Background: Cylindrocladium black rot of peanut is caused by the fungus Calonectria ilicicola (anamorph: Cylindrocladium parasiticum). This quarantined plants pathogen, causes this diseasethat threatens the healthy production of peanuts. The objective of this study was to screen andexplore the extracts of biocontrol bacteria against C. ilicicola.
Results: A bacterial strain XYDY-1 was isolated from saline-alkali soil samples collected near peanut plants and identified as Bacillus velezensis based on morphological characteristics, 16S rDNA, and gyrB sequence analyses. The bacterial suspension of XYDY-1 exhibited significant inhibitory effects on the growth of eight pathogenic fungi, including C. ilicicola, Aspergillus niger, Fusarium pseudograminearum, F. oxysporum, F. neocosmosporiellum, Sclerotium rolfsii, Rhizoctonia solanikühn, and Sclerotinia sclerotiorum. Extracellular enzyme assays revealed that XYDY-1 possessed protease, cellulase, amylase, chitinase, and β-1,3-glucanase activities. Furthermore, genomic analysis confirmed the presence of genes srfAD, fenB, ituA, and bmyA, which encode surfactin, fengycin, iturin, and bacillomycin D, respectively, all of which contribute to the inhibition of hyphal growth. Ultra-high-performance liquid chromatography coupled with quadrupole-electrostatic field orbitrap high-resolution tandem mass spectrometry (UPLC-QE Orbitrap MS/MS) analysis detected antifungal compounds in B. velezensis metabolites, including 8-hydroxyquinoline, tunicamycin, Validamycin A, chloramphenicol palmitate, pyocyanin, and Surfactin C. 8-Hydroxyquinoline, tunicamycin, Surfactin C and Validamycin A exhibited significant antifungal activity in assays conducted with pure compounds. Of these, 8-hydroxyquinoline at a concentration of 10 mg/mL displayed the highest efficacy, yielding an inhibition rate of 98.31%. Additionally, greenhouse pot experiments demonstrated that the culture filtrate of XYDY-1 significantly promoted peanut plant growth, increasing fresh and dry biomass by 39.02% and 39.09%, respectively, compared to control treatments with culture medium alone. Moreover, the culture filtrate enhanced peanut resistance to C. ilicicola, achieving a biocontrol efficacy exceeding 56.41%.
Conclusion: B. velezensis XYDY-1, a plant-growth-promoting rhizobacterium, was able to protect peanuts from C. ilicicola infection and is a promising biocontrol agent.It can provide scientific basis for the development of new biological control pesticides, reduce the use of chemical pesticides, and promote the sustainable development of agriculture.
{"title":"Novel antifungal metabolites from Bacillus velezensis XYDY-1 effectively control peanut Cylindrocladium black rot caused by Calonectria ilicicola.","authors":"Xinying Song, Xia Zhang, Ying Li, Guofeng Wei, Zhiqing Guo, Kang He, Yucheng Chi, Manlin Xu","doi":"10.1186/s12866-025-04687-w","DOIUrl":"https://doi.org/10.1186/s12866-025-04687-w","url":null,"abstract":"<p><strong>Background: </strong>Cylindrocladium black rot of peanut is caused by the fungus Calonectria ilicicola (anamorph: Cylindrocladium parasiticum). This quarantined plants pathogen, causes this diseasethat threatens the healthy production of peanuts. The objective of this study was to screen andexplore the extracts of biocontrol bacteria against C. ilicicola.</p><p><strong>Results: </strong>A bacterial strain XYDY-1 was isolated from saline-alkali soil samples collected near peanut plants and identified as Bacillus velezensis based on morphological characteristics, 16S rDNA, and gyrB sequence analyses. The bacterial suspension of XYDY-1 exhibited significant inhibitory effects on the growth of eight pathogenic fungi, including C. ilicicola, Aspergillus niger, Fusarium pseudograminearum, F. oxysporum, F. neocosmosporiellum, Sclerotium rolfsii, Rhizoctonia solanikühn, and Sclerotinia sclerotiorum. Extracellular enzyme assays revealed that XYDY-1 possessed protease, cellulase, amylase, chitinase, and β-1,3-glucanase activities. Furthermore, genomic analysis confirmed the presence of genes srfAD, fenB, ituA, and bmyA, which encode surfactin, fengycin, iturin, and bacillomycin D, respectively, all of which contribute to the inhibition of hyphal growth. Ultra-high-performance liquid chromatography coupled with quadrupole-electrostatic field orbitrap high-resolution tandem mass spectrometry (UPLC-QE Orbitrap MS/MS) analysis detected antifungal compounds in B. velezensis metabolites, including 8-hydroxyquinoline, tunicamycin, Validamycin A, chloramphenicol palmitate, pyocyanin, and Surfactin C. 8-Hydroxyquinoline, tunicamycin, Surfactin C and Validamycin A exhibited significant antifungal activity in assays conducted with pure compounds. Of these, 8-hydroxyquinoline at a concentration of 10 mg/mL displayed the highest efficacy, yielding an inhibition rate of 98.31%. Additionally, greenhouse pot experiments demonstrated that the culture filtrate of XYDY-1 significantly promoted peanut plant growth, increasing fresh and dry biomass by 39.02% and 39.09%, respectively, compared to control treatments with culture medium alone. Moreover, the culture filtrate enhanced peanut resistance to C. ilicicola, achieving a biocontrol efficacy exceeding 56.41%.</p><p><strong>Conclusion: </strong>B. velezensis XYDY-1, a plant-growth-promoting rhizobacterium, was able to protect peanuts from C. ilicicola infection and is a promising biocontrol agent.It can provide scientific basis for the development of new biological control pesticides, reduce the use of chemical pesticides, and promote the sustainable development of agriculture.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Potato common scab, incited by pathogenic Streptomyces species, poses a significant threat to agriculture. The biocontrol agent Streptomyces sp. strain PBSH9 has shown remarkable field efficacy, yet its underlying antibacterial mechanisms remain unclear. To bridge this knowledge gap, we employed an integrated transcriptomic, proteomic, and metabolomic approach to compare PBSH9 under high (8-day) and low (2-day) antibacterial activity conditions. Transcriptomics identified 2,653 differentially expressed genes (DEGs), primarily enriched in oxidative phosphorylation and β-lactam resistance pathways. Proteomics quantified 32 differentially abundant proteins (DAPs), which were also predominantly involved in energy metabolism. Critically, metabolomic profiling of 1,299 differential metabolites (DAMs) revealed the core of the antibacterial activity: a massive > 28-fold accumulation of the antibiotics L-anticapsin and bacilysin, coupled with a significant 1.08- to 2.85-fold increase in several aminoglycoside antibiotics, including neomycin B and kanamycin. This enhanced antibiotic production was supported by the systematic upregulation of energy metabolism pathways, such as oxidative phosphorylation and the TCA cycle. Multi-dimensional correlation networks linked antibiotic accumulation to DEGs (st, phzF) and DAPs. Our findings demonstrate that the potent biocontrol activity of PBSH9 stems from a metabolic reprogramming that fuels the synergistic accumulation of a diverse antibiotic arsenal. This study provides a comprehensive molecular blueprint for optimizing and engineering this promising biocontrol strain.
{"title":"Multi-omics integration to elucidate the antibacterial mechanism of Streptomyces sp. strain PBSH9.","authors":"Feng Wang, Min Zhang, Jianjun Hao, Liwei Wang, Qian Zhao, Lijun Ding, Liying Hu, Xiaoyu Zhang","doi":"10.1186/s12866-026-04754-w","DOIUrl":"https://doi.org/10.1186/s12866-026-04754-w","url":null,"abstract":"<p><p>Potato common scab, incited by pathogenic Streptomyces species, poses a significant threat to agriculture. The biocontrol agent Streptomyces sp. strain PBSH9 has shown remarkable field efficacy, yet its underlying antibacterial mechanisms remain unclear. To bridge this knowledge gap, we employed an integrated transcriptomic, proteomic, and metabolomic approach to compare PBSH9 under high (8-day) and low (2-day) antibacterial activity conditions. Transcriptomics identified 2,653 differentially expressed genes (DEGs), primarily enriched in oxidative phosphorylation and β-lactam resistance pathways. Proteomics quantified 32 differentially abundant proteins (DAPs), which were also predominantly involved in energy metabolism. Critically, metabolomic profiling of 1,299 differential metabolites (DAMs) revealed the core of the antibacterial activity: a massive > 28-fold accumulation of the antibiotics L-anticapsin and bacilysin, coupled with a significant 1.08- to 2.85-fold increase in several aminoglycoside antibiotics, including neomycin B and kanamycin. This enhanced antibiotic production was supported by the systematic upregulation of energy metabolism pathways, such as oxidative phosphorylation and the TCA cycle. Multi-dimensional correlation networks linked antibiotic accumulation to DEGs (st, phzF) and DAPs. Our findings demonstrate that the potent biocontrol activity of PBSH9 stems from a metabolic reprogramming that fuels the synergistic accumulation of a diverse antibiotic arsenal. This study provides a comprehensive molecular blueprint for optimizing and engineering this promising biocontrol strain.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of yeast culture supplementation during the green grass period on growth performance, immune function, and rumen health in grazing yak.","authors":"Yandi Peng, Zhuoma Cisang, Yangji Cidan, Guifang Liu, Dan Wu, Fei Gao, Shijun Wen, Yanbin Zhu","doi":"10.1186/s12866-026-04762-w","DOIUrl":"https://doi.org/10.1186/s12866-026-04762-w","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s12866-026-04740-2
Qimei Yang, Wen Zhang, Hui Liu, Min Xu
{"title":"Transcriptomics combined with metabolomics to elucidate the mechanisms of bacterial otitis media infection: insights from mitochondrial dysfunction.","authors":"Qimei Yang, Wen Zhang, Hui Liu, Min Xu","doi":"10.1186/s12866-026-04740-2","DOIUrl":"https://doi.org/10.1186/s12866-026-04740-2","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s12866-026-04752-y
Yinghui Zhang, Chaoyue Guo, Huifei Wang, Xiaoxia Ren, Liuqing Zhang, Lingxiang Xin, Junping Li, Nan Wang, Lei Xu
{"title":"Construction of an RPA-CRISPR visualization system for rapid detection of Burkholderia mallei.","authors":"Yinghui Zhang, Chaoyue Guo, Huifei Wang, Xiaoxia Ren, Liuqing Zhang, Lingxiang Xin, Junping Li, Nan Wang, Lei Xu","doi":"10.1186/s12866-026-04752-y","DOIUrl":"https://doi.org/10.1186/s12866-026-04752-y","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myxobolus bengalensis is a significant fish parasite responsible for disease and economic losses in aquaculture; however, information on its pathogenicity and impact on fish health remains limited. This study aimed to identify the morphological and molecular features of Myxobolus bengalensis and investigate the immunological changes in infected Labeo catla. Symptomatic fish showed signs of disease, including extreme lethargy, a slender body with a large head (growth retardation), and pale gills with the presence of whitish cysts in the gill lamellae. The Myxozoan parasite was isolated from infected L. catla tissue samples and preliminarily identified as M. bengalensis based on morphology, 18S rRNA PCR sequencing, and phylogenetic analysis. Tissue specimens were collected and underwent examination of immune-related gene expression (in the liver and kidney). The M. bengalensis spores isolated from the gills were ellipsoidal, with ovoid polar capsules. Sequencing and phylogenetic analysis of the 18S rRNA region revealed a ~ 1700 bp fragment, confirming the parasite's identity and placing it within the same clade as other M. bengalensis isolates. The transcription analysis of genes associated with inflammation (TNF-α, IL-1β, iNOS), immune activation (TLR 4, C3, MYD88, NOD 1), and both innate and adaptive immune responses (IFN-γ, Hsp70, Mx, IgM) further highlights that M. bengalensis modulates the expression of genes in the liver and kidney tissue samples of infected L. catla. There is limited data available on the host-pathogen response during M. bengalensis infection; thus, this study provides key insights into the morphology, pathogenicity, and immunological impacts of M. bengalensis in L. catla.
{"title":"Outbreak of gill myxoboliosis causing mass mortality in Labeo catla: pathological effects and immune modulation in host.","authors":"Vikash Kumar, Basanta Kumar Das, Souvik Dhar, Anupam Adhikari, Payoja Mohanty, Asim Kumar Jana","doi":"10.1186/s12866-026-04759-5","DOIUrl":"https://doi.org/10.1186/s12866-026-04759-5","url":null,"abstract":"<p><p>Myxobolus bengalensis is a significant fish parasite responsible for disease and economic losses in aquaculture; however, information on its pathogenicity and impact on fish health remains limited. This study aimed to identify the morphological and molecular features of Myxobolus bengalensis and investigate the immunological changes in infected Labeo catla. Symptomatic fish showed signs of disease, including extreme lethargy, a slender body with a large head (growth retardation), and pale gills with the presence of whitish cysts in the gill lamellae. The Myxozoan parasite was isolated from infected L. catla tissue samples and preliminarily identified as M. bengalensis based on morphology, 18S rRNA PCR sequencing, and phylogenetic analysis. Tissue specimens were collected and underwent examination of immune-related gene expression (in the liver and kidney). The M. bengalensis spores isolated from the gills were ellipsoidal, with ovoid polar capsules. Sequencing and phylogenetic analysis of the 18S rRNA region revealed a ~ 1700 bp fragment, confirming the parasite's identity and placing it within the same clade as other M. bengalensis isolates. The transcription analysis of genes associated with inflammation (TNF-α, IL-1β, iNOS), immune activation (TLR 4, C3, MYD88, NOD 1), and both innate and adaptive immune responses (IFN-γ, Hsp70, Mx, IgM) further highlights that M. bengalensis modulates the expression of genes in the liver and kidney tissue samples of infected L. catla. There is limited data available on the host-pathogen response during M. bengalensis infection; thus, this study provides key insights into the morphology, pathogenicity, and immunological impacts of M. bengalensis in L. catla.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s12866-025-04694-x
Oluwadamilola M Makinde, Muiz O Akinyemi, Carlos Bezuidenhout, Rasheed A Adeleke, Chibundu N Ezekiel
{"title":"Antibiogram of isolated bacteria and overview of resistome and virulome of multi-drug resistant Escherichia coli from ready-to-eat foods vended in Lagos, Nigeria.","authors":"Oluwadamilola M Makinde, Muiz O Akinyemi, Carlos Bezuidenhout, Rasheed A Adeleke, Chibundu N Ezekiel","doi":"10.1186/s12866-025-04694-x","DOIUrl":"https://doi.org/10.1186/s12866-025-04694-x","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Xizang (formerly known as Tibet in English) has one of the highest tuberculosis (TB) incidence rates in China. The region's extreme altitudes (≥ 3000 m) and hypoxic environment present substantial challenges for conventional diagnostic methods. Additionally, the clinical and biological characteristics of TB at high altitudes remain poorly understood.
Method: TB-seq, a third-generation nanopore-targeted sequencing method, was used to analyze sputum samples from 158 confirmed pulmonary TB patients in Xizang. Bacterial load was quantified, a drug-resistance gene landscape was generated, and these findings were correlated with clinical phenotypes. A matched low-altitude group (< 1000 m) was included to investigate the effects of altitude on Mycobacterium tuberculosis biology.
Result: In Xizang, retreatment cases accounted for the majority of TB patients (58.23%). Type I TB was the most common form (79.75%), while non-type I forms were observed only in retreatment patients (P < 0.01). Bacterial load decreased significantly with increasing age (P < 0.001), was higher in retreatment cases (P = 0.013), and positively correlated with white blood cell and neutrophil counts (P < 0.05). Drug-resistant mutations were identified in 22.78% of patients, primarily as mono-resistance (63.9%), with key resistance-associated genes being rpsL (47.2%), rpoB (38.9%), and katG (33.3%). Compared to low-altitude controls, the high-altitude group had a significantly lower bacterial load (P < 0.01), reduced overall drug resistance (23.7% vs. 38.2%, P < 0.01), no rrs mutations, and a significantly lower pncA mutation rate (P < 0.05).
Conclusion: Tuberculosis in Xizang is marked by a high proportion of retreatment cases, low pathogen burden, and a reduced rate of drug resistance-associated gene mutations. Altitude appears to suppress bacterial quantity and may select for specific resistance mechanisms. These findings support the need for targeted TB control strategies in Xizang and underscore the complex interactions among the environment, the pathogen, and the host.
{"title":"Characterization of pulmonary tuberculosis in high-altitude region using nanopore targeted sequencing.","authors":"Anyue Xia, Qiu Zhong, Xiaohui Yu, Shiying Liu, Jingyu Lin, Sijuan Ding, Dongfang Feng, Bin Zhu, Maoshi Li, Shangshi Li, Xianglong Zeng, Huan Xu","doi":"10.1186/s12866-026-04761-x","DOIUrl":"https://doi.org/10.1186/s12866-026-04761-x","url":null,"abstract":"<p><strong>Background: </strong>Xizang (formerly known as Tibet in English) has one of the highest tuberculosis (TB) incidence rates in China. The region's extreme altitudes (≥ 3000 m) and hypoxic environment present substantial challenges for conventional diagnostic methods. Additionally, the clinical and biological characteristics of TB at high altitudes remain poorly understood.</p><p><strong>Method: </strong>TB-seq, a third-generation nanopore-targeted sequencing method, was used to analyze sputum samples from 158 confirmed pulmonary TB patients in Xizang. Bacterial load was quantified, a drug-resistance gene landscape was generated, and these findings were correlated with clinical phenotypes. A matched low-altitude group (< 1000 m) was included to investigate the effects of altitude on Mycobacterium tuberculosis biology.</p><p><strong>Result: </strong>In Xizang, retreatment cases accounted for the majority of TB patients (58.23%). Type I TB was the most common form (79.75%), while non-type I forms were observed only in retreatment patients (P < 0.01). Bacterial load decreased significantly with increasing age (P < 0.001), was higher in retreatment cases (P = 0.013), and positively correlated with white blood cell and neutrophil counts (P < 0.05). Drug-resistant mutations were identified in 22.78% of patients, primarily as mono-resistance (63.9%), with key resistance-associated genes being rpsL (47.2%), rpoB (38.9%), and katG (33.3%). Compared to low-altitude controls, the high-altitude group had a significantly lower bacterial load (P < 0.01), reduced overall drug resistance (23.7% vs. 38.2%, P < 0.01), no rrs mutations, and a significantly lower pncA mutation rate (P < 0.05).</p><p><strong>Conclusion: </strong>Tuberculosis in Xizang is marked by a high proportion of retreatment cases, low pathogen burden, and a reduced rate of drug resistance-associated gene mutations. Altitude appears to suppress bacterial quantity and may select for specific resistance mechanisms. These findings support the need for targeted TB control strategies in Xizang and underscore the complex interactions among the environment, the pathogen, and the host.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1186/s12866-026-04778-2
Wenbo Ji, Zhiming Dong, Ming Luo, Benzhong Fu, Qiang Sheng, Jian Han
{"title":"Optimized fermentation of Myxococcus fulvus WCH05 enhances biocontrol of pear fire blight in the field.","authors":"Wenbo Ji, Zhiming Dong, Ming Luo, Benzhong Fu, Qiang Sheng, Jian Han","doi":"10.1186/s12866-026-04778-2","DOIUrl":"https://doi.org/10.1186/s12866-026-04778-2","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}