Chandra S, Devkota K, B. s, Curtiss C, Swarnkar A, Khanna A, S. M
High bone turnover in renal osteodystrophy is a rare clinical entity nowadays due to the early diagnosis and treatment of secondary hyperparathyroidism. Since it is a diagnosis of exclusion, a formidable diagnostic challenge exists when the likelihood of malignancy is high in elderly patients suffering from chronic kidney disease.
{"title":"Cancer or Not? A Case of High Turnover Bone Disease with Review of Literature","authors":"Chandra S, Devkota K, B. s, Curtiss C, Swarnkar A, Khanna A, S. M","doi":"10.16966/2380-5498.222","DOIUrl":"https://doi.org/10.16966/2380-5498.222","url":null,"abstract":"High bone turnover in renal osteodystrophy is a rare clinical entity nowadays due to the early diagnosis and treatment of secondary hyperparathyroidism. Since it is a diagnosis of exclusion, a formidable diagnostic challenge exists when the likelihood of malignancy is high in elderly patients suffering from chronic kidney disease.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Nicolino Md, Ivonne Rs, Geovani Es, Karina Rl, C. Ab, R. Cm, L. Ec, Miguel Ar, Omar Rcm, Gilberto Pa, Laurain Ar, V. Cr, C. da, Koens S
Introduction: Hyperphosphatemia (HPFT) is a complication that is exacerbated proportionally to the degree of kidney damage, and leads to vascular calcification and increased cardiovascular risk. The objective of the present study is to determine the frequency of hyperphosphatemia in patients with chronic dialysis treatment. Material and methods: This is a cross-sectional, observational, retrospective and analytical study. Real-life national multicenter study, conducted from January 1 to March 31, 2022. It includes subjects with chronic dialysis (>3 months stay), >16 years, from the public and private sectors. Does not include patients treated with phosphate binders or vitamin D receptor analogs; only treated with calcium derivatives in different formulations. Gender, age, causes of kidney failure, serum phosphorus values (mg/dL), calcium (mg/dL) and parathyroid hormone (pg/mL) are identified. Results: 2,176 subjects, 1,205 from the public sector (55%) and 971 private (45%). 1,063 (49%) male and 1,113 female (51%), with a mean age of 51.4 years (range 16-88). 794 with diabetes (36%), 559 arterial hypertension (26%) and 823 unknown (38%). The mean serum calcium values were 8.75 mg/dL (SD ± 1.01; range: 6.1-12.7) and phosphorus 5.15 mg/dL (SD ± 3.04; range: 2.5-18.1). 1,435 subjects presented HPFT (66%), 903 mild (41%), 450 moderate (21%, mean 5.7 mg/dL) and 82 severe (4%, mean: 9.2 mg/dL). Parathyroid hormone was determined in 33% (mean 614.87 pg/ mL, SD 628.64; range: 53.3 -3,803). Conclusions: HPFT is frequent in patients with chronic dialysis, it affects regardless of gender, age, primary cause of kidney disease and even after receiving adequate dialysis treatment. Significant increase in HPFT was observed in peritoneal dialysis patients.
{"title":"Hyperphosphatemia in Dialysis Patients National Multicenter Study","authors":"Antonio Nicolino Md, Ivonne Rs, Geovani Es, Karina Rl, C. Ab, R. Cm, L. Ec, Miguel Ar, Omar Rcm, Gilberto Pa, Laurain Ar, V. Cr, C. da, Koens S","doi":"10.16966/2380-5498.225","DOIUrl":"https://doi.org/10.16966/2380-5498.225","url":null,"abstract":"Introduction: Hyperphosphatemia (HPFT) is a complication that is exacerbated proportionally to the degree of kidney damage, and leads to vascular calcification and increased cardiovascular risk. The objective of the present study is to determine the frequency of hyperphosphatemia in patients with chronic dialysis treatment. Material and methods: This is a cross-sectional, observational, retrospective and analytical study. Real-life national multicenter study, conducted from January 1 to March 31, 2022. It includes subjects with chronic dialysis (>3 months stay), >16 years, from the public and private sectors. Does not include patients treated with phosphate binders or vitamin D receptor analogs; only treated with calcium derivatives in different formulations. Gender, age, causes of kidney failure, serum phosphorus values (mg/dL), calcium (mg/dL) and parathyroid hormone (pg/mL) are identified. Results: 2,176 subjects, 1,205 from the public sector (55%) and 971 private (45%). 1,063 (49%) male and 1,113 female (51%), with a mean age of 51.4 years (range 16-88). 794 with diabetes (36%), 559 arterial hypertension (26%) and 823 unknown (38%). The mean serum calcium values were 8.75 mg/dL (SD ± 1.01; range: 6.1-12.7) and phosphorus 5.15 mg/dL (SD ± 3.04; range: 2.5-18.1). 1,435 subjects presented HPFT (66%), 903 mild (41%), 450 moderate (21%, mean 5.7 mg/dL) and 82 severe (4%, mean: 9.2 mg/dL). Parathyroid hormone was determined in 33% (mean 614.87 pg/ mL, SD 628.64; range: 53.3 -3,803). Conclusions: HPFT is frequent in patients with chronic dialysis, it affects regardless of gender, age, primary cause of kidney disease and even after receiving adequate dialysis treatment. Significant increase in HPFT was observed in peritoneal dialysis patients.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahoungou Gh, Niama Ac, Batchi-Bouyou Al, E. Dt, Ngabe En, Essie Dm, Bothard Hb, Loumingou R
Introduction: Chronic renal failure (CRF) is a real health problem in Congo. It is with the aim of enacting preventive measures on the subject that we have undertaken to conduct a survey to assess the level of knowledge and perceptions of kidney disease among people with a higher level.
{"title":"Knowledge and Perceptions of Kidney Disease among Workers of Marien Ngouabi University, Republic of the Congo","authors":"Mahoungou Gh, Niama Ac, Batchi-Bouyou Al, E. Dt, Ngabe En, Essie Dm, Bothard Hb, Loumingou R","doi":"10.16966/2380-5498.223","DOIUrl":"https://doi.org/10.16966/2380-5498.223","url":null,"abstract":"Introduction: Chronic renal failure (CRF) is a real health problem in Congo. It is with the aim of enacting preventive measures on the subject that we have undertaken to conduct a survey to assess the level of knowledge and perceptions of kidney disease among people with a higher level.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Different methods of prevention and reduction of mortality have been studied, such as the placement of a transjugular intrahepatic portosystemic shunt (TIPS) [4]. This technique has been used successfully in individuals with recurrent ascites with excellent results in terms of morbidity and mortality [5]. However, further trials are needed to consolidate its efficacy in the treatment of hepatorenal dysfunction and its benefit-risk assessment [6-8].
{"title":"Prevention of Hepatorenal Syndrome, as a Complication of Liver Cirrhosis","authors":"Abuabara-Franco E, Sáenz-López J, Restom-Arrieta J, Bohórquez-Rivero J, Licona-Vera C, Angulo Mn, Vasquez Cb","doi":"10.16966/2380-5498.227","DOIUrl":"https://doi.org/10.16966/2380-5498.227","url":null,"abstract":"Different methods of prevention and reduction of mortality have been studied, such as the placement of a transjugular intrahepatic portosystemic shunt (TIPS) [4]. This technique has been used successfully in individuals with recurrent ascites with excellent results in terms of morbidity and mortality [5]. However, further trials are needed to consolidate its efficacy in the treatment of hepatorenal dysfunction and its benefit-risk assessment [6-8].","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutting K, Naman J, Mitchell Ns, Josephson M, Saunders Mr
Background: Weight gain after kidney transplant has been demonstrated to have adverse effects on allograft function and longevity. We sought to determine both the prevalence of post-transplant weight gain and factors associated with weight gain.
{"title":"Kidney Transplant Recipients’ Weight Change and their Behaviors and Attitudes Related to Diet and Exercise","authors":"Nutting K, Naman J, Mitchell Ns, Josephson M, Saunders Mr","doi":"10.16966/2380-5498.208","DOIUrl":"https://doi.org/10.16966/2380-5498.208","url":null,"abstract":"Background: Weight gain after kidney transplant has been demonstrated to have adverse effects on allograft function and longevity. We sought to determine both the prevalence of post-transplant weight gain and factors associated with weight gain.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. G., Depine Sa, Vélez-Verbel M, Dianda D, G. L., Chaparro Mc, C. J., Vélez-Verbel D, Cotes N, Vargas Wp, Chartouni-Narvaez S, Raad M, Cadena-Bonfanti A, Musso Cg
Aim: The novel coronavirus disease 2019 (COVID-19) was first described in Wuhan, China, in December 2019. It has since spread worldwide, leading to high morbidity and mortality. Patients with chronic renal failure on dialysis who also have a confirmed diagnosis of active infection represent a risk group because infections are the second cause of death in this group, followed by immunosuppression caused by the weakening of the innate immunity by uremic toxins. This study aimed to describe the clinical characteristics of patients undergoing haemodialysis who also have a confirmed diagnosis for COVID-19 and its association with short-term outcomes.
{"title":"Monitoring System, Evolution and Prognosis in Renal Patients on Haemodialysis Infected by Severe Acute Respiratory Syndrome Coronavirus 2","authors":"A. G., Depine Sa, Vélez-Verbel M, Dianda D, G. L., Chaparro Mc, C. J., Vélez-Verbel D, Cotes N, Vargas Wp, Chartouni-Narvaez S, Raad M, Cadena-Bonfanti A, Musso Cg","doi":"10.16966/2380-5498.209","DOIUrl":"https://doi.org/10.16966/2380-5498.209","url":null,"abstract":"Aim: The novel coronavirus disease 2019 (COVID-19) was first described in Wuhan, China, in December 2019. It has since spread worldwide, leading to high morbidity and mortality. Patients with chronic renal failure on dialysis who also have a confirmed diagnosis of active infection represent a risk group because infections are the second cause of death in this group, followed by immunosuppression caused by the weakening of the innate immunity by uremic toxins. This study aimed to describe the clinical characteristics of patients undergoing haemodialysis who also have a confirmed diagnosis for COVID-19 and its association with short-term outcomes.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
López Yp, T. Monzon, F. Alonso, Viñau Bq, M. González, F. Valga, S. Hillebrand, J. Betancor, F. Henríquez, G. Antón
Patients with Chronic Kidney Disease on Dialysis (CDRD) have a major risk of developing cancer when compared with the general population [1], thyroid carcinoma being the most common in the first group of patients [2]. The definitive treatment is thyroidectomy, but in patients at risk of recurrence ablative therapy with radioactive iodine I-131 is necessary [2]. We present the clinical case of a 61-year-old patient on hemodialysis with a slow growing anterior cervical tumor studied for more than two years until the diagnosis of papillary thyroid carcinoma. Initially the patient received surgical treatment and is currently awaiting treatment with radioactive iodine I-131.
{"title":"Cervical Tumor in Patient on Chronic Hemodialysis about a Case","authors":"López Yp, T. Monzon, F. Alonso, Viñau Bq, M. González, F. Valga, S. Hillebrand, J. Betancor, F. Henríquez, G. Antón","doi":"10.16966/2380-5498.216","DOIUrl":"https://doi.org/10.16966/2380-5498.216","url":null,"abstract":"Patients with Chronic Kidney Disease on Dialysis (CDRD) have a major risk of developing cancer when compared with the general population [1], thyroid carcinoma being the most common in the first group of patients [2]. The definitive treatment is thyroidectomy, but in patients at risk of recurrence ablative therapy with radioactive iodine I-131 is necessary [2]. We present the clinical case of a 61-year-old patient on hemodialysis with a slow growing anterior cervical tumor studied for more than two years until the diagnosis of papillary thyroid carcinoma. Initially the patient received surgical treatment and is currently awaiting treatment with radioactive iodine I-131.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Urgent-Start Peritoneal Dialysis (USPD) is increasingly used worldwide and represents a safe, convenient and cost-effective method to initiate dialysis. However, good catheter insertion techniques are imperative to avoid postoperative complications. While percutaneous catheter insertion by Seldinger technique is considered a safe method with few post-operative complications, comparisons with surgical operation technique are needed, especially in China, where there a few reports on the outcome of percutaneous catheter insertion by Seldinger technique in USPD patients.
{"title":"Urgent-Start Peritoneal Dialysis: A Comparison of Catheter Insertion Using Seldinger Technique and Surgical Operation","authors":"Y. c, Yang N, Wang K, Lin H, L. l","doi":"10.16966/2380-5498.220","DOIUrl":"https://doi.org/10.16966/2380-5498.220","url":null,"abstract":"Background: Urgent-Start Peritoneal Dialysis (USPD) is increasingly used worldwide and represents a safe, convenient and cost-effective method to initiate dialysis. However, good catheter insertion techniques are imperative to avoid postoperative complications. While percutaneous catheter insertion by Seldinger technique is considered a safe method with few post-operative complications, comparisons with surgical operation technique are needed, especially in China, where there a few reports on the outcome of percutaneous catheter insertion by Seldinger technique in USPD patients.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The increase in life expectancy, as well as in chronic diseases, has resulted in giving emphasis not only to medical interventions, but to the continuous care of the patient. The measurement of Quality of Life (QOL) of haemodialysis patients provides information relevant to their needs and the consequences of haemodialysis in their life, which could be used to implement interventions that will lead to the improvement of their QOL.
{"title":"Quality of Life of Haemodialysis Patients and Complications of CVC and AA","authors":"T. D., Papasavva A, K. A","doi":"10.16966/2380-5498.219","DOIUrl":"https://doi.org/10.16966/2380-5498.219","url":null,"abstract":"Background: The increase in life expectancy, as well as in chronic diseases, has resulted in giving emphasis not only to medical interventions, but to the continuous care of the patient. The measurement of Quality of Life (QOL) of haemodialysis patients provides information relevant to their needs and the consequences of haemodialysis in their life, which could be used to implement interventions that will lead to the improvement of their QOL.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type-2 diabetes is a metabolic disorder with vast complications. Uric acid (UA) was recently discovered as a risk biomarker for the development of type-2 diabetes. Several studies have found a significant association of Hyperuricemia with Hypertension (HTN), renal complications and cardiovascular disease. However, no study has found an association of hyperuricemia with the development of essential hypertension, nephropathy and Diabetic Kidney Disease (DKD) among type-2 diabetics. Moreover, in the past no study has found cut off points for serum uric acids for the development of DKD/CKD among diabetics with sensitivity and specificity, which was achieved in the current study. We collected 10,300 type-2 diabetics data for more than 15 years in a cross sectional retrospective manner. 17% demonstrated hyperuricemia while 16% were found to be DKD. Significant correlations were found between serum UA and other variables (serum creatinine, systolic and diastolic BP, microalbumin and spot urine protein). Levels of UA were observed to be elevated among patients with HTN, nephropathy and DKD (p<0.0001). Similarly, serum creatinine, systolic and diastolic BP, microalbuminuria and spot urine protein were higher for the group with hyperuricemia (p<0.0001). Pearson’s (χ²) and logistic regression with odds ratio demonstrated that hyperuricemia was significantly associated with HTN (odds ratio 2.5; 95% CI 1.8 to 23.4; p<0.0001). Similarly, hyperuricemia was significantly associated with the development of nephropathy and DKD/CKD; odds ratio 2.1 (95% CI 1.46 to 2.8; p<0.0001) and 27.3 (95% CI 14 to 53; p<0.0001), respectively. Moreover, regression model between serum UA and serum creatinine was also significantly associated with each other and proves our hypothesis that UA linearly causes an increase in the blood creatinine with the following relationship : Serum creatinine=0.221 + [0.154 × serum UA]. ROC for DKD and serum UA demonstrated that with AUC of 0.98 (95% CI 0.961 to 0.986), UA level of 6.8 was 91% sensitive and 79% specific for the development and significant association with DKD/CKD (p<0.0001). This is the first study of its kind that has demonstrated significant associations of UA with HTN, nephropathy and DKD. It is the time to revise the normal levels of UA among type-2 diabetics and to initiate regular screening for hyperuricemia to prevent further diabetes complications.
2型糖尿病是一种代谢紊乱，有很多并发症。尿酸(UA)最近被发现是2型糖尿病发展的风险生物标志物。一些研究发现高尿酸血症与高血压(HTN)、肾脏并发症和心血管疾病有显著关联。然而，没有研究发现高尿酸血症与2型糖尿病患者的原发性高血压、肾病和糖尿病肾病(DKD)的发展有关。此外，过去没有研究发现血清尿酸对于糖尿病患者DKD/CKD发展具有敏感性和特异性的截断点，本研究实现了这一点。我们以横断面回顾性的方式收集了超过15年的10300例2型糖尿病患者的数据。17%为高尿酸血症，16%为DKD。血清UA与其他变量(血清肌酐、收缩压和舒张压、微量白蛋白和斑点尿蛋白)存在显著相关性。在HTN、肾病和DKD患者中UA水平升高(p<0.0001)。同样，高尿酸血症组血清肌酐、收缩压和舒张压、微量白蛋白尿和斑点尿蛋白均高于对照组(p<0.0001)。Pearson 's (χ²)和logistic回归显示高尿酸血症与HTN显著相关(比值比2.5;95% CI 1.8 ~ 23.4;p < 0.0001)。同样，高尿酸血症与肾病和DKD/CKD的发展显著相关;优势比2.1 (95% CI 1.46 ~ 2.8;p<0.0001)和27.3 (95% CI 14 ~ 53;分别为p < 0.0001)。此外，血清UA与血清肌酐的回归模型也相互显著相关，证明了我们的假设，即UA线性导致血肌酐升高，关系如下:血清肌酐=0.221 + [0.154 ×血清UA]。DKD和血清UA的ROC结果显示，AUC为0.98 (95% CI 0.961 ~ 0.986)， UA水平为6.8时，DKD/CKD的敏感性为91%，特异性为79%，且与DKD/CKD显著相关(p<0.0001)。这是同类研究中首次证明UA与HTN、肾病和DKD有显著关联。是时候修改2型糖尿病患者的正常尿酸水平，并开始定期筛查高尿酸血症，以防止进一步的糖尿病并发症。
{"title":"Involvement of Serum Uric Acid in Essential Hypertension, Progressive Proteinuria and Impairment in Renal Function among Type-2 Diabetic Patients","authors":"Aziz Kma","doi":"10.16966/2380-5498.206","DOIUrl":"https://doi.org/10.16966/2380-5498.206","url":null,"abstract":"Type-2 diabetes is a metabolic disorder with vast complications. Uric acid (UA) was recently discovered as a risk biomarker for the development of type-2 diabetes. Several studies have found a significant association of Hyperuricemia with Hypertension (HTN), renal complications and cardiovascular disease. However, no study has found an association of hyperuricemia with the development of essential hypertension, nephropathy and Diabetic Kidney Disease (DKD) among type-2 diabetics. Moreover, in the past no study has found cut off points for serum uric acids for the development of DKD/CKD among diabetics with sensitivity and specificity, which was achieved in the current study. We collected 10,300 type-2 diabetics data for more than 15 years in a cross sectional retrospective manner. 17% demonstrated hyperuricemia while 16% were found to be DKD. Significant correlations were found between serum UA and other variables (serum creatinine, systolic and diastolic BP, microalbumin and spot urine protein). Levels of UA were observed to be elevated among patients with HTN, nephropathy and DKD (p<0.0001). Similarly, serum creatinine, systolic and diastolic BP, microalbuminuria and spot urine protein were higher for the group with hyperuricemia (p<0.0001). Pearson’s (χ²) and logistic regression with odds ratio demonstrated that hyperuricemia was significantly associated with HTN (odds ratio 2.5; 95% CI 1.8 to 23.4; p<0.0001). Similarly, hyperuricemia was significantly associated with the development of nephropathy and DKD/CKD; odds ratio 2.1 (95% CI 1.46 to 2.8; p<0.0001) and 27.3 (95% CI 14 to 53; p<0.0001), respectively. Moreover, regression model between serum UA and serum creatinine was also significantly associated with each other and proves our hypothesis that UA linearly causes an increase in the blood creatinine with the following relationship : Serum creatinine=0.221 + [0.154 × serum UA]. ROC for DKD and serum UA demonstrated that with AUC of 0.98 (95% CI 0.961 to 0.986), UA level of 6.8 was 91% sensitive and 79% specific for the development and significant association with DKD/CKD (p<0.0001). This is the first study of its kind that has demonstrated significant associations of UA with HTN, nephropathy and DKD. It is the time to revise the normal levels of UA among type-2 diabetics and to initiate regular screening for hyperuricemia to prevent further diabetes complications.","PeriodicalId":92052,"journal":{"name":"International journal of nephrology and kidney failure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67391235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：