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The proper study of man is man 对人的适当研究就是对人的研究
Biosilico
Pub Date : 2003-03-01 DOI: 10.1016/S1478-5382(03)02288-1
J.C. Louis (freelance writer)
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引用次数: 2
Computational biology: biological insight from 1s and 0s 计算生物学:从15到0的生物学洞察力
Biosilico
Pub Date : 2003-03-01 DOI: 10.1016/S1478-5382(03)02260-1
Harold R Garner , Alexander Pertsemlidis

There is no doubt that both computational biology and bioinformatics, and the interface of computer science and biology in general, are central to the future of biological research. The disciplines span a process that begins with data collection, analysis, classification, and integration and ends with interpretation, modeling, visualization, and prediction. Data mining may play a role in the middle, depending on the size of the dataset. Overall, the focus is on identifying opportunities and developing computational solutions (including algorithms, models, tools, and databases) that can be used for experimental design, data analysis and interpretation and hypothesis generation. The fundamental challenges are to describe, analyze, simulate and predict the dynamics of life processes.

毫无疑问，计算生物学和生物信息学，以及计算机科学和生物学的接口，对生物学研究的未来至关重要。这些学科跨越了一个过程，从数据收集、分析、分类和集成开始，到解释、建模、可视化和预测结束。数据挖掘可能在中间发挥作用，这取决于数据集的大小。总体而言，重点是识别机会和开发计算解决方案(包括算法，模型，工具和数据库)，可用于实验设计，数据分析和解释以及假设生成。基本的挑战是描述、分析、模拟和预测生命过程的动态。
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引用次数: 4
BioSig: an informatics framework for representing the physiological responses of living cells BioSig:表示活细胞生理反应的信息学框架
Biosilico
Pub Date : 2003-03-01 DOI: 10.1016/S1478-5382(03)02230-3
Bahram Parvin , Daniel E. Callahan

Subcellular experimental datasets and detailed cell models are required before modeling of whole organs. Cell modeling requires repeated interaction between simulation and experimental data. This review describes a coupled system of informatics and instrument control suitable for extracting information at the subcellular level. The BioSig informatics framework annotates time-series images with experimental variables and computed representation such as physiological responses, whereas visual servoing optical microscopy (VSOM) is used for adaptive perturbation and interaction with living cells.

在整个器官建模之前，需要亚细胞实验数据集和详细的细胞模型。细胞建模需要模拟和实验数据之间的反复相互作用。本文介绍了一种适用于亚细胞水平信息提取的信息学和仪器控制耦合系统。BioSig信息学框架用实验变量和计算表示(如生理反应)注释时间序列图像，而视觉伺服光学显微镜(VSOM)用于自适应扰动和与活细胞的相互作用。
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引用次数: 3
Welcome to BIOSILICO 欢迎来到biosilicon
Biosilico
Pub Date : 2003-03-01 DOI: 10.1016/S1478-5382(03)02291-1
Meran Owen (Launch Editor)
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引用次数: 0
Finding value in in silico biology 发现硅生物的价值
Biosilico
Pub Date : 2003-03-01 DOI: 10.1016/S1478-5382(03)02218-2
Alex L. Bangs, Thomas S. Paterson

Interest in adopting biological simulation and modeling in the pharmaceutical industry is high, but concerns remain over how soon the technology will pay off. Through a top-down approach to modeling the biology relevant to a disease, Entelos has been able to provide significant value for its research partners. The key to this value comes from understanding clinical outcomes in discovery or development well before any human trial occurs. This knowledge can then be applied to improve research strategy and decision-making throughout the pipeline. Applications include target validation and prioritization, candidate prioritization, biomarker identification and pre-clinical and clinical study optimization.

制药行业对采用生物模拟和建模的兴趣很高，但人们仍然担心这项技术多久能取得成效。通过自上而下的方法来建模与疾病相关的生物学，Entelos已经能够为其研究合作伙伴提供重要的价值。实现这一价值的关键在于，在进行任何人体试验之前，了解发现或开发中的临床结果。然后，这些知识可以应用于改进整个管道的研究策略和决策。应用包括目标验证和优先排序，候选优先排序，生物标志物鉴定以及临床前和临床研究优化。
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引用次数: 7
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