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An international survey to better understand the current incidence, severity, and management of VOD/SOS. 为更好地了解 VOD/SOS 目前的发病率、严重程度和管理情况而进行的一项国际调查。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-07 DOI: 10.1038/s41409-024-02434-9
Marion Larue, Myriam Labopin, Eolia Brissot, Ahmed S Alaskar, Mahmoud Aljurf, Mutlu Arat, Frederic Baron, Ali Bazarbachi, Fabio Ciceri, Selim Corbacioglu, Fiona L Dignan, Michelle Kenyon, Florent Malard, Arnon Nagler, Antonio Pagliuca, Annalisa Ruggeri, Ibrahim Yakoub-Agha, Yishan Ye, Rafael F Duarte, Tapani Ruutu, Enric Carreras, Zinaida Peric, Mohamad Mohty

This international questionnaire survey aimed to explore the current incidence, diagnostic policies, management, and outcomes of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) among healthcare providers involved in the management of these patients. A questionnaire was e-mailed to practitioners with an interest in allogeneic hematopoietic cell transplantation (allo-HCT). Of the respondents, 144 of 215 (67.0%) felt that early detection or diagnosis of VOD/SOS was difficult. Regarding diagnostic criteria, 142 (66.1%) already declared using the 2023 EBMT refined criteria. Most respondents (163/215, 75.8%) found these recent refined EBMT criteria useful for diagnosis, and 193 (89.8%) found the severity criteria easy to use. The major risk factors identified for VOD/SOS were a second allo-HCT (41.4%), pre-existing liver disease (54.9%), and prior use of antibody-drug conjugates (49.8%). Preferences for starting VOD/SOS treatment varied, with 61 (28.4%) preferring initiating therapy at a mild stage, and 122 (56.7%) preferring the moderate stage. In summary, this survey provided valuable insight into the challenges and opportunities of the identification and management of VOD/SOS. By improving current knowledge and increasing collaboration among healthcare professionals, early detection, management, and clinical outcomes for patients with this potentially serious complication can also be improved.

这项国际性问卷调查旨在了解参与治疗静脉闭塞性疾病/窦腔阻塞综合征（VOD/SOS）的医护人员目前的发病率、诊断政策、管理和治疗效果。我们通过电子邮件向对异体造血细胞移植（allo-HCT）感兴趣的从业人员发送了调查问卷。在 215 位受访者中，有 144 位（67.0%）认为 VOD/SOS 的早期发现或诊断比较困难。关于诊断标准，142 位受访者（66.1%）已宣布使用 2023 年 EBMT 改良标准。大多数受访者（163/215，75.8%）认为这些最新修订的 EBMT 标准有助于诊断，193 人（89.8%）认为严重程度标准易于使用。VOD/SOS的主要风险因素是第二次异体肝细胞移植（41.4%）、既往肝病（54.9%）和既往使用抗体药物共轭物（49.8%）。开始 VOD/SOS 治疗的偏好各不相同，61 人（28.4%）偏好在轻度阶段开始治疗，122 人（56.7%）偏好在中度阶段开始治疗。总之，这项调查为我们深入了解 VOD/SOS 的识别和管理所面临的挑战和机遇提供了宝贵的资料。通过提高现有知识水平和加强医护人员之间的合作，还可以改善这种潜在严重并发症患者的早期发现、管理和临床疗效。
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引用次数: 0
Transplant in myeloma: individualized approaches needed depending on context, access and biology. 骨髓瘤的移植：需要根据具体情况、获取途径和生物学特性采取个性化方法。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-06 DOI: 10.1038/s41409-024-02428-7
Héctor A Vaquera-Alfaro, Andrés Gómez-De León, Nihar Desai, Nikita Mehra, Ghulam Rehman Mohyuddin
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引用次数: 0
Impact of daratumumab on collection and engraftment in multiple myeloma patients undergoing hematopoietic stem cell mobilization with G-CSF plus on-demand plerixafor. 达拉单抗对使用G-CSF和按需普利沙佛进行造血干细胞动员的多发性骨髓瘤患者的采集和移植的影响。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-04 DOI: 10.1038/s41409-024-02432-x
Giuseppe Bertuglia, Bruno Garibaldi, Andrea Casson, Barbara Sarina, Francesca Gay, Silvio Mercadante, Jacopo Mariotti, Mattia D'agostino, Daniela Taurino, Stefania Oliva, Alessandra Larocca, Daniele Mannina, Chiara De Philippis, Giulia Benevolo, Tiziana Francisci, Marco Lorenzi, Benedetto Bruno, Armando Santoro, Sara Bringhen, Roberto Mina, Stefania Bramanti
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引用次数: 0
(Donor) age is more than just a number…. (捐赠者）年龄不仅仅是一个数字....
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-04 DOI: 10.1038/s41409-024-02420-1
Colin Vale, Amelia A Langston
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引用次数: 0
Correction: Significance of men's health in long-term survivors of allogeneic stem cell transplantation. 更正：男性健康对异体干细胞移植长期存活者的意义。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-04 DOI: 10.1038/s41409-024-02415-y
Laila Schneidewind, Thomas Neumann, Nadette Peters, Jennifer Kranz, Kai A Probst, Florian H Heidel, Oliver W Hakenberg, William Krüger
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引用次数: 0
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation: Data Management Group - Poster Session (P771-P782). 欧洲血液和骨髓移植学会第 50 届年会：数据管理小组 - 海报会议（P771-P782）。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-01 DOI: 10.1038/s41409-024-02354-8
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引用次数: 0
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation: Nurses Group - Poster Sessions (NP001-NP079). 欧洲血液和骨髓移植学会第 50 届年会：护士组 - 海报会议 (NP001-NP079)。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-01 DOI: 10.1038/s41409-024-02350-y
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引用次数: 0
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session (O009-O154). 欧洲血液和骨髓移植学会第 50 届年会：医生--口头会议（O009-O154）。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-01 DOI: 10.1038/s41409-024-02347-7
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引用次数: 0
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation: Psychiatry and Psychology Group - Poster Session (P756-P761). 欧洲血液和骨髓移植学会第 50 届年会：精神病学和心理学组 - 海报会议（P756-P761）。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-01 DOI: 10.1038/s41409-024-02351-x
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引用次数: 0
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation: Patient Advocacy - Poster Session (P808-P815). 欧洲血液和骨髓移植学会第 50 届年会：患者宣传 - 海报会议 (P808-P815)。
IF 4.5 2区 医学 Q1 HEMATOLOGY
Bone Marrow Transplantation
Pub Date : 2024-10-01 DOI: 10.1038/s41409-024-02359-3
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引用次数: 0
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