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Identification of Social and Occupational Risk Factors Associated with CKDu (Chronic Kidney Disease of Unknown Etiology) Patients Living in an Agricultural Community in Kebithigollewa, Sri Lanka 与生活在斯里兰卡Kebithigollewa农业社区的CKDu(病因不明的慢性肾脏疾病)患者相关的社会和职业风险因素的鉴定
Pub Date : 2021-01-01 DOI: 10.16966/2380-5498.217
Lowe C, Kumarasinghe N
Aim: To identify the social and occupational risk factors associated with CKDu (Chronic Kidney Disease of unknown etiology) patients living in an agricultural community in Kebithigollewa, Sri Lanka.
目的:确定与生活在斯里兰卡Kebithigollewa农业社区的CKDu(病因不明的慢性肾脏疾病)患者相关的社会和职业危险因素。
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引用次数: 0
Acute Kidney Failure during Preeclampsia at Parakou University Hospital in Benin in 2019: Diagnostic and Therapeutic Aspects 2019年贝宁帕拉库大学医院子痫前期急性肾衰竭:诊断和治疗方面
Pub Date : 2021-01-01 DOI: 10.16966/2380-5498.204
Tchaou Ba, Ahoui S, Samaké Bm, Tchégnonsi Ncf, Eteka E, Ngangen Nongni Ae, Chobli M
Background: Acute renal injury during preeclampsia is a relatively common complication in intensive care and grafted with significant morbidity and mortality.
背景:子痫前期急性肾损伤是重症监护和移植手术中比较常见的并发症,发病率和死亡率都很高。
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引用次数: 0
Loud P2 on Cardiac Auscultation: A Useful Clinical Clue to Fluid Overload 心脏听诊上的高P2声:液体负荷的有用临床线索
Pub Date : 2021-01-01 DOI: 10.16966/2380-5498.210
E. K, A. S, Dashti R
Patients with renal disease are at risk of fluid overload which escalates as the disease progresses. In the present study, we evaluated the increase in the intensity of the second heart sound generated by its pulmonary component (P2) and its correlation with fluid overload in such patients. To confirm its potentials and avoid interference with patients with cardiac disease; we included only those who lacked echocardiographic evidence of (a) ASD or VSD, (b) primary cardiac defects associated with high P2 viz pulmonary aneurysm, mitral stenosis and myocardial disease, (c) primary cardiac defects associated with soft P2 viz pulmonary stenosis, pulmonary atresia and tetralogy of Fallot, (d) primary cardiac defects associated with low A2 viz mitral regurgitation, aortic regurgitation, low diastolic arterial pressure, severe immobile aortic valve disease. To assess the extent of fluid overload; the clinical examination was complemented with radiological imaging as well as the echocardiographic measurement of systolic pulmonary arterial pressure. There was a significant correlation between P2 intensity and fluid changes. In conclusion; load P2 is a useful clinical clue to fluid overload and decline in its intensity correlates with the extent of fluid removal.
肾脏疾病患者有体液超载的危险,这种危险随着疾病的进展而加剧。在本研究中,我们评估了这类患者由其肺成分(P2)产生的第二心音强度的增加及其与液体过载的关系。确认其电位,避免干扰心脏病患者;我们只纳入了那些缺乏超声心动图证据的患者:(a) ASD或VSD, (b)与高P2型肺动脉动脉瘤、二尖瓣狭窄和心肌疾病相关的原发性心脏缺陷,(c)与软P2型肺动脉狭窄、肺闭锁和法洛四联症相关的原发性心脏缺陷,(d)与低A2型二尖瓣反流、主动脉反流、低舒张动脉压、严重不动主动脉瓣疾病相关的原发性心脏缺陷。评估流体过载的程度;临床检查辅以放射成像和超声心动图测量收缩期肺动脉压。P2强度与流体变化有显著相关性。结论;负荷P2是一个有用的临床线索,液体超载,其强度下降与液体清除的程度相关。
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引用次数: 0
Multifrequency Bioimpedance Phase Angle as a Tool to Predict Maturation Failure of Native Fistulae for Hemodialysis 多频生物阻抗相位角作为预测血液透析原生瘘成熟失败的工具
Pub Date : 2021-01-01 DOI: 10.16966/2380-5498.215
Daza Jl, Galindo Jf, Villaquiran Mr, Valenzuela Ed, Cardenas A, Daza Lj, Correcha Mc, de Jong J, Prieto Ydlc, Gutierrez G, Puello L
Background and objectives: An arteriovenous fistula is considered to be an ideal vascular access for patients receiving hemodialysis, its main limitation is its high failure rate to achieve maturation and long-term functionality loss. Multiple strategies have attempted to identify patients at risk. Bioelectrical impedance has shown to be a valuable resource in the determination of the hydration status, and the measurement of the phase angle through this method has demonstrated to be a good indicator of the nutritional state and it’s related as a general marker of survival. The objective of this study is to analyze the role of plasma albumin and phase angle measured through bioelectrical impedance as tools useful for predicting failure of arteriovenous fistulas.
背景与目的:动静脉瘘被认为是血液透析患者理想的血管通路,其主要限制是其成熟失败率高和长期功能丧失。有多种策略试图识别有风险的患者。生物电阻抗已被证明是测定水合状态的宝贵资源,通过这种方法测量相位角已被证明是营养状态的良好指标,并作为生存的一般标志。本研究的目的是分析血浆白蛋白和通过生物电阻抗测量的相位角作为预测动静脉瘘失败的有用工具的作用。
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引用次数: 0
Compensation Capacity of The Living-Related Donor’s Remnant Kidney and Recipient’s Transplanted Kidney 活体供者残肾与受者移植肾的代偿能力
Pub Date : 2020-12-28 DOI: 10.21203/rs.3.rs-132281/v1
Xin Huang, Bin-rong Ma, Wenhao Lin, Kun Shao, Huimin An, J. Dai, Da Xu, P. Zhou, Ju-ping Zhao
Background: Compensatory renal growth following nephrectomy is common. We try to explore the compensatory capacity of the living-related donor’s remnant kidney and recipient’s transplanted kidney in terms of the glomerular filtration rate (GFR) one month after transplantation. Methods: Clinical data of 94 patients who received living-related kidney transplantation in our hospital between June 2007 and December 2017 were reviewed retrospectively. GFR was calculated by 99mTc-DTPA detection. The GFR compensatory capacity of donor’s remnant and donated kidneys in their new milieus after transplantation was compared. The differential value (D-value) of split renal function was defined as postoperative GFR - preoperative ipsilateral GFR. The compensatory percentage (C-percentage) of split renal function was defined as (postoperative GFR - preoperative ipsilateral GFR)/preoperative ipsilateral GFR. Results: The median D-value of the donor’s remnant kidney increased by 20.8 ml/(min·1.73m2)[IQR=8.9-29.6 ml/(min·1.73m2)] with a C-percentage of 46.6% (IQR=17.0%-73.0%). The median D-value of the donated kidney increased by 30.6 ml/(min·1.73m2)[IQR=19.8-42.3 ml/(min·1.73m2)] with a C-percentage of 67.8% (IQR=39.6%-94.7%). Multivariable analysis showed that only split preoperative GFR in the donor was the independent predictor for C-percentage of the split kidney. Conclusions: Renal function could be well preserved and compensated after kidney donation in most donors and recipients in Chinese population. Healthy donors with a good GFR before operation possessed a mighty functional compensation capacity.
背景:肾切除术后代偿性肾生长很常见。我们试图通过移植后一个月的肾小球滤过率(glomerular filtration rate, GFR)来探讨活体供体残肾和受体移植肾的代偿能力。方法:回顾性分析2007年6月至2017年12月我院94例活体肾移植患者的临床资料。采用99mTc-DTPA检测计算GFR。比较移植后供体残肾和供体肾在新环境下的GFR代偿能力。劈裂肾功能的差值(d值)定义为术后GFR -术前同侧GFR。劈裂肾功能代偿百分率(c百分比)定义为(术后GFR -术前同侧GFR)/术前同侧GFR。结果:供者残肾中位d值增加20.8 ml/(min·1.73m2)[IQR=8.9 ~ 29.6 ml/(min·1.73m2)], c百分比为46.6% (IQR=17.0% ~ 73.0%)。捐献肾d值中位数增加30.6 ml/(min·1.73m2)[IQR=19.8 ~ 42.3 ml/(min·1.73m2)], c百分比为67.8% (IQR=39.6% ~ 94.7%)。多变量分析显示,只有供者术前GFR分裂是肾分裂c百分比的独立预测因子。结论:中国大多数供者和受者肾脏捐献后肾功能均能得到很好的保存和补偿。术前GFR良好的健康供者具有强大的功能代偿能力。
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引用次数: 0
Changes in Renal Function One Year after Radical Nephrectomy for Cancer Compared to Kidney Donation 与肾脏捐献相比,癌症根治性肾切除术一年后肾功能的变化
Pub Date : 2020-01-01 DOI: 10.16966/2380-5498.185
D. Ct, Matheus We, U. Ferreira, M. Mazzali, De Lima Ml
Purpose: Adaptive changes to acute reduction in renal mass after radical nephrectomy can cause Chronic Kidney Disease (CKD) more frequently in patients with renal cancer compared to kidney donors. The aim of this study was to compare changes in Estimated Glomerular Filtration Rate (eGFR) 1-year after radical nephrectomy for cancer vs kidney donation and to identify risk factors for CKD.
目的:与肾供者相比,根治性肾切除术后肾肿块急性缩小的适应性改变可更频繁地导致肾癌患者慢性肾脏疾病(CKD)。本研究的目的是比较癌症根治性肾切除术与肾脏捐赠后1年估计肾小球滤过率(eGFR)的变化,并确定CKD的危险因素。
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引用次数: 1
Incidental Renal Disorders Found at Necropsies of Violent Death Victims 在暴力死亡受害者的尸检中发现偶然的肾脏疾病
Pub Date : 2019-01-01 DOI: 10.16966/2380-5498.176
Obiorah Cc, Edi Po
Background: The burden of CKD in our environment remains high while biopsy uptake is low, making for high level of uncertainty in the morphologic characterization of renal disorders. Aim: To evaluate kidney necropsy tissues of violent death victims, asymptomatic of renal disorders, with a view to detecting lesions of clinical interest and determining the morphologic features of such lesions. Also to review the literature for silent conditions that advances the course of CKD. Materials and Methods: Prospective cohort study carried out on kidney necropsy tissues of violent death victims who in their antemortem states were asymptomatic of renal disorders. Subjects were firearm and road traffic accident victims irrespective of gender and age brought to UPTH morgue in January 2017, whose close relatives consented. Information confirming that decedents were asymptomatic of a renal disorder was obtained from deceased’s close relatives. Necropsy tissues were processed using standard operating procedures for histopathology of renal biopsies, and slides were read by the authors using light microscopy only. Results: Forty-three tissues were collected-41 males and 2 females. Mean and peak ages were 29.3 (4.9) and 21-30 years with 25/43 (58.1%). Twenty cases (46.5%) showed glomerular pathologies composed of 18.6% FSGS and 27.9% MPGN. Twenty three cases (53.5%) were devoid of histologic evidence of glomerular injury. All cases showed evidence of variable degrees of acute tubular injury with ten cases (23.3%) showing PAS positive casts. Four cases (two each from FSGS and MPGN) displayed chronic interstitial nephritis with mild fibrosis. There was thickening of the arteriolar tunica media in 12 bodies (27.9%). Conclusion: Prevalence of asymptomatic CKD is very high among the youths of our locality. Glomerular lesions constitute common pathogenetic bases unlike tubulointerstitial and vascular lesions which were uncommon. Enunciating measures that targeted the youths aimed at reducing rate of smoking and abuse of common analgesics like paracetamol as well as measures that will improve the overall socioeconomic status and encourage routine medical examinations may reverse the upward trend of asymptomatic CKD among our youths.
背景:在我们的环境中,CKD的负担仍然很高,而活检摄取很低,这使得肾脏疾病的形态学特征具有很高的不确定性。目的:对无肾脏疾病症状的暴力死亡患者的肾脏尸检组织进行评估,以发现临床关注的病变并确定这些病变的形态学特征。同时也回顾了促进CKD进程的沉默条件的文献。材料与方法:对死前无肾脏疾病症状的暴力死亡患者的肾脏尸检组织进行前瞻性队列研究。研究对象是2017年1月被带到UPTH停尸房的枪支和道路交通事故受害者,无论性别和年龄,其近亲同意。从死者的近亲处获得了确认死者无肾脏疾病症状的信息。尸检组织采用肾活检组织病理学的标准操作程序进行处理,作者仅使用光学显微镜读取切片。结果:采集组织43份,其中男性41份,女性2份。平均和高峰年龄分别为29.3岁(4.9%)和21-30岁(25/43)(58.1%)。肾小球病变20例(46.5%),其中FSGS占18.6%,MPGN占27.9%。23例(53.5%)无肾小球损伤的组织学证据。所有病例均有不同程度的急性肾小管损伤,其中10例(23.3%)为PAS阳性铸型。4例(FSGS和MPGN各2例)表现为慢性间质性肾炎伴轻度纤维化。小动脉中膜增厚12例(27.9%)。结论:无症状慢性肾病在我区青少年中患病率较高。肾小球病变是常见的发病基础,而小管间质病变和血管病变并不常见。制定针对青少年的措施,旨在减少吸烟率和对乙酰氨基酚等常见镇痛药的滥用,以及提高整体社会经济地位和鼓励常规医学检查的措施,可能会扭转我们的年轻人中无症状慢性肾病的上升趋势。
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引用次数: 0
How Does the Multi-Disciplinary Team Impact Chronic Kidney Disease Management? 多学科团队如何影响慢性肾脏疾病的管理?
Pub Date : 2019-01-01 DOI: 10.16966/2380-5498.177
H. B, F. M.
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引用次数: 0
The Characteristics, Management and Outcome of Patients Receiving Acute Dialysis in Swaziland (Eswatini) 斯威士兰(Eswatini)急性透析患者的特点、管理和预后
Pub Date : 2019-01-01 DOI: 10.16966/2380-5498.180
D. Tal, T Chirima, G Kinsala, D. Simelane, N. Hlatshwayo, Dlamini Na, X. Dlamini, Kunene Ts, Dlamini Sw, N Matekere
Background: Eswatini, a land-locked country in Southern Africa with a population of about 1.4 million, is one of the few countries in Africa where dialysis is available as part of the country’s health plan. This is the first study of the pattern of kidney disease amongst patients receiving acute dialysis in the country. Methods: This was a retrospective folder review of patients who were dialysed at Eswatini’s three institutions where dialysis is offered. Patients dialysed acutely from the 1st of June 2015 to the 31st of May 2016 were included. A data collection form was used to collect information on patient demographics (de-identified), co-morbidities, reason for referral for dialysis, place of referral, basic investigations, and outcome in terms of renal recovery, need for chronic dialysis and 30 day mortality. The study was approved by the National Health Research Review Board, the Ethics committee of Eswatini. A waiver of consent was granted as patient information was de-identified. Data from the data collection forms was entered into Microsoft Excel and RStudio software for analysis by the principal investigators. Preliminary Results: A total number of 219 patients received acute dialysis over the study period. Ages ranged from 9 months to 84 years. Most underwent acute haemodialysis with only 4 undergoing acute peritoneal dialysis. The majority (131) 59.8% were male. Co-morbidities included HIV in 124 (56.6%), hypertension in 118 (54.1%), diabetes in 48 (21.9%), and urinary tract obstruction in 13 (5.9%). A total of 87 (39.7%) patients had received Tenofovir Disoproxil Fumarate for treatment of HIV. Of the patients with available data, those achieving partial or full renal recovery within 30 days totaled 42 (19.2%), and 88 (40.2%) went onto chronic dialysis. There were 31 deaths (out 189 identified folders) (16.4%) within 30 days. Conclusions: Dialysis requiring patients in Eswatini include the young and old. The most notable risk factors are hypertension and HIV, as well as recent use of Tenofovir Disoproxil Fumarate. A large proportion of patients present with advanced kidney disease that requires ongoing renal replacement therapy. Improved management of the identified risk factors for acute and chronic kidney disease may reduce the number of patients requiring dialysis in Eswatini.
背景:斯瓦蒂尼是南部非洲的一个内陆国家,人口约140万,是非洲为数不多的将透析作为国家卫生计划一部分的国家之一。这是对该国接受急性透析的患者中肾脏疾病模式的首次研究。方法:这是对在Eswatini的三家提供透析的机构进行透析的患者的回顾性资料回顾。纳入2015年6月1日至2016年5月31日急性透析患者。数据收集表用于收集患者人口统计信息(去识别)、合并症、转诊透析的原因、转诊地点、基本调查、肾脏恢复结果、慢性透析需求和30天死亡率。这项研究得到了国家健康研究审查委员会、斯威士兰伦理委员会的批准。当患者信息被去识别时,授予放弃同意。数据收集表中的数据被输入到Microsoft Excel和RStudio软件中,由主要研究者进行分析。初步结果:研究期间共有219例患者接受急性透析治疗。年龄从9个月到84岁不等。大多数接受了急性血液透析,只有4人接受了急性腹膜透析。男性占多数(131例),占59.8%。合并症包括艾滋病124例(56.6%),高血压118例(54.1%),糖尿病48例(21.9%),尿路梗阻13例(5.9%)。87例(39.7%)患者接受富马酸替诺福韦二氧吡酯治疗HIV。在有可用数据的患者中,在30天内肾脏部分或完全恢复的患者共有42人(19.2%),88人(40.2%)进行了慢性透析。在30天内有31例死亡(在189个确定的文件夹中)(16.4%)。结论:斯瓦蒂尼需要透析的患者包括年轻人和老年人。最显著的危险因素是高血压和艾滋病毒,以及最近使用富马酸替诺福韦二吡酯。很大比例的患者存在晚期肾脏疾病,需要持续的肾脏替代治疗。改善对已确定的急性和慢性肾脏疾病危险因素的管理可能会减少斯瓦蒂尼需要透析的患者数量。
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引用次数: 0
A Review of Midodrine for the Treatment of Intradialytic Hypotension Midodrine治疗低血压的研究进展
Pub Date : 2019-01-01 DOI: 10.16966/2380-5498.169
S. V.
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引用次数: 0
期刊
International journal of nephrology and kidney failure
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