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Brain research. Molecular brain research最新文献

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Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata. 5 -羟色胺2A、2C和3受体mRNA在脊髓和延髓中的分布。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00049-3
M. Fonseca, Yan G Ni, D. Dunning, R. Miledi
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引用次数: 109
Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study. 内聚寡肽酶A在大鼠中枢神经系统中的表达:非放射性原位杂交研究。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00066-3
M. Hayashi, R. S. Pires, N. Rebouças, L. Britto, A. Camargo
{"title":"Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study.","authors":"M. Hayashi, R. S. Pires, N. Rebouças, L. Britto, A. Camargo","doi":"10.1016/S0169-328X(01)00066-3","DOIUrl":"https://doi.org/10.1016/S0169-328X(01)00066-3","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"51 1","pages":"86-93"},"PeriodicalIF":0.0,"publicationDate":"2001-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85716565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2. NF-Y结合是神经元芳香l -氨基酸脱羧酶基因启动子被poup结构域蛋白Brn-2转激活所必需的。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00063-8
C. Dugast, M. Weber
{"title":"NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2.","authors":"C. Dugast, M. Weber","doi":"10.1016/S0169-328X(01)00063-8","DOIUrl":"https://doi.org/10.1016/S0169-328X(01)00063-8","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"122 1","pages":"58-70"},"PeriodicalIF":0.0,"publicationDate":"2001-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86445735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase. 通过盐酸盐受体和PI3激酶激活纹状体神经元p44/p42 MAP激酶。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00071-7
Gordon Fuller, Karen Veitch, Lai Kwan Ho, L. Cruise, B. Morris
{"title":"Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.","authors":"Gordon Fuller, Karen Veitch, Lai Kwan Ho, L. Cruise, B. Morris","doi":"10.1016/S0169-328X(01)00071-7","DOIUrl":"https://doi.org/10.1016/S0169-328X(01)00071-7","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"193 1","pages":"126-32"},"PeriodicalIF":0.0,"publicationDate":"2001-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79693866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells. Forskolin通过抑制有丝分裂原活化蛋白激酶抑制C6细胞诱导型一氧化氮合酶mRNA的表达。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00047-X
J. Won, J. K. Lee, H. Suh
{"title":"Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells.","authors":"J. Won, J. K. Lee, H. Suh","doi":"10.1016/S0169-328X(01)00047-X","DOIUrl":"https://doi.org/10.1016/S0169-328X(01)00047-X","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"10 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2001-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84196743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice. 转基因ALS小鼠脊髓运动神经元线粒体DNA的氧化损伤。
Pub Date : 2001-04-18 DOI: 10.1016/S0169-328X(01)00029-8
H. Warita, Takeshi Hayashi, T. Murakami, Y. Manabe, K. Abe
{"title":"Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice.","authors":"H. Warita, Takeshi Hayashi, T. Murakami, Y. Manabe, K. Abe","doi":"10.1016/S0169-328X(01)00029-8","DOIUrl":"https://doi.org/10.1016/S0169-328X(01)00029-8","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"3 1","pages":"147-52"},"PeriodicalIF":0.0,"publicationDate":"2001-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89835928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 109
Gene expression profile in Alzheimer's brain screened by molecular indexing. 用分子索引法筛选阿尔茨海默病脑基因表达谱。
Pub Date : 2001-02-19 DOI: 10.1016/S0169-328X(00)00223-0
M. Doyu, K. Sawada, N. Mitsuma, J. Niwa, M. Yoshimoto, Y. Fujii, G. Sobue, K. Kato
{"title":"Gene expression profile in Alzheimer's brain screened by molecular indexing.","authors":"M. Doyu, K. Sawada, N. Mitsuma, J. Niwa, M. Yoshimoto, Y. Fujii, G. Sobue, K. Kato","doi":"10.1016/S0169-328X(00)00223-0","DOIUrl":"https://doi.org/10.1016/S0169-328X(00)00223-0","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"22 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2001-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87518277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells. 生长抑素受体sst2对胶质瘤细胞生长因子信号级联的影响。
Pub Date : 2001-02-19 DOI: 10.1016/S0169-328X(00)00225-4
J. Held-Feindt, F. Forstreuter, T. Pufe, R. Mentlein
{"title":"Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells.","authors":"J. Held-Feindt, F. Forstreuter, T. Pufe, R. Mentlein","doi":"10.1016/S0169-328X(00)00225-4","DOIUrl":"https://doi.org/10.1016/S0169-328X(00)00225-4","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"6 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"2001-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82060896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Diffuse brain injury induces local expression of Na+/myo-inositol cotransporter in the rat brain. 弥漫性脑损伤诱导Na+/肌醇共转运蛋白在大鼠脑内的局部表达。
Pub Date : 2001-01-31 DOI: 10.1016/s0168-0102(00)81560-6
T. Ueda, A. Iwata, H. Komatsu, N. Aihara, K. Yamada, S. Ugawa, S. Shimada
{"title":"Diffuse brain injury induces local expression of Na+/myo-inositol cotransporter in the rat brain.","authors":"T. Ueda, A. Iwata, H. Komatsu, N. Aihara, K. Yamada, S. Ugawa, S. Shimada","doi":"10.1016/s0168-0102(00)81560-6","DOIUrl":"https://doi.org/10.1016/s0168-0102(00)81560-6","url":null,"abstract":"","PeriodicalId":9159,"journal":{"name":"Brain research. Molecular brain research","volume":"38 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"2001-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89918829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Activation of nuclear factor-kappaB in the rabbit spinal cord following ischemia and reperfusion. 兔脊髓缺血再灌注后核因子κ b的活化。
S Zhang, T Tobaru, J A Zivin, D A Shackelford

The transcription factor NF-kappaB is a ubiquitously expressed inducible regulator of a broad range of genes. Recent studies have shown that activation of NF-kappaB predominantly is associated with protecting cells from apoptosis, but in some cell models, it is associated with promoting cell death. We used a rabbit spinal cord model of reversible ischemia to determine whether NF-kappaB was activated by ischemic and reperfusion injury. DNA binding activity of NF-kappaB was analyzed by an electrophoretic mobility shift assay in animals subjected to varying durations of ischemia and reperfusion. A low level of constitutive NF-kappaB DNA binding was detected in normal lumbar spinal cord extracts. Animals subjected to a short ischemic insult of 15 min, from which they usually recover neurologic function, had a significant increase in the amount of active NF-kappaB in nuclear extracts after 18 h reperfusion. There was no change in nuclear NF-kappaB DNA binding in animals occluded for 60 min that are permanently paraplegic and exhibit extensive neuropathological damage. The amount of deoxycholate-releasable NF-kappaB sequestered in the cytosol, however, decreased after 18 h reperfusion in rabbits occluded for 60 min. This correlated with a decrease in the amount of RelA(p65) NF-kappaB subunit. The results suggest that activation of NF-kappaB after a limited ischemic injury may participate in a neuroprotective response and not in cell death.

转录因子NF-kappaB是一种广泛表达的基因诱导调节因子。最近的研究表明NF-kappaB的激活主要与保护细胞免于凋亡有关,但在某些细胞模型中,它与促进细胞死亡有关。我们采用兔脊髓可逆性缺血模型,观察NF-kappaB是否在缺血和再灌注损伤后被激活。通过电泳迁移位移法分析不同缺血再灌注时间动物NF-kappaB的DNA结合活性。在正常的腰椎脊髓提取物中检测到低水平的构成性NF-kappaB DNA结合。经15分钟短缺血损伤的动物通常会恢复神经功能,再灌注18 h后核提取物中活性NF-kappaB的含量显著增加。在永久性截瘫和广泛神经病理损伤的动物中,核NF-kappaB DNA结合没有变化。然而,在封闭60分钟的家兔中,再灌注18小时后,胞浆中分离的脱氧胆碱释放NF-kappaB的数量减少。这与RelA(p65) NF-kappaB亚基的数量减少有关。结果表明,有限缺血性损伤后NF-kappaB的激活可能参与神经保护反应,而不是参与细胞死亡。
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引用次数: 0
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Brain research. Molecular brain research
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