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Evaluation of Chemopreventive Potential and Regulated Toxicity of a Phyto-fabricated Silver Nanoformulation using Bark Extract of Saraca asoca in Acute Myeloid Leukemia Mice in vivo and in vitro 用菝葜树皮提取物制备的银纳米制剂对急性髓系白血病小鼠体内和体外的化学预防潜力和调控毒性评价
Pub Date : 2022-01-11 DOI: 10.29011/2577-2201.100048
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引用次数: 0
The Case for Moxibustion for Painful Syndromes: History, principles and rationale. 艾灸治疗疼痛综合征的案例:历史、原则和原理。
Pub Date : 2022-01-01 Epub Date: 2022-02-23 DOI: 10.29011/2577-2201.100053
Nigel C Dawes, Joyce K Anastasi

Traditional Chinese Medicine (TCM) has evolved over thousands of years. TCM practitioners use various approaches (such as acupuncture and tai chi) as well as herbal products to address health problems. Though lesser known in the west, the practice of Moxibustion is an integral part of Traditional East Asian Medicine. Moxibustion is an important non-invasive treatment that has shown to be beneficial in treating painful syndromes including neuropathy. It has been suggested that moxibustion may alleviate neuroinflammation by inhibiting NF-kB and by activating Nrf2. These anti-inflammatory and protective mechanisms could be key to exploring the use of moxibustion in treating other etiologies of neuropathy including HIV. There is ample scope for future study in this area and consideration of the history, development and practical applications of moxibustion therapy may be of help in this regard. This article seeks to explore the background, principles, and application of moxibustion in the clinical setting with particular emphasis on its potential for symptom management in the treatment of neuropathy and pain.

传统中医(TCM)已有数千年的发展历史。中医师使用各种方法(如针灸和太极)以及草药产品来解决健康问题。虽然艾灸在西方鲜为人知,但它是东亚传统医学不可或缺的一部分。艾灸是一种重要的非侵入性疗法,对治疗包括神经病变在内的疼痛综合症很有益处。有研究表明,艾灸可通过抑制 NF-kB 和激活 Nrf2 来缓解神经炎症。这些抗炎和保护机制可能是探索艾灸治疗包括艾滋病在内的其他病因性神经病变的关键。这一领域的研究还有很大的发展空间,对艾灸疗法的历史、发展和实际应用进行研究可能会有所帮助。本文旨在探讨艾灸疗法的背景、原理和临床应用,特别强调艾灸在治疗神经病变和疼痛的症状管理方面的潜力。
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引用次数: 0
A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, Herbo-Mineral Drug in Patients with Viral Fever 草药矿物药物ZingiVir-H治疗病毒性发热的安全性和有效性的初步临床研究
Pub Date : 2021-09-08 DOI: 10.29011/2577-2201.100044
Hareendran Nair, Rajani A Nayar, G. Sreekumar, Sheeja Chandran, SP Parvathy, KV ManeshKumar, Sreejith Satheesan, Shan Sasidharan
A viral infection develops when an organism’s body is attacked by pathogenic viruses, and infectious virus particles attach to and enter susceptible cells. There are a few antiviral medicines available to manage the viral infection. The objective of this pilot clinical study was to demonstrate the preliminary evaluation on the efficacy and safety of ZingiVir-H, a herbomineral Ayurvedic preparation in hospitalized adults diagnosed with viral infection. A total of thirty patients above 18 years of age presenting with fever were enrolled from 3rd October 2019 to 28th December 2019 for conducting the pre-test and post-test clinical trial. All the patients were administered with ZingiVir-H tablet (500 mg) orally every 4th hour along with lukewarm water after light meal. The intervention was continued until the body temperature became normal. Body temperature, Complete Blood Count (CBC), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (C-RP), Liver Function Test (LFT), and Renal Function Test (RFT) were recorded after treatment, first follow-up (on 7th day of discharge) and 2nd follow-up (on 30th day from first follow-up date). LFT and RFT were observed before treatment and 2nd follow-up (on 30th day from first follow-up date) and the results obtained were analyzed statistically. Repeated measurements with ANOVA recorded a significant decrease in body temperature (within an average of 4.3 days), CBC, ESR, C-RP after the intervention. The LFT and RFT parameters before and after treatments were within the recommended clinical range which established the hepato-renal safety of the ZingiVir-H in the study subjects. This study proved that ZingiVir-H is highly effective and safe in managing viral fever (jwara). Citation: Nair HJ, Nayar RA, Sreekumar GS, Chandran S, Parvathy SP, et al. (2021) A Pilot Clinical Study to Evaluate the Safety and Efficacy of ZingiVir-H, HerboMineral Drug in Patients with Viral Fever. Curr Res Complement Altern Med 5: 144. DOI: 10.29011/2577-2201.100044 2 Volume 5; Issue 01 Curr Res Complement Altern Med, an open access journal ISSN: 2577-2201
当生物体受到病原病毒的攻击,感染性病毒颗粒附着并进入易感细胞时,就会发生病毒感染。有几种抗病毒药物可用于治疗病毒感染。这项试点临床研究的目的是证明ZingiVir-H(一种草药阿育吠陀制剂)对确诊为病毒感染的住院成人的疗效和安全性的初步评估。从2019年10月3日至2019年12月28日,共有30名18岁以上出现发烧的患者被纳入试验前和试验后临床试验。所有患者每4小时口服一次ZingiVir-H片(500mg),并在餐后加温水。干预一直持续到体温恢复正常。记录治疗后、第一次随访(出院第7天)和第二次随访(第一次随访后第30天)的体温、全血细胞计数(CBC)、红细胞沉降率(ESR)、C反应蛋白(C-RP)、肝功能测试(LFT)和肾功能测试(RFT)。在治疗前和第二次随访(第一次随访后第30天)观察LFT和RFT,并对所得结果进行统计学分析。ANOVA重复测量记录了干预后体温(平均4.3天内)、CBC、ESR、C-RP的显著下降。治疗前后的LFT和RFT参数均在推荐的临床范围内,这确定了ZingiVir-H在研究受试者中的肝肾安全性。这项研究证明ZingiVir-H在治疗病毒性发热(jwara)方面是非常有效和安全的。引文:Nair HJ、Nayar RA、Sreekumar GS、Chandran S、Parvathy SP等人(2021)一项评估ZingiVir-H(HerboMineral药物)治疗病毒性发热患者安全性和有效性的试点临床研究。Curr Res Complement Altern Med 5:144。DOI:10.29011/22577-2201.100044 2第5卷;第01期Curr Res Complement Altern Med,开放获取期刊ISSN:2577-2201
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引用次数: 1
Evaluation of Local Chromotherapy on Carrageenaninduced Acute Inflammatory Pain in Rats 局部显色疗法对卡拉胶致大鼠急性炎性疼痛的影响
Pub Date : 2021-01-01 DOI: 10.29011/2577-2201.100043
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引用次数: 0
Ethnomedicinal survey in two villages of Cumilla district, Bangladesh 孟加拉国卡米拉地区两个村庄的民族医学调查
Pub Date : 2021-01-01 DOI: 10.29011/2577-2201.100045
B. Islam, Promita Deb, M. Rahmatullah
Introduction: Folk medicines play an important part among the village people in Bangladesh. The main objective of the present study was to carry out a randomized ethnomedicinal survey among the folk medicine practitioners (Kavirajes) of two villages, Parati and Panjab, located in Cumilla Sadar south sub-district of Cumilla district in Bangladesh. Methods: Informed consent was obtained from the Kavirajes and surveys were conducted with the help of a semi-structured questionnaire and the guided field-walk method. Interviews were carried on in the Kaviraje’s native language – Bengali. After completing the survey, voucher specimens were deposited into the Bangladesh National Herbarium for complete identification. Results: It was observed that the Kavirajes of the two villages used 16 plant species which were distributed into 16 distinct families. Plants belonging to these 16 families were used for the treatment of various ailments such as jaundice, blood dysentery, asthma in infants, leukorrhea, dysentery, abdominal pain, lower abdominal fat, lower back pain, tachycardia, and painful abscess. The major plant part used were leaves (50%), followed by bark and gum (13.2% each), and young shoot, whole plant, pith, and bulb (6% each). Kavirajes, once plentiful are becoming scarce both as to numbers and to their medicinal knowledge. The present survey points to possible plants that need to be pharmacologically assessed as to their traditional uses. Conclusion: The plant information collected in the present survey is suggestive of significant prospects for further scientific research towards discovery of lead compounds and possibly better drugs.
简介:民间医药在孟加拉国的乡村人民中扮演着重要的角色。本研究的主要目的是对位于孟加拉国Cumilla Sadar南区的两个村庄Parati和Panjab的民间医生(Kavirajes)进行随机民族医学调查。方法:获得Kavirajes的知情同意,采用半结构化问卷和引导实地行走法进行调查。采访是用卡瓦拉杰的母语孟加拉语进行的。在完成调查后,代金券标本被存放在孟加拉国国家植物标本室进行全面鉴定。结果:两村的Kavirajes利用了16种植物,分布在16个不同科。这16个科的植物被用于治疗各种疾病,如黄疸、血痢、婴儿哮喘、白带、痢疾、腹痛、下腹部脂肪、下背部疼痛、心动过速和疼痛性脓肿。植物的主要部分是叶片(50%),其次是树皮和树胶(各占13.2%),其次是嫩枝、整株、髓和鳞茎(各占6%)。曾经丰富的Kavirajes在数量和医学知识方面都变得稀缺。目前的调查指出了可能需要对其传统用途进行药理学评估的植物。结论:本调查收集到的植物信息为进一步科学研究发现先导化合物和更好的药物提供了重要前景。
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引用次数: 0
Effects of a Single Dose of Teacrine, Caffeine, or their Combination on Subjective Feelings, As Well as Heart Rate and Blood Pressure in Adults 单剂量泪腺、咖啡因或其组合对成人主观感觉、心率和血压的影响
Pub Date : 2018-12-21 DOI: 10.29011/2577-2201/100034
R. Bloomer, M. Butawan, M. L. Stockton, Nicholas J. G. Smith
Background: Theacrine is structurally similar to caffeine, and reported to improve mood and cognition in human subjects. The purpose of the present study was to determine the impact of theacrine on subjective mood, cognitive performance, Heart Rate (HR) and Blood Pressure (BP). Methods: 24 men (aged: 24.3±6.1) and 26 women (aged: 23.4±3.5) ingested a placebo, theacrine (Teacrine®, Compound Solutions, Inc.) at 25mg, at 125mg, caffeine at 150mg, or theacrine at 125mg + caffeine at 150mg on five separate occasions, separated by approximately one week. HR and BP were measured before ingestion and at 30 minutes, 1, 2, 3, 4, and 5 hours post ingestion. Subjects rated their subjective feelings at the above times, and performed the Trail Making Test (TMT) of cognitive performance at baseline and at hours 2 and 4 post ingestion. Results: Treatment with theacrine had little impact on HR and BP, with only marginal increases noted (~3 bpm; ~3mm Hg). No condition effects were noted for the TMT (p>0.05), with similar scores noted for all conditions. Effects were noted for subjective feelings such as attentive, focus, energy, and motivation to exercise; with the caffeine and theacrine+caffeine generally noted to have the most favorable scores, with theacrine at 25mg and placebo generally noted to have the least favorable scores. Conclusion: These findings indicate that theacrine, when used alone at 125mg or in combination with caffeine, does not result in any significant increase in HR or BP but may improve measures of subjective feelings in healthy men and women.
背景:茶碱在结构上与咖啡因相似,据报道可以改善人类受试者的情绪和认知。本研究的目的是确定茶碱对主观情绪、认知表现、心率和血压的影响。方法:24名男性(年龄:24.3±6.1)和26名女性(年龄:23.4±3.5)在5个不同的场合分别服用安慰剂、茶acrine (Teacrine®,Compound Solutions Inc.) 25mg、125mg、150mg咖啡因或茶acrine 125mg + 150mg咖啡因,间隔大约一周。分别在摄食前和摄食后30分钟、1、2、3、4、5小时测量心率和血压。受试者在上述时间对其主观感受进行评分,并在基线和摄入后2小时和4小时进行认知表现的轨迹测试(TMT)。结果:茶树碱治疗对心率和血压影响不大,仅轻微升高(~ 3bpm;~ 3毫米汞柱)。TMT没有条件影响(p < 0.05),所有条件的得分相似。注意到主观感受的影响,如注意力、注意力、精力和锻炼的动机;咖啡因和茶碱+咖啡因通常得分最高,25毫克的茶碱和安慰剂通常得分最低。结论:这些发现表明,当单独使用125毫克或与咖啡因联合使用时,茶碱不会导致HR或BP的任何显着增加,但可能改善健康男性和女性的主观感受。
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引用次数: 1
Merging Ayurvedic Ashwagandha with Traditional Chinese Medicine Part 1. Foundation in Ashwagandha: Physiological Effects, Clinical Efficacy, and Properties 阿育吠陀与传统中医的融合第一部分。Ashwagandha基金会:生理效果、临床疗效和特性
Pub Date : 2018-10-12 DOI: 10.29011/2577-2201/100033
M. Forman, Nicholas A Kerna
Traditional Chinese Medicine (TCM) has a methodical and organized system for the classification of herbal medicines. These classifications have been developed over many hundreds of years of careful observation and documentation of each of the traditional herbs and their effect on the human body. Due to isolation and long distances between different countries and cultures, certain significant herbal medicines (such as Ashwagandha from India) are not currently classified per TCM principles. The systems of Ayurveda and TCM are juxtaposed, herein, to establish a parallel between the two systems. In TCM, each herbal substance has its distinct attributes; therefore, a side-by-side comparison was made between each relevant herb and Ashwagandha. Because of this comparison, in the TCM herbal classification system, Ashwagandha can be categorized as “Tonify Qi” and “Tonify Blood and Essence”. This comparison, depicted in (Table 1), provides evidence to classify Ashwagandha in TCM accurately and establishes a methodology by which other relevant herbal medicines can be joined with Chinese medicine and classified under TCM categories and terms.
中医学对草药的分类有一个系统而有条理的系统。这些分类是经过数百年对每种传统草药及其对人体影响的仔细观察和记录而形成的。由于不同国家和文化之间的隔离和远距离,某些重要的草药(如来自印度的Ashwagandha)目前没有按照中医学原则进行分类。阿育吠陀和中医的系统在这里并列,以建立两个系统之间的平行关系。在中医学中,每种草药都有其独特的属性;因此,对每种相关草药和Ashwagandha进行了并排比较。正因为如此,在中药分类体系中,阿什瓦干达可以分为“益气”和“补血益精”。这种比较如(表1)所示,为准确地将Ashwagandha在中医中进行分类提供了证据,并建立了一种方法,通过该方法可以将其他相关草药与中医结合起来,并根据中医类别和术语进行分类。
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引用次数: 3
New Development of Chinese Medicine by Integrating Traditional Chinese Medicine with Western Medicine 中西医结合:中医的新发展
Pub Date : 2018-09-05 DOI: 10.29011/2577-2201/100032
Tianxing Xu, Qin Wang
Based on more than 20 years’ research and clinical practice as well as based on the Traditional Chinese Medicine (TCM) theory, the author developed new concepts on TCM. These new concepts include: The Yin-Yang and Five-element theory is updated to Yin-Yang and Six-element theory. Under this new theory, wood, fire, • earth, metal, water, the traditional five elements in the TCM theory has been extended to six elements by adding the new element of Qi, which is called the new Wood-Fire-Earth-Metal-Water-Qi theory. Heart, liver, spleen, lung, kidney, the traditional Five-Zang • 1 theory is extended to the Six-Zang theory by adding the organ of pancreas, which is named as the new Heart-Liver-Spleen-Lung-KidneyPancreas theory. Changing the relationship between “elements” and “Zang-Fu • 2 “ in the TCM theory and the relationship of subjugation and reverse restriction in the five elements; and analyzing the evolution of meridian (main and collateral channels) system and twelve meridians lingers; creatively proposing the distribution and movement model of the five Qi elements The description on pericardium in the TCM theory is replaced by spleen. The author also proposed the hypothesis that • formation of extraordinary organs3 (Qi-Heng-Zhi-Fu) was the results of generation and transformation between Six-Zang organs and Six-Fu organs. By comparing the triple-energizer system in the TCM with the lymph system in western medicine, the author proposed the • concept of new triple-energizer system, which are helpful for us to understand the TCM in the way of the western medicine system. By using the digital technology to explain the meridian system and their movement patterns in human body, the author • explained the concept of acupoint. The adoption of digital technology in meridian system have made a full integration of the TCM and western medicine. These new concepts not only improved and developed the TCM theory, promoted its integration with western medicine, but also explored a new theory and method for development of the TCM theory, disease prevention and treatment. Under the direction of the new concepts, the cure rate of common diseases was significantly increased, cure cycle was shortened, and the curative effect on the patients with complicated diseases was very remarkable, leading to over 85% of an average cure rate. Note: 1A collective term for the heart, liver, spleen, lung and kidney. 2A collective term for all internal organs, including zang orangs ,fu organs ,and extra fu organs. 3A collective term for the brain, marrow, bones, blood vessels, gallbladder and uterus. They are so called because their physiological properties are different from both ordinary zang and fu organs. Citation: Xu T, Wang Q (2018) New Development of Chinese Medicine by Integrating Traditional Chinese Medicine with Western Medicine. Curr Res Complement Altern Med: CRCAM-132. DOI:10.29011/ 2577-2201 /100032 2 Volume 2018; Issue 03 Curr Res Complement Altern Med, an open acc
作者在20多年的研究和临床实践的基础上,以中医理论为基础,提出了新的中医学概念。这些新概念包括:阴阳五行学说更新为阴阳六行学说。在木、火、土、金、水这一新理论的指导下,中医理论中传统的五行通过添加气的新元素而扩展为六行,称为新木火土金水气理论。心、肝、脾、肺、肾,将传统的五脏学说扩充为六藏学说,增加胰腺器官,命名为新的心肝脾肺肾胰腺学说。改变中医理论中“行”与“藏•二”的关系,改变五行中的亡国与逆阻的关系,分析经络的演变系统和十二经脉徘徊;创造性地提出了五气的分布和运动模式中医理论中对心包的描述被脾所取代。作者还提出了“奇衡之符”的形成是“六脏”与“六福”生成转化的结果。通过对中医三焦系统与西医淋巴系统的比较,提出了新三焦系统的概念,有助于我们从西医系统的角度理解中医。运用数字技术解释人体经络系统及其运动规律,阐述了穴位的概念。经络系统采用数字化技术,实现了中西医的全面融合。这些新观念不仅完善和发展了中医理论,促进了中医学与西方医学的融合,而且为中医理论的发展、疾病预防和治疗探索了新的理论和方法。在新理念的指导下,常见病治愈率显著提高,治愈周期缩短,对复杂疾病患者的疗效非常显著,平均治愈率达到85%以上。注:1A心、肝、脾、肺和肾的统称。2A所有内脏器官的统称,包括藏器官、附器官和额外的附器官。3A大脑、骨髓、骨骼、血管、胆囊和子宫的统称。之所以叫它们,是因为它们的生理特性不同于普通的内脏和内脏。引文:徐涛,王Q(2018)中西医结合促进中医药发展。Curr Res Complement Altern Med:CRCAM-132。DOI:10.29011/2577-2201/100032 2018年第2卷;第03期Curr Res Complement Altern Med,开放获取期刊ISSN:2577-2201
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引用次数: 0
Acupuncture in Cancer Care: Is it a Really Feasible and Attractive Therapeutic Option? A Single-Centre Experience 癌症治疗中的针灸:它真的是一个可行和有吸引力的治疗选择吗?单一中心体验
Pub Date : 2018-06-26 DOI: 10.29011/2577-2201/100031
P. Giovanis, A. Ronchi, M. Marcante, F. Zustovich, D. Pastorelli
Background: Complementary and Alternative medicine (CAM) is commonly used by cancer patients (pts). Recent randomised controlled trials showed that acupuncture is safe, effective and feasible for the management of cancer-related fatigue and other adverse events of anti-neoplastic therapies. Materials and Methods: Since November 2012 we have been offering a supportive care program of 20 minutes’ weekly session of acupuncture for the management of chemotherapy-induced nausea/vomiting, hot flashes, cancer-related fatigue, xerostomia. A brochure regarding indications and techniques was offered to all cancer patients who received a systemic anticlastic therapy (Chemotherapy, Target Therapy, Endocrine Treatment) and/or radiation therapy. Results: More than 500 pts affected by solid tumours or lymphoma were treated in our Operative Unit during the period of the project. None of them preferred to receive acupuncture in addition to the specific pharmacological treatment. Conclusion: Cancer pts of the district of Belluno, Italy did not demonstrate any interest in acupuncture for the management of side effects of anti-neoplastic treatments.
背景:补充和替代医学(CAM)是癌症患者常用的药物。最近的随机对照试验表明,针灸治疗癌症相关疲劳和其他抗肿瘤治疗不良事件是安全、有效和可行的。材料和方法:自2012年11月以来,我们一直提供每周20分钟的针灸支持性护理计划,用于治疗化疗引起的恶心/呕吐、潮热、癌症相关疲劳和口干症。为所有接受系统性抗癌治疗(化疗、靶向治疗、内分泌治疗)和/或放射治疗的癌症患者提供了一本关于适应症和技术的小册子。结果:在项目期间,我们的手术室治疗了500多名实体瘤或淋巴瘤患者。除了特定的药物治疗外,他们都不喜欢接受针灸治疗。结论:意大利贝卢诺地区癌症患者对针灸治疗抗肿瘤的副作用不感兴趣。
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引用次数: 0
期刊
Current research in complementary & alternative medicine
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