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Journal of digestive diseases and hepatology最新文献

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Predictors of Hepatic Fat Fraction Measured by Magnetic Resonance Imaging in Adults with Non-alcoholic Fatty Liver Disease 磁共振成像测量非酒精性脂肪肝成人肝脏脂肪分数的预测因素
Pub Date : 2023-04-13 DOI: 10.29011/2574-3511.100090
Débora Gonçalves, Da Silva, Beatriz Francisco, Barbosa Rodrigues, Josue Da, Silva Brito, A. Amato, Debora Goncalves da Silva
) Predictors of Hepatic Fat Fraction Measured by Magnetic Resonance Imaging in Adults with Non-alcoholic Fatty Liver Disease
磁共振成像测量成人非酒精性脂肪肝患者肝脏脂肪分数的预测因素
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引用次数: 0
The Sensitivity and the Specificity of the Fecal Immunochemical Testing in Detecting Colonic Cancerous and Precancerous Lesions among the Lebanese Population 黎巴嫩人群中粪便免疫化学检测结肠癌和癌前病变的敏感性和特异性
Pub Date : 2023-04-10 DOI: 10.29011/2574-3511.100091
Tawbeh Hussien, El Zein Zeinab, Hachem Sara, Hallal Marwa, Alborz Haji, Jibaii Soukayna, Matar Rami, Hallal Mahmoud
The Sensitivity and the Specificity of the Fecal Immunochemical Testing in Detecting Colonic Cancerous and Precancerous Lesions among the Lebanese Population
黎巴嫩人群中粪便免疫化学检测结肠癌和癌前病变的敏感性和特异性
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引用次数: 0
Incidence, Diagnosis, and Management of Hepatocellular Carcinoma: Current Perspectives and Future Direction 肝细胞癌的发病率、诊断和治疗:目前的观点和未来的方向
Pub Date : 2023-02-24 DOI: 10.29011/2574-3511.100088
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引用次数: 0
Development of a Self-Report Questionnaire for Patients and their Families to Prevent Faecal Incontinence in Daily Life 预防日常生活中尿失禁的患者及家属自述问卷的编制
Pub Date : 2023-01-30 DOI: 10.29011/2574-3511.100087
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引用次数: 0
A Case of Serotonergic Gastric Neuroendocrine Tumor with Fibrous Stroma an Unusual EUS Finding 5 -羟色胺能性胃神经内分泌肿瘤伴纤维间质1例EUS异常发现
Pub Date : 2022-11-25 DOI: 10.29011/2574-3511.100086
Noriyuki Arakawa, A. Irisawa, K. Ishida, Yoshiko, Yamaguchi, A. Yamabe, M. Eizuka, H. Wakabayashi
Our patient was a man in his eighties who was referred to our department after a screening endoscopy indicated some abnormalities. Upper gastrointestinal endoscopy identified a 6-mm submucosal tumor in the posterior wall of the lesser curvature
我们的病人是一位八十多岁的男性,他在内窥镜检查发现一些异常后被转介到我科。上消化道内窥镜检查发现小弯后壁一个6毫米的粘膜下肿瘤
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引用次数: 0
The Videocapsule Endoscopy Role in the Early Diagnosis of Small Bowel Melanoma Metastasis: A Particular “Coal Black” Endoscopic Appearance 视频胶囊内镜在小肠黑色素瘤转移早期诊断中的作用:一种特殊的“煤黑色”内镜外观
Pub Date : 2022-11-10 DOI: 10.29011/2574-3511.100085
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引用次数: 0
Growth Failure, Micronutrient Deficiency and Autoimmunity – A New Phenotype of Hennekam Syndrome 生长衰竭、微量营养素缺乏和自身免疫——亨内卡姆综合征的一种新表型
Pub Date : 2022-09-23 DOI: 10.29011/2574-3511.100083
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引用次数: 0
Analysis of Hepatitis B Virus Pre-S Gene in Hepatocellular Carcinoma and Paracancerous Tissues from Southern China 中国南方地区肝细胞癌及癌旁组织中乙型肝炎病毒前s基因的分析
Pub Date : 2022-09-15 DOI: 10.29011/2574-3511.100082
P. Zhu, Peiyao Shi, Leijing Duan, Xian Jin, Y. Tan, Fenfang, Lei, Qingxia Liu
Gene in Abstract: Chronic hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC), and the HBV pre-S gene plays a critical role in the molecular pathogenesis of HBV-related HCC. We have investigated whether there are particular HBV pre-S gene mutations associated with HCC in patients from southern China. The HBV pre-S gene was examined in 100 paraffin-embedded tumor tissue and 100 paraffin-embedded paracancerous tissue samples from patients with HCC by nested polymerase chain reaction (PCR). The HBV pre-S genes with potentially important mutations from tumor tissue samples were sequenced and aligned with the published HBV pre-S gene sequence. Twelve patients (12.0%) had pre-S mutations; six had a pre-S1 deletion, one patient had a pre-S2_ deletion, five patients had both a pre-S deletion, and a pre-S2 mutation. Among them, two patients contained pre-S1 insertion and two patients contained pre-S1 start codon mutation. Two patients (2.0%) of hepatocellular carcinoma paracancerous tissue had pre-S mutation and two patients had pre-S1 + pre-S2 deletion. The pre-S sequence of HBV contained stop codon in four patients of HCC, leading to truncated pre-S protein and changed protein structure. These results suggest that HBV pre-S gene deletion mutation and insertion mutation in HCC tissues and paracancerous tissues lead to truncated HBV pre-S protein or protein changes, which may be related to the occurrence of hepatocellular carcinoma.
摘要:慢性乙型肝炎病毒(HBV)感染是引起肝细胞癌(HCC)的主要原因之一,HBV前s基因在HBV相关HCC的分子发病机制中起关键作用。我们研究了中国南方患者中是否存在与HCC相关的特定HBV前s基因突变。采用巢式聚合酶链反应(nested polymerase chain reaction, PCR)检测100例肝癌患者石蜡包埋肿瘤组织和石蜡包埋癌旁组织标本中HBV前s基因的表达。对肿瘤组织样本中具有潜在重要突变的HBV前s基因进行测序,并与已发表的HBV前s基因序列进行比对。12例患者(12.0%)存在pre-S突变;6例患者存在s1前缺失,1例患者存在s2前缺失,5例患者同时存在s前缺失和s2前突变。其中2例患者含有pre-S1插入,2例患者含有pre-S1起始密码子突变。2例(2.0%)肝细胞癌癌旁组织存在pre-S突变,2例存在pre-S1 + pre-S2缺失。4例HCC患者HBV前s序列含有停止密码子,导致前s蛋白截短,蛋白结构改变。这些结果提示,HCC组织和癌旁组织中HBV前s基因缺失突变和插入突变导致HBV前s蛋白截短或蛋白改变,可能与肝细胞癌的发生有关。
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引用次数: 0
Late Recurrence after Successful Radiofrequency Ablation for Barrett’s Neoplasia: A Case Report 巴雷特瘤成功射频消融后晚期复发1例报告
Pub Date : 2022-08-11 DOI: 10.29011/2574-3511.100080
J. Louwers, I. N. B. Ilse, G. Raicu, B. Weusten
Radiofrequency ablation (RFA) preceded by endoscopic resection of visible lesions is the current standard of care for patients with early neoplastic Barrett’s esophagus (BE). Neoplastic recurrences after successful endoscopic treatment are rare, and the incidence of recurrence is highest in the first years of follow-up. However, studies evaluating long-term durability of endoscopic treatment in BE are lacking, with only few studies exceeding a median follow-up time of five years. Hereby we report on a case with a neoplastic recurrence 12 years after successful endoscopic treatment of dysplastic BE with RFA. The knowledge that neoplastic recurrences can occur even after more than a decade of initial treatment stresses the importance of long-term endoscopic follow-up with detailed inspection of the neosquamous mucosa.
射频消融(RFA)前内镜切除可见病变是目前治疗早期肿瘤性巴雷特食管(BE)患者的标准。成功的内镜治疗后肿瘤复发是罕见的,复发率最高的是在第一年的随访。然而,评估内窥镜治疗BE的长期持久性的研究缺乏,只有少数研究超过5年的中位随访时间。在此,我们报告一例肿瘤复发的情况下,成功的内镜治疗发育不良BE与RFA 12年。认识到肿瘤复发甚至可以在超过十年的初始治疗后发生,强调了长期内窥镜随访和详细检查新鳞状黏膜的重要性。
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引用次数: 0
Frequency of Disagreement between Liver Ultrasound and Elastography in the Diagnosis of Cirrhosis 肝脏超声与弹性成像在肝硬化诊断中的不一致频率
Pub Date : 2022-08-03 DOI: 10.29011/2574-3511.100079
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引用次数: 0
期刊
Journal of digestive diseases and hepatology
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