F. Rezaei, R. Sharifi, F. Jalilian
{"title":"Prevalence of Oral and Pharyngeal Cancers in Kermanshah Province, Iran: A Ten-year Period","authors":"H. Mozaffari, B. Izadi, M. Sadeghi, F. Rezaei, R. Sharifi, F. Jalilian","doi":"10.3923/IJCR.2016.169.175","DOIUrl":"https://doi.org/10.3923/IJCR.2016.169.175","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"42 1","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78227235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.3923/IJCR.2016.140.151
J. Boateng, R. L. Miller-Ceb, L. Shackelfor, M. Verghese
{"title":"Modifying Effects of Pistachio Nuts on Antioxidant Enzymes in Azoxymethane (AOM)-induced Formation of Aberrant Crypt Foci","authors":"J. Boateng, R. L. Miller-Ceb, L. Shackelfor, M. Verghese","doi":"10.3923/IJCR.2016.140.151","DOIUrl":"https://doi.org/10.3923/IJCR.2016.140.151","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"68 1","pages":"140-151"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75648744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.3923/IJCR.2016.128.139
H. Shaaban, N. Hafez, H. Ragab, Areeg Ibrahim El Abadi
{"title":"Nuclear and Cytoplasmic Expression of Survivin in Breast Carcinoma: Correlation with Clinicopathological Parameters","authors":"H. Shaaban, N. Hafez, H. Ragab, Areeg Ibrahim El Abadi","doi":"10.3923/IJCR.2016.128.139","DOIUrl":"https://doi.org/10.3923/IJCR.2016.128.139","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"39 1","pages":"128-139"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88905946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.3923/IJCR.2016.122.127
Bekesho Geleta, E. Makonnen, S. Abay
{"title":"N-myc Downstream Regulated Gene1 (NDRG1) in Cancer Metastasis and Therapeutics","authors":"Bekesho Geleta, E. Makonnen, S. Abay","doi":"10.3923/IJCR.2016.122.127","DOIUrl":"https://doi.org/10.3923/IJCR.2016.122.127","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"7 1","pages":"122-127"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90410489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.3923/IJCR.2016.109.121
Bekesho Geleta, E. Makonnen, S. Abay
{"title":"Cyclic Dependent Kinases (CDKs) in Cancer Pathogenesis and Therapeutics","authors":"Bekesho Geleta, E. Makonnen, S. Abay","doi":"10.3923/IJCR.2016.109.121","DOIUrl":"https://doi.org/10.3923/IJCR.2016.109.121","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"63 1","pages":"109-121"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83105249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Alabi, O. Adebawo, O. Daini, S. Somiari, R. Somiari
{"title":"HSPD1, HSPB1 and VDAC1 are Over-expressed in Invasive Ductal Carcinoma of the Breast","authors":"M. Alabi, O. Adebawo, O. Daini, S. Somiari, R. Somiari","doi":"10.3923/IJCR.2016.82.91","DOIUrl":"https://doi.org/10.3923/IJCR.2016.82.91","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"3 1","pages":"82-91"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79771363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coconut Flour (CF) (Cocos nucifera L.) is a sweet by-product of coconut milk that has multifarious utility. The objective of this study was to investigate the chemopreventive potential of coconut flour extracts (defatted and whole) through determination of phytochemical content, antioxidative potential and cytotoxic effects on Caco-2 cells. Phytochemical (total phenolic, total flavonoid) content, Trolox Equivalent Antioxidant Capacity (TEAC), free radical-scavenging ability of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Potential (FRAP) were determined according to standard protocols. Lactate dehydrogenase (LDH) release (cytotoxicity assay) was used to measure in vitro cell damage of Caco-2 colon cancer cells. Activity of antioxidant enzymes was determined with selected concentrations of extracts (25, 50 and 100 μg mLG). Apoptotic activity was assessed through the activity of caspase-3 and DNA fragmentation Enzyme-Linked Immunosorbant Assay (ELISA). Anti-inflammatory activity was assessed through measuring cycloxygenase-2 (Cox-2). Total phenolic and flavonoid content was 55.46±1.70 mg GAE/100 g and 17.84±2.33 mg CE/100 g. The TEAC was 0.65±0.05 μmol TE/100 g. The DPPH was IC50-74 mg mLG . The FRAP was 0.31±0.21 mmol/Fe gG and ORAC was 2387.78±88.68 μM TE gG 14.13±1.25 mmol/Fe gG. The LDH (%) release for 12 and 24 h was 45.8% at 50 μg mLG and 63.5% at 25 μg mLG. Caspase-3 was 15.46±0.639, Cox-2 was 0.30 U mLG and DNA fragmentation ELISA was 0.39 EF at 50 μg mLG. The results for the antioxidant and detoxification enzymes yielded: Glutathione-S-Transferase (GST) 2.12±0.32 nmol minG mLG, catalase (CAT) 24.65±0.40 U mgG, Glutathione Peroxidase (GPx) 30.4±0 nmol minG mLG, superoxide dismutase (SOD) 305.90±3.89 U mLG and glutathione (GSH) 24.4±0 nmol mLG. Results of this study revealed high phenolic and flavonoid content and suggested cytotoxic and antioxidative potential of coconut flour extracts.
{"title":"Antioxidant Potential of Coconut Flour in Caco-2 Colon Cancer Cells","authors":"L. Smith, J. Patterson, L. Walker, M. Verghese","doi":"10.3923/IJCR.2016.29.39","DOIUrl":"https://doi.org/10.3923/IJCR.2016.29.39","url":null,"abstract":"Coconut Flour (CF) (Cocos nucifera L.) is a sweet by-product of coconut milk that has multifarious utility. The objective of this study was to investigate the chemopreventive potential of coconut flour extracts (defatted and whole) through determination of phytochemical content, antioxidative potential and cytotoxic effects on Caco-2 cells. Phytochemical (total phenolic, total flavonoid) content, Trolox Equivalent Antioxidant Capacity (TEAC), free radical-scavenging ability of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Potential (FRAP) were determined according to standard protocols. Lactate dehydrogenase (LDH) release (cytotoxicity assay) was used to measure in vitro cell damage of Caco-2 colon cancer cells. Activity of antioxidant enzymes was determined with selected concentrations of extracts (25, 50 and 100 μg mLG). Apoptotic activity was assessed through the activity of caspase-3 and DNA fragmentation Enzyme-Linked Immunosorbant Assay (ELISA). Anti-inflammatory activity was assessed through measuring cycloxygenase-2 (Cox-2). Total phenolic and flavonoid content was 55.46±1.70 mg GAE/100 g and 17.84±2.33 mg CE/100 g. The TEAC was 0.65±0.05 μmol TE/100 g. The DPPH was IC50-74 mg mLG . The FRAP was 0.31±0.21 mmol/Fe gG and ORAC was 2387.78±88.68 μM TE gG 14.13±1.25 mmol/Fe gG. The LDH (%) release for 12 and 24 h was 45.8% at 50 μg mLG and 63.5% at 25 μg mLG. Caspase-3 was 15.46±0.639, Cox-2 was 0.30 U mLG and DNA fragmentation ELISA was 0.39 EF at 50 μg mLG. The results for the antioxidant and detoxification enzymes yielded: Glutathione-S-Transferase (GST) 2.12±0.32 nmol minG mLG, catalase (CAT) 24.65±0.40 U mgG, Glutathione Peroxidase (GPx) 30.4±0 nmol minG mLG, superoxide dismutase (SOD) 305.90±3.89 U mLG and glutathione (GSH) 24.4±0 nmol mLG. Results of this study revealed high phenolic and flavonoid content and suggested cytotoxic and antioxidative potential of coconut flour extracts.","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"139 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77227177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Rajamanick, S. Gurudeeban, K. Satyavani, T. Ramanathan
Acanthus ilicifolius (Acanthaceae) has received considerable attention due to its wide range of traditional usage in Indian system of medicine. The chemopreventive effect of ethanol extracts of Acanthus ilicifolius (AIEE) on N-nitrosodiethylamine (DEN, 200 mg kgG)-induced experimental liver tumour was investigated in male Wistar rats. Experimental rats were orally treated with AIEE (400 mg kgG b.wt.) for 1 week before the injection of diethyl nitrosamine and continued to be 14 weeks. The changes of lipid peroxidation, antioxidants and membrane bound enzymes were studied in AIEE treated experimental and control rats. The result indicates AIEE treatment effectively suppressed liver tumour induced with DEN as revealed by decrease in the levels of extend of alanine transaminase, aspartate transaminase, alkaline phosphatase, lipid peroxidase, glutathione peroxidase and glutathione-S-transferase with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumour bearing rats. The result of the study concludes significant chemopreventive effect of AIEE against DEN induced liver tumour.
{"title":"Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis","authors":"E. Rajamanick, S. Gurudeeban, K. Satyavani, T. Ramanathan","doi":"10.3923/IJCR.2016.1.16","DOIUrl":"https://doi.org/10.3923/IJCR.2016.1.16","url":null,"abstract":"Acanthus ilicifolius (Acanthaceae) has received considerable attention due to its wide range of traditional usage in Indian system of medicine. The chemopreventive effect of ethanol extracts of Acanthus ilicifolius (AIEE) on N-nitrosodiethylamine (DEN, 200 mg kgG)-induced experimental liver tumour was investigated in male Wistar rats. Experimental rats were orally treated with AIEE (400 mg kgG b.wt.) for 1 week before the injection of diethyl nitrosamine and continued to be 14 weeks. The changes of lipid peroxidation, antioxidants and membrane bound enzymes were studied in AIEE treated experimental and control rats. The result indicates AIEE treatment effectively suppressed liver tumour induced with DEN as revealed by decrease in the levels of extend of alanine transaminase, aspartate transaminase, alkaline phosphatase, lipid peroxidase, glutathione peroxidase and glutathione-S-transferase with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumour bearing rats. The result of the study concludes significant chemopreventive effect of AIEE against DEN induced liver tumour.","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"4 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82952920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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