Pub Date : 2026-01-22DOI: 10.1186/s12882-026-04759-7
Jasjeet Chhoker, Jada Drennan, Janine Farragher
{"title":"Prehabilitation interventions to support the postoperative recovery of adult kidney transplant candidates: a scoping review.","authors":"Jasjeet Chhoker, Jada Drennan, Janine Farragher","doi":"10.1186/s12882-026-04759-7","DOIUrl":"10.1186/s12882-026-04759-7","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":"117"},"PeriodicalIF":2.4,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1186/s12882-026-04763-x
María Pérez-Fernández, Mara A McAdams-DeMarco, Ana Alonso-Fuente, Susana López-Ongil, Fernando Tornero-Molina, Diego Rodríguez-Puyol, Patricia Martínez-Miguel
{"title":"Survey of Spanish nephrologists' opinion on the applicability of Fried's geriatric frailty criteria in patients with end-stage renal disease.","authors":"María Pérez-Fernández, Mara A McAdams-DeMarco, Ana Alonso-Fuente, Susana López-Ongil, Fernando Tornero-Molina, Diego Rodríguez-Puyol, Patricia Martínez-Miguel","doi":"10.1186/s12882-026-04763-x","DOIUrl":"10.1186/s12882-026-04763-x","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":"116"},"PeriodicalIF":2.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The burden of acute kidney injury (AKI) in low- and middle-income countries is frequently underestimated, often due to limited diagnostic resources and underreporting. Information about the burden of AKI would help inform the implementation of health policies and improve the allocation of health resources aimed at enhancing patient outcomes. This study determined the pooled incidence of AKI and associated mortality in Nigeria.
Method: A systematic search of PubMed, African Journals Online (AJOL), and Google Scholar was conducted to identify relevant studies on AKI in both adult and paediatric populations in Nigeria between 1980 and 2024. Case reports, case series, and abstracts without full text on AKI were excluded. The pooled incidence of AKI and the associated all-cause mortality rate were estimated using meta-analytic methods. The Joanna-Briggs scoring was used for risk bias assessment. The study protocol was registered with PROSPERO (CRD42024620822).
Results: The initial systematic literature search identified 384 articles from which 44 eligible hospital-based studies involving 123,324 participants were included. The median age of the study participants was 31.1 years, and the median proportion of females was 42.9%. The overall pooled incidence of AKI in this study was 15.0% [CI: 12.0-18.0%], based on 44 studies, with I2 = 99.3% and p < 0.001. The pooled incidence of AKI in the adult and paediatric populations was 18.0% [CI: 12.0%-25.0%, n = 22 studies, I2 = 99.0%, p < 0.001], and 12.0% [CI: 9.0%-15.0%, n = 20 studies, I2 = 99.2%, p < 0.001], respectively. The leading aetiologies of AKI were hypovolaemia (32.3%), sepsis (28.8%), malaria (12.8%), and acute glomerulonephritis (11.5%). The most common criteria used in diagnosing AKI were those outlined in the Kidney Disease Improving Global Outcomes (KDIGO) guidelines in 27 studies (58.7%). There was a significant difference in the pooled incidence of AKI with the different diagnostic criteria (p < 0.001). About 46.0% of the AKI population presented in stage 3, and haemodialysis was the kidney replacement therapy option in 76.2% of those dialysed. The overall pooled all-cause mortality rate in patients with AKI was 26.0% [CI: 19.0%-33.0%], n = 34 studies, I2 = 92.6%, p < 0.001, 34 studies.
Limitations of the study: The review included only hospital-based studies, and high heterogeneity was observed in the studies. Therefore, the results should be interpreted with caution.
Conclusion: The incidence and mortality rates of AKI in Nigeria are high. Prompt and adequate treatment of the underlying and preventable causes may reduce the disease burden.
背景：在低收入和中等收入国家，急性肾损伤（AKI）的负担经常被低估，通常是由于有限的诊断资源和漏报。有关AKI负担的信息将有助于为卫生政策的实施提供信息，并改善旨在提高患者预后的卫生资源分配。本研究确定了尼日利亚AKI的总发病率和相关死亡率。方法：系统检索PubMed、African Journals Online （AJOL）和谷歌Scholar，以确定1980年至2024年间尼日利亚成人和儿科人群AKI的相关研究。排除病例报告、病例系列和没有AKI全文的摘要。使用荟萃分析方法估计AKI的总发病率和相关的全因死亡率。乔安娜-布里格斯评分被用于风险偏差评估。研究方案已在PROSPERO注册（CRD42024620822）。结果：最初的系统文献检索确定了384篇文章，其中包括44项符合条件的基于医院的研究，涉及123,324名参与者。研究参与者的中位年龄为31.1岁，女性中位比例为42.9%。基于44项研究，本研究AKI的总合并发病率为15.0% [CI: 12.0-18.0%], I2 = 99.3%, p 2 = 99.0%, p 2 = 99.2%, p 2 = 92.6%， p研究的局限性：本综述仅纳入基于医院的研究，研究中观察到高度异质性。因此，研究结果应谨慎解读。结论：尼日利亚AKI发病率高，死亡率高。及时和充分治疗潜在的和可预防的病因可以减轻疾病负担。
{"title":"Incidence of acute kidney injury and associated mortality in Nigeria: systematic review and meta-analysis.","authors":"Oluseyi Ademola Adejumo, Imuetinyan Rahsida Edeki, Olalekan Ezekiel Ojo, Manmak Mamven, Bala Waziri, Emmanuel Effa, Timothy Olusegun Olanrewaju, Ogochukwu Chinedum Okoye, Dapo Sunday Oyedepo, Muhammad Aliyu Makusidi, Udeme-Abasi Udoudo Nelson, Oyinkansola Aderinsola Omoloja, Muzamil Olamide Hassan, Bolanle Aderonke Omotosho, Udeme Ekpenyong Ekrikpo, Fatiu Abiola Arogundade","doi":"10.1186/s12882-026-04747-x","DOIUrl":"https://doi.org/10.1186/s12882-026-04747-x","url":null,"abstract":"<p><strong>Background: </strong>The burden of acute kidney injury (AKI) in low- and middle-income countries is frequently underestimated, often due to limited diagnostic resources and underreporting. Information about the burden of AKI would help inform the implementation of health policies and improve the allocation of health resources aimed at enhancing patient outcomes. This study determined the pooled incidence of AKI and associated mortality in Nigeria.</p><p><strong>Method: </strong>A systematic search of PubMed, African Journals Online (AJOL), and Google Scholar was conducted to identify relevant studies on AKI in both adult and paediatric populations in Nigeria between 1980 and 2024. Case reports, case series, and abstracts without full text on AKI were excluded. The pooled incidence of AKI and the associated all-cause mortality rate were estimated using meta-analytic methods. The Joanna-Briggs scoring was used for risk bias assessment. The study protocol was registered with PROSPERO (CRD42024620822).</p><p><strong>Results: </strong>The initial systematic literature search identified 384 articles from which 44 eligible hospital-based studies involving 123,324 participants were included. The median age of the study participants was 31.1 years, and the median proportion of females was 42.9%. The overall pooled incidence of AKI in this study was 15.0% [CI: 12.0-18.0%], based on 44 studies, with I<sup>2</sup> = 99.3% and p < 0.001. The pooled incidence of AKI in the adult and paediatric populations was 18.0% [CI: 12.0%-25.0%, n = 22 studies, I<sup>2</sup> = 99.0%, p < 0.001], and 12.0% [CI: 9.0%-15.0%, n = 20 studies, I<sup>2</sup> = 99.2%, p < 0.001], respectively. The leading aetiologies of AKI were hypovolaemia (32.3%), sepsis (28.8%), malaria (12.8%), and acute glomerulonephritis (11.5%). The most common criteria used in diagnosing AKI were those outlined in the Kidney Disease Improving Global Outcomes (KDIGO) guidelines in 27 studies (58.7%). There was a significant difference in the pooled incidence of AKI with the different diagnostic criteria (p < 0.001). About 46.0% of the AKI population presented in stage 3, and haemodialysis was the kidney replacement therapy option in 76.2% of those dialysed. The overall pooled all-cause mortality rate in patients with AKI was 26.0% [CI: 19.0%-33.0%], n = 34 studies, I<sup>2</sup> = 92.6%, p < 0.001, 34 studies.</p><p><strong>Limitations of the study: </strong>The review included only hospital-based studies, and high heterogeneity was observed in the studies. Therefore, the results should be interpreted with caution.</p><p><strong>Conclusion: </strong>The incidence and mortality rates of AKI in Nigeria are high. Prompt and adequate treatment of the underlying and preventable causes may reduce the disease burden.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of everolimus pharmacokinetic monitoring based on trough concentration and area under the blood concentration time curve in kidney transplantation.","authors":"Shota Fukae, Yoichi Kakuta, Soichi Matsumura, Ryo Tanaka, Masataka Kawamura, Shigeaki Nakazawa, Norio Nonomura","doi":"10.1186/s12882-026-04754-y","DOIUrl":"10.1186/s12882-026-04754-y","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":"111"},"PeriodicalIF":2.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1186/s12882-025-04529-x
Jiebo Huang, Xiaofan Cai, Xingmei Yao, Jingying Shen, Huijuan Wu, Ji Fang, Bingbing Zhu, Hao Wang
{"title":"Differences and significance of macrophage subtypes and regulatory T lymphocytes in the expression of interstitial fibrosis in diabetic nephropathy at different stages.","authors":"Jiebo Huang, Xiaofan Cai, Xingmei Yao, Jingying Shen, Huijuan Wu, Ji Fang, Bingbing Zhu, Hao Wang","doi":"10.1186/s12882-025-04529-x","DOIUrl":"10.1186/s12882-025-04529-x","url":null,"abstract":"","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":" ","pages":"110"},"PeriodicalIF":2.4,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号