Journal of childhood & developmental disorders最新文献

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Clinic Follow up and Neurological Disability in Children Following Pregnancies Complicated by Preterm Rupture of Membranes and Preeclampsia. 因胎膜早破和子痫前期并发症而怀孕的儿童的临床随访和神经系统残疾。

Journal of childhood & developmental disorders

Pub Date : 2021-01-01 Epub Date: 2021-05-31

Laura Paulson, Dianne Thornhill, Jennifer Armstrong

Context: Preeclampsia and preterm premature rupture of membranes (PPROM) have been associated with perinatal brain injury. Despite a strong understanding of the relationships between preterm birth and neurologic deficits, and between PPROM and preeclampsia and preterm birth, the relationship between PPROM and preeclampsia and neurologic disability is not well characterized.

Objective: We compared trends in neurologic deficits in children born to mothers with these conditions and described differences in patient characteristics among follow up visit attendance.

Methods: We conducted a prospective cohort study of women with preeclampsia or PPROM. Neurologic deficits were assessed with the Pediatric Stroke Outcome Measure at follow up visits through age 10 years. Eighty nine of the 178 women enrolled completed at least one follow up. Results: Among children born >32 weeks, PPROM showed higher left and right sided sensorimotor deficits at initial follow (p=0.045, p=0.01). In children born ≤ 32 weeks, preeclampsia had higher language production deficits at 3 year follow up (p=0.05).Sensorimotor deficits were greater and sustained in PPROM. Language production deficits were predominant among after 2 years of age in preeclampsia. Racial disparities were found in clinic attendance rates, with Black families most affected.

Conclusion: Differences in neurodevelopmental patterns suggest differences in underlying neuronal injuries. Neurologic assessment should occur routinely throughout early childhood to detect delayed deficits after PPROM and preeclampsia and ensure inclusion of underserved or at risk populations.

背景：先兆子痫和早产胎膜早破（PPROM）与围产期脑损伤有关。尽管人们对早产和神经系统缺陷之间的关系以及子痫前期和早产之间的关系有了深入的了解，但子痫前期和早产与神经系统残疾之间的关系还没有得到很好的描述：我们比较了患有这些疾病的母亲所生婴儿神经系统缺陷的趋势，并描述了随访患者特征的差异：我们对患有子痫前期或早产儿猝死症的妇女进行了一项前瞻性队列研究。方法：我们对患有子痫前期或先兆子痫的妇女进行了前瞻性队列研究，在 10 岁前的随访中使用儿科卒中结果测量法评估了她们的神经功能缺损情况。在 178 名登记的妇女中，有 89 名完成了至少一次随访。研究结果在出生大于 32 周的患儿中，PPROM 患儿在初次随访时左侧和右侧感觉运动障碍程度较高（P=0.045，P=0.01）。在出生不足 32 周的儿童中，先兆子痫患儿在 3 年随访时的语言表达障碍程度更高（p=0.05）。先兆子痫患者两岁后主要出现语言表达障碍。在就诊率方面发现了种族差异，黑人家庭受影响最大：结论：神经发育模式的差异表明潜在的神经元损伤存在差异。神经系统评估应在整个幼儿期常规进行，以检测先兆流产和子痫前期后的延迟性缺陷，并确保纳入服务不足或高危人群。

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引用次数: 0

Educating a Child with Down Syndrome in an Inclusive Kindergarten Classroom 在全纳幼儿园课堂中教育唐氏综合症儿童

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.36648/2472-1786.5.2.81

Lema Kabashi, Louise A. Kaczmarek

This case study describes the journey of a kindergartner with Down Syndrome in an inclusive classroom. Characteristics of the participant are discussed in comparison to characteristics of children with Down Syndrome and the impact of those characteristics for the child’s overall development. Various strategies that were effectively used to facilitate the child’s participation, transitioning, academics, and social skills are addressed. The child’s improvements in various areas of development as a result of inclusion in the kindergarten classroom are discussed. Finally, investigating the efficacy of inclusion for children with moderate to severe intellectual disabilities is recommended for further research.

本案例研究描述了一名唐氏综合症儿童在包容性课堂中的历程。将参与者的特征与唐氏综合症儿童的特征进行比较，并讨论这些特征对儿童整体发展的影响。各种策略被有效地用于促进儿童的参与、过渡、学术和社会技能。在幼儿园的课堂包容的结果，儿童在发展的各个领域的改进进行了讨论。最后，建议进一步研究纳入对中重度智障儿童的疗效。

引用次数: 6

Conners 3-Parent (Short): Measurement Invariance Across Gender, Concurrent and Discriminant Validities Conners 3-Parent (Short):跨性别、并发效度和判别效度的测量不变性

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.4172/2472-1786.100079

R. Gomez, A. Vance

The study examined measurement invariance (configural, factor loadings, thresholds, and error variances), and equivalencies of latent mean scores of the Conners 3-Parent (Short); (C 3-P (S)) across maternal ratings of clinic-referred boys (N = 354) and girls (N = 151), aged 7 to 17 years. It also examined the concurrent and discriminant validities of the scores for the C 3-P (S). Confirmatory factor analysis (CFA) indicated support for the theorized six-factor model. For this model, there was support for full measurement invariance and equivalencies for the latent mean scores. There was also support for the concurrent and discriminant validities of the scores for the C 3-P (S) scales. The findings are discussed in relation to the use of the C 3-P (S).

该研究检验了Conners 3-Parent (Short)的测量不变性(结构、因子负荷、阈值和误差方差)和潜在平均分数的等效性;(C 3-P (S))在7至17岁的临床转诊男孩(N = 354)和女孩(N = 151)的母亲评分中。它还检验了c3 - p (S)分数的并发效度和判别效度。验证性因子分析(CFA)表明支持理论化的六因素模型。对于该模型，支持潜在平均分数的完全测量不变性和等效性。c3 - p (S)量表得分的并发效度和判别效度也得到了支持。研究结果讨论了有关使用c3 - p (S)。

引用次数: 0

Adrenoleukodystrophy linked to Chromosome X with Neuropsychiatric Symptoms and Frontal Involvement: Case Report 肾上腺脑白质营养不良与X染色体相关，伴有神经精神症状和额叶受累:病例报告

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.4172/2472-1786.100084

S. Garza, Arturo Garza PeÃ±a, RaÃºl CalderÃ³n, J. Santos-GuzmÃ¡n, Carlos Aguirre Velázquez

Leukodystrophies are a rare group of genetic disorders that affect white matter of the central and peripheral nervous system. We present a clinical case of X-linked adrenoleukodystrophy (X-ALD) in a 9-year old male patient. The patient initially presented with neuropsychiatric symptoms characterized by impulsiveness, hyperactivity, and loss of reading and writing abilities. MRI scan showed a frontal involvement of both cerebral hemispheres. Based on this experience, we recommend that patients with hyperactivity and impulsiveness, and loss of previously acquired abilities such as reading and writing should be thoroughly evaluated to rule out the presence of X-ALD. After making the diagnosis with a complete serum fatty acid profile accompanied by the radiologic findings aforementioned, the patient underwent bone marrow transplant, without a favorable outcome after one year of follow-up.

白质营养不良症是一种罕见的遗传性疾病，影响中枢和周围神经系统的白质。我们提出一个临床病例的x -连锁肾上腺脑白质营养不良(X-ALD)在一个9岁的男性患者。患者最初表现为冲动、多动、读写能力丧失等神经精神症状。核磁共振扫描显示两个大脑半球的额叶受累。基于这一经验，我们建议对多动、冲动以及丧失先前获得的阅读和写作能力的患者进行彻底的评估，以排除X-ALD的存在。在诊断完整的血清脂肪酸谱并伴有上述影像学检查后，患者接受了骨髓移植，随访一年未见好转。

引用次数: 0

The Evolving Parent: Outline of the Evolution of Parenting Styles 演进中的父母:教养方式演变的概要

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.4172/2472-1786.100081

E. Rodriquez

引用次数: 0

The Cardiac Autonomic Control System Response to Submaximal Exercise Test in Children with Cerebral Palsy Compared to Typical Peer 脑瘫儿童心脏自主控制系统对亚极限运动测试的反应与典型同龄人的比较

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.36648/2472-1786.5.2.83

B. Bhat, Arshad Hussain, W. Qadir, S. Dar

Background: In spite of advances in assessment and management of patients with Autism Spectrum Disorders (ASDs) in west, developing countries including India are lagging far behind in child psychiatry, let alone ASDs. The aims of our study were to find the socio-demographic and clinical profile of children with ASDs in a child psychiatry unit. Methods and Materials: This was a Cross sectional observational descriptive study conducted in Outpatient child psychiatry clinic. Semi-structured questionnaire was used to record the socio-demographic status. The diagnosis of ASDs was made on the basis of Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM IV-TR) after a thorough clinical assessment which was also confirmed by consultant in charge child psychiatry. Intelligence quotient was assessed by clinical psychologist. Descriptive statistical analysis was done and presented as frequencies and percentages. Results: A total of 55 patients were diagnosed with ASDs. Most of the patients were less than 9 years with 52.73% in 4-7 years age group and 21.82% in 7-9 year age group. Males (78.18%) out-numbered females. 52.73% belonged to Nuclear Family and 63.63% were from rural background. 70.91% were staying at home. Autism was the most frequent diagnosis in 61.82% of the patients followed by Pervasive Developmental Disorder not otherwise specified (PDD NOS) in 30.91%. Co-morbid mental retardation (MR) was present in 47(85.45%) of our subjects. Conclusion: 10.4% of children and adolescents with psychiatric disorders were having ASDs with autistic disorder and PDD NOS representing more than 90% of these cases. Despite the growing global attention for inclusive education to these children, only 3% of our cases were receiving inclusive education and about 70% of cases were staying at home.

背景:尽管西方在自闭症谱系障碍(asd)患者的评估和管理方面取得了进展，但包括印度在内的发展中国家在儿童精神病学方面远远落后，更不用说asd了。我们研究的目的是在儿童精神科找到自闭症儿童的社会人口学和临床概况。方法与材料:本研究是在门诊儿童精神病学门诊进行的横断面观察性描述性研究。采用半结构式问卷记录社会人口状况。asd的诊断依据《精神障碍诊断与统计手册，第四版，文本修订版》(DSM IV-TR)，经过全面的临床评估，并由负责儿童精神病学的咨询师确认。由临床心理学家评定智商。进行描述性统计分析，并以频率和百分比表示。结果:共55例患者被诊断为asd。以9岁以下患者居多，其中4 ~ 7岁占52.73%，7 ~ 9岁占21.82%。男性(78.18%)多于女性。52.73%属于核心家庭，63.63%来自农村。70.91%的人待在家里。自闭症是最常见的诊断，占61.82%，其次是无其他特征的广泛性发育障碍(PDD NOS)，占30.91%。47例(85.45%)存在共病性精神发育迟滞。结论:10.4%的儿童和青少年精神障碍患者存在asd合并自闭症和PDD NOS，占其中的90%以上。尽管全球越来越关注对这些孩子的全纳教育，但我们的病例中只有3%接受了全纳教育，约70%的病例留在家里。

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引用次数: 0

Needs, Habits and Children’s Wellbeing 需求、习惯和儿童的幸福

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.4172/2472-1786.100080

F. Köksal

引用次数: 0

The Potential Benefits of PTH Analogs in Prevention of Pathological Fractures in Cerebral Palsy PTH类似物在预防脑瘫病理性骨折中的潜在益处

Journal of childhood & developmental disorders

Pub Date : 2019-01-01 DOI: 10.36648/2472-1786.5.3.86

Patrisha Shelley, L. Edwards, Rafik Jacob

Osteoporosis is a detrimental disorder of bone that puts patients at increased risk of pathologic fractures. Patients with cerebral palsy (CP), due to a multitude of factors, are at increased risk of developing this disorder. Studies in the past have looked at various treatment options for these patients to reduce and/or prevent pathologic fractures. Most studies have looked into the use of bisphosphonates for prevention. Teriparatide is a recombinant PTH analog that has been shown to increase bone mineral density and reduce fragility fractures in adults with non- CP related osteoporosis. Despite the reduction seen in these studies, empirical evidence for the use of PTH analogs in CP related osteoporosis is scarce. PTH analogs, like Teriparatide, have shown to be beneficial in patients with non-CP related osteoporosis, further studies need to be performed to assess its benefit for patients with CP related osteoporosis.

骨质疏松症是一种有害的骨骼疾病，它会增加患者发生病理性骨折的风险。脑瘫(CP)患者，由于多种因素，在发展这种疾病的风险增加。过去的研究着眼于这些患者的各种治疗选择，以减少和/或预防病理性骨折。大多数研究都着眼于使用双膦酸盐进行预防。特立帕肽是一种重组甲状旁腺激素类似物，已被证明可以增加骨密度，减少成人非CP相关性骨质疏松症的脆性骨折。尽管在这些研究中看到了减少，但在CP相关骨质疏松症中使用甲状旁腺激素类似物的经验证据很少。甲状旁腺激素类似物，如特立帕肽，已被证明对非CP相关性骨质疏松症患者有益，需要进一步的研究来评估其对CP相关性骨质疏松症患者的益处。

引用次数: 1

Arteriovenous Malformation in a Youth with Atypical Autism Symptoms. 非典型自闭症青少年动静脉畸形

Journal of childhood & developmental disorders

Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI: 10.4172/2472-1786.100042

Veena Sison, Tracy Stackhouse, Robert Breeze, Terry Hall, Pamela McKenzie, Nicole Tartaglia

Cerebral arteriovenous malformations (AVMs) present a challenge to diagnose in children with developmental disability, because of the overlap in behavioral symptoms and neurologic manifestations. They have been very rarely reported in conjunction with autism spectrum disorder. This case involves a 13 year old male with a history of autism spectrum disorder and significant behavioral issues diagnosed with a thalamic AVM following lateralizing neurologic symptoms. Despite radiosurgical treatment, hemorrhage followed consequently causing extensive neurologic injury and death. This case emphasizes the need for close follow up and coordination within a medical home for children with developmental disabilities. A multidisciplinary team approach is ideal to allow detection of subtle neurologic changes over time that may be masked as behavioral difficulties.

脑动静脉畸形(AVMs)由于行为症状和神经系统表现的重叠，对发育性残疾儿童的诊断提出了挑战。它们很少与自闭症谱系障碍结合在一起。本病例涉及一名13岁男性，有自闭症谱系障碍病史和明显的行为问题，诊断为丘脑动静脉畸形，伴有侧化神经症状。尽管放射外科治疗，出血随后导致广泛的神经损伤和死亡。这一案例强调了在医疗院里对发育性残疾儿童进行密切跟进和协调的必要性。一个多学科团队的方法是理想的，允许检测细微的神经系统变化随着时间的推移，可能被掩盖为行为困难。

引用次数: 3

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