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Journal of clinical & anatomic pathology (JCAP)最新文献

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Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings 幽门螺杆菌胃炎/十二指肠炎在小儿兄弟姐妹中的共存
Pub Date : 2013-09-05 DOI: 10.17303/JCAP.2013.103
J. Sauter, S. K. Nayar, Paige D. Anders, Michael A. D'amico, K. Butnor, R. Wilcox
Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of Sarcina co-existing with Helicobacter pylori organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and Helicobacter pylori has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology permits Sarcina to be readily identified on routine sections. Detection of these organisms in gastric biopsies should prompt consideration of gastric outlet obstruction and/or delayed gastric emptying as a possible etiologic factor.
肉瘤是革兰氏阳性厌氧菌,与胃排空延迟和胃出口梗阻有关。我们描述了两例骨骼肌与幽门螺杆菌共存的儿科兄弟姐妹,他们在四个月内分别表现为幽门梗阻,继发于严重的胃炎/十二指肠炎。据我们所知,幽门螺杆菌和肌酸杆菌的共存在以前还没有报道过。其特有的四分体包裹形态允许在常规切片上很容易识别。在胃活检中检测到这些微生物时,应考虑胃出口梗阻和/或胃排空延迟作为可能的病因。
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引用次数: 25
Three-Dimensional Tumor Cell Cultures and the Role of Tissue Biorepositories in Personalized Medicine 三维肿瘤细胞培养和组织生物储存库在个性化医疗中的作用
Pub Date : 2013-08-20 DOI: 10.17303/JCAP.2013.E101
K. Valyi‐Nagy
Tissue biorepositories have long been critically important for medical research by providing human tissues for scholarly investigations. In addition to this traditional research role, tissue banks are rapidly assuming new roles in the clinical side of medicine. In the modern era of personalized medicine, tissue biorepositories are increasingly expected to establish close collaborations with clinical and laboratory units and provide banked tissues for a variety of tests that in turn will guide clinical decision making tailored to the patient [1-4]. This new role of biorepositories requires the development of novel complex standard operating procedures (SOPs) for tissue collection, processing and storage that can provide tissues ideal for a variety of novel molecular and other tests [1,3,4].
长期以来,组织生物储存库通过为学术研究提供人体组织,对医学研究至关重要。除了这个传统的研究角色,组织库在医学的临床方面正在迅速承担新的角色。在个性化医疗的现代时代,人们越来越期望组织生物储存库与临床和实验室单位建立密切合作,并为各种测试提供组织库,从而指导针对患者的临床决策[1-4]。生物储存库的这种新作用需要开发用于组织收集、处理和储存的新型复杂标准操作程序(sop),为各种新型分子和其他测试提供理想的组织[1,3,4]。
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引用次数: 1
Recognizing the Limitations and Pitfalls of Cytology for Anaplastic Carcinoma within Hürthle Cell (Oncocytic) Carcinomas 认识到<s:1>细胞癌(嗜瘤细胞)内间变性癌的细胞学局限性和缺陷
Pub Date : 2013-08-08 DOI: 10.17303/jcap.2015.2.102
T. Richardson, Shirley Yan, Elizabeth M. Kurian
Fine needle aspiration is an initial method for diagnosis of enlarged thyroid nodules. Hurthle cell neoplasm is usually cytomorphologically distinct from undifferentiated/anaplastic thyroid carcinoma, except when there is marked atypia. Herein we contrast two cases, highlighting Hurthle cell atypia mimicking anaplastic change versus true anaplastic thyroid carcinoma. The first case is of a 44 year old female with a rapidly enlarging thyroid mass presenting with an outside fine needle aspiration diagnosis of anaplastic thyroid carcinoma; however the thyroidectomy found only a Hurthle cell follicular carcinoma with a component of cytologic atypia. The second case is from an 81 year old female with acute onset neck swelling. The cytologic evaluation was suspicious for a Hurthle cell neoplasm only, while the thyroidectomy showed Hurthle cell follicular carcinoma with anaplastic thyroid carcinoma. Hurthle cell neoplasm may have marked atypia, for which anaplastic thyroid carcinoma is important to exclude. Since fine needle aspirations have sampling limitations, subsequent surgical excision is essential in determining the correct diagnosis in cases of cytologic Hurthle cell neoplasm which may harbor anaplastic thyroid carcinoma.
细针穿刺是诊断甲状腺结节肿大的初步方法。Hurthle细胞瘤通常在细胞形态学上不同于未分化/间变性甲状腺癌,除非有明显的异型性。在此,我们对比了两个病例,突出了模拟间变性变化的Hurthle细胞异型性与真正的间变性甲状腺癌。第一例是一名44岁女性,甲状腺肿块迅速增大,经外细针穿刺诊断为间变性甲状腺癌;然而,甲状腺切除术仅发现Hurthle细胞滤泡癌伴细胞学异型性成分。第二个病例来自一名81岁女性,急性颈部肿胀。细胞学检查怀疑仅为Hurthle细胞肿瘤,而甲状腺切除术显示Hurthle细胞滤泡癌合并间变性甲状腺癌。Hurthle细胞肿瘤可能有明显的异型性,排除甲状腺间变性癌是很重要的。由于细针穿刺有取样限制,对于可能含有间变性甲状腺癌的细胞学Hurthle细胞肿瘤,后续手术切除对于确定正确诊断至关重要。
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引用次数: 0
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Journal of clinical & anatomic pathology (JCAP)
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