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Beyond the Algorithm: Ethical Challenges in AI-Driven Skin Cancer Diagnosis.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-16 DOI: 10.1093/bjd/ljae490
Magnus Lynch
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引用次数: 0
The emerging role of regulatory T cells in the immunopathogenesis of vitiligo and implications for treatment.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-14 DOI: 10.1093/bjd/ljae472
Yang Liu, Ziqi Liu, Dan Li, Xuanxuan He, Leihong Xiang, Bin Li, Chengfeng Zhang

Vitiligo is an autoimmune skin disease that targets pigment-producing melanocytes and results in depigmentation. This disfiguring condition frequently affects visible areas of the body and therefore causes a heavy psychological burden and a decreased quality of life. Although remains intractable, the evergrowing understanding of its immunopathogenesis has dramatically shaped the treatment paradigm for vitiligo. With the impact of autoreactive cytotoxic T cells explained extensively, accumulating evidence suggests the unique role of regulatory T (Treg) cells in the immune microenvironment of vitiligo. We systematically reviewed Treg deficiency, instability, reduced vitality and dysfunction reported in vitiligo patients, combined with novel findings regarding Treg function modulation in autoimmune backgrounds including metabolic alteration, post-translational modifications and interaction with other immune cells. We further summarized classic and advanced Treg-targeted therapeutics in vitiligo practice and research. Herein, we aimed to display the updated knowledge of Treg cells in vitiligo, providing insights into novel Treg-based therapeutic strategies.

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引用次数: 0
Comment on "A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council"- A case of Rhabdomyolysis Induced by Upadacitinib.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-13 DOI: 10.1093/bjd/ljae485
Edoardo Mortato, Marina Talamonti, Claudia Paganini, Alfredo Belcastro, Luca Bianchi, Marco Galluzzo
{"title":"Comment on \"A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council\"- A case of Rhabdomyolysis Induced by Upadacitinib.","authors":"Edoardo Mortato, Marina Talamonti, Claudia Paganini, Alfredo Belcastro, Luca Bianchi, Marco Galluzzo","doi":"10.1093/bjd/ljae485","DOIUrl":"https://doi.org/10.1093/bjd/ljae485","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimal important difference of pain numeric rating scale in patients with Hidradenitis suppurativa: results from THESEUS.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-13 DOI: 10.1093/bjd/ljae486
Tim Pickles, John R Ingram
{"title":"Minimal important difference of pain numeric rating scale in patients with Hidradenitis suppurativa: results from THESEUS.","authors":"Tim Pickles, John R Ingram","doi":"10.1093/bjd/ljae486","DOIUrl":"https://doi.org/10.1093/bjd/ljae486","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Oncogenic alterations in KIR3DL1 in cutaneous acral CD8+ lymphoproliferative disorder' by Wobser et al.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-13 DOI: 10.1093/bjd/ljae487
Baptiste Louveau, Fanélie Jouenne, Caroline Ram-Wolff, Maxence Mancini, Adèle De Masson, Samia Mourah, Maxime Battistella
{"title":"Comment on 'Oncogenic alterations in KIR3DL1 in cutaneous acral CD8+ lymphoproliferative disorder' by Wobser et al.","authors":"Baptiste Louveau, Fanélie Jouenne, Caroline Ram-Wolff, Maxence Mancini, Adèle De Masson, Samia Mourah, Maxime Battistella","doi":"10.1093/bjd/ljae487","DOIUrl":"https://doi.org/10.1093/bjd/ljae487","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new frontier in drug discovery for skin cancer through electronic medical records.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-13 DOI: 10.1093/bjd/ljae489
Lea Dousset, Kiarash Khosrotehrani
{"title":"A new frontier in drug discovery for skin cancer through electronic medical records.","authors":"Lea Dousset, Kiarash Khosrotehrani","doi":"10.1093/bjd/ljae489","DOIUrl":"https://doi.org/10.1093/bjd/ljae489","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Behind the scenes' of a clinic appointment: Insights from the patient experience of eczema.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-11 DOI: 10.1093/bjd/ljae488
Ria Patel
{"title":"'Behind the scenes' of a clinic appointment: Insights from the patient experience of eczema.","authors":"Ria Patel","doi":"10.1093/bjd/ljae488","DOIUrl":"https://doi.org/10.1093/bjd/ljae488","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating artificial intelligence into skin cancer pathways; the opportunities and obstacles.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-11 DOI: 10.1093/bjd/ljae480
Buket Beresford-Wylie, Samuel Ashcroft, Bindi Gaglani, Alice Green, Robert W Smillie, Katie Tucker, Ameet Bakhai, Ben Esdaile, Ioulios Palamaras
{"title":"Integrating artificial intelligence into skin cancer pathways; the opportunities and obstacles.","authors":"Buket Beresford-Wylie, Samuel Ashcroft, Bindi Gaglani, Alice Green, Robert W Smillie, Katie Tucker, Ameet Bakhai, Ben Esdaile, Ioulios Palamaras","doi":"10.1093/bjd/ljae480","DOIUrl":"https://doi.org/10.1093/bjd/ljae480","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term observation to determine durable efficacy and safety of novel paediatric atopic dermatitis treatment, nemolizumab.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-10 DOI: 10.1093/bjd/ljae479
Soo Ick Cho, Jung-Im Na
{"title":"Long-term observation to determine durable efficacy and safety of novel paediatric atopic dermatitis treatment, nemolizumab.","authors":"Soo Ick Cho, Jung-Im Na","doi":"10.1093/bjd/ljae479","DOIUrl":"https://doi.org/10.1093/bjd/ljae479","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient preferences for treatment of Bowen's disease.
IF 11 1区 医学 Q1 DERMATOLOGY
British Journal of Dermatology
Pub Date : 2024-12-09 DOI: 10.1093/bjd/ljae477
Shima Ahmady, Klara Mosterd, Maud H E Jansen, Nicole W J Kelleners-Smeets, Brigitte A B Essers

Background: Discrete choice experiments (DCEs) are increasingly used to understand and quantify patient preferences for a variety of treatments, services or screening in order to analyse the choices patients make when faced with different alternatives. The aim of this DCE was to examine patient preferences for the treatment of Bowen's disease.

Methods: A DCE was conducted alongside a randomised controlled non-inferiority trial comparing the effectiveness of surgical excision, MAL-PDT, and 5-fluorouracil cream as treatments for Bowen's disease. Preferences were elicited by presenting patients with choice tasks between surgical excision, MAL-PDT, and 5-fluorouracil cream with the following attributes: effectiveness, cosmetic outcome, side effects, treatment duration and process. A mixed logit model was used to account for the panel nature of the data (repeated choices for each respondents) and heterogeneity in preference.

Results: A total of 215 patients completed the DCE. Patients have a clear preference for excision and non-invasive therapies were less valued, as indicated by the large and negative label effect.Both moderate and good to excellent cosmetic outcomes were accepted and preferred to poor cosmetic outcomes for all treatments. In addition, none or mild to moderate side effects were considered acceptable and preferred to severe side effects.

Conclusion: Patients show a clear preference for surgical excision, and of the two non-invasive treatments, 5-fluorouracil cream is preferred to MAL-PDT. Treatment choice is also determined by attributes such as effectiveness, cosmetic outcome and side effects. In the context of shared decision making for Bowen's disease, it is important to discuss the elements of treatment that patients value to ensure that an informed decision is made.

{"title":"Patient preferences for treatment of Bowen's disease.","authors":"Shima Ahmady, Klara Mosterd, Maud H E Jansen, Nicole W J Kelleners-Smeets, Brigitte A B Essers","doi":"10.1093/bjd/ljae477","DOIUrl":"https://doi.org/10.1093/bjd/ljae477","url":null,"abstract":"<p><strong>Background: </strong>Discrete choice experiments (DCEs) are increasingly used to understand and quantify patient preferences for a variety of treatments, services or screening in order to analyse the choices patients make when faced with different alternatives. The aim of this DCE was to examine patient preferences for the treatment of Bowen's disease.</p><p><strong>Methods: </strong>A DCE was conducted alongside a randomised controlled non-inferiority trial comparing the effectiveness of surgical excision, MAL-PDT, and 5-fluorouracil cream as treatments for Bowen's disease. Preferences were elicited by presenting patients with choice tasks between surgical excision, MAL-PDT, and 5-fluorouracil cream with the following attributes: effectiveness, cosmetic outcome, side effects, treatment duration and process. A mixed logit model was used to account for the panel nature of the data (repeated choices for each respondents) and heterogeneity in preference.</p><p><strong>Results: </strong>A total of 215 patients completed the DCE. Patients have a clear preference for excision and non-invasive therapies were less valued, as indicated by the large and negative label effect.Both moderate and good to excellent cosmetic outcomes were accepted and preferred to poor cosmetic outcomes for all treatments. In addition, none or mild to moderate side effects were considered acceptable and preferred to severe side effects.</p><p><strong>Conclusion: </strong>Patients show a clear preference for surgical excision, and of the two non-invasive treatments, 5-fluorouracil cream is preferred to MAL-PDT. Treatment choice is also determined by attributes such as effectiveness, cosmetic outcome and side effects. In the context of shared decision making for Bowen's disease, it is important to discuss the elements of treatment that patients value to ensure that an informed decision is made.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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