{"title":"Hemodialysis versus peritoneal dialysis in elderly ESRD patients: a retrospective cohort study on survival and the role of comorbidities.","authors":"Ruizhi Yu, Yunfei Yan, Junjie Lin, Hucai Li, Youqing Cai, Lixin Wang, Xusheng Liu, Zhiren He","doi":"10.1186/s12882-026-04783-7","DOIUrl":"https://doi.org/10.1186/s12882-026-04783-7","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s12882-026-04762-y
Lan Zeng, Min Lu, Jeong Min Lee, Haoyue Niu, Ying Fu, Yao Yao, Wen Tang, Jie Jiang, Jiuyi Ma, Ligang Cui
{"title":"The accuracy of ultrasound viscoelastic imaging in evaluating renal fibrosis and interstitial inflammation of chronic kidney disease.","authors":"Lan Zeng, Min Lu, Jeong Min Lee, Haoyue Niu, Ying Fu, Yao Yao, Wen Tang, Jie Jiang, Jiuyi Ma, Ligang Cui","doi":"10.1186/s12882-026-04762-y","DOIUrl":"https://doi.org/10.1186/s12882-026-04762-y","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s12882-026-04791-7
Vicky Jenny Rebecka Wetterstrand, Thomas Kallemose, Jesper Juul Larsen, Lennart Friis Hansen, Lisbet Brandi
{"title":"A longitudinal prospective study investigating serial measurements of plasma neutrophil gelatinase-associated lipocalins (NGAL) for the prediction of chronic kidney disease and acute kidney injury in emergency department patients.","authors":"Vicky Jenny Rebecka Wetterstrand, Thomas Kallemose, Jesper Juul Larsen, Lennart Friis Hansen, Lisbet Brandi","doi":"10.1186/s12882-026-04791-7","DOIUrl":"https://doi.org/10.1186/s12882-026-04791-7","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s12882-026-04777-5
Tooba Noor, Zareen Kiran, Muhammad Tassaduq Khan, Farina Hanif
{"title":"Predictive role and clinical correlation of copeptin in patients with type 2 diabetes mellitus associated nephropathy approaching end-stage renal disease.","authors":"Tooba Noor, Zareen Kiran, Muhammad Tassaduq Khan, Farina Hanif","doi":"10.1186/s12882-026-04777-5","DOIUrl":"https://doi.org/10.1186/s12882-026-04777-5","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s12882-026-04771-x
Bohan Luo, Kun Fang, Shan Zhong, Wenjia Di
{"title":"Organ-preserving management of chronic renal hydatid cyst with 10-year asymptomatic progression: a case report.","authors":"Bohan Luo, Kun Fang, Shan Zhong, Wenjia Di","doi":"10.1186/s12882-026-04771-x","DOIUrl":"https://doi.org/10.1186/s12882-026-04771-x","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1186/s12882-026-04775-7
Xiaoyan Zhang, Shi Jin, Xuantong Dai, Chenlin Yao, Ziyi Zhao, Fujun Lin, Yiqin Shi
Background: Alport syndrome (AS) is the most common inherited glomerular disease among patients with chronic kidney disease. With exome sequencing now widely used in clinical practice, pathogenic variants in Alport-related genes (COL4A3/COL4A4/COL4A5) are increasingly identified in patients with diverse phenotypes, including proteinuria‑predominant disease and kidney failure of unknown etiology. Diagnostic complexity further increases when COL4A3/COL4A4/COL4A5 variants are co‑inherited with pathogenic variants associated with other genetic kidney disorders.
Case presentation: We reported a 31‑year‑old male presenting with kidney failure, significant proteinuria, familial hematuria and hyperlipidemia. Whole‑exome sequencing (WES) identified two pathogenic variants: a hemizygous COL4A5 variant (c.2105G > A; p.Gly702Asp) and a heterozygous APOE Kyoto variant (c.127C > T; p.Arg43Cys). Given the potential dual diagnosis of AS and lipoprotein glomerulopathy (LPG), a kidney biopsy was performed. Histologic examination revealed uneven thickness of the glomerular basement membrane consistent with the diagnosis of AS, but no LPG-related lesions were observed, indicating incomplete penetrance of APOE Kyoto variant. Cascade family screening detected APOE Kyoto variant in the patient's father and elder sister, both of whom lacked proteinuria until follow-up period.
Conclusion: This case highlights the complementary role of kidney biopsy alongside WES in AS with complex genetic mechanisms. It also illustrates the incomplete penetrance of APOE Kyoto, common among Chinese carriers.
{"title":"Deciphering the complexity: a case of kidney failure with co-inheritance of COL4A5 and APOE variants.","authors":"Xiaoyan Zhang, Shi Jin, Xuantong Dai, Chenlin Yao, Ziyi Zhao, Fujun Lin, Yiqin Shi","doi":"10.1186/s12882-026-04775-7","DOIUrl":"https://doi.org/10.1186/s12882-026-04775-7","url":null,"abstract":"<p><strong>Background: </strong>Alport syndrome (AS) is the most common inherited glomerular disease among patients with chronic kidney disease. With exome sequencing now widely used in clinical practice, pathogenic variants in Alport-related genes (COL4A3/COL4A4/COL4A5) are increasingly identified in patients with diverse phenotypes, including proteinuria‑predominant disease and kidney failure of unknown etiology. Diagnostic complexity further increases when COL4A3/COL4A4/COL4A5 variants are co‑inherited with pathogenic variants associated with other genetic kidney disorders.</p><p><strong>Case presentation: </strong>We reported a 31‑year‑old male presenting with kidney failure, significant proteinuria, familial hematuria and hyperlipidemia. Whole‑exome sequencing (WES) identified two pathogenic variants: a hemizygous COL4A5 variant (c.2105G > A; p.Gly702Asp) and a heterozygous APOE Kyoto variant (c.127C > T; p.Arg43Cys). Given the potential dual diagnosis of AS and lipoprotein glomerulopathy (LPG), a kidney biopsy was performed. Histologic examination revealed uneven thickness of the glomerular basement membrane consistent with the diagnosis of AS, but no LPG-related lesions were observed, indicating incomplete penetrance of APOE Kyoto variant. Cascade family screening detected APOE Kyoto variant in the patient's father and elder sister, both of whom lacked proteinuria until follow-up period.</p><p><strong>Conclusion: </strong>This case highlights the complementary role of kidney biopsy alongside WES in AS with complex genetic mechanisms. It also illustrates the incomplete penetrance of APOE Kyoto, common among Chinese carriers.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s12882-026-04748-w
Justin David Tse, Sourabh Kharait
{"title":"Renal potassium wasting from hydroxychloroquine at therapeutic doses: a case report.","authors":"Justin David Tse, Sourabh Kharait","doi":"10.1186/s12882-026-04748-w","DOIUrl":"https://doi.org/10.1186/s12882-026-04748-w","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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