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Evaluation of Sleep Quality and Psychological Profiles in Patients with Chronic Painful Temporomadibular Disorders 慢性疼痛性颞下颌障碍患者的睡眠质量和心理特征评价
Pub Date : 2020-06-30 DOI: 10.14476/jomp.2020.45.2.23
Hye-Mi Jeon, Kyunghun Han, Hye-Min Ju, Yong-Woo Ahn, S. Ok, Sung-Hee Jeong
Purpose:Purpose: Temporomadibular disorders (TMDs) can result in chronic pain, which is often associated with psychological and sleep disturbance. Increased levels of psychological and sleep impairments are often related with poor treatment outcomes. The purpose of the present study was to evaluate clinical features, psychological profiles and the prevalence of clinical insomnia in TMD patients with chronic pain and to suggest an effective treatment approach. Methods:Methods: A total of 200 TMD patients who had visited the Pusan National University Hospital dental clinic for treatment of their pain were recruited from June 2018 through December 2019. TMD patients were classified into an acute (n=100) and chronic (n=100) group and compared the clinical symptoms. The primary diagnosis of TMD were catego-rized as TMD with joint pain group (TMD_J), TMD with muscle pain group (TMD_M) and TMD with joint-muscle mixed pain group (TMD_JM). Self- report measures of sleep quality and psychological profiles were evaluated via the Insomnia Severity Index (ISI) and the Korean Stress Response Inventory (SRI). Independent t-tests, Mann-Whitney U-tests, and chi-squared test were used for the statistical analysis. Results:Results: Chronic TMD patients showed higher pain intensity, as well as higher prevalence of related symptoms (headache, musculoskeletal pain) and myogenous pain. They also had significantly higher scores in all SRI parameters and a higher percentage of clinical insomnia than acute TMD patients. Conclusions:Conclusions: Based on the above results, psychological profiles and sleep quality assessments are necessary to provide essential data that will allow for improved treatment of chronic TMD patients.
目的:目的:颞下颌关节紊乱病(TMDs)可导致慢性疼痛,通常与心理和睡眠障碍有关。心理和睡眠障碍水平的增加通常与治疗结果不佳有关。本研究的目的是评估慢性疼痛TMD患者的临床特征、心理特征和临床失眠的患病率,并提出有效的治疗方法。方法:方法:从2018年6月到2019年12月,共有200名TMD患者在釜山国立大学医院牙科诊所接受治疗。将TMD患者分为急性组(n=100)和慢性组(n=100),并比较其临床症状。TMD的初步诊断分为TMD伴关节痛组(TMD_J)、TMD伴肌肉疼痛组(TMD_M)和TMD伴联合肌肉混合疼痛组(TMD_JM)。通过失眠严重程度指数(ISI)和韩国压力反应量表(SRI)对睡眠质量和心理状况的自我报告测量进行评估。统计分析采用独立t检验、Mann-Whitney U检验和卡方检验。结果:慢性TMD患者表现出更高的疼痛强度,以及更高的相关症状(头痛、肌肉骨骼疼痛)和肌源性疼痛的发生率。他们在所有SRI参数上的得分也明显高于急性TMD患者,临床失眠的比例也更高。结论:结论:基于上述结果,心理状况和睡眠质量评估是必要的,以提供必要的数据,从而改善慢性TMD患者的治疗。
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引用次数: 1
Fungal Osteomyelitis of Temporomandibular Joint and Skull Base Caused by Chronic Otitis Media 慢性中耳炎所致颞下颌关节及颅底真菌性骨髓炎
Pub Date : 2020-03-30 DOI: 10.14476/jomp.2020.45.1.12
B. Kim, Keun jeong Park, Jung Eun Lee, Younjung Park, J. Kwon, S. Kim, Jong-hoon Choi, Hyung-Joon Ahn
Chronic otitis media (COM) is a chronic inflammatory disease which affects the middle ear, mastoid cavity. It presents hearing loss, ear pain, dizziness, headache, temporomandibular joint (TMJ) inflammation and intracranial complication. Intracranial complications such as skull base osteomyelitis (SBO) may occur secondary to COM due to transmission of infection by a number of possible routes. SBO is an uncommon condition with a significant morbidity and mortality if not treated in the early stages. We report a-67-year-old male patient with diabetes and untreated COM who presented atypical severe TMJ, periorbital and postmandibular pain. By computerized tomography (CT), magnetic resonance imaging (MRI) and whole body bone scan (WBBS), he was diagnosed with SBO spreading from untreated COM via infective arthritis of TMJ. Through this case, we suggest proper utilization of diagnostic imaging, especially CT or MRI for the early detection of SBO in the case of COM accompanying with the greater risk of infection developments such as diabetes.
慢性中耳炎是一种影响中耳乳突腔的慢性炎症性疾病。它表现为听力损失、耳痛、头晕、头痛、颞下颌关节(TMJ)炎症和颅内并发症。颅内并发症,如颅底骨髓炎(SBO)可继发于COM,由于感染的传播途径多种多样。SBO是一种罕见的疾病,如果不及早治疗,发病率和死亡率都很高。我们报告了一名67岁男性糖尿病患者和未经治疗的COM,他表现出不典型的严重TMJ,眶周和下颌后疼痛。通过计算机断层扫描(CT)、磁共振成像(MRI)和全身骨扫描(WBBS),诊断为未经治疗的COM经TMJ感染性关节炎传播的SBO。通过本病例,我们建议适当使用诊断成像,特别是CT或MRI,在COM病例中早期发现SBO,并伴有更大的感染发展风险,如糖尿病。
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引用次数: 1
Treatment of Drug-Induced Erythema Multiforme: Case Report 药物性多发性红斑的治疗1例报告
Pub Date : 2019-12-30 DOI: 10.14476/JOMP.2019.44.4.183
Hae-Ohk Lee, Hye-Min Ju, Ji-Yeon Lee, Hye-Mi Jeon, Kyung-Hee Kim, S. Ok, Yong-Woo Ahn, Sung-Hee Jeong
Received November 18, 2019 Revised December 11, 2019 Accepted December 11, 2019 Erythema multiforme (EM) is an inflammatory immune-mediated mucosal disease. EM is classified as EM minor or EM major, depending on the severity of symptoms. Most patients with minor or major forms of EM have oral lesions. EM can occur as a result of adverse drug reactions but this is difficult to establish. Several indicators have been developed that can be used as a criterion of evaluation to ensure objectivity in identifying the causality of adverse drug reactions. The Naranjo algorithm was used in the evaluation to ensure objectivity in identifying the causality of adverse drug reactions. There were two cases of patients suspected of having EM induced by drugs. They were both assessed using the Naranjo algorithm to confirm the causality of the disease.
接收日期2019年11月18日修订日期2019年12月11日接受日期2019年10月11日多形性红斑(EM)是一种炎症性免疫介导的粘膜疾病。EM根据症状的严重程度分为轻微EM或严重EM。大多数患有轻微或主要EM的患者都有口腔病变。EM可能是药物不良反应的结果,但这很难确定。已经制定了一些指标,可作为评估标准,以确保在确定药物不良反应因果关系时的客观性。评估中使用了Naranjo算法,以确保确定药物不良反应因果关系的客观性。有两例患者怀疑有药物诱导的EM。他们都使用Naranjo算法进行了评估,以确认疾病的因果关系。
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引用次数: 0
Interleukin-8 and Matrix Metalloprotease 9 as Salivary Biomarkers of Pain in Patients with Temporomandibular Disorder Myalgia: A Pilot Study 白细胞介素-8和基质金属蛋白酶9作为颞下颌关节紊乱性肌痛患者疼痛的唾液生物标志物:一项初步研究
Pub Date : 2019-12-30 DOI: 10.14476/jomp.2019.44.4.160
Yang Mi Park, Yong-Woo Ahn, Sung-Hee Jeong, Hye-Min Ju, Hye-Mi Jeon, Kyung-Hee Kim, S. Ok
Purpose: To search the salivary factors that objectively indicate an pain in myalgia patients with temporomandibular joint disorder (TMD) and determine the possibility of the factors as pain-biomarkers. Methods: Participants consisted of pain-free 15 persons (male 7, female 8, mean age±standard deviation (SD); 26.8±16.04 years) and 45 myalgia patients with TMD (male 21, female 24, mean age±SD; 27.98±13.01 years). They were divided into a pain-free group (numerical rating scale [NRS] score 0), a mild pain group (NRS 1-4), a moderate pain group (NRS 5-6), and a severe pain group (NRS 7-10) and members of all groups were age, sex matched. Interleukin-8 (IL-8) and matrix metalloprotease 9 (MMP-9) were selected as pain biomarkers, by searching the Gene Expression Omnibus database and analyzing pain-relat-ed genes. Enzyme-linked immunosorbent assays were used to measure the concentration of IL-8 and MMP-9 in the patients’ saliva. Results: IL-8 and MMP-9 levels were statistically significantly higher in pain groups than in the pain-free group. Greater differences were observed in patients with acute pain (with painful duration under 3 months) than in the control group and in female patients than in male. Conclusions: Salivary IL-8 and MMP-9 may play a role as biomarkers of myalgia in patients with TMD.
目的:寻找客观指示颞下颌关节紊乱病(TMD)肌痛患者疼痛的唾液因素,并确定这些因素作为疼痛生物标志物的可能性。方法:参与者包括15名无疼痛者(男7名,女8名,平均年龄±标准差(SD);26.8±16.04岁)和45例TMD肌痛患者(男21例,女24例,平均年龄±SD;27.98±13.01岁)。他们被分为无痛组(数字评定量表[NRS]评分0)、轻度疼痛组(NRS 1-4)、中度疼痛组(NR 5-6)和重度疼痛组(NRS 7-10),所有组的成员年龄、性别匹配。通过检索基因表达综合数据库并分析疼痛相关基因,选择白细胞介素-8(IL-8)和基质金属蛋白酶9(MMP-9)作为疼痛生物标志物。采用酶联免疫吸附法测定患者唾液中IL-8和MMP-9的浓度。结果:疼痛组的IL-8和MMP-9水平明显高于无疼痛组。急性疼痛患者(疼痛持续时间在3个月以下)的差异比对照组大,女性患者的差异比男性大。结论:唾液IL-8和MMP-9可能是TMD患者肌痛的生物标志物。
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引用次数: 1
Patient Expectations of Visiting Department of Oral Medicine for Burning Mouth Syndrome: Relationship between Expectations and Clinical and Psychological Characteristics 烧伤口综合征门诊病人期望值与临床心理特征的关系
Pub Date : 2019-12-30 DOI: 10.14476/jomp.2019.44.4.147
Hye-Kyoung Kim, Mee-Eun Kim
Received November 22, 2019 Revised November 29, 2019 Accepted December 3, 2019 Purpose: The aims of this study were to investigate the expectation of patients with burning mouth syndrome (BMS) and assess the relationship between patient expectations and clinical and psychological characteristics. Methods: Eligibility was retrospectively assessed on 93 patients with BMS. A total of five questionnaires on patients’ expectation for a visit, pain, sleep quality (Pittsburgh Sleep Quality Index), cognition (Pain Catastrophizing Scale) and psychological distress (Symptom Checklist-90 revised) were measured. Results: Sixty-five patients were included in this study. The top 3 priorities of expectation for a treatment visit to the Department of Oral Medicine were as following; “I want my pain to be free”; “I want to understand why it hurts”; “I want to communicate better with doctors about pain”. Patients with priority of pain relief showed poor sleep quality than patients who are more interested in the disease related information. Conclusions: To improve treatment outcomes of BMS, clinicians should improve their own understanding of patients who are suffering from BMS. Inquiring about the patient expectations may be one of them, and it would contribute to the enhancement of patients’ overall well-being.
接收日期2019年11月22日修订日期2019年12月29日接受日期2019年2月3日目的:本研究旨在调查灼口综合征(BMS)患者的期望值,并评估患者期望值与临床和心理特征之间的关系。方法:对93例BMS患者进行回顾性评价。共测量了5份关于患者就诊期望、疼痛、睡眠质量(匹兹堡睡眠质量指数)、认知(疼痛灾难量表)和心理困扰(症状自评量表90修订版)的问卷。结果:65名患者被纳入本研究。口腔医学科就诊的三大优先事项如下:;“我希望我的痛苦是自由的”;“我想知道为什么会痛”;“我想更好地与医生沟通疼痛”。与对疾病相关信息更感兴趣的患者相比,优先缓解疼痛的患者睡眠质量较差。结论:为了提高BMS的治疗效果,临床医生应该提高自己对BMS患者的理解。询问患者的期望可能是其中之一,这将有助于提高患者的整体幸福感。
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引用次数: 0
Palatal Rugae Pattern in Korean Children and Adolescents 韩国儿童和青少年的腭嵴模式
Pub Date : 2019-12-30 DOI: 10.14476/jomp.2019.44.4.169
Na-hee Kim, Yeong-Gwan Im, Ji-yeon Kim, Byung-Gook Kim
Purpose: To determine whether the morphological features of the palatal rugae are associated with sex and age in children and adolescents. Methods: A total of 300 diagnostic models of the palatal rugae of children and adolescents were collected. The models were classified into male and female and<13- and ≥13-year-old groups. The palatal rugae pattern, and the number and length of palatal rugae plicae, were analyzed. Results: The number of palatal rugae plicae was higher in females than in males, however, the difference was negligible. In the group aged 13 years or more, the number was higher in the male group on the left side. There was no association between the number of palatal rugae plicae and age group. The type I pattern was the most common in both males and females. The length of palatal rugae plicae was greater in males than in females. There was no association between the length of palatal rugae plicae and age group. Conclusions: The number and length of palatal rugae were associated with sex, but the morphological features of the palatal rugae could not distinguish between children and adolescents. These findings suggest that the palatal rugae have limited value for identification of individuals.
目的:探讨儿童和青少年腭纹的形态特征是否与性别和年龄有关。方法:收集儿童、青少年腭纹诊断模型300例。模型分为男、女、<13岁和≥13岁组。分析了腭皱襞的形态、皱襞的数量和长度。结果:女性腭皱襞数目多于男性,但差异可忽略不计。在13岁以上的年龄组中,左侧男性组的数字更高。腭皱襞数目与年龄组无明显关系。I型模式在男性和女性中最常见。雄性上颚皱襞长度大于雌性。腭皱襞长度与年龄组无明显关系。结论:腭纹的数量和长度与性别有关,但腭纹的形态特征不能区分儿童和青少年。这些发现表明,腭纹对个体的识别价值有限。
{"title":"Palatal Rugae Pattern in Korean Children and Adolescents","authors":"Na-hee Kim, Yeong-Gwan Im, Ji-yeon Kim, Byung-Gook Kim","doi":"10.14476/jomp.2019.44.4.169","DOIUrl":"https://doi.org/10.14476/jomp.2019.44.4.169","url":null,"abstract":"Purpose: To determine whether the morphological features of the palatal rugae are associated with sex and age in children and adolescents. Methods: A total of 300 diagnostic models of the palatal rugae of children and adolescents were collected. The models were classified into male and female and<13- and ≥13-year-old groups. The palatal rugae pattern, and the number and length of palatal rugae plicae, were analyzed. Results: The number of palatal rugae plicae was higher in females than in males, however, the difference was negligible. In the group aged 13 years or more, the number was higher in the male group on the left side. There was no association between the number of palatal rugae plicae and age group. The type I pattern was the most common in both males and females. The length of palatal rugae plicae was greater in males than in females. There was no association between the length of palatal rugae plicae and age group. Conclusions: The number and length of palatal rugae were associated with sex, but the morphological features of the palatal rugae could not distinguish between children and adolescents. These findings suggest that the palatal rugae have limited value for identification of individuals.","PeriodicalId":91332,"journal":{"name":"Journal of oral medicine and pain","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41343215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Non-Odontogenic Toothache Caused by the Fungal Ball of Maxillary Sinus: Case Reports 上颌窦真菌球引起的非牙源性牙痛1例
Pub Date : 2019-12-30 DOI: 10.14476/jomp.2019.44.4.174
J. Ha, Won Jung, Kyung-Eun Lee, Bong-Jik Suh
A fungal ball (FB) of the paranasal sinuses is a chronic, non-invasive fungal sinusitis defined as the accumulation of dense aggregation of fungal hyphae in a sinus cavity. A patient with FB infection in a sinus cavity has usually non-specific symptoms such as post-nasal drip, nasal congestion, headache. However, facial pain and toothache can be developed if FB infection is in maxillary sinus. The aim of this case report is to present two cases of FB of the maxillary sinus which caused toothache in the upper molar region. It is also to make dental practitioners consider the non-odontogenic origins of toothache and to pay special attention to avoid unnecessary dental treatment.
副鼻窦真菌球(FB)是一种慢性非侵袭性真菌鼻窦炎,定义为真菌菌丝在鼻窦腔内密集聚集的积累。鼻窦腔FB感染患者通常有非特异性症状,如后滴鼻、鼻塞、头痛。然而,如果FB感染在上颌窦,可发展为面部疼痛和牙痛。本病例报告的目的是提出两个上颌窦FB引起牙痛在上磨牙区。这也是为了让牙科医生考虑牙痛的非牙源性起源,并特别注意避免不必要的牙科治疗。
{"title":"Non-Odontogenic Toothache Caused by the Fungal Ball of Maxillary Sinus: Case Reports","authors":"J. Ha, Won Jung, Kyung-Eun Lee, Bong-Jik Suh","doi":"10.14476/jomp.2019.44.4.174","DOIUrl":"https://doi.org/10.14476/jomp.2019.44.4.174","url":null,"abstract":"A fungal ball (FB) of the paranasal sinuses is a chronic, non-invasive fungal sinusitis defined as the accumulation of dense aggregation of fungal hyphae in a sinus cavity. A patient with FB infection in a sinus cavity has usually non-specific symptoms such as post-nasal drip, nasal congestion, headache. However, facial pain and toothache can be developed if FB infection is in maxillary sinus. The aim of this case report is to present two cases of FB of the maxillary sinus which caused toothache in the upper molar region. It is also to make dental practitioners consider the non-odontogenic origins of toothache and to pay special attention to avoid unnecessary dental treatment.","PeriodicalId":91332,"journal":{"name":"Journal of oral medicine and pain","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43730730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Assessment of the Thickness of the Roof of the Glenoid Fossa Using Cone Beam Computed Tomography in Orthognathic Surgery Patients: A Preliminary Study 应用锥束计算机断层扫描技术评估正颌外科患者的Glenoid Fossa顶部厚度的初步研究
Pub Date : 2019-12-30 DOI: 10.14476/jomp.2019.44.4.154
Hyun-Jeong Park, Yo-Seob Seo, Sung-Hoon Lim, J. Ryu
Received November 24, 2019 Revised December 16, 2019 Accepted December 17, 2019 Purpose: The aim of this study was to assess the change in thickness of the roof of the glenoid fossa (RGF) in patients undergoing orthognathic surgery using cone-beam computed tomography (CBCT) images. Methods: This retrospective study measured the thickness of the RGF in 19 patients (10 males, 9 females) who underwent orthognathic surgery at Chosun University Dental Hospital. The thickness of the RGF was measured perpendicularly between the ‘glenoid fossa line’ and ‘middle cranial fossa line’ on parasagittal and paracoronal reconstructions. Results: The mean RGF thickness increased from 0.83±0.44 mm to 0.86±0.46 mm after surgery. The average change in thickness of the RGF was 0.17±0.18 mm. The thickness of the RGF in the temporomandibular joint (TMJ) showed no significant difference by sex, and the change in thickness of the TMJ did not vary by surgical method. Conclusions: We found that the thickness of the RGF increased after orthognathic surgery, as revealed by CBCT. Further studies including larger numbers of subjects and long-term follow-up are needed to confirm the results of this study.
目的:本研究的目的是利用锥束计算机断层扫描(CBCT)图像评估正颌手术患者关节盂窝(RGF)顶部厚度的变化。方法:本回顾性研究测量了在朝鲜大学牙科医院接受正颌手术的19例患者(10男9女)的RGF厚度。在矢状面和冠状面重建时,垂直测量“盂窝线”和“颅中窝线”之间RGF的厚度。结果:术后RGF平均厚度由0.83±0.44 mm增加至0.86±0.46 mm。RGF厚度的平均变化为0.17±0.18 mm。颞下颌关节(TMJ) RGF的厚度在性别上无显著差异,手术方式对TMJ厚度的变化无显著影响。结论:我们发现正颌手术后RGF的厚度增加,CBCT显示。需要进一步的研究,包括更大数量的受试者和长期随访来证实本研究的结果。
{"title":"Assessment of the Thickness of the Roof of the Glenoid Fossa Using Cone Beam Computed Tomography in Orthognathic Surgery Patients: A Preliminary Study","authors":"Hyun-Jeong Park, Yo-Seob Seo, Sung-Hoon Lim, J. Ryu","doi":"10.14476/jomp.2019.44.4.154","DOIUrl":"https://doi.org/10.14476/jomp.2019.44.4.154","url":null,"abstract":"Received November 24, 2019 Revised December 16, 2019 Accepted December 17, 2019 Purpose: The aim of this study was to assess the change in thickness of the roof of the glenoid fossa (RGF) in patients undergoing orthognathic surgery using cone-beam computed tomography (CBCT) images. Methods: This retrospective study measured the thickness of the RGF in 19 patients (10 males, 9 females) who underwent orthognathic surgery at Chosun University Dental Hospital. The thickness of the RGF was measured perpendicularly between the ‘glenoid fossa line’ and ‘middle cranial fossa line’ on parasagittal and paracoronal reconstructions. Results: The mean RGF thickness increased from 0.83±0.44 mm to 0.86±0.46 mm after surgery. The average change in thickness of the RGF was 0.17±0.18 mm. The thickness of the RGF in the temporomandibular joint (TMJ) showed no significant difference by sex, and the change in thickness of the TMJ did not vary by surgical method. Conclusions: We found that the thickness of the RGF increased after orthognathic surgery, as revealed by CBCT. Further studies including larger numbers of subjects and long-term follow-up are needed to confirm the results of this study.","PeriodicalId":91332,"journal":{"name":"Journal of oral medicine and pain","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45331550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Outcomes of Venlafaxine and Duloxetine in Refractory Burning Mouth Syndrome Patients 文拉法辛和度洛西汀治疗难治性灼口综合征的疗效
Pub Date : 2019-09-30 DOI: 10.14476/JOMP.2019.44.3.83
Moon-Jong Kim, H. Kho
Received July 31, 2019 Revised August 30, 2019 Accepted August 30, 2019 Purpose: Venlafaxine and duloxetine have been shown to be effective in the treatment of neuropathic pain disorders. However, knowledge about the efficacy of venlafaxine and duloxetine on burning mouth syndrome (BMS) is still insufficient. The purpose of this study was to investigate the efficacy of venlafaxine and duloxetine on refractory BMS patients. Methods: Twelve refractory BMS patients who were prescribed venlafaxine or duloxetine were included in this study. These patients did not respond to previous administration of clonazepam, alpha-lipoic acid, gabapentin, and nortriptyline. All participants were the primary type of BMS patients who had no local and systemic factors related to the oral burning sensation. The intensities of oral symptoms following venlafaxine or duloxetine administration were compared with those before administration and at baseline. Results: Venlafaxine and duloxetine were prescribed to four and nine patients, respectively. One patient was prescribed both medications in turn. Among them, only two patients showed improvement of oral symptoms without side effects. In the other ten patients, symptoms failed to improve. Six of them reported that the drug was ineffective, and four of them stopped taking the medications on their own due to intolerable side effects, such as insomnia, constipation, drowsiness, dizziness, and xerostomia. Conclusions: Venlafaxine and duloxetine may only relieve oral symptoms in a minority of refractory BMS patients. Further large-scale studies are needed to determine the potential clinical factors that could predict the efficacy of venlafaxine and duloxetine.
目的:文拉法辛和度洛西汀已被证明可有效治疗神经性疼痛疾病。然而,关于文拉法辛和度洛西汀治疗灼口综合征(BMS)的疗效的知识仍然不足。本研究的目的是探讨文拉法辛和度洛西汀对难治性BMS患者的疗效。方法:选取12例服用文拉法辛或度洛西汀的难治性BMS患者作为研究对象。这些患者对先前给予氯硝西泮、α -硫辛酸、加巴喷丁和去甲替林没有反应。所有的参与者都是BMS患者的主要类型,没有与口腔烧灼感相关的局部和全身因素。将文拉法辛或度洛西汀给药后的口腔症状强度与给药前和基线时进行比较。结果:文拉法辛处方4例,度洛西汀处方9例。一名患者轮流服用这两种药物。其中,仅有2例患者口腔症状改善且无副作用。另外10名患者的症状没有改善。其中6人报告说药物无效,其中4人因失眠、便秘、嗜睡、头晕、口干等难以忍受的副作用而自行停止服用。结论:文拉法辛和度洛西汀仅能缓解少数难治性BMS患者的口腔症状。需要进一步的大规模研究来确定可能预测文拉法辛和度洛西汀疗效的潜在临床因素。
{"title":"Treatment Outcomes of Venlafaxine and Duloxetine in Refractory Burning Mouth Syndrome Patients","authors":"Moon-Jong Kim, H. Kho","doi":"10.14476/JOMP.2019.44.3.83","DOIUrl":"https://doi.org/10.14476/JOMP.2019.44.3.83","url":null,"abstract":"Received July 31, 2019 Revised August 30, 2019 Accepted August 30, 2019 Purpose: Venlafaxine and duloxetine have been shown to be effective in the treatment of neuropathic pain disorders. However, knowledge about the efficacy of venlafaxine and duloxetine on burning mouth syndrome (BMS) is still insufficient. The purpose of this study was to investigate the efficacy of venlafaxine and duloxetine on refractory BMS patients. Methods: Twelve refractory BMS patients who were prescribed venlafaxine or duloxetine were included in this study. These patients did not respond to previous administration of clonazepam, alpha-lipoic acid, gabapentin, and nortriptyline. All participants were the primary type of BMS patients who had no local and systemic factors related to the oral burning sensation. The intensities of oral symptoms following venlafaxine or duloxetine administration were compared with those before administration and at baseline. Results: Venlafaxine and duloxetine were prescribed to four and nine patients, respectively. One patient was prescribed both medications in turn. Among them, only two patients showed improvement of oral symptoms without side effects. In the other ten patients, symptoms failed to improve. Six of them reported that the drug was ineffective, and four of them stopped taking the medications on their own due to intolerable side effects, such as insomnia, constipation, drowsiness, dizziness, and xerostomia. Conclusions: Venlafaxine and duloxetine may only relieve oral symptoms in a minority of refractory BMS patients. Further large-scale studies are needed to determine the potential clinical factors that could predict the efficacy of venlafaxine and duloxetine.","PeriodicalId":91332,"journal":{"name":"Journal of oral medicine and pain","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47811243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vestibular Schwannoma Presenting with Orofacial Dysesthesia: A Case Report 前庭神经鞘瘤表现为口面部感觉障碍1例报告
Pub Date : 2019-09-30 DOI: 10.14476/JOMP.2019.44.3.123
I. H. Park, Seurin Kim, Younjung Park, Hyung-Joon Ahn, S. Kim, Jong-hoon Choi, J. Kwon
Received July 23, 2019 Revised August 9, 2019 Accepted August 9, 2019 Vestibular schwannoma, also known as acoustic neuroma, is a rare benign brainstem tumor surrounding the vestibular division of the 8th cranial nerve. The presenting symptoms are hearing loss, tinnitus, and dizziness. Unabated growth can compress 5th (trigeminal nerve) and 7th (facial nerve) cranial nerve, which can cause nerve dysfunction such as orofacial pain, sensory abnormalities, or trigeminal neuralgia. We report a 51-year-old woman who presented with orofacial dysesthesia on her left side of the face with abnormal findings on 5th cranial nerve and 8th (vestibulocochlear nerve) cranial nerve examination. Brain magnetic resonance imaging scan revealed cerebellopontine angle tumor. She was referred to a neurosurgeon and diagnosed with vestibular schwannoma.
前庭神经鞘瘤,又称听神经瘤,是一种少见的良性脑干肿瘤,位于第8脑神经前庭区周围。主要症状是听力丧失、耳鸣和头晕。不减不减的生长可压迫第5(三叉神经)和第7(面神经)颅神经,引起口面痛、感觉异常或三叉神经痛等神经功能障碍。我们报告了一位51岁的女性,她表现为左侧面部感觉异常,并在第5脑神经和第8脑神经(前庭耳蜗神经)检查中发现异常。脑磁共振显示脑桥小脑角肿瘤。她被转介给神经外科医生,并被诊断为前庭神经鞘瘤。
{"title":"Vestibular Schwannoma Presenting with Orofacial Dysesthesia: A Case Report","authors":"I. H. Park, Seurin Kim, Younjung Park, Hyung-Joon Ahn, S. Kim, Jong-hoon Choi, J. Kwon","doi":"10.14476/JOMP.2019.44.3.123","DOIUrl":"https://doi.org/10.14476/JOMP.2019.44.3.123","url":null,"abstract":"Received July 23, 2019 Revised August 9, 2019 Accepted August 9, 2019 Vestibular schwannoma, also known as acoustic neuroma, is a rare benign brainstem tumor surrounding the vestibular division of the 8th cranial nerve. The presenting symptoms are hearing loss, tinnitus, and dizziness. Unabated growth can compress 5th (trigeminal nerve) and 7th (facial nerve) cranial nerve, which can cause nerve dysfunction such as orofacial pain, sensory abnormalities, or trigeminal neuralgia. We report a 51-year-old woman who presented with orofacial dysesthesia on her left side of the face with abnormal findings on 5th cranial nerve and 8th (vestibulocochlear nerve) cranial nerve examination. Brain magnetic resonance imaging scan revealed cerebellopontine angle tumor. She was referred to a neurosurgeon and diagnosed with vestibular schwannoma.","PeriodicalId":91332,"journal":{"name":"Journal of oral medicine and pain","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43982634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of oral medicine and pain
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