{"title":"Trump administration is expanding global gag rule to export its ideology worldwide.","authors":"Carole Sekimpi","doi":"10.1136/bmj.s335","DOIUrl":"https://doi.org/10.1136/bmj.s335","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s335"},"PeriodicalIF":42.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Corruption\" in UK's overseas training scheme is debated by Pakistani MPs as High Commission calls for \"urgent action\".","authors":"Emma Wilkinson","doi":"10.1136/bmj.s340","DOIUrl":"https://doi.org/10.1136/bmj.s340","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s340"},"PeriodicalIF":42.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pitting nurses and doctors against each other will not help solve workforce problems.","authors":"Tiago Correia, Martin McKee","doi":"10.1136/bmj.s341","DOIUrl":"https://doi.org/10.1136/bmj.s341","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s341"},"PeriodicalIF":42.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Type 2 diabetes: SGLT-2 inhibitors should be offered as first line treatment, doctors are told.","authors":"Jacqui Wise","doi":"10.1136/bmj.s333","DOIUrl":"https://doi.org/10.1136/bmj.s333","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s333"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Blanco, Elizabeth Loder, Sophie Cook, Martí Casals, Jordi Cortés, Aïda Cadellans-Arróniz, Victor Zárate, Ella Hubbard, Sara Schroter
<p><strong>Objectives: </strong>To identify variables associated with non-prospective registration of clinical trials submitted to <i>The BMJ</i>; examine deficiencies in registration, disclosure of deficiencies, and subsequent publication status of such trials; and assess the authors' claims of prospective registration.</p><p><strong>Design: </strong>Observational study.</p><p><strong>Setting: </strong><i>The BMJ,</i> London.</p><p><strong>Population: </strong>239 of 287 submissions to <i>The BMJ</i> (2019-23) reporting clinical trial results as defined by the International Committee of Medical Journal Editors (ICMJE) and flagged by editors as potentially not prospectively registered, and 239 trials prospectively registered in an ICJME accepted registry from a randomised list of all clinical trial submissions in the same period.</p><p><strong>Main outcome measures: </strong>Study outcomes included non-prospective registration in an ICJME accepted registry and, for non-prospectively registered trials, deficiencies in registration deficiencies in registration (retrospective in an ICJME accepted registry, registration in a non-ICJME accepted registry, or no registration), delay in registration of retrospectively registered trials, and subsequent publication status. Time to publication and disclosure of registration deficiencies on publication were also assessed, along with the journal's impact factor and whether the journal claimed adherence to the ICMJE registration recommendations.</p><p><strong>Results: </strong>Reduced odds of non-prospective registration in an ICMJE accepted registry were associated with larger sample sizes (101-500 <i>v</i> 1-100; odds ratio 0.43, 95% confidence interval 0.22 to 0.84), corresponding authors from Oceania (reference: Europe; 0.35, 0.14 to 0.82), a greater number of authors (10 <i>v</i> 5; 0.71, 0.59 to 0.87), mention of Consolidated Standards Of Reporting Trials (0.22, 0.06 to 0.67), more recent submissions (2021-23 <i>v</i> 2019-20; 0.63, 0.42 to 0.95), and presence of funding (eg, non-profit <i>v</i> no funding or no information; 0.20, 0.09 to 0.41). Higher odds were observed for corresponding authors based in Asia (reference: Europe; 1.75, 1.07 to 2.89). Of 176 trials not prospectively registered in an ICMJE accepted registry submitted between 2019 and 2021, 146 (83%) were retrospectively registered (median delay 193 days), 23 (13%) were unregistered, and seven (4%) were registered in a non-ICJME accepted registry. Most (155 trials, 88%) were subsequently published; 138 (89%) of these appeared in journals with an impact factor (median 5.39) and 96 (62%) in journals claiming adherence to the ICMJE recommendations. The median time from initial submission to <i>The BMJ</i> to publication was 12 months. Only about one sixth explicitly disclosed registration deficiencies on publication. Of 72 authors responding about prospective registration on submission, 60 (83%) incorrectly claimed adherence.</p><p><strong>Con
目的：确定与提交给BMJ的非前瞻性临床试验注册相关的变量；审查此类试验在注册、缺陷披露和随后的发表状况方面的缺陷；并评估作者对预期注册的主张。设计：观察性研究。地点：英国医学杂志，伦敦。人群：向BMJ（2019-23）提交的287份临床试验结果报告中，有239份报告了国际医学期刊编辑委员会（ICMJE）定义的临床试验结果，并被编辑标记为可能未前瞻性注册，239项试验从同期提交的所有临床试验随机列表中被ICJME接受注册。主要结局指标：研究结果包括在ICJME认可的注册中心进行非前瞻性注册，对于非前瞻性注册的试验，注册缺陷（在ICJME认可的注册中心进行回顾性注册，在非ICJME认可的注册中心进行注册，或没有注册），回顾性注册试验的注册延迟，以及随后的发表状态。还评估了发表时间和发表时披露的注册缺陷，以及期刊的影响因子和期刊是否声称遵守了ICMJE的注册建议。结果：在ICMJE接受的注册中心中，非前瞻性注册的几率降低与样本量较大（101-500 v 1-100；比值比0.43,95%可信区间0.22至0.84）、来自大洋洲的通讯作者（参考文献：欧洲；0.35,0.14至0.82）、更多的作者（10 v 5; 0.71, 0.59至0.87）、提到联合报告试验标准（0.22,0.06至0.67）、更近期的提交(2021-23 v 2019-20；0.63, 0.42至0.95)，以及是否存在资金（例如，非营利性v没有资金或没有信息；0.20,0.09至0.41）。在亚洲的通讯作者中观察到更高的几率（参考文献：欧洲；1.75,1.07至2.89）。在2019年至2021年期间提交的176项试验中，146项（83%）试验回顾性注册（中位延迟193天），23项（13%）试验未注册，7项（4%）试验在非icjme接受的注册中注册。大多数（155项试验，88%）随后发表；其中138篇（89%）发表在影响因子（中位数5.39）的期刊上，96篇（62%）发表在声称遵循ICMJE建议的期刊上。从最初提交给BMJ到发表的中位时间是12个月。只有大约六分之一的人在公布时明确披露了注册缺陷。在72位作者中，有60位（83%）错误地声明了依从性。结论：许多被BMJ拒绝在ICMJE接受的注册中进行非前瞻性注册的试验后来在高影响力期刊上发表，声称遵守ICMJE的建议，通常没有披露注册缺陷。
{"title":"Analysis of non-prospective trial registration in clinical trials submitted to <i>The BMJ</i>: observational study.","authors":"David Blanco, Elizabeth Loder, Sophie Cook, Martí Casals, Jordi Cortés, Aïda Cadellans-Arróniz, Victor Zárate, Ella Hubbard, Sara Schroter","doi":"10.1136/bmj-2025-086467","DOIUrl":"10.1136/bmj-2025-086467","url":null,"abstract":"<p><strong>Objectives: </strong>To identify variables associated with non-prospective registration of clinical trials submitted to <i>The BMJ</i>; examine deficiencies in registration, disclosure of deficiencies, and subsequent publication status of such trials; and assess the authors' claims of prospective registration.</p><p><strong>Design: </strong>Observational study.</p><p><strong>Setting: </strong><i>The BMJ,</i> London.</p><p><strong>Population: </strong>239 of 287 submissions to <i>The BMJ</i> (2019-23) reporting clinical trial results as defined by the International Committee of Medical Journal Editors (ICMJE) and flagged by editors as potentially not prospectively registered, and 239 trials prospectively registered in an ICJME accepted registry from a randomised list of all clinical trial submissions in the same period.</p><p><strong>Main outcome measures: </strong>Study outcomes included non-prospective registration in an ICJME accepted registry and, for non-prospectively registered trials, deficiencies in registration deficiencies in registration (retrospective in an ICJME accepted registry, registration in a non-ICJME accepted registry, or no registration), delay in registration of retrospectively registered trials, and subsequent publication status. Time to publication and disclosure of registration deficiencies on publication were also assessed, along with the journal's impact factor and whether the journal claimed adherence to the ICMJE registration recommendations.</p><p><strong>Results: </strong>Reduced odds of non-prospective registration in an ICMJE accepted registry were associated with larger sample sizes (101-500 <i>v</i> 1-100; odds ratio 0.43, 95% confidence interval 0.22 to 0.84), corresponding authors from Oceania (reference: Europe; 0.35, 0.14 to 0.82), a greater number of authors (10 <i>v</i> 5; 0.71, 0.59 to 0.87), mention of Consolidated Standards Of Reporting Trials (0.22, 0.06 to 0.67), more recent submissions (2021-23 <i>v</i> 2019-20; 0.63, 0.42 to 0.95), and presence of funding (eg, non-profit <i>v</i> no funding or no information; 0.20, 0.09 to 0.41). Higher odds were observed for corresponding authors based in Asia (reference: Europe; 1.75, 1.07 to 2.89). Of 176 trials not prospectively registered in an ICMJE accepted registry submitted between 2019 and 2021, 146 (83%) were retrospectively registered (median delay 193 days), 23 (13%) were unregistered, and seven (4%) were registered in a non-ICJME accepted registry. Most (155 trials, 88%) were subsequently published; 138 (89%) of these appeared in journals with an impact factor (median 5.39) and 96 (62%) in journals claiming adherence to the ICMJE recommendations. The median time from initial submission to <i>The BMJ</i> to publication was 12 months. Only about one sixth explicitly disclosed registration deficiencies on publication. Of 72 authors responding about prospective registration on submission, 60 (83%) incorrectly claimed adherence.</p><p><strong>Con","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"e086467"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Taking the guesswork out of clinical trial registration information.","authors":"David Blanco, Elizabeth Loder, Sara Schroter","doi":"10.1136/bmj.s298","DOIUrl":"https://doi.org/10.1136/bmj.s298","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s298"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GP deserts: Data show chronic shortage of family doctors in England.","authors":"Stephanie Santos Paulo","doi":"10.1136/bmj.s301","DOIUrl":"https://doi.org/10.1136/bmj.s301","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s301"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study claiming that substituting nurses for doctors is safe and effective is flawed, say experts.","authors":"Gareth Iacobucci","doi":"10.1136/bmj.s336","DOIUrl":"https://doi.org/10.1136/bmj.s336","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s336"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linking my chronic pain with trauma.","authors":"Barbara L Holtzman","doi":"10.1136/bmj.s59","DOIUrl":"https://doi.org/10.1136/bmj.s59","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s59"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clarity is needed about liability when medical AI fails.","authors":"Gordon C Wishart, Robert Kellar","doi":"10.1136/bmj.s320","DOIUrl":"https://doi.org/10.1136/bmj.s320","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"392 ","pages":"s320"},"PeriodicalIF":42.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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