International journal of pharmacy and pharmaceutical research最新文献

英文中文

Comparison of Mean Post-Operative Pain Score with Pre-Incisional Versus Postoperative Injection of Bupivacaine in Patients Undergoing Elective Surgery. 择期手术患者术前注射布比卡因与术后注射布比卡因的术后平均疼痛评分比较

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-08-01 Epub Date: 2023-08-30

Muhammad Bilal Akbar, Babar Hameed

The most important concern after the surgical intervention is pain which needs to be addressed for better compliance and early mobilization to avoid other complications. The need for a better analgesic and time of administration is the key to success.

Objective: To compare the mean post-operative pain score with pre-incisional versus post-operative injection of bupivacaine in patients undergoing elective surgery.

Study design: This Randomized controlled trial was conducted in the General surgery department, National Hospital & Medical Centre, Lahore from 24-02-20 to 24-11-20. Data was collected through Non-probability consecutive sampling. The cases of both genders with an age range of 18-60 years undergoing elective surgeries were selected. They were divided into two groups. The cases in group A were given pre-incision bupivacaine and group B with post-operative bupivacaine and were assessed 1 hour after surgery regarding pain on VAS.

Results: In the present study there were a total of 64 cases with 32 in each group. The mean age in group A was 47.56±7.51 years while in group B was 49.13±8.03 years. There were 19 (59.37%) males in group A vs 18 (56.25%) in group B. The mean post-operative pain in group A was 3.07±0.67 vs 3.59±0.91 in group B on VAS with p= 0.03. Mean post-operative pain in males was 3.12±0.65 vs 3.47±0.86 and in females, it was 3.21±0.66 vs 3.53±0.90 in groups A and B with p values of 0.21 and 0.23 respectively. Mean Post-operative pain was 3.11±0.66 vs 3.44±0.83 in the age group 18-39 years and 3.08±0.68 vs 3.47±0.88 in age group 40 to 60 years in group A and B with p values of 0.25 and 0.20 respectively. There was a significant difference in terms of postoperative pain in cases undergoing open cholecystectomy where pain was 3.21±0.78 vs 3.86±1.02 in group A and B respectively with p= 0.01. Whereas no difference was seen in the rest of the variables.

Conclusion: Mean post-operative pain is significantly better in cases treated with pre-incisional bupivacaine as compared to post-operative bupivacaine and this difference was also seen as significantly high in cases undergoing open cholecystectomy.

手术治疗后最重要的问题是疼痛，这需要得到解决，以提高患者的依从性和早期活动能力，避免其他并发症。需要更好的镇痛剂和给药时间是成功的关键：比较择期手术患者术前与术后注射布比卡因的平均术后疼痛评分：这项随机对照试验于 20 年 2 月 24 日至 20 年 11 月 24 日在拉合尔国立医院和医疗中心普外科进行。数据通过非概率连续抽样收集。选取了 18-60 岁接受择期手术的男女病例。他们被分为两组。A 组病例在手术前使用布比卡因，B 组病例在手术后使用布比卡因，并在手术后 1 小时根据 VAS 对疼痛进行评估：本研究共有 64 例病例，每组 32 例。A 组的平均年龄为（47.56±7.51）岁，B 组为（49.13±8.03）岁。A 组有 19 名男性（59.37%），B 组有 18 名男性（56.25%）。术后疼痛 VAS 平均值为 3.07±0.67，B 组为 3.59±0.91，P= 0.03。A 组和 B 组男性术后平均疼痛为 3.12±0.65 vs 3.47±0.86，女性术后平均疼痛为 3.21±0.66 vs 3.53±0.90，P 值分别为 0.21 和 0.23。A 组和 B 组 18-39 岁年龄组的平均术后疼痛为 3.11±0.66 vs 3.44±0.83，40-60 岁年龄组的平均术后疼痛为 3.08±0.68 vs 3.47±0.88，P 值分别为 0.25 和 0.20。接受开腹胆囊切除术的患者术后疼痛明显不同，A 组和 B 组分别为 3.21±0.78 对 3.86±1.02，P= 0.01。结论：A 组和 B 组的术后平均疼痛明显优于 A 组和 B 组，P= 0.01：结论：使用切口前布比卡因治疗的病例术后平均疼痛明显优于术后布比卡因治疗的病例，这种差异在开腹胆囊切除术病例中也明显较高。

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引用次数: 0

Unveiling the Neurocognitive Potential: A Comprehensive Evaluation on Acetylcholine and Memory-Enhancing Activity of Ethanol Extract from Ficus benghalensis in Scopolamine-Induced Amnesia 揭示神经认知潜能:对东莨菪碱致健忘症乙酰胆碱和榕树乙醇提取物增强记忆活性的综合评价

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.3.11

Sunkara Sivananda Swaroop, Dudday Venkata Vyshnavi, Jeethuri Rajesh

Ficus benghalensis , is a medicinal plant with potential pharmacological properties. This study aimed to comprehensively evaluate the memory-enhancing activity of an ethanol extract from Ficus benghalensis and its impact on acetylcholine levels in a scopolamine-induced amnesia model. Albino Wister rats were used for the experiments. The ethanol extract from Ficus benghalensis was prepared and administered to the rats at a dose of 100, 200 mg/kg. The scopolamine-induced amnesia model was established by injecting scopolamine. The memory and cognitive function of the rat were assessed using appropriate behavioral tests, such as the elevated plus maze, and passive avoidance test. Acetylcholinesterase activity was measured using specific biochemical assays. The ethanol extract from Ficus benghalensis at a dose of 200 mg/kg exhibited significant memory enhancement in the scopolamine-induced amnesia model. The treated group showed improved performance compared to the control group. Furthermore, the extract demonstrated inhibitory effects on acetylcholineesterase activity, leading to increased levels of acetylcholine. These findings contribute to the understanding of the neurocognitive potential of Ficus benghalensis and its therapeutic implications in memory-related disorders.

榕树是一种具有潜在药理作用的药用植物。本研究旨在全面评估榕树乙醇提取物的记忆增强活性及其对东莨菪碱诱导的健忘症模型中乙酰胆碱水平的影响。实验采用白化Wister大鼠。制备榕树乙醇提取物，给药剂量分别为100、200 mg/kg。通过注射东莨菪碱建立东莨菪碱致健忘症模型。采用适当的行为测试，如高架+迷宫和被动回避测试，评估大鼠的记忆和认知功能。采用特异性生化法测定乙酰胆碱酯酶活性。榕树乙醇提取物剂量为200 mg/kg时，在东莨菪碱诱导的遗忘模型中表现出显著的记忆增强作用。与对照组相比，治疗组表现出更好的表现。此外，提取物对乙酰胆碱酯酶活性有抑制作用，导致乙酰胆碱水平升高。这些发现有助于了解榕树的神经认知潜能及其对记忆相关疾病的治疗意义。

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引用次数: 0

IN-SILICO DESIGN OF PURINE 2,6 DIONES ASPHOSPHODIESTERASE INHIBITORS 嘌呤2,6二酮磷酸二酯酶抑制剂的计算机设计

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.28.1.43

Sreeja S., Vani V., Akhila A., Anagha S. Anil, Rizwan Bin Nizar M., Sapna Sivanthie Suresh Kumar

引用次数: 0

From Evidence to Global Recognition: Utilizing Statistics in Ayurvedic Practice 从证据到全球认可:在阿育吠陀实践中利用统计数据

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.28.1.30

Namdeo D. Dongare, Vd. Mayuri Shingnapurkar- Kawale, Vd. Priya A. Thakare, Dr. Milind N. Suryawanshi

引用次数: 0

Conceptual Study of Yapana Basti in Jara as a Rasayana 梵语中作为一种拉萨耶那的巴斯提的概念研究

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.1.33

Kavita B Sutagatti, Samiuzzama Davalbhai

In Ayurveda management strategies are preventive and curative. Panchakarma is one of the vital branches of Ayurveda, which deals mainly elimination of vitiated doshas from the body. Basti is considered as superior, because of its specific indications and action. Though shodhana is contraindicated in Bala and Vrudha, Basti is indicated. Ageing is an inescapable reality of the human existence, plays a crucial role in the global demographic transition. According to UN Population Division, there will be 2elderly persons for every child by 2050. This implies the aged60 and above, which currently constitute less than 20% of the population will account for32% of the population by2050. In kalajajara as vata prakopa occurs naturally, and results in mamsa bala kshaya that is degenerative condition. Basti is the first line of treatment for the vatadosha. Yapana is a type of basti which sustains supports and maintains the life and provides longevity. It can be given in all season, any time and in all age groups. Yapana basti enhances status of shukra, mamsa and gives bala to the body and checks the process of aging enhances the tissues, alleviating the disease, support and maintains the life. Rasayana is a specialized type of treatment influencing the fundamental aspect of body like dhatu, Agni, srotas and ojas etc. and boosts tejas and immune system. Here an attempt is made to understand the role/ effects of yapana basti in jara as rasayana to prevent and maintain the process of ageing and improving generalized health in Jarā ava stha.

在阿育吠陀管理策略是预防和治疗。Panchakarma是阿育吠陀的重要分支之一，主要是清除体内被破坏的能量。Basti被认为是更好的，因为它具有特定的适应症和作用。虽然在Bala和Vrudha中，shodhana是禁忌的，但Basti是指的。老龄化是人类生存不可回避的现实，在全球人口结构转型中起着至关重要的作用。根据联合国人口司的数据，到2050年，老年人和儿童的比例将达到2比1。这意味着目前占人口不到20%的60岁及以上的人口到2050年将占人口的32%。在卡拉贾哈拉，由于vata prakopa自然发生，导致mamsa bala kshaya，这是一种退行性疾病。巴斯提是治疗瓦塔多沙的第一线药物。Yapana是一种支撑和维持生命并提供长寿的基础。它可以在所有季节，任何时间和所有年龄组进行。Yapana basti提高了舒克拉，乳房的地位，给身体提供巴拉，检查衰老过程，增强组织，减轻疾病，支持和维持生命。Rasayana是一种特殊类型的治疗，影响身体的基本方面，如dhatu, Agni, srotas和ojas等，增强tejas和免疫系统。本文试图了解耆那瓦人在耆那瓦人的健康状况和预防和维持衰老过程中的作用/影响。

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引用次数: 0

Parkinson’s Disease: A Systematic Review of Neurodegenerative Disease and Its Management 帕金森病:神经退行性疾病及其管理的系统综述

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.3.15

Arpit Dwivedi, Srishti Awasthi, Avanish Maurya, Saumya Awasthi, Anurag Mishra, A. Mishra, Bhavana Dubey, Ruchi Singh

引用次数: 0

Multi-Disciplinary Approach and Need of Intravenous to Oral Conversion in Hospital and Role of the Pharmacist in Rational Use of Antimicrobials 医院静脉转口服的多学科途径、需求及药师在抗菌药物合理使用中的作用

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.3.7

Ancy Chacko, Jibin James, Abhishek B J, Ansu chacko

Multi-disciplinary approach and IV to oral conversion are important aspects of rational use of antimicrobials in hospitals. Most of the time patients admitted to the hospital with any serious condition are first given an intra venous route of administration. Some of patient will continue with IV where as some will be converted to oral administration. The shift from iv to oral depends on disease severity, co-morbidity, and drug bioavailability. Body weight-based conversion of intravenous to oral should be practiced for effective and tolerable treatment and for good therapeutic outcome. But this conversion from IV to oral is not applicable in all patients whose GI absorption is altered. IV administration is mostly effective in highly infected patient and in septicemic for their early recovery. But long-term iv administration leads to iv abuse that includes phlebitis, infiltration, hematoma. Prolonged iv administration of psychotropic drugs like Carbamazepine leads to sleep abnormalities, decreased gait, anxiety disorders. Nowadays irrational use of IV antibiotics is increasing, hence to avoid irrational use of antibiotics IV should be converted to oral at proper time and guidelines. Role of clinical pharmacist in switching IV to oral includes monitoring, educating and practicing as per the guidelines.

多学科途径和静脉注射转口服是医院合理使用抗菌药物的重要方面。大多数情况下，入院的重症患者首先给予静脉内给药途径。有些病人将继续静脉注射，有些病人将转为口服给药。从静脉注射到口服的转变取决于疾病严重程度、合并症和药物的生物利用度。为获得有效和可耐受的治疗效果和良好的治疗结果，应实行以体重为基础的静脉注射转为口服。但这种从静脉注射到口服的转变并不适用于所有胃肠道吸收改变的患者。静脉给药对高度感染和败血症患者的早期康复最有效。但长期静脉注射会导致静脉滥用，包括静脉炎、浸润、血肿。长期静脉注射卡马西平等精神药物会导致睡眠异常、步态减少、焦虑障碍。目前静脉注射抗生素的不合理使用日益增多，为避免不合理使用抗生素，应在适当的时间和指导下将静脉注射转为口服。临床药师在静脉注射转口服中的作用包括监督、教育和实践。

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引用次数: 0

Antihypertensive Activity and ADR Survey of Amlodipine and Telmisartan in Hypertension 氨氯地平与替米沙坦对高血压的降压活性及不良反应调查

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.28.2.24

Kiran S. Gaykwad, Abhay A. Nirmal, Gokul M. Davkar, Ajinkya M. Sonune

引用次数: 0

Cardiac TB: A Diagnostic Challenge 心脏结核:诊断挑战

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.4.16

Ashish Kushwaha, Sapna Kumari

引用次数: 0

Effect of Menoveda Akira Tablet against Anxiety; an In-Vivo Zebra Fish Model Study 梅诺维达明叶片抗焦虑作用的研究斑马鱼体内模型研究

International journal of pharmacy and pharmaceutical research

Pub Date : 2023-01-01 DOI: 10.25166/ijppr.2023.27.1.37

Nidhi Dixit, Mainuddin Ikramuddin, Aakriti Dubey

引用次数: 0

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International journal of pharmacy and pharmaceutical research

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