Pub Date : 2015-05-06DOI: 10.1186/S40810-014-0001-5
N. Boutros, R. Lajiness-O'Neill, Andrew Zillgitt, A. Richard, S. Bowyer
{"title":"EEG changes associated with autistic spectrum disorders","authors":"N. Boutros, R. Lajiness-O'Neill, Andrew Zillgitt, A. Richard, S. Bowyer","doi":"10.1186/S40810-014-0001-5","DOIUrl":"https://doi.org/10.1186/S40810-014-0001-5","url":null,"abstract":"","PeriodicalId":91583,"journal":{"name":"Neuropsychiatric electrophysiology","volume":"1 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2015-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/S40810-014-0001-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65756848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-06DOI: 10.1186/S40810-014-0002-4
V. Knott, D. Impey, J. Choueiry, Dylan Smith, S. de la Salle, Salman Saghir, Meaghan Smith, Elise Beaudry, V. Ilivitsky, A. Labelle
{"title":"An acute dose, randomized trial of the effects of CDP-Choline on Mismatch Negativity (MMN) in healthy volunteers stratified by deviance detection level","authors":"V. Knott, D. Impey, J. Choueiry, Dylan Smith, S. de la Salle, Salman Saghir, Meaghan Smith, Elise Beaudry, V. Ilivitsky, A. Labelle","doi":"10.1186/S40810-014-0002-4","DOIUrl":"https://doi.org/10.1186/S40810-014-0002-4","url":null,"abstract":"","PeriodicalId":91583,"journal":{"name":"Neuropsychiatric electrophysiology","volume":"1 1","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"2015-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/S40810-014-0002-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65756402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01Epub Date: 2015-12-18DOI: 10.1186/s40810-015-0014-8
Robert J Thoma, Jason Long, Mollie Monnig, Ronald A Yeo, Helen Petropoulos, Charles Gasparovic, Jessica Pommy, Paul G Mullins
Background: Impairment in auditory sensory gating (ASG) has been documented in alcohol dependence [1]. Likewise, it has been shown that ASG becomes abnormal during alcohol administration in otherwise healthy individuals [2]. Patterns of gating abnormality associated with alcohol use are likely associated with an alcohol responsive neurochemical like glutamate (Glu), particularly since it is well-established that alcohol affects NMDA receptors and that glutamatergic functioning is abnormal in both acute alcohol use and in alcohol dependence [3]. Hence, a link between Glu metabolite levels and ASG was hypothesized. It was first hypothesized that Glu and ASG abnormality would be found in groups with alcohol dependence. A second hypothesis was that across groups, greater Glu would predict reduced ASG.
Methods: Groups were comprised of healthy, non-drinking controls (Controls, N = 4), individuals with current alcohol dependence (AUD-current, N = 6), and with alcohol dependence in remission for at least 1 year (AUD-remission, N = 6). Participants underwent a diagnostic assessment for alcohol consumption, MRI, 1H-MRS for in vivo assessment of Glu and other metabolites, and MEG scanning during a paired click protocol. ASG was computed as the ratio of the source strength of the 50 ms component in the event related field (ERF) to the second click in the pair divided by the source strength of the 50 ms component to the first click in the pair.
Results: Univariate MANOVAs controlling for age and gender revealed a significant effect for group on Glu and ASG, such that ASG ratios were significantly elevated, implying weakened gating. Glu concentration was reduced in AUD-current relative to the other two groups. Further analysis revealed that when additionally controlling for the group effect, reduced Glu predicted increasing impairment in ASG.
Conclusions: The overall results were consistent with the hypothesis that differences in Glu metabolite levels associated with alcohol dependence result in impaired ASG.
{"title":"<sup>1</sup>H-MRS glutamate level predicts auditory sensory gating in alcohol dependence: Preliminary results.","authors":"Robert J Thoma, Jason Long, Mollie Monnig, Ronald A Yeo, Helen Petropoulos, Charles Gasparovic, Jessica Pommy, Paul G Mullins","doi":"10.1186/s40810-015-0014-8","DOIUrl":"10.1186/s40810-015-0014-8","url":null,"abstract":"<p><strong>Background: </strong>Impairment in auditory sensory gating (ASG) has been documented in alcohol dependence [1]. Likewise, it has been shown that ASG becomes abnormal during alcohol administration in otherwise healthy individuals [2]. Patterns of gating abnormality associated with alcohol use are likely associated with an alcohol responsive neurochemical like glutamate (Glu), particularly since it is well-established that alcohol affects NMDA receptors and that glutamatergic functioning is abnormal in both acute alcohol use and in alcohol dependence [3]. Hence, a link between Glu metabolite levels and ASG was hypothesized. It was first hypothesized that Glu and ASG abnormality would be found in groups with alcohol dependence. A second hypothesis was that across groups, greater Glu would predict reduced ASG.</p><p><strong>Methods: </strong>Groups were comprised of healthy, non-drinking controls (Controls, <i>N</i> = 4), individuals with current alcohol dependence (AUD-current, <i>N</i> = 6), and with alcohol dependence in remission for at least 1 year (AUD-remission, <i>N</i> = 6). Participants underwent a diagnostic assessment for alcohol consumption, MRI, 1H-MRS for in vivo assessment of Glu and other metabolites, and MEG scanning during a paired click protocol. ASG was computed as the ratio of the source strength of the 50 ms component in the event related field (ERF) to the second click in the pair divided by the source strength of the 50 ms component to the first click in the pair.</p><p><strong>Results: </strong>Univariate MANOVAs controlling for age and gender revealed a significant effect for group on Glu and ASG, such that ASG ratios were significantly elevated, implying weakened gating. Glu concentration was reduced in AUD-current relative to the other two groups. Further analysis revealed that when additionally controlling for the group effect, reduced Glu predicted increasing impairment in ASG.</p><p><strong>Conclusions: </strong>The overall results were consistent with the hypothesis that differences in Glu metabolite levels associated with alcohol dependence result in impaired ASG.</p>","PeriodicalId":91583,"journal":{"name":"Neuropsychiatric electrophysiology","volume":"1 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39000653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1186/s40810-015-0003-y
S. R. Devore Best
{"title":"Combined ketamine and transcranial magnetic stimulation for treatment resistant depression in the context of chronic OCD: a case report","authors":"S. R. Devore Best","doi":"10.1186/s40810-015-0003-y","DOIUrl":"https://doi.org/10.1186/s40810-015-0003-y","url":null,"abstract":"","PeriodicalId":91583,"journal":{"name":"Neuropsychiatric electrophysiology","volume":"1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40810-015-0003-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65756415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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