Kelsey Wilson, M. Detsika, E. Poulaki, H. Gakiopoulou, E. Lianos
Of the various cells comprising the glomerulus (endothelial, mesangial, resident macrophages, and visceral glomerular epithelial cells also known as podocytes), the latter are most vulnerable to various forms of glomerular injury (Diabetes, Hypertension, immunemediated, etc.) that frequently progress to end-stage kidney disease (ESKD). This is due to their non-replicative, terminally differentiated highly specialized nature. Specifically, they exhibit a high rate of vesicular traffic as evidenced by multiple coated vesicles and coated pits along their basolateral domain and have a high capacity for protein synthesis and posttranslational modifications because of a well-developed endoplasmic reticulum and a large Golgi apparatus [1]. Podocyte depletion consequent to injury is a well-established mechanism underlying glomerular scarring (sclerosis) while progressive glomerulosclerosis leads to ESKD [2]. It is, therefore, not surprising that strategies assessing ways to protect podocytes against injury are being explored.
{"title":"Morphometric Effects of HO-1 Deficiency and Overexpression in Rat Glomeruli and Podocytes","authors":"Kelsey Wilson, M. Detsika, E. Poulaki, H. Gakiopoulou, E. Lianos","doi":"10.47275/2332-4864-118","DOIUrl":"https://doi.org/10.47275/2332-4864-118","url":null,"abstract":"Of the various cells comprising the glomerulus (endothelial, mesangial, resident macrophages, and visceral glomerular epithelial cells also known as podocytes), the latter are most vulnerable to various forms of glomerular injury (Diabetes, Hypertension, immunemediated, etc.) that frequently progress to end-stage kidney disease (ESKD). This is due to their non-replicative, terminally differentiated highly specialized nature. Specifically, they exhibit a high rate of vesicular traffic as evidenced by multiple coated vesicles and coated pits along their basolateral domain and have a high capacity for protein synthesis and posttranslational modifications because of a well-developed endoplasmic reticulum and a large Golgi apparatus [1]. Podocyte depletion consequent to injury is a well-established mechanism underlying glomerular scarring (sclerosis) while progressive glomerulosclerosis leads to ESKD [2]. It is, therefore, not surprising that strategies assessing ways to protect podocytes against injury are being explored.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"520 1","pages":"1 - 1"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77201505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelsey Wilson, Maria G Detsika, Elpida Poulaki, Harikleia Gakiopoulou, Elias A Lianos
{"title":"Morphometric Effects of HO-1 Deficiency and Overexpression in Rat Glomeruli and Podocytes.","authors":"Kelsey Wilson, Maria G Detsika, Elpida Poulaki, Harikleia Gakiopoulou, Elias A Lianos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"6 2","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39872652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-02DOI: 10.17303/jcap.2017.3.101
N. Ghanee, Selene Saraf, M. N. Kilo, Kristina Waggoner
J Clin Anat Pathol 2017 | Vol 3: 101 Abstract Gingival Squamous Cell Carcinoma (SCC) may present with varied clinical and histological appearances. Proliferative verrucous Leukoplakia (PVL) is a high risk non-homogenous leukoplakia. PVL has a high probability of recurrence and has shown a high rate of malignant transformation to either squamous cell carcinoma or verrucous carcinoma. This paper discusses two cases of gingival PVL with malignant transformation. Both patients were female, ages 62 and 70 who were seen at the oral pathology clinic in Kaiser. The initial biopsy results on both cases were suggestive of PVL. Close observation and repeated follow up visits showed recurrent lesions and subsequently early detection of SCC.
{"title":"Proliferative Verrucous Leukoplakia of the Gingiva, Report of two Cases with Malignant Transformation","authors":"N. Ghanee, Selene Saraf, M. N. Kilo, Kristina Waggoner","doi":"10.17303/jcap.2017.3.101","DOIUrl":"https://doi.org/10.17303/jcap.2017.3.101","url":null,"abstract":"J Clin Anat Pathol 2017 | Vol 3: 101 Abstract Gingival Squamous Cell Carcinoma (SCC) may present with varied clinical and histological appearances. Proliferative verrucous Leukoplakia (PVL) is a high risk non-homogenous leukoplakia. PVL has a high probability of recurrence and has shown a high rate of malignant transformation to either squamous cell carcinoma or verrucous carcinoma. This paper discusses two cases of gingival PVL with malignant transformation. Both patients were female, ages 62 and 70 who were seen at the oral pathology clinic in Kaiser. The initial biopsy results on both cases were suggestive of PVL. Close observation and repeated follow up visits showed recurrent lesions and subsequently early detection of SCC.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75284290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-02DOI: 10.17303/jcap.2019.4.103
S. Roma, C. Pace, A. Amico, I. Lenci, S. Francioso, C. Chiaramonte, F. Chegai, A. Orlacchio
To date, there are still no clear data on the validity of Shear Waves Elastography (SWE) techniques in assessing liver fibrosis. Our study aimed to compare the stiffness liver values obtained with SWE techniques with Transient Elastography (TE) and to identify the threshold values for the different degrees of fibrosis. We enrolled 11 healthy subjects and 48 patients with chronic liver disease. They all performed TE, 33 patients and healthy subjects were evaluated withPoint SWE and 15 patients with 2D-SWE. The differences between techniques and TE, evaluated with student’s t-test, were not statistically significant (p>0,05). The cut-offs of SWE technique were for F≥2 6,2 kPa; F≥3 7,65 kPa; F=4 13 kPa. SWE techniques have good potential in assessing liver fibrosis; moreover, being elastosonography quick and easy to perform, it could be integrated into the clinical practice of the ultrasound examination.
{"title":"Evaluation of Liver Fibrosis in Cirrhotic Patients: Comparison between Elastoso- nography and Fibroscan","authors":"S. Roma, C. Pace, A. Amico, I. Lenci, S. Francioso, C. Chiaramonte, F. Chegai, A. Orlacchio","doi":"10.17303/jcap.2019.4.103","DOIUrl":"https://doi.org/10.17303/jcap.2019.4.103","url":null,"abstract":"To date, there are still no clear data on the validity of Shear Waves Elastography (SWE) techniques in assessing liver fibrosis. Our study aimed to compare the stiffness liver values obtained with SWE techniques with Transient Elastography (TE) and to identify the threshold values for the different degrees of fibrosis. We enrolled 11 healthy subjects and 48 patients with chronic liver disease. They all performed TE, 33 patients and healthy subjects were evaluated withPoint SWE and 15 patients with 2D-SWE. The differences between techniques and TE, evaluated with student’s t-test, were not statistically significant (p>0,05). The cut-offs of SWE technique were for F≥2 6,2 kPa; F≥3 7,65 kPa; F=4 13 kPa. SWE techniques have good potential in assessing liver fibrosis; moreover, being elastosonography quick and easy to perform, it could be integrated into the clinical practice of the ultrasound examination.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80994147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-02DOI: 10.17303/jcap.2019.4.104
Rosete Nogueira, PhD Auxiliary, Pedro Luís Cardoso, Ana Azevedo, Marcos Gomes, Cláudia Almeida, Catarina Varela, A. C. Braga, Jorge Correia Pinto
Objective: To produce reference values for the placental weight (PW), Placental diameters (PDs), Placental thickness (PT), placental weight ratio (PW-R) and birth/placental weight ratio (BPW-R) in singleton gestations as a function of gestational age (GA). Study Design and Setting: A retrospective 4-years case study of singleton placentas reports between, 1st of January 2014 to 31st of December 2017. The placentas were sent for histopathological diagnosis to Embryofetal Pathology Laboratory, Centro de Genetica Clínica (CGC), Porto, Portugal. In a cohort of singleton placentas, PW, PDs, PT, PW-R, and BPW-R were analyzed to produce percentile curves. Considering the inclusion criteria, 1,951 singleton placentas were selected from a sample of 7,321 placentas. We recorded the PW, PDs, PT, PW-R, and BPW-R between 12th and 41st GA. Results: PW, PDs, PW-R and BPW-R tables and percentiles curves for singleton placentas across GA were produced. Conclusions: Placental percentile curves may act as a reference for other populations as well until population-specific curves can be produced. PDs could predict placental volume and could help to estimate the prenatal PW-R and BPW-R.
{"title":"Placental Biometric Parameters: The Usefulness of Placental Weight Ratio and Birth/Placental Weight Ratio Percentile Curves for Singleton Gestations as a Function of Gestational age","authors":"Rosete Nogueira, PhD Auxiliary, Pedro Luís Cardoso, Ana Azevedo, Marcos Gomes, Cláudia Almeida, Catarina Varela, A. C. Braga, Jorge Correia Pinto","doi":"10.17303/jcap.2019.4.104","DOIUrl":"https://doi.org/10.17303/jcap.2019.4.104","url":null,"abstract":"Objective: To produce reference values for the placental weight (PW), Placental diameters (PDs), Placental thickness (PT), placental weight ratio (PW-R) and birth/placental weight ratio (BPW-R) in singleton gestations as a function of gestational age (GA). Study Design and Setting: A retrospective 4-years case study of singleton placentas reports between, 1st of January 2014 to 31st of December 2017. The placentas were sent for histopathological diagnosis to Embryofetal Pathology Laboratory, Centro de Genetica Clínica (CGC), Porto, Portugal. In a cohort of singleton placentas, PW, PDs, PT, PW-R, and BPW-R were analyzed to produce percentile curves. Considering the inclusion criteria, 1,951 singleton placentas were selected from a sample of 7,321 placentas. We recorded the PW, PDs, PT, PW-R, and BPW-R between 12th and 41st GA. Results: PW, PDs, PW-R and BPW-R tables and percentiles curves for singleton placentas across GA were produced. Conclusions: Placental percentile curves may act as a reference for other populations as well until population-specific curves can be produced. PDs could predict placental volume and could help to estimate the prenatal PW-R and BPW-R.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89378608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-02DOI: 10.17303/jcap.2019.4.102
K. Zhao
Severe or irreversible shock is a final stage of shock. After treatment of severe shock still exist persistent low microcirculatory perfusion, refractory hypotension, and cell injury, which are 3 main pathogenesis factors and should be looking for new approach to treat it. It has shown that some new therapeutic targets are related to the treatment of the 3 factors, which includes pulse pressure with persistent low perfusion, ASMCs hyperpolarization with refractory hypotension, mitochondrial dysfunction with cell injury, SIRT1 activity with mitochondrial dysfunction. A new anti- shock medicine-polyda-tin has effected on these new therapeutic targets, which has been going to clinical trial in China and America.
{"title":"Novel Therapeutic Targets in Severe Shock Treatment","authors":"K. Zhao","doi":"10.17303/jcap.2019.4.102","DOIUrl":"https://doi.org/10.17303/jcap.2019.4.102","url":null,"abstract":"Severe or irreversible shock is a final stage of shock. After treatment of severe shock still exist persistent low microcirculatory perfusion, refractory hypotension, and cell injury, which are 3 main pathogenesis factors and should be looking for new approach to treat it. It has shown that some new therapeutic targets are related to the treatment of the 3 factors, which includes pulse pressure with persistent low perfusion, ASMCs hyperpolarization with refractory hypotension, mitochondrial dysfunction with cell injury, SIRT1 activity with mitochondrial dysfunction. A new anti- shock medicine-polyda-tin has effected on these new therapeutic targets, which has been going to clinical trial in China and America.","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77685002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-03DOI: 10.17303/jcap.2013.1.101
{"title":"Clinicopathologic Aspects of Ecthyma Gangrenosum in Pediatric Patients: A Case Series and Review of the Literature","authors":"","doi":"10.17303/jcap.2013.1.101","DOIUrl":"https://doi.org/10.17303/jcap.2013.1.101","url":null,"abstract":"","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80646876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphometric Image Analysis as a Tool in the Diagnosis of Transected Squamous Neoplasms","authors":"K. Mudaliar","doi":"10.17303/JCAP.2013.102","DOIUrl":"https://doi.org/10.17303/JCAP.2013.102","url":null,"abstract":"","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74299728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer L Sauter, Suresh K Nayar, Paige D Anders, Michael D'Amico, Kelly J Butnor, Rebecca L Wilcox
Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of Sarcina co-existing with Helicobacter pylori organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and Helicobacter pylori has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology permits Sarcina to be readily identified on routine sections. Detection of these organisms in gastric biopsies should prompt consideration of gastric outlet obstruction and/or delayed gastric emptying as a possible etiologic factor.
{"title":"Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings.","authors":"Jennifer L Sauter, Suresh K Nayar, Paige D Anders, Michael D'Amico, Kelly J Butnor, Rebecca L Wilcox","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><i>Sarcina</i> are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of <i>Sarcina</i> co-existing with <i>Helicobacter pylori</i> organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and <i>Helicobacter pylori</i> has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology permits <i>Sarcina</i> to be readily identified on routine sections. Detection of these organisms in gastric biopsies should prompt consideration of gastric outlet obstruction and/or delayed gastric emptying as a possible etiologic factor.</p>","PeriodicalId":90888,"journal":{"name":"Journal of clinical & anatomic pathology (JCAP)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33039890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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