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Dietary Trends in Crohn's Disease: A Comparison with Healthy Controls. 克罗恩病的饮食趋势:与健康对照的比较
Pub Date : 2025-01-01 Epub Date: 2025-03-14 DOI: 10.29011/2577-2201.100267
Brian Devorkin, Fabio Cominelli, Abigail Raffner Basson

Crohn's disease (CD) is a chronic inflammatory bowel disease that significantly impacts patients' quality of life. Diet plays a critical role in modulating inflammation and disease activity, with high intake of added sugars, artificial sweeteners, and processed foods linked to worsened symptoms. Despite this, many CD patients continue to consume diets high in pro-inflammatory ingredients that may not align with clinical recommendations. A prospective, questionnaire-based study was conducted among 52 adult participants (29 CD, 23 HC) recruited from the Digestive Disease Institute at University Hospitals Cleveland Medical Center as part of a larger diet intervention study. CD participants had a higher intake of fructose, total protein, arachidic acid, and white potato starchy vegetable compared to HC. HEI-2015 component scores for dairy, and intake of Greens and Beans were all significantly lower for CD compared to HC. There was also a trend for lower HEI-2015 total scores among CD participants compared to HC, suggesting slightly poorer dietary quality. Strategies to reduce intake of pro-inflammatory nutrients, such as saturated fats, trans fats and added sugars, and to promote nutrient-dense foods may enhance dietary quality in patients with CD. Further research is warranted to explore these trends and their clinical implications. This study aimed to compare dietary patterns between CD patients and healthy controls (HC) to identify potential targets for nutritional intervention.

克罗恩病(CD)是一种慢性炎症性肠病,严重影响患者的生活质量。饮食在调节炎症和疾病活动方面起着关键作用,大量摄入添加糖、人工甜味剂和加工食品与症状恶化有关。尽管如此,许多乳糜泻患者继续食用富含促炎成分的饮食,这可能与临床建议不符。一项前瞻性的、基于问卷的研究从克利夫兰医学中心大学医院消化疾病研究所招募了52名成年参与者(29名CD, 23名HC),作为一项更大的饮食干预研究的一部分。与HC相比,CD参与者摄入了更多的果糖、总蛋白、花生酸和白马铃薯淀粉类蔬菜。与HC相比,乳糜泻的乳制品、蔬菜和豆类摄入量的HEI-2015成分得分均显著低于HC。与HC相比,CD参与者的HEI-2015总分也有较低的趋势,这表明饮食质量略差。减少促炎营养素的摄入,如饱和脂肪、反式脂肪和添加糖,以及促进营养密集食物的摄入,可能会提高乳糜泻患者的饮食质量。需要进一步的研究来探索这些趋势及其临床意义。本研究旨在比较乳糜泻患者和健康对照(HC)之间的饮食模式,以确定营养干预的潜在目标。
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引用次数: 0
Sexual Minority Men Living with HIV's Interest in Yoga vs. MBSR as an Adjunct to an App-Based Positive Affect Intervention: A Focus Group Study. 感染艾滋病毒的性少数男性对瑜伽的兴趣与正念减压作为基于应用程序的积极影响干预的辅助:一项焦点小组研究。
Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.29011/2577-2201.100270
K Marie Sizemore, Ali Talan, Anxhela Kalia, Judith T Moskowitz, Elizabeth L Addington, Shannon Gray, H Jonathon Rendina

Purpose: Sexual minority men (SMM) living with HIV experience significant mental health disparities. Studies show positive psychological interventions (PPI) and mindfulness-based interventions (MBI) can have a positive impact on people LWH, however, limited research has explored this among SMM LWH. The current study explores two MBIs (MBSR and yoga) as potential adjuncts to an app-based PPI, which was designed to reduce stress for SMM LWH.

Methods: These data are from a sub-study of a proof-of-concept pilot. The pilot enrolled 22 SMM LWH, who used an app-based PPI for 90 days. Following completion of this initial study, participants were invited to participate in a focus group discussion, which explored SMM LWH's interest in MBSR vs. restorative yoga as adjunct programs to the app-based PPI.

Results: A third of participants from the initial study attended the focus group (N=7). All focus group participants were racial minorities (71.4% Black, 14.3% Hispanic/Latino, 14.3% Multiracial), with an average age of 32.14yrs (SD=4.87). When asked about initial interest, most participants said they would prefer restorative yoga over MBSR. In the discussion that followed, three main themes and eleven subthemes emerged, which elucidated SMM LWH's attitudes toward MBI, as well as their perceived barriers and facilitators for both yoga and MBSR.

Conclusions: The study provides insight into racial minority SMM LWH's comparative interest in two MBIs and suggests that yoga may be a feasible adjunct to the app-based PPI. However, inequities regarding access to yoga remain an important issue for SMM LWH and must be addressed.

目的:感染艾滋病毒的性少数男性(SMM)存在显著的心理健康差异。研究表明,积极心理干预(PPI)和正念干预(MBI)可以对低生命周期人群产生积极影响,然而,在SMM低生命周期人群中探索这一点的研究有限。目前的研究探索了两种mbbs(正念减压和瑜伽)作为基于应用程序的PPI的潜在辅助,该应用程序旨在减轻SMM LWH的压力。方法:这些数据来自一个概念验证试点的子研究。该试验招募了22名SMM LWH,他们使用基于应用程序的PPI 90天。在初步研究完成后,参与者被邀请参加焦点小组讨论,探讨SMM LWH对正念减压与恢复性瑜伽作为基于应用程序的PPI辅助项目的兴趣。结果:来自最初研究的三分之一的参与者参加了焦点小组(N=7)。所有焦点小组参与者均为少数种族(黑人71.4%,西班牙裔/拉丁裔14.3%,多种族14.3%),平均年龄32.14岁(SD=4.87)。当被问及最初的兴趣时,大多数参与者表示他们更喜欢恢复瑜伽而不是正念减压。在随后的讨论中,出现了三个主题和十一个副主题,阐明了SMM LWH对MBI的态度,以及他们对瑜伽和正念减压的感知障碍和促进因素。结论:该研究提供了少数种族SMM LWH对两种mbi的比较兴趣的见解,并表明瑜伽可能是基于应用程序的PPI的可行辅助。然而,关于获得瑜伽的不平等仍然是SMM LWH的一个重要问题,必须解决。
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引用次数: 0
Advising Around Cannabis for Sleep: Clearing Up the Smoke. 关于大麻睡眠的建议:清除烟雾。
Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.29011/2577-2201.100233
Stephanie Tung, Peter R Chai, Manan M Nayak, Ilana M Braun
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引用次数: 0
The Effectiveness of Ear Acupuncture on Quality of Life and Emotional Disorders in Nursing Professionals During the Covid-19 Pandemic: A Randomized Clinical Trial 耳针对Covid-19大流行期间护理专业人员生活质量和情绪障碍的有效性:一项随机临床试验
Pub Date : 2023-11-10 DOI: 10.29011/2577-2201.100213
Abstract The objective was to evaluate the effectiveness of ear acupuncture on quality of life and emotional disorders in nursing professionals during the COVID-19 pandemic. This was a clinical trial carried out with 179 professionals, who were randomized into two groups, namely: intervention, which received ear acupuncture, and control, which received no treatment. The Depression, Anxiety, and Stress Scale-21, the Event Impact Scale-Revised, and the World Health Organization Quality of Life-Bref were used. The analysis was carried out using Generalized Estimating Equations. Ear acupuncture improved quality of life and levels of stress, anxiety, and depression in the intervention group compared to the control group.
目的评价耳针对新冠肺炎大流行期间护理专业人员生活质量和情绪障碍的影响。这是一项有179名专业人员参与的临床试验,他们被随机分为两组,即干预组,接受耳针治疗,对照组,不接受治疗。使用抑郁、焦虑和压力量表-21、事件影响量表-修订版和世界卫生组织生活质量指南。利用广义估计方程进行分析。与对照组相比,耳针改善了干预组的生活质量和压力、焦虑和抑郁水平。
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引用次数: 0
Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages Chavanprash的Prakshape调味品:利用时代的协同作用
Pub Date : 2023-11-08 DOI: 10.29011/2577-2201.100212
Towards the conclusion of the tedious process of preparing chavanprash, a powdered herb combination known as prakshape is introduced. Many of these herbs have already been utilized in the initial stage of creating the decoction, which is the basis of chavanprash. The perplexing aspect is the necessity to incorporate the same herbs once more as prakshape during the final step, highlighting the intriguing nature of this addition and its associated benefits. The inclusion of prakshape proves to be ingenious for multiple reasons. Firstly, the incorporation of powdered herbs in prakshape ensures that the entire herb, along with all its phytochemical components, becomes part of the formulation. In contrast, the decoction process only extracts water - soluble components into the solution. This inclusion allows for a broader range of active compounds to be present in the final product. Secondly, the addition of prakshape serves to reintroduce volatile and heat-labile compounds that may have been lost during the extended heating process. Additionally, the inclusion of bamboo (Bambusa arundinacea) manna particles in prakshape contributes to an enhanced drug-delivery system. From a pharmacological standpoint, the incorporation of prakshape ingredients reinforces the therapeutic effects of the formulation and promotes synergy among the herbs. The principles underlying the use of prakshapecan further be utilized for the development of new awaleha and ksheerpakformulations, potentially yielding more potent effects.
在准备chavanprash的繁琐过程中,介绍了一种称为prakshape的粉末状草药组合。这些草药中的许多已经在创建汤剂的初始阶段被使用,这是chavanprash的基础。令人困惑的是,在最后一步中,有必要再次将相同的草药作为prakshape,突出了这种添加的有趣性质及其相关的好处。prakshape的加入被证明是非常巧妙的,原因有很多。首先,在prakshape中加入粉末草药确保整个草药及其所有植物化学成分成为配方的一部分。相反,煎煮过程只将水溶性成分提取到溶液中。这种包含允许在最终产品中存在更广泛的活性化合物。其次,prakshape的加入有助于重新引入挥发性和热不稳定的化合物,这些化合物可能在延长的加热过程中丢失。此外,在prakshape中包含竹(Bambusa arundinacea)甘露颗粒有助于增强药物传递系统。从药理学的角度来看,prakshape成分的结合加强了配方的治疗效果,并促进了草药之间的协同作用。使用prakshapecan的基本原理进一步用于开发新的awaleha和ksheerpakformulations,可能产生更有效的效果。
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引用次数: 0
An Integrative Approach for Improving and Managing Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD): A Case Report 改善和管理经前综合征(PMS)和经前烦躁不安障碍(PMDD)的综合方法:1例报告
Pub Date : 2023-10-27 DOI: 10.29011/2577-2201.100211
Abstract Premenstrual syndrome (PMS) describes symptoms a woman experiences in the luteal phase of menstruation, including physical, emotional, and/or behavioral changes ranging from mild to severe. Premenstrual dysphoric disorder (PMDD) shares defining emotional and behavioral attributes with PMS, though it is the most severe form classified as a depressive disorder. Women are increasingly interested in seeking natural or alternative therapies to address these conditions. The purpose of this case report is to share the experience of one woman who had improvements in premenstrual headaches, menstrual cramping and flow, and intense psychiatric symptoms associated with a diagnosis of PMDD within three months of using Lepidium peruvianum (maca), bio-identical progesterone therapy, and magnesium supplementation. Within four months, normalization of LH levels was achieved. Further, upon reducing or resolving symptoms, she continued to maintain this improvement for three months on Lepidium peruvianum, magnesium, and a B-complex. This case also provides clinical utility for personalized care utilizing a combination of natural therapies alongside bioidentical hormone therapy. Keywords: PMS, PMDD, Lepidium peruvianum, Bio-identical progesterone, Magnesium, B vitamins, Case report Abbreviations: Bid: twice daily; cap: capsule; caps: capsules; CBC: complete blood count; CMP: comprehensive metabolic panel; DC: discontinue; FSH: follicle-stimulating hormone; GABA: gammaaminobutyric acid; H: high; HPA: hypothalamus-pituitary-adrenal; LH: luteinizing hormone; LN: low-normal; mcg/L: micrograms per liter; mIU/mL: milli-international units per milliliter; Mg: milligrams; mg/mL: milligrams per milliliter; mm: millimeter; MRI: magnetic resonance imaging; NA: not applicable; nmol/L: nanomoles per liter; ng/mL: nanograms per milliliter; NSAIDs: nonsteroidal anti-inflammatory drugs; PHQ-9: patient health questionnaire-9; PMDD: premenstrual dysphoric disorder; pg/mL: picograms per milliliter; PMS: premenstrual syndrome; qd: once daily; qhs: bedtime; SR: slow-release; SSRI: selective serotonin reuptake inhibitor; TSH: thyroid stimulating hormone; uIU/mL: micro: international units per milliliter; WNL: within normal limits.
经前综合征(PMS)描述了女性在月经黄体期经历的症状,包括身体、情绪和/或行为上的变化,从轻微到严重。经前烦躁不安(PMDD)与经前综合症有着相同的情绪和行为特征,尽管它是被归类为抑郁症的最严重形式。女性越来越有兴趣寻求自然疗法或替代疗法来解决这些问题。本病例报告的目的是分享一名妇女的经验,她在使用玛卡(Lepidium pervianum, maca)、生物同型黄体酮治疗和镁补充剂三个月内,经前头痛、经期痉挛和经血流量以及与经前抑郁症诊断相关的强烈精神症状得到改善。在四个月内,LH水平达到了正常化。此外,在症状减轻或缓解后,她继续服用紫穗草、镁和b复合物3个月。该病例还提供了个性化护理的临床应用,利用自然疗法和生物相同激素疗法的组合。关键词:经前症候群,经前不悦症,佩带韭,生物同型黄体酮,镁,B族维生素,病例报告帽子:胶囊;帽子:胶囊;CBC:全血细胞计数;CMP:综合代谢组;直流:停止;促卵泡激素;GABA: γ氨基丁酸;H:高;HPA:肾上腺皮质;LH:黄体生成素;LN:低正常;mcg/L:微克/升;mIU/mL:毫升国际单位;Mg:毫克;mg/mL:毫克/毫升;mm:毫米;MRI:磁共振成像;NA:不适用;nmol/L:纳摩尔每升;ng/mL:纳克/毫升;NSAIDs:非甾体抗炎药;PHQ-9:患者健康问卷-9;PMDD:经前烦躁不安;pg/mL:皮克每毫升;PMS:经前综合症;Qd:每日一次;qh:睡觉;SR:缓释;SSRI:选择性血清素再摄取抑制剂;TSH:促甲状腺激素;uIU/mL: micro:国际单位每毫升;在正常范围内。
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引用次数: 0
Improvements in Premenstrual Syndrome, Primary Dysmenorrhea, and Menorrhagia with Natural Therapies: A Case Report 自然疗法改善经前期综合征、原发性痛经和月经过多:1例报告
Pub Date : 2023-10-05 DOI: 10.29011/2577-2201.100207
Premenstrual syndrome, primary dysmenorrhea, and abnormal uterine bleeding are separate but intertwined aspects of women’s reproductive health. Symptoms can include, but are not limited to, heavy menstrual cycles, painful periods, abdominal cramping
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引用次数: 1
Hepatoprotective Effects of Tetrapleura tetraptera (Schum. & Thonn.) Taub. Stem Bark Extracts in Drug-induced Toxicities in Rats 四翅四胸膜对肝脏的保护作用。,Thonn)。陶布。茎皮提取物对大鼠药物毒性的影响
Pub Date : 2023-10-02 DOI: 10.29011/2577-2201.100201
Hepatotoxicity is an issue of global concern because of numerous liver-related deaths over the years. In addition, the conventional hepatoprotective and hepatocurative drugs used are more expensive, not easily accessible, and sometimes have serious adverse effects. These reasons account for why many have resorted to traditional plant medicines. This study evaluated the hepatoprotective effects of aqueous and hydroethanolic stem bark extracts of Tetrapleura tetraptera, a commonly used traditional medicinal plant, in paracetamol and carbon tetrachloride-induced hepatotoxicities in rats. Pulverized stem bark samples of 500 g each were soaked in 1000 mL boiled water and 1000 mL 50% hydroethanol respectively for 24 hours and filtered. Filtrates were concentrated over a water bath and designated as aqueous stem bark extract (ASE) and hydroethanolic stem bark extract (HSE). Extracts were evaluated for LD 50 value, phytochemical constituents, free radical scavenging effects and heavy metals. Fifty-seven male Wistar albino rats weighing 120-180 g were divided into nineteen groups (n=3/group). The LD 50 for both extracts were found to be above 5000 mg/kg b.wt. This study showed HSE had higher amounts of phytochemicals than ASE. Again, this study also showed that HSE and ASE had greater levels of liver percentage protection than Silymarin. Furthermore, the liver antioxidant profile study proved that HSE and ASE could protect the liver. These results suggest that ASE and HSE, through their antioxidant activities, have hepatoprotective and hepatocurative effects against paracetamol and carbon tetrachloride-induced hepatotoxicities in rats and could be developed as potential liver protective agents.
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引用次数: 0
Treatment of Canine Spontaneous Pneumothorax by Traditional Chinese Veterinary Medicine: A Case Report 中药治疗犬自发性气胸1例
Pub Date : 2023-09-23 DOI: 10.29011/2577-2201.100096
Spontaneous pneumothorax is a common clinical condition in small animals. It is frequently found in medium and large breed dogs (e
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引用次数: 0
The Effectiveness of Short Meditation on Attentional Performance: A Quick Classroom Activity 短暂冥想对注意力表现的有效性:一个快速的课堂活动
Pub Date : 2023-09-22 DOI: 10.29011/2577-2201.100203
Undergraduate students suffer from stress and attention problems throughout their academic career. This is a great time for students to learn a new skill; meditation practices have been shown to improve mental and physical health and our activity can introduce them to this beneficial practice. Utilizing the learning-cycle approach, we had students first engage with a problem, explore interpretations, conduct a meditation experiment, and then interpret and explain results. This short activity investigates the impact of focused-breathing meditation on the attention of students using the psychomotor vigilance test (PVT). The within subjects’ design showed that a majority of students see reaction time improvements with just 5-minutes of meditation or 5-minutes of being sedentary. This has been repeated over many years and in both an introductory biology course and as well in a 300-level neuroscience techniques course. We also investigated if the amount of sleep the previous night would impact performance changes, but this was found to have no effect. Our 5-minute meditation activity taught with the learning-cycle approach can be quickly added to any neuroscience, biology, behavior, or psychology course. Further discussion focuses on the stress response, the neurophysiology of meditation, brain electrical activity, brain regions, and impact of behaviors on physiology
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引用次数: 0
期刊
Current research in complementary & alternative medicine
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