International journal of pharmacy and pharmaceutical research最新文献

{"title":"A Review of Diagnostic Techniques for Parkinson’s Disease","authors":"Vanita G. Kanse, Megh M. Thosar","doi":"10.25166/ijppr/2022.24.3.1","DOIUrl":"https://doi.org/10.25166/ijppr/2022.24.3.1","url":null,"abstract":"Parkinson's disease is the second most common progressive neurodegenerative disorder in older people. Idiopathic Parkinson's Disease is associated with risk factors such as aging, family history, pesticide exposure, and environmental chemicals (e.g., synthetic heroin use). It is caused by a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal Lewy Bodies. Its underlying causes are unknown. Despite significant advances in neurodegenerative disease research since James Parkinson's first medical description of Parkinson's disease in 1817, these disorders continue to pose significant diagnostic and treatment challenges. A valid diagnosis at early disease stages is critical because it can help accommodate differential prognostic and disease management approaches, elucidate reliable clinicopathological relationships ideally at prodromal stages, and would make it easier to evaluate innovative treatments in clinical trials. The pursuit of early diagnosis in Parkinson's disease and atypical Parkinsonian syndromes, however, is hampered by significant clinical and pathological heterogeneity, which can affect disease presentation and progression. Therefore, more accurate more specific diagnostic techniques are required to differentiate Parkinson’s disease from other neurological conditions.","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43574113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptual Review of Pravala (Coral) – A Marine Source of Natural Calcium","authors":"Geeta G. Gadad, Vikram Singh, B. Sundar","doi":"10.25166/ijppr/2022.23.3.1","DOIUrl":"https://doi.org/10.25166/ijppr/2022.23.3.1","url":null,"abstract":"Background: Pravala (Coral) is one among the nine ratnas (precious stones), as categorized by all the texts of Rasashastra. Pravala is widely used in ayurvedic practice being a rich source of natural calcium and various trace elements. Objective: To critically review and highlight potential natural sources of calcium:pravala from classical and contemporary literature with recent research works. Data source: Ancient Indian literature, Classical texts of Rasa shastra from Rasa Hridaya Tantra (9th Cent. A.D) to Rasa Tarangini (20th Cent. A.D). Materials and Methods: Present work has reviewed and compiled a detailed description of Pravalaparyaya (synonyms), utpatti (Occurrence), bheda (types), grahya/agrahya laxanas (Considerable/Nonconsiderable properties for medicinal preparations), guna karma (Pharmacological and therapeutic properties), shodhana (Purification), Marana (Incineration), pishtikalpana (fine powder), matra (Dose) amayika prayoga (Therapeutic utility) and Yogas (Compound formulations) with its contemporary science relevance. Result: Data from the critical review of classical and contemporary research works. Conclusion: Pravala being natural source of calcium, is administered in the form of Bhasma (Calyx) and Pishti (Paste)for curing ailments such as Amlapitta (Hyperacidity), Netra Roga (Eye diseases), and Hridaya Roga (Cardiac diseases). Pravala is having pitta shamaka (Soothing effect) and Asthiposhaka (Bone mineralization) properties ideally indicated to treat mainly disorders of pitta aggravation and asthikshaya (Calcium deficiency).","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69237916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Assessment of Structural Changes in Vankshan Sandhi Hip Joint with Respect to Avascular Necrosis in Sickle Cell Anemia A Prospective Observational Study","authors":"P. Thakare, Sudam L. Kate, Girish T. Kulkarni, M. Suryawanshi, S. Jadhav","doi":"10.25166/ijppr.2022.25.1.6","DOIUrl":"https://doi.org/10.25166/ijppr.2022.25.1.6","url":null,"abstract":"","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69237454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Analysis of Formulation andProbable Mode of Action of Avipattikara churna: A Comprehensive Review","authors":"Geeta G. Gadad, K. S. Gudaganatti","doi":"10.25166/ijppr/2021.22.2.1","DOIUrl":"https://doi.org/10.25166/ijppr/2021.22.2.1","url":null,"abstract":"Background: The mode of action of a compound Ayurvedic formulation is a critical and essential issue to be concentrated in assuring the therapeutic efficacy and safety based on its composition. Avipattikara Churna is one of the commonly used formulations containing herbs-mineral drugs. Objective: To emphasize the rationality of Avipattikara Churna and its mode of action by classical and contemporary review. Data Source: Classical texts like Vangasena Samhita, Bhaishajya Ratnavali, Rasendra Sara sangraha, Rasendra Chintamani, and published research works. Material and Methods: In the present study a critical analysis based on ingredients and probable mode of action of Avipattikara Churna in different indicated clinical conditions like agnimandya (digestive impairment), vibandha (constipation), amlapitta (hyperacidity), arsha (piles), mutraghata (retention of urine) and prameha (diabetes mellitus) were done based on classical and contemporary research works. Result: Data from the critical review of classical and contemporary research works. Conclusion: Avipattikara Churna is a versatile formulation used in a wide range of gastrointestinal disorders. By this review, it can be emphasized that Avipattikara Churna, which is in clinical practice for Amlapitta (Hyperacidity) and vibandha (constipation) is a tailored formula by its ingredients. In-vivo studies not only justify the effectiveness of the formulation but provide more evidence of the safety and efficacy of the formulation. Clinical research works substantiate its significant gastroprotective activity.","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47525947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Optimization of Novel Vaginal Microsphere Gel of Clotrimazole","authors":"Snehal Bhabad, Snehal Bhabad .","doi":"10.25166/ijppr.2021.v22i02.38","DOIUrl":"https://doi.org/10.25166/ijppr.2021.v22i02.38","url":null,"abstract":"The objective of the study was to develop and evaluate\u0000sustained release microsphere gel for the drug clotrimazole\u0000to be administered through the vaginal route. The effect of\u0000polymer ethylcellulose and carbopol 934 on entrapment\u0000efficiency and diffusion behavior were investigated\u0000respectively. A 32 full-factorial design was used to optimize\u0000the formulation of Microsphere gel. Microspheres were\u0000characterized by SEM, FTIR, Entrapment efficiency, and\u0000particle size. Gels were evaluated for in-vitro drug release in\u0000simulated vaginal fluid. The microsphere loaded with\u0000clotrimazole in bioadhesive carbopol gel formulation was\u0000evaluated for various physicochemical studies and was\u0000found to be satisfactory. The rheological profile shows the\u0000gel formation at desired condition. It is evaluated for\u0000spreadability, drug content, In-vitro drug diffusion, stability\u0000study, and bioadhesive study. It may be concluded that\u0000spray drying is a suitable method for microsphere\u0000preparation and microsphere gel can be used as a novel\u0000drug delivery system to prolonge release of clotrimazole for\u0000vaginal candidiasis.","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46264501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on Anti-Inflammatory Activity of The Traditional Plants Plumbago zeylanica(Chitra)","authors":"A. Yadav, Avadh Biharee, Ramesh Kumar, Patel, L. Chaudhari, Dheeraj Dubey","doi":"10.25166/ijppr.2021.v22i01.14","DOIUrl":"https://doi.org/10.25166/ijppr.2021.v22i01.14","url":null,"abstract":"Medicinal plants have long been utilised as a source of\u0000medicine and are in high demand throughout the world.\u0000They've been around for a long time, and they've been\u0000utilised to cure and prevent ailments. Plumbago zeylanica is\u0000a medicinal plant that is frequently utilised for its medicinal\u0000properties. It contains several bioactive compounds like\u0000napthoquinones, flavonoids, alkaloids, glycosides, steroids,\u0000tri-terpenoids, tannins, fixed oils, fats, proteins, etc. among\u0000all plumbagin is most important bioactive compounds. It\u0000possesses wide range of pharmaceutical activities such as\u0000anti-inflammatory, antimicrobial, anti-cancer, anti-ulcer,\u0000antidiabetic etc. Several investigations on its\u0000pharmacological activity have been conducted. The goal of\u0000this review is to provide a comprehensive understanding of\u0000P. zeylanica's chemical composition and pharmacological\u0000action.","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43127159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Floating Tablets of Ranitidine Hydrochloride with Liquorice as Natural Ulcer Protective Agent","authors":"Poonam Sansarwal, Sunaina Sharma, Richa Ohri","doi":"10.25166/ijppr.2020.v17i01.04","DOIUrl":"https://doi.org/10.25166/ijppr.2020.v17i01.04","url":null,"abstract":"The concurrent trend in pharmaceutical evolution accentuates the effectiveness of floating tablets over conventional dosage form. Furthermore, it facilitates site-specificity, controlled release and is irrespective of gastric emptying. The present study was carried out to enhance the bioavailability of Ranitidine HCl, a floating dosage form with controlled release. Ranitidine HCl has a narrow absorption window in the gastrointestinal tract; therefore its absorption was improved by modifying the dosage form. The action potential of a drug is synergized by combining it with a natural ulcer protective agent that is liquorice. The tablets were prepared by wet granulation method. The batches were formulated using a different ratio of HPMC K15 and Carbopol. It ensures the effectiveness of the formulation variable on drug release and buoyancy property of the delivery system. The prepared formulations show significant results obtained by pharmacopoeial quality control tests. In-vitro dissolution study was also performed to check whether the ratio of polymers was optimum for controlled release or not. The present study suggests that the Ranitidine HCl and liquorice together are well compatible with each other. However, the effectiveness of the drug combination partially depends upon the ratio of polymers. Poonam Sansarwal, Sunaina Sharma, Richa Ohri 1. Himalayan Institute of Pharmacy, Kala-amb, Himachal Pradesh, India-173030 2. LBR college of Pharmacy, Panchkula, Haryana, India-134109 Submission: 23 November 2019 Accepted: 29 November 2019 Published: 30 December 2019 www.ijppr.humanjournals.com Citation: Richa Ohri et al. Ijppr.Human, 2019; Vol. 17 (1): 38-59. 39 INTRODUCTION Most of the medicaments are administered by oral route due to high patient compliance. However, the ideal drug delivery system needs two basic components. Firstly, the drug should be delivered at a predetermined rate for a prolonged time, for the prevention of fluctuation in plasma concentration. Secondly, the drug should bind solely to its selective receptor. Unfortunately, available systems do not relay such kind of properties. Hence the time demands modification in conventional dosage form for the betterment of therapeutic efficacy and drug safety [1, 2]. Manufacturing sustained release or controlled release drug delivery systems can help overcome the above-mentioned drawbacks. For instance, the major risk factor is decreased bioavailability due to the narrow absorption window. So far several new approaches such as bioadhesive, floating, swelling-activated drug delivery systems were made to lengthen the Gastric Retention Time (GRT)[3]. The existing trend in pharmaceutical evolution accentuates the effectiveness of floating tablets over conventional dosage form. On inference, it facilitates site-specificity, controlled release and is irrespective of gastric emptying[4, 5].Floating tablet tending to keep afloat for several hours. The buoyancy of tablets is achieved by gas generating","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47589991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential.","authors":"Andrea Lavado,&nbsp;Xiufang Guo,&nbsp;Alec St Smith,&nbsp;Nesar Akanda,&nbsp;Candace Martin,&nbsp;Yunqing Cai,&nbsp;Dan Elbrecht,&nbsp;My Tran,&nbsp;Jean-Paul Bryant,&nbsp;Alisha Colon,&nbsp;Christopher J Long,&nbsp;Stephen Lambert,&nbsp;Dave Morgan,&nbsp;James J Hickman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There has been a tremendous amount of research into the causes of Amyotrophic Lateral Sclerosis (ALS), but yet very few treatment options beyond amelioration of symptoms. A holistic approach has shown anecdotal evidence of slowing disease progression and this treatment, known as the Deanna protocol (DP), postulates that ALS is a metabolic disease caused by glutamate that induces toxicity. In this study, glutamate exposure to human motoneurons was investigated and found not to significantly affect cell viability or electrophysiological properties. However, varicosities were observed in axons suggestive of transport impairment that was dose dependent for glutamate exposure. Surprisingly, a subset of the components of the DP eliminated these varicosities. To verify this finding a human SOD1 patient-derived iPSC line was examined and significant numbers of varicosities were present without glutamate treatment, compared to the iPSC control, indicating the possibility of a common mechanism despite different origins for the varicosities. Importantly, the DP ameliorated these varicosities by over 70% in the patient derived cells as well. These results are consistent with much of the literature on ALS and give hope for treatment not only for arresting disease progression using compounds considered safe but also the potential for restoration of function.</p>","PeriodicalId":92533,"journal":{"name":"International journal of pharmacy and pharmaceutical research","volume":"11 1","pages":"348-374"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326589/pdf/nihms958630.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36858703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}