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Identification and characterization of a novel transcriptional factor Spt7 involved in conidia formation and mycelium development in Aspergillus niger. 参与黑曲霉分生孢子形成和菌丝发育的新型转录因子Spt7的鉴定和表征。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-20 DOI: 10.1186/s12866-026-04866-3
Zeyu Xu, Jie Li, Jia Su, Jingran Wang, Zhanglei Cao, Yuhong Liu, Depei Wang, Xianli Xue
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引用次数: 0
An ArsR-type transcriptional regulator, SoxR, regulates sulfur oxidization (Sox) system in Cupriavidus pinatubonensis JMP134. arsr型转录调控因子SoxR调控pinatubonensis JMP134的硫氧化（Sox）系统。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-19 DOI: 10.1186/s12866-026-04764-8
Rui Gao, Honglei Liu, Huiyuan Yu, Fulin Ge, Xia Lu, Huaiwei Liu, Yongzhen Xia, Yutao Wang, Luying Xun

Thiosulfate serves as a critical intermediate in the sulfur biogeochemical cycle and is frequently oxidized by the sulfur oxidation (Sox) system to sulfate in bacteria. Cupriavidus pinatubonensis JMP134 employs a complete Sox system to oxidize S2O32- to SO42-, yet the regulatory mechanisms underlying this process remain unclear. A regulator gene located adjacent to the sox genes cluster encodes an ArsR-type transcriptional regulator (SoxR). Here we report the regulation of the sox genes by SoxR in C. pinatubonensis JMP134. The sox genes are transcribed as an operon from a promoter in the front of soxR. SoxR binds to DNA 23-bp downstream of the transcription start site, blocking the sox transcription. We present evidence that SoxR does not directly respond to S2O32- but instead reacts with reactive sulfane sulfur via Cys43 and Cys98, and this interaction is contingent upon a functional Sox system. These findings will deepen our understanding of the regulation of the Sox system in bacteria.

硫代硫酸盐是硫生物地球化学循环的关键中间体，在细菌中经常被硫氧化（Sox）系统氧化为硫酸盐。pinatubonensis JMP134利用完整的Sox系统将S2O32-氧化为SO42-，但这一过程的调控机制尚不清楚。位于sox基因簇附近的调控基因编码arsr型转录调控因子（SoxR）。本文报道了SoxR在C. pinatubonensis JMP134中对sox基因的调控。sox基因转录为sor前部启动子的操纵子。sox与转录起始位点下游23bp的DNA结合，阻断sox转录。我们提供的证据表明，SoxR不直接与S2O32反应，而是通过Cys43和Cys98与活性磺胺硫反应，这种相互作用取决于功能性的Sox体系。这些发现将加深我们对细菌中Sox系统调控的理解。
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引用次数: 0
Probiotic potential of Companilactobacillus alimentarius Y4 in alleviating ciprofloxacin-resistant Salmonella-induced intestinal inflammation through microbiota-metabolite modulation. 肠道菌群代谢物调节对环丙沙星耐药沙门氏菌肠道炎症的影响
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-19 DOI: 10.1186/s12866-026-04920-0
Tajin Wang, Shuo Wang, Tao Wan, Qi Cui, Lili Guan, Chengguang He, Jingrui Chen, Lingcong Kong, Haipeng Zhang, Hongxia Ma
{"title":"Probiotic potential of Companilactobacillus alimentarius Y4 in alleviating ciprofloxacin-resistant Salmonella-induced intestinal inflammation through microbiota-metabolite modulation.","authors":"Tajin Wang, Shuo Wang, Tao Wan, Qi Cui, Lili Guan, Chengguang He, Jingrui Chen, Lingcong Kong, Haipeng Zhang, Hongxia Ma","doi":"10.1186/s12866-026-04920-0","DOIUrl":"https://doi.org/10.1186/s12866-026-04920-0","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic regulation of selenium yeast and vitamin E on the rumen microbiota-VFA-liver axis in lambs. 酵母硒和维生素E对羔羊瘤胃微生物群- vfa -肝轴的协同调节作用。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-19 DOI: 10.1186/s12866-026-04785-3
Shangwu Ma, Yuzhu Sha, Xiaoyong Ma, Haibo Wang, Shengguo Zhao, Ting Jiao
{"title":"Synergistic regulation of selenium yeast and vitamin E on the rumen microbiota-VFA-liver axis in lambs.","authors":"Shangwu Ma, Yuzhu Sha, Xiaoyong Ma, Haibo Wang, Shengguo Zhao, Ting Jiao","doi":"10.1186/s12866-026-04785-3","DOIUrl":"https://doi.org/10.1186/s12866-026-04785-3","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-occurrence of blaKPC and blaOXA-48 genes in Klebsiella pneumoniae isolates from a tertiary-care hospital in Ecuador and evidence of emerging genotypic-phenotypic AMR inconsistencies. 厄瓜多尔一家三级医院肺炎克雷伯菌分离株中blaKPC和blaOXA-48基因的共存以及新出现的基因型-表型抗菌素耐药性不一致的证据
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04940-w
David Fernández-Salvatierra, Carmen María González-Domenech, Gabriel Morey-León, Juan Carlos Fernández-Cadena
{"title":"Co-occurrence of bla<sub>KPC</sub> and bla<sub>OXA-48</sub> genes in Klebsiella pneumoniae isolates from a tertiary-care hospital in Ecuador and evidence of emerging genotypic-phenotypic AMR inconsistencies.","authors":"David Fernández-Salvatierra, Carmen María González-Domenech, Gabriel Morey-León, Juan Carlos Fernández-Cadena","doi":"10.1186/s12866-026-04940-w","DOIUrl":"https://doi.org/10.1186/s12866-026-04940-w","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of grazing and housing system on growth performance, serum indices, rumen fermentation parameters, and microbial community in Gangba sheep. 放牧与圈养制度对岗坝羊生长性能、血清指标、瘤胃发酵参数和微生物群落的影响
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04936-6
Yining Xie, Xiaokang Jing, Zhaohan Zhan, Yongqi Tan, Liang Chen, Hongfu Zhang
{"title":"Effects of grazing and housing system on growth performance, serum indices, rumen fermentation parameters, and microbial community in Gangba sheep.","authors":"Yining Xie, Xiaokang Jing, Zhaohan Zhan, Yongqi Tan, Liang Chen, Hongfu Zhang","doi":"10.1186/s12866-026-04936-6","DOIUrl":"https://doi.org/10.1186/s12866-026-04936-6","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of human cutaneous leishmaniasis: comparison between ITS1-PCR and ITS1-219 next generation sequencing. 人皮肤利什曼病的诊断：ITS1-PCR与ITS1-219下一代测序的比较。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04961-5
Hanan Al-Jawabreh, Suheir Ereqat, Amer Al-Jawabreh, Lina Dana, Abedelmajeed Nasereddin
{"title":"Diagnosis of human cutaneous leishmaniasis: comparison between ITS1-PCR and ITS1-219 next generation sequencing.","authors":"Hanan Al-Jawabreh, Suheir Ereqat, Amer Al-Jawabreh, Lina Dana, Abedelmajeed Nasereddin","doi":"10.1186/s12866-026-04961-5","DOIUrl":"https://doi.org/10.1186/s12866-026-04961-5","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of antifungal activity, mechanism of action, and zebrafish toxicity of N-(3-fluorobenzyl)-N,3-dimethylbut-2-enamide. N-（3-氟苯基）-N，3-二甲基丁-2-氨基酰胺抗真菌活性、作用机制和斑马鱼毒性的评价。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04898-9
Wenjie Hu, Jingyi Yu, Xuebin Zhang, Wanqing Chen, Qian Jiang
{"title":"Evaluation of antifungal activity, mechanism of action, and zebrafish toxicity of N-(3-fluorobenzyl)-N,3-dimethylbut-2-enamide.","authors":"Wenjie Hu, Jingyi Yu, Xuebin Zhang, Wanqing Chen, Qian Jiang","doi":"10.1186/s12866-026-04898-9","DOIUrl":"https://doi.org/10.1186/s12866-026-04898-9","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-resolved, preclinical safety evaluation of infant-derived Clostridium butyricum S-45-5 as a probiotic candidate. 基因组解析，丁酸梭菌S-45-5作为益生菌候选物的临床前安全性评估。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04905-z
Han Sol Kim, Sung-Oh Sohn, Young-Hyo Chang, Jong-Soo Lee, Jong-Keun Kim
{"title":"Genome-resolved, preclinical safety evaluation of infant-derived Clostridium butyricum S-45-5 as a probiotic candidate.","authors":"Han Sol Kim, Sung-Oh Sohn, Young-Hyo Chang, Jong-Soo Lee, Jong-Keun Kim","doi":"10.1186/s12866-026-04905-z","DOIUrl":"https://doi.org/10.1186/s12866-026-04905-z","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory microbiota maturation enables machine learning based age prediction in chickens. 呼吸微生物群的成熟使基于机器学习的鸡年龄预测成为可能。
IF 4.2 2区 生物学 Q2 MICROBIOLOGY
BMC Microbiology
Pub Date : 2026-03-18 DOI: 10.1186/s12866-026-04947-3
Alejandro Moreno-León, Ane López-Morales, Ursula Höfle, Marta Barral, Natàlia Majó, José Luis Lavín
{"title":"Respiratory microbiota maturation enables machine learning based age prediction in chickens.","authors":"Alejandro Moreno-León, Ane López-Morales, Ursula Höfle, Marta Barral, Natàlia Majó, José Luis Lavín","doi":"10.1186/s12866-026-04947-3","DOIUrl":"https://doi.org/10.1186/s12866-026-04947-3","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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