首页 > 最新文献

Advances in epidemiology最新文献

英文 中文
Forecasting Age-Specific Brain Cancer Mortality Rates Using Functional Data Analysis Models 使用功能数据分析模型预测年龄特异性脑癌死亡率
Pub Date : 2015-02-09 DOI: 10.1155/2015/721592
K. Pokhrel, C. Tsokos
Incidence and mortality rates are considered as a guideline for planning public health strategies and allocating resources. We apply functional data analysis techniques to model age-specific brain cancer mortality trend and forecast entire age-specific functions using exponential smoothing state-space models. The age-specific mortality curves are decomposed using principal component analysis and fit functional time series model with basis functions. Nonparametric smoothing methods are used to mitigate the existing randomness in the observed data. We use functional time series model on age-specific brain cancer mortality rates and forecast mortality curves with prediction intervals using exponential smoothing state-space model. We also present a disparity of brain cancer mortality rates among the age groups together with the rate of change of mortality rates. The data were obtained from the Surveillance, Epidemiology and End Results (SEER) program of the United States. The brain cancer mortality rates, classified under International Classification Disease code ICD-O-3, were extracted from SEERStat software.
发病率和死亡率被视为规划公共卫生战略和分配资源的准则。我们应用功能数据分析技术对特定年龄的脑癌死亡率趋势进行建模,并使用指数平滑状态空间模型预测整个特定年龄的函数。采用主成分分析法对年龄死亡率曲线进行分解,并拟合带有基函数的函数时间序列模型。采用非参数平滑方法减轻观测数据中存在的随机性。我们使用函数时间序列模型对年龄特异性脑癌死亡率进行预测,并使用指数平滑状态空间模型预测具有预测区间的死亡率曲线。我们还展示了不同年龄组之间脑癌死亡率的差异以及死亡率的变化率。数据来自美国的监测、流行病学和最终结果(SEER)项目。根据国际疾病分类代码ICD-O-3分类的脑癌死亡率从SEERStat软件中提取。
{"title":"Forecasting Age-Specific Brain Cancer Mortality Rates Using Functional Data Analysis Models","authors":"K. Pokhrel, C. Tsokos","doi":"10.1155/2015/721592","DOIUrl":"https://doi.org/10.1155/2015/721592","url":null,"abstract":"Incidence and mortality rates are considered as a guideline for planning public health strategies and allocating resources. We apply functional data analysis techniques to model age-specific brain cancer mortality trend and forecast entire age-specific functions using exponential smoothing state-space models. The age-specific mortality curves are decomposed using principal component analysis and fit functional time series model with basis functions. Nonparametric smoothing methods are used to mitigate the existing randomness in the observed data. We use functional time series model on age-specific brain cancer mortality rates and forecast mortality curves with prediction intervals using exponential smoothing state-space model. We also present a disparity of brain cancer mortality rates among the age groups together with the rate of change of mortality rates. The data were obtained from the Surveillance, Epidemiology and End Results (SEER) program of the United States. The brain cancer mortality rates, classified under International Classification Disease code ICD-O-3, were extracted from SEERStat software.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"36 5 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2015-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88095283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Association between Obesity and Cancer: An Analysis Using the Competing Risk Regression Approach 肥胖与癌症之间的关系:使用竞争风险回归方法的分析
Pub Date : 2015-01-12 DOI: 10.1155/2015/132961
M. Bimali, Jianghua He
Cox model has been the commonly used method in past analyses of association between obesity and the risk estimates of cancer in situations where the subjects have also died (or could die) of noncancer events (competing events). The Cox model does not address the presence of competing events convincingly. The competing risk approach accommodates the fact that individuals who died of other causes (competing events) will never die of cancer and thus provides more realistic estimates. This study uses the competing risk approach to study the association of obesity and cancer mortality and compare the analysis results with those based on the traditional Cox model. It was seen that while the cause-specific hazard rate of cancer is significantly higher for obese population compared to normal weight population, the difference is not significant using competing risk approach. We demonstrated that higher cause-specific hazard rate does not necessarily imply higher incidence rate and in situations involving competing events we recommend using competing risk approach in addition to the Cox regression model.
Cox模型一直是过去分析肥胖与癌症风险评估之间关系的常用方法,在这种情况下,受试者也死于(或可能死于)非癌症事件(竞争事件)。考克斯模型没有令人信服地解决竞争事件的存在。竞争风险方法考虑到这样一个事实,即死于其他原因(竞争事件)的个体永远不会死于癌症,因此提供了更现实的估计。本研究采用竞争风险方法研究肥胖与癌症死亡率的关系,并与传统Cox模型的分析结果进行比较。研究发现,虽然肥胖人群的癌症原因特异性危险率明显高于正常体重人群,但使用竞争风险方法,差异不显著。我们证明了较高的原因特异性危险率并不一定意味着较高的发病率,在涉及竞争事件的情况下,我们建议在Cox回归模型之外使用竞争风险方法。
{"title":"Association between Obesity and Cancer: An Analysis Using the Competing Risk Regression Approach","authors":"M. Bimali, Jianghua He","doi":"10.1155/2015/132961","DOIUrl":"https://doi.org/10.1155/2015/132961","url":null,"abstract":"Cox model has been the commonly used method in past analyses of association between obesity and the risk estimates of cancer in situations where the subjects have also died (or could die) of noncancer events (competing events). The Cox model does not address the presence of competing events convincingly. The competing risk approach accommodates the fact that individuals who died of other causes (competing events) will never die of cancer and thus provides more realistic estimates. This study uses the competing risk approach to study the association of obesity and cancer mortality and compare the analysis results with those based on the traditional Cox model. It was seen that while the cause-specific hazard rate of cancer is significantly higher for obese population compared to normal weight population, the difference is not significant using competing risk approach. We demonstrated that higher cause-specific hazard rate does not necessarily imply higher incidence rate and in situations involving competing events we recommend using competing risk approach in addition to the Cox regression model.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"4 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81388203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Epidemiological Transition in Urban Population of Maharashtra 马哈拉施特拉邦城市人口的流行病学转变
Pub Date : 2014-11-18 DOI: 10.1155/2014/328102
Rahul Koli, Srinivas Goli, R. Doshi
Our objective is to assess epidemiological transition in urban Maharashtra in India in past two decades. We used the medically certified causes of death (MCCD) data from urban areas of Maharashtra, 1990–2006. Cause-specific death rate was estimated, standardized for age groups, and projected by using an exponential linear regression model. The results indicate that the burden of mortality due to noncommunicable conditions increased by 25% between 1990 and 2006 and will add 20% more by 2020. Among specific causes, the “diseases of the circulatory system” were consistently the leading CoD between 1990 and 2006. The “infectious and parasitic disease” and “diseases related to respiratory system” were the second and third leading causes of death, respectively. For children and young population, the leading cause of death was the “certain conditions originating in the prenatal period” and “injury and poisoning,” respectively, among both sexes. Among adults, the leading cause of death was “infectious and parasitic diseases.” In case of the adult female and elderly population, “diseases of circulatory system” caused the most deaths. Overall the findings foster that socioeconomically developed and demographically advanced urban Maharashtra bears the double burden of disease-specific mortality.
我们的目标是评估过去二十年来印度马哈拉施特拉邦城市的流行病学转变。我们使用了1990-2006年马哈拉施特拉邦城市地区医学证明的死亡原因(MCCD)数据。对死因特异性死亡率进行估计,对年龄组进行标准化,并使用指数线性回归模型进行预测。结果表明,1990年至2006年期间,非传染性疾病造成的死亡负担增加了25%,到2020年将再增加20%。在具体原因中,“循环系统疾病”在1990年至2006年期间一直是主要的死因。“传染病和寄生虫病”和“与呼吸系统有关的疾病”分别是第二和第三大死亡原因。在儿童和青年人口中,男女死亡的主要原因分别是"产前产生的某些情况"和"伤害和中毒"。在成年人中,死亡的主要原因是“传染病和寄生虫病”。在成年女性和老年人中,“循环系统疾病”导致的死亡最多。总体而言,研究结果表明,社会经济发达和人口发达的马哈拉施特拉邦城市承受着特定疾病死亡率的双重负担。
{"title":"Epidemiological Transition in Urban Population of Maharashtra","authors":"Rahul Koli, Srinivas Goli, R. Doshi","doi":"10.1155/2014/328102","DOIUrl":"https://doi.org/10.1155/2014/328102","url":null,"abstract":"Our objective is to assess epidemiological transition in urban Maharashtra in India in past two decades. We used the medically certified causes of death (MCCD) data from urban areas of Maharashtra, 1990–2006. Cause-specific death rate was estimated, standardized for age groups, and projected by using an exponential linear regression model. The results indicate that the burden of mortality due to noncommunicable conditions increased by 25% between 1990 and 2006 and will add 20% more by 2020. Among specific causes, the “diseases of the circulatory system” were consistently the leading CoD between 1990 and 2006. The “infectious and parasitic disease” and “diseases related to respiratory system” were the second and third leading causes of death, respectively. For children and young population, the leading cause of death was the “certain conditions originating in the prenatal period” and “injury and poisoning,” respectively, among both sexes. Among adults, the leading cause of death was “infectious and parasitic diseases.” In case of the adult female and elderly population, “diseases of circulatory system” caused the most deaths. Overall the findings foster that socioeconomically developed and demographically advanced urban Maharashtra bears the double burden of disease-specific mortality.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"12 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2014-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87610949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Effect of Early Initiation of Breastfeeding on Neonatal Mortality among Low Birth Weight in Aceh Province, Indonesia: An Unmatched Case Control Study 印度尼西亚亚齐省早期开始母乳喂养对低出生体重新生儿死亡率的影响:一项无与伦比的病例对照研究
Pub Date : 2014-11-11 DOI: 10.1155/2014/358692
Satrinawati Berkat, R. Sutan
Background. Early initiation of breastfeeding is the breastfeed that is received by the baby within the first hour of birth. It is recommended to reduce infant mortality and illness. Objective. To assess the effect of early initiation of breastfeeding on neonatal mortality for low birth weight in Aceh province, Indonesia. Method. In this qualitative study unmatched case controls were used as the design. Data was collected in 8 districts in Aceh province, Indonesia, between January and December 2012. The total sample for this study was 500 LBW who were born between 2010 and 2012, subdivided into 250 LBW who died in neonatal period and 250 LBW who survived during neonatal period. Result. Thermal care and hygienic practice were not significantly associated with neonatal mortality among LBW. Feeding and early initiation of breastfeeding were associated. Discussion. Early initiation of breastfeeding had an effect on neonatal mortality for the low birth weight in Aceh province, Indonesia. The risk of mortality was decreased for those neonates who accepted breast milk within the first hour after birth. Therefore it is concluded that a new strategy to promote and improve the coverage of the initiation of breastfeeding is needed.
背景。早期母乳喂养是指婴儿在出生后一小时内接受的母乳喂养。建议降低婴儿死亡率和发病率。目标。评估早期开始母乳喂养对印度尼西亚亚齐省低出生体重新生儿死亡率的影响。方法。本定性研究采用不匹配病例对照作为设计。2012年1月至12月期间在印度尼西亚亚齐省的8个县收集了数据。本研究的总样本为2010年至2012年出生的500名LBW,其中250名LBW在新生儿期死亡,250名LBW在新生儿期存活。结果。热护理和卫生实践与低体重新生儿死亡率无显著相关。喂养和早期开始母乳喂养是相关的。讨论。在印度尼西亚亚齐省,早期开始母乳喂养对低出生体重新生儿死亡率有影响。在出生后一小时内接受母乳喂养的新生儿死亡风险降低。因此,结论是需要一项新的战略来促进和提高开始母乳喂养的覆盖率。
{"title":"The Effect of Early Initiation of Breastfeeding on Neonatal Mortality among Low Birth Weight in Aceh Province, Indonesia: An Unmatched Case Control Study","authors":"Satrinawati Berkat, R. Sutan","doi":"10.1155/2014/358692","DOIUrl":"https://doi.org/10.1155/2014/358692","url":null,"abstract":"Background. Early initiation of breastfeeding is the breastfeed that is received by the baby within the first hour of birth. It is recommended to reduce infant mortality and illness. Objective. To assess the effect of early initiation of breastfeeding on neonatal mortality for low birth weight in Aceh province, Indonesia. Method. In this qualitative study unmatched case controls were used as the design. Data was collected in 8 districts in Aceh province, Indonesia, between January and December 2012. The total sample for this study was 500 LBW who were born between 2010 and 2012, subdivided into 250 LBW who died in neonatal period and 250 LBW who survived during neonatal period. Result. Thermal care and hygienic practice were not significantly associated with neonatal mortality among LBW. Feeding and early initiation of breastfeeding were associated. Discussion. Early initiation of breastfeeding had an effect on neonatal mortality for the low birth weight in Aceh province, Indonesia. The risk of mortality was decreased for those neonates who accepted breast milk within the first hour after birth. Therefore it is concluded that a new strategy to promote and improve the coverage of the initiation of breastfeeding is needed.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2014-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81895109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Prevalence and Determinants of Appropriate Health Seeking Behaviour among Known Diabetics: Results from a Community-Based Survey 已知糖尿病患者中适当求医行为的患病率和决定因素:一项基于社区的调查结果
Pub Date : 2014-11-11 DOI: 10.1155/2014/793286
Sheleaswani Inche Zainal Abidin, R. Sutan, K. Shamsuddin
Introduction. Living with diabetes requires patients to have good self-monitoring of their disease and treatment. Appropriate health seeking behavior is important to minimize complications and improve quality of life. Methodology. A community-based, cross-sectional study of disease events and experiences from diagnosis to the time of study was conducted among 460 known diabetics in Tanjong Karang district. The aim of this study was to describe the current pattern of health seeking behavior and its determinants among rural communities. Appropriate diabetic health services utilization was defined as using modern treatment either through oral hypoglycemics or insulin injections, obtained from either a public or private health facility. Result. 85.9% of respondents reported having appropriate health seeking behaviour at the time of the house-to-house community survey. Multivariate logistic regression analysis revealed that appropriate health seeking behaviour was significantly associated with age of respondent, presence of comorbidity, family history of diabetes, distance from health facilities, perceived family support, and history of early treatment seeking at diagnosis and duration of disease. Conclusion. The present population has better appropriate health seeking behavior and provision of knowledge with strong family support in diabetic care which are important in control and prevention of diabetic complication that need to be emphasized.
介绍。糖尿病患者需要对自己的病情和治疗进行良好的自我监测。适当的健康寻求行为对于减少并发症和提高生活质量非常重要。方法。对丹戎卡朗地区460名已知糖尿病患者进行了一项基于社区的、从诊断到研究时间的疾病事件和经历的横断面研究。本研究的目的是描述当前农村社区的求医行为模式及其决定因素。适当利用糖尿病保健服务的定义是,通过从公共或私人保健设施获得的口服降糖药或胰岛素注射,使用现代治疗方法。结果:85.9%的应答者报告在挨家挨户社区调查时有适当的求医行为。多因素logistic回归分析显示,适当的求医行为与被调查者的年龄、合并症的存在、糖尿病家族史、与卫生设施的距离、感知到的家庭支持、诊断时的早期求医史和疾病持续时间显著相关。结论。目前人群在糖尿病护理中有较好的健康寻求行为和较强的家庭支持知识提供,这对糖尿病并发症的控制和预防具有重要意义,值得重视。
{"title":"Prevalence and Determinants of Appropriate Health Seeking Behaviour among Known Diabetics: Results from a Community-Based Survey","authors":"Sheleaswani Inche Zainal Abidin, R. Sutan, K. Shamsuddin","doi":"10.1155/2014/793286","DOIUrl":"https://doi.org/10.1155/2014/793286","url":null,"abstract":"Introduction. Living with diabetes requires patients to have good self-monitoring of their disease and treatment. Appropriate health seeking behavior is important to minimize complications and improve quality of life. Methodology. A community-based, cross-sectional study of disease events and experiences from diagnosis to the time of study was conducted among 460 known diabetics in Tanjong Karang district. The aim of this study was to describe the current pattern of health seeking behavior and its determinants among rural communities. Appropriate diabetic health services utilization was defined as using modern treatment either through oral hypoglycemics or insulin injections, obtained from either a public or private health facility. Result. 85.9% of respondents reported having appropriate health seeking behaviour at the time of the house-to-house community survey. Multivariate logistic regression analysis revealed that appropriate health seeking behaviour was significantly associated with age of respondent, presence of comorbidity, family history of diabetes, distance from health facilities, perceived family support, and history of early treatment seeking at diagnosis and duration of disease. Conclusion. The present population has better appropriate health seeking behavior and provision of knowledge with strong family support in diabetic care which are important in control and prevention of diabetic complication that need to be emphasized.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"2014 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2014-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75470467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Prevalence of Fascioliasis in Cattle Slaughtered in Sokoto Metropolitan Abattoir, Sokoto, Nigeria 尼日利亚索科托大都会屠宰场屠宰牛中片形吸虫病的流行情况
Pub Date : 2014-11-09 DOI: 10.1155/2014/247258
A. A. Magaji, K. Ibrahim, M. D. Salihu, M. Saulawa, A. A. Mohammed, A. Musawa
The prevalence of fascioliasis in cattle slaughtered in the Sokoto metropolitan abattoir was investigated. Faeces and bile samples were collected and processed using formal ether concentration technique. Gross lesions from 224 out of 1,313 slaughtered cattle were randomly selected and examined. Out of the 224 cattle examined, 95 (42.41%) were males and 129 (57.59%) were females. Out of 95 male cattle examined, 27 (28.42%) were infected and out of 129 females 35 (27.13%) were infected. Based on breed, infection rates were 31 (31.0%), and 31 (25.2%) for breeds of Sokoto Gudali and Red Bororo respectively. No infection was recorded in White Fulani breed. Lesions observed were more in males than in females and more in Red Bororo than in Sokoto Gudali. Overall, prevalence of infection with Fasciola was 27.68%. There was no statistically significant association between infection and breed and between infection and sex of the animals sampled . Regular treatment of all animals with an effective flukicide, as well as snail habitat control, tracing source of animals, public enlightenment about the disease, proper abattoir inspection, adequate and clean water supply to animals, and payment of compensation of condemned tissues and organs infested with the parasite by government were suggested.
对索科托大都会屠宰场屠宰的牛中片形吸虫病的流行情况进行了调查。收集粪便和胆汁标本,采用乙醚浓缩技术进行处理。从1313头屠宰牛中随机抽取224头的肉眼病变进行检查。224头牛中,雄性95头(42.41%),雌性129头(57.59%)。在检查的95头公牛中,27头(28.42%)被感染,129头母牛中35头(27.13%)被感染。按品种分,“古达利”和“红波罗罗”的感染率分别为31(31.0%)和31(25.2%)。白富拉尼品种无感染记录。观察到的病变男性多于女性,红Bororo多于Sokoto Gudali。总体而言,片形吸虫感染率为27.68%。感染与品种之间以及感染与所取样动物的性别之间没有统计学上的显著关联。建议用有效的杀虫剂定期治疗所有动物,控制蜗牛栖息地,追踪动物来源,公众对疾病的认识,适当的屠宰场检查,为动物提供充足和清洁的水,以及政府对被寄生虫感染的组织和器官进行赔偿。
{"title":"Prevalence of Fascioliasis in Cattle Slaughtered in Sokoto Metropolitan Abattoir, Sokoto, Nigeria","authors":"A. A. Magaji, K. Ibrahim, M. D. Salihu, M. Saulawa, A. A. Mohammed, A. Musawa","doi":"10.1155/2014/247258","DOIUrl":"https://doi.org/10.1155/2014/247258","url":null,"abstract":"The prevalence of fascioliasis in cattle slaughtered in the Sokoto metropolitan abattoir was investigated. Faeces and bile samples were collected and processed using formal ether concentration technique. Gross lesions from 224 out of 1,313 slaughtered cattle were randomly selected and examined. Out of the 224 cattle examined, 95 (42.41%) were males and 129 (57.59%) were females. Out of 95 male cattle examined, 27 (28.42%) were infected and out of 129 females 35 (27.13%) were infected. Based on breed, infection rates were 31 (31.0%), and 31 (25.2%) for breeds of Sokoto Gudali and Red Bororo respectively. No infection was recorded in White Fulani breed. Lesions observed were more in males than in females and more in Red Bororo than in Sokoto Gudali. Overall, prevalence of infection with Fasciola was 27.68%. There was no statistically significant association between infection and breed and between infection and sex of the animals sampled . Regular treatment of all animals with an effective flukicide, as well as snail habitat control, tracing source of animals, public enlightenment about the disease, proper abattoir inspection, adequate and clean water supply to animals, and payment of compensation of condemned tissues and organs infested with the parasite by government were suggested.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"55 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73133906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 48
Epidemiological Investigation of Canine Leishmaniasis in Southern Morocco 摩洛哥南部犬利什曼病流行病学调查
Pub Date : 2014-09-24 DOI: 10.1155/2014/104697
S. Boussaa, M. Kasbari, A. Mzabi, A. Boumezzough
Dogs are the major reservoir of Leishmania infantum, the causative agent of human and canine visceral leishmaniasis in the Mediterranean basin. In Morocco, canine leishmaniasis (CanL) is usually believed to be widespread mainly, if not only, in the northern regions and few data are available about the situation in southern parts of the country. Here, we report the results of a preliminary, clinical, and serological study carried out in 2004–2007, in four provinces of southern Morocco. Serological analyses were processed using two different Elisa techniques, a homemade Elisa test and IDVET commercial kit, and confirmed by two different western blot (WB) tests, homemade and LDBIO commercial kits. We highlighted the presence of CanL infection in southern regions, known until then as free of the disease: 19.8% (48/243) of examined dogs displayed clinical signs compatible with CanL and the seroprevalence was particularly high, respectively, 81.8% and 87.8% by Elisa and western blot tests. Our current developed and validated homemade (Elisa and WB) tools will be cost-effective and useful for next large-scale epidemiological studies on Moroccan leishmaniasis animal reservoir.
犬类是幼利什曼原虫的主要宿主,幼利什曼原虫是地中海盆地人类和犬内脏利什曼病的病原体。在摩洛哥,犬利什曼病(CanL)通常被认为主要(如果不是仅仅)在北部地区广泛传播,关于该国南部地区情况的数据很少。在这里,我们报告了2004-2007年在摩洛哥南部四个省进行的初步、临床和血清学研究的结果。采用两种不同的Elisa技术(自制Elisa试验和IDVET商用试剂盒)进行血清学分析,并采用两种不同的western blot (WB)试验(自制试剂盒和LDBIO商用试剂盒)进行确认。我们强调了CanL感染在南部地区的存在,直到那时才被称为无疾病:19.8%(48/243)的被检查犬表现出与CanL相符的临床症状,血清阳性率特别高,Elisa和western blot检测分别为81.8%和87.8%。我们目前开发和验证的自制(Elisa和WB)工具将具有成本效益,并可用于下一次摩洛哥利什曼病动物水库的大规模流行病学研究。
{"title":"Epidemiological Investigation of Canine Leishmaniasis in Southern Morocco","authors":"S. Boussaa, M. Kasbari, A. Mzabi, A. Boumezzough","doi":"10.1155/2014/104697","DOIUrl":"https://doi.org/10.1155/2014/104697","url":null,"abstract":"Dogs are the major reservoir of Leishmania infantum, the causative agent of human and canine visceral leishmaniasis in the Mediterranean basin. In Morocco, canine leishmaniasis (CanL) is usually believed to be widespread mainly, if not only, in the northern regions and few data are available about the situation in southern parts of the country. Here, we report the results of a preliminary, clinical, and serological study carried out in 2004–2007, in four provinces of southern Morocco. Serological analyses were processed using two different Elisa techniques, a homemade Elisa test and IDVET commercial kit, and confirmed by two different western blot (WB) tests, homemade and LDBIO commercial kits. We highlighted the presence of CanL infection in southern regions, known until then as free of the disease: 19.8% (48/243) of examined dogs displayed clinical signs compatible with CanL and the seroprevalence was particularly high, respectively, 81.8% and 87.8% by Elisa and western blot tests. Our current developed and validated homemade (Elisa and WB) tools will be cost-effective and useful for next large-scale epidemiological studies on Moroccan leishmaniasis animal reservoir.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"4 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2014-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74658896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Estimating Cancer Latency Times Using a Weibull Model 使用威布尔模型估计癌症潜伏期
Pub Date : 2014-08-31 DOI: 10.1155/2014/746769
Diana L. Nadler, I. Zurbenko
Mathematical models can be useful tools in exploring population disease trends over time and can be used to gain insight into the fundamental mechanisms of cancer development. In this paper, we provide a systematic comparison between the exact and the approximate solutions for estimating the length of time between the biological initiation of cancer and diagnosis through the development of a Weibull-like survival model. A total of 1,608,484 malignant primary cancers were used in the analysis using cancer incidence data obtained from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. We find that the approximate solution provides a reliable comparison of the latency periods for different types of cancer and has no significant effect on the estimation accuracy, which differs from the exact solution by 0% to 11.3%. Thirty-five of the 44 cancers in this analysis were found to progress silently for 10 years or longer prior to detection representing 89% of the patients in this analysis. The results of this analysis differentiate cancer types that progress undetected over a period of years to identify new opportunities for early detection which increases the likelihood of successful treatment and alleviates the ever-growing cancer burden.
数学模型可以成为探索人口疾病随时间变化趋势的有用工具,并可用于深入了解癌症发展的基本机制。在本文中,我们提供了一个系统的比较精确和近似的解决方案,以估计从生物学开始的癌症和诊断之间的时间长度通过weibull样生存模型的发展。共有1608484例恶性原发性癌症被用于分析,分析数据来自美国国家癌症研究所的监测、流行病学和最终结果(SEER)项目。我们发现近似解提供了不同类型癌症潜伏期的可靠比较,并且对估计精度没有显著影响,估计精度与精确解相差0%至11.3%。在该分析中,44例癌症中有35例在检测前悄无声息地进展了10年或更长时间,占该分析中患者的89%。这项分析的结果区分了在一段时间内未被发现的进展的癌症类型,以确定早期发现的新机会,从而增加成功治疗的可能性并减轻日益增长的癌症负担。
{"title":"Estimating Cancer Latency Times Using a Weibull Model","authors":"Diana L. Nadler, I. Zurbenko","doi":"10.1155/2014/746769","DOIUrl":"https://doi.org/10.1155/2014/746769","url":null,"abstract":"Mathematical models can be useful tools in exploring population disease trends over time and can be used to gain insight into the fundamental mechanisms of cancer development. In this paper, we provide a systematic comparison between the exact and the approximate solutions for estimating the length of time between the biological initiation of cancer and diagnosis through the development of a Weibull-like survival model. A total of 1,608,484 malignant primary cancers were used in the analysis using cancer incidence data obtained from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. We find that the approximate solution provides a reliable comparison of the latency periods for different types of cancer and has no significant effect on the estimation accuracy, which differs from the exact solution by 0% to 11.3%. Thirty-five of the 44 cancers in this analysis were found to progress silently for 10 years or longer prior to detection representing 89% of the patients in this analysis. The results of this analysis differentiate cancer types that progress undetected over a period of years to identify new opportunities for early detection which increases the likelihood of successful treatment and alleviates the ever-growing cancer burden.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"41 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88556116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
Predictors of Work-Related Musculoskeletal Disorders among Commercial Minibus Drivers in Accra Metropolis, Ghana 加纳阿克拉大都会商业小巴司机与工作相关的肌肉骨骼疾病预测因素
Pub Date : 2014-08-21 DOI: 10.1155/2014/384279
J. K. Abledu, E. B. Offei, G. Abledu
Background. The objective of this study is to determine the prevalence and predictors of work-related musculoskeletal disorders (WMSDs) among a sample of commercial minibus drivers in the Accra Metropolis of Ghana. Methods. The participating drivers () were recruited from various lorry terminals and assessed by using a semistructured questionnaire that included the Nordic Musculoskeletal Questionnaire (NMQ). Results. Of the 148 drivers, 116 (78.4%) reported having WMSDs during the previous 12 months. The prevalence of the various WMSD domains was low back pain (58.8%), neck pain (25%), upper back pain (22.3%), shoulder pain (18.2%), knee pain (14.9%), ankle pain (9.5%), wrist pain (7.4%), elbow pain (4.7%), and hip/thigh pain (2.7%). Multiple logistic regression analysis adjusted for possible confounders showed that less physical activity (OR = 4.9; 95% CI = 1.5–16.5; ), driving more than 12 hours per day (OR = 2.9; 95% CI = 1.1–7.8; ), and driving at least 5 days per week (OR = 3.7; 95% CI = 1.4–9.4; ) were significantly associated with WMSDs among this cohort of drivers. Conclusion. These modifiable factors may be targets for preventive strategies to reduce the incidence of WMSDs among occupational minibus drivers in Ghana.
背景。本研究的目的是确定与工作相关的肌肉骨骼疾病(WMSDs)在加纳阿克拉大都会的商业小巴司机样本中的患病率和预测因素。方法。参与调查的司机是从各个卡车码头招募的,并通过半结构化问卷(包括北欧肌肉骨骼问卷(NMQ))进行评估。结果。在148名司机中,116名(78.4%)报告在过去12个月内患有wmsd。WMSD各领域的患病率为腰痛(58.8%)、颈部疼痛(25%)、上背部疼痛(22.3%)、肩部疼痛(18.2%)、膝关节疼痛(14.9%)、踝关节疼痛(9.5%)、腕关节疼痛(7.4%)、肘部疼痛(4.7%)和髋关节/大腿疼痛(2.7%)。对可能的混杂因素进行校正后的多元logistic回归分析显示,体力活动减少(OR = 4.9;95% ci = 1.5-16.5;)每天开车超过12小时(OR = 2.9);95% ci = 1.1-7.8;),每周开车至少5天(OR = 3.7;95% ci = 1.4-9.4;)在这组司机中与wmsd显著相关。结论。这些可改变的因素可能是预防战略的目标,以减少职业小巴司机中WMSDs的发病率。
{"title":"Predictors of Work-Related Musculoskeletal Disorders among Commercial Minibus Drivers in Accra Metropolis, Ghana","authors":"J. K. Abledu, E. B. Offei, G. Abledu","doi":"10.1155/2014/384279","DOIUrl":"https://doi.org/10.1155/2014/384279","url":null,"abstract":"Background. The objective of this study is to determine the prevalence and predictors of work-related musculoskeletal disorders (WMSDs) among a sample of commercial minibus drivers in the Accra Metropolis of Ghana. Methods. The participating drivers () were recruited from various lorry terminals and assessed by using a semistructured questionnaire that included the Nordic Musculoskeletal Questionnaire (NMQ). Results. Of the 148 drivers, 116 (78.4%) reported having WMSDs during the previous 12 months. The prevalence of the various WMSD domains was low back pain (58.8%), neck pain (25%), upper back pain (22.3%), shoulder pain (18.2%), knee pain (14.9%), ankle pain (9.5%), wrist pain (7.4%), elbow pain (4.7%), and hip/thigh pain (2.7%). Multiple logistic regression analysis adjusted for possible confounders showed that less physical activity (OR = 4.9; 95% CI = 1.5–16.5; ), driving more than 12 hours per day (OR = 2.9; 95% CI = 1.1–7.8; ), and driving at least 5 days per week (OR = 3.7; 95% CI = 1.4–9.4; ) were significantly associated with WMSDs among this cohort of drivers. Conclusion. These modifiable factors may be targets for preventive strategies to reduce the incidence of WMSDs among occupational minibus drivers in Ghana.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81469391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Metabolic Syndrome according to Three Definitions in Hammam-Sousse Sahloul Heart Study: A City Based Tunisian Study 代谢综合征在hamam - sousse - Sahloul心脏研究中的三种定义:突尼斯城市研究
Pub Date : 2014-08-05 DOI: 10.1155/2014/891297
Imen Boumaiza, A. Omezzine, M. Romdhane, J. Rejeb, L. Rebhi, Lobna Bouacida, S. Neffati, N. B. Rejeb, A. Abdelaziz, A. Bouslama
Objectives. Metabolic syndrome (MetS) is a major risk factor of CVD. The aim of the present study is to determine the prevalence of the MetS, its components, and its different profiles according to NCEP-ATP III 2001, IDF 2005, and JIS 2009 definitions in Hammam-Sousse Sahloul Heart Study (HSHS). Study Design. The study involved 1121 participants (364 men and 757 women; sex-ratio  =  0.48; mean age  =  47.49 ± 16.24 years) living in Hammam Sousse city, located in the east of Tunisia. Methods. Anthropometric parameters, blood pressure, lipids levels, glycemia, insulinemia, and body mass index were measured. Statistical analyses were performed by SPSS16.0. Results. The percentage of participants who had MetS defined according to NCEP ATP III, IDF 2005, and JIS 2009 definitions was respectively, 29.5%, 38.4%, and 39.6%. With regard to gender, the prevalence of MetS is higher in men than in women according to IDF 2005 definition (38.5% men versus 38.3% women, ) and according to JIS 2009 definition (41.8% men versus 38.6% women, ), whereas, according to NCEP ATP III definition, the prevalence of MetS is higher in women than in men (30% versus 28.6%, ). The prevalence of MetS increased with increasing age according to the three definitions () and peaked in the oldest age group (≥70 years) according to IDF 2005 and JIS 2009. Furthermore, a significant difference in the prevalence of MetS components according to gender was observed. Indeed, the abdominal obesity is the most frequent MetS compound in women group, but hypertension and low HDL-C are the most frequent in men. In addition, according to the three definitions, the most frequent MetS profile in our study is “higher waist circumference, hypertension, and low HDL-C.” Conclusion. The high prevalence of MetS is a serious public health problem in Hammam-Sousse Sahloul community. Higher waist circumference, hypertension, and low HDL-C were the most frequent profile in our study.
目标。代谢综合征(MetS)是心血管疾病的主要危险因素。本研究的目的是根据NCEP-ATP III 2001、IDF 2005和JIS 2009在hamam - sousse Sahloul心脏研究(HSHS)中的定义,确定met的患病率、其组成部分和不同的概况。研究设计。该研究涉及1121名参与者(364名男性和757名女性;性别比= 0.48;平均年龄= 47.49±16.24岁),居住在突尼斯东部的Hammam Sousse市。方法。测量了人体测量参数、血压、血脂水平、血糖、胰岛素血症和体重指数。采用SPSS16.0进行统计学分析。结果。根据NCEP ATP III、IDF 2005和JIS 2009定义的MetS的参与者比例分别为29.5%、38.4%和39.6%。就性别而言,根据IDF 2005年的定义(38.5%的男性对38.3%的女性)和JIS 2009年的定义(41.8%的男性对38.6%的女性),MetS在男性中的患病率高于女性,而根据NCEP ATP III的定义,MetS在女性中的患病率高于男性(30%对28.6%)。根据三种定义(),met的患病率随着年龄的增长而增加,根据IDF 2005和JIS 2009,在年龄最大的年龄组(≥70岁)达到高峰。此外,根据性别,观察到MetS成分的患病率存在显着差异。确实,腹部肥胖是女性人群中最常见的代谢产物,而高血压和低HDL-C是男性人群中最常见的代谢产物。此外,根据这三种定义,我们研究中最常见的met特征是“腰围高、高血压和低HDL-C”。结论。在hamam - sousse Sahloul社区,met的高流行率是一个严重的公共卫生问题。在我们的研究中,高腰围、高血压和低HDL-C是最常见的特征。
{"title":"Metabolic Syndrome according to Three Definitions in Hammam-Sousse Sahloul Heart Study: A City Based Tunisian Study","authors":"Imen Boumaiza, A. Omezzine, M. Romdhane, J. Rejeb, L. Rebhi, Lobna Bouacida, S. Neffati, N. B. Rejeb, A. Abdelaziz, A. Bouslama","doi":"10.1155/2014/891297","DOIUrl":"https://doi.org/10.1155/2014/891297","url":null,"abstract":"Objectives. Metabolic syndrome (MetS) is a major risk factor of CVD. The aim of the present study is to determine the prevalence of the MetS, its components, and its different profiles according to NCEP-ATP III 2001, IDF 2005, and JIS 2009 definitions in Hammam-Sousse Sahloul Heart Study (HSHS). Study Design. The study involved 1121 participants (364 men and 757 women; sex-ratio  =  0.48; mean age  =  47.49 ± 16.24 years) living in Hammam Sousse city, located in the east of Tunisia. Methods. Anthropometric parameters, blood pressure, lipids levels, glycemia, insulinemia, and body mass index were measured. Statistical analyses were performed by SPSS16.0. Results. The percentage of participants who had MetS defined according to NCEP ATP III, IDF 2005, and JIS 2009 definitions was respectively, 29.5%, 38.4%, and 39.6%. With regard to gender, the prevalence of MetS is higher in men than in women according to IDF 2005 definition (38.5% men versus 38.3% women, ) and according to JIS 2009 definition (41.8% men versus 38.6% women, ), whereas, according to NCEP ATP III definition, the prevalence of MetS is higher in women than in men (30% versus 28.6%, ). The prevalence of MetS increased with increasing age according to the three definitions () and peaked in the oldest age group (≥70 years) according to IDF 2005 and JIS 2009. Furthermore, a significant difference in the prevalence of MetS components according to gender was observed. Indeed, the abdominal obesity is the most frequent MetS compound in women group, but hypertension and low HDL-C are the most frequent in men. In addition, according to the three definitions, the most frequent MetS profile in our study is “higher waist circumference, hypertension, and low HDL-C.” Conclusion. The high prevalence of MetS is a serious public health problem in Hammam-Sousse Sahloul community. Higher waist circumference, hypertension, and low HDL-C were the most frequent profile in our study.","PeriodicalId":91644,"journal":{"name":"Advances in epidemiology","volume":"13 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2014-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75805041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Advances in epidemiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1