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The SHIELD scheme in the West Midlands Region, United Kingdom. Midland Thoracic Society Research Group. 英国西米德兰兹地区的SHIELD计划。米德兰胸科学会研究小组。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.791
P F Gannon, P S Burge

Objective: To study the general and specific incidence of occupational asthma within a defined geographic area; to audit the diagnosis of occupational asthma; to determine proposed mechanisms of asthma; and to determine the employment state of workers at diagnosis.

Design: A surveillance scheme of physicians likely to see cases of occupational asthma.

Setting: The West Midlands Region of the United Kingdom.

Subjects: Workers with occupational asthma diagnosed within the boundaries of the West Midlands Region.

Main measures: Demographic data, employer, agent to which exposed, date of diagnosis, method of diagnosis, proposed mechanism of asthma, and employment state.

Results: A recognised incidence of 43 (95% confidence interval CI 35-52) new cases per million general workers per year was detected. Specific occupational incidences varied from 1833 (95% CI 511-2990) per million paint sprayers to eight per million clerks. Specific incidence by District Health Authority varied from 103 in Solihull to 14 per million general workers in South Warwickshire. Agents to which workers were exposed at the time of diagnosis were generally well recognised (isocyanates 20.4%, flour 8.5%, colophony 8.3%). The most commonly used method of diagnosis was serial peak expiratory flow (PEF) measurement. Its use varied (specialist unit 72%, general chest physicians 50%, compensation board 48%). Workers were still exposed and therefore could have usefully performed PEF readings in 4% of cases where they were omitted from the specialist centre, 16% seen by chest physicians, and 2% seen by the Compensation Board. Other methods of diagnosis were used only infrequently outside the specialist unit. Fifty six per cent of reporting physicians considered that the mechanism of asthma was allergy compared with 18% who believed that it was irritation. Twenty eight per cent of workers were exposed to the suspected causative agent at the time of diagnosis, 38% were either on long term sickness absence, had retired, or had become unemployed. More workers (38%) who were exposed to agents recognised for statutory compensation before the 1991 changes seen at the specialist centre reach compensation and were reported to the scheme by the Compensation Board than those seen by chest physicians (9%).

Conclusions: These recognised incidences are likely to be an underestimate of the true incidence. They highlight at risk occupations and suggest underdiagnosis in some District Health Authorities. They suggest that diagnostic methods are underused outside specialist centres and that the mechanism of asthma is generally considered to be allergic.

目的:了解一定地理区域内职业性哮喘的一般和特殊发病率;审核职业性哮喘的诊断;确定哮喘的发病机制;并在诊断时确定工人的就业状况。设计:对可能看到职业性哮喘病例的医生进行监测。背景:英国的西米德兰地区。研究对象:在西米德兰兹地区被诊断为职业性哮喘的工人。主要测量指标:人口统计资料、用人单位、暴露对象、诊断日期、诊断方法、哮喘发病机制、就业状况。结果:每年每百万普通工人检测到43例(95%置信区间CI 35-52)新发病例。具体职业发生率从每百万喷漆工1833例(95% CI 511-2990)到每百万职员8例不等。地区卫生局统计的具体发病率从索利赫尔的103‰到南沃里克郡的14‰不等。工人在诊断时所接触的物质通常被很好地识别(异氰酸酯20.4%,面粉8.5%,树脂8.3%)。最常用的诊断方法是连续呼气峰流量(PEF)测量。它的使用各不相同(专科单位72%,普通胸科医生50%,补偿委员会48%)。工作人员仍然暴露在辐射中,因此,在被专家中心忽略的4%的病例中,在胸科医生看到的16%的病例中,在补偿委员会看到的2%的病例中,工作人员可以有效地进行PEF读数。其他诊断方法仅在专科单位之外很少使用。56%的报告医生认为哮喘的机制是过敏,18%的人认为是刺激。28%的工人在诊断时接触到疑似病原体,38%的工人要么长期病假,要么已经退休,要么已经失业。在1991年改革前接触过获得法定补偿的代理的工人(38%)在专科中心获得补偿并由补偿委员会报告给该计划的人数多于胸科医生(9%)。结论:这些公认的发病率可能低估了真实的发病率。它们突出了高危职业,并建议一些地区卫生当局诊断不足。他们认为诊断方法在专科中心之外没有得到充分利用,哮喘的机制通常被认为是过敏性的。
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引用次数: 95
Toxicological investigations on silicon carbide. 1. Inhalation studies. 碳化硅的毒理学研究。1. 吸入研究。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.797
J Bruch, B Rehn, H Song, E Gono, W Malkusch

The question of lung damage as a result of exposure to silicon carbide (SiC) was investigated by inhalation experiments to obtain information on the qualitative response of lung tissue to the test substance (SiC). For comparison, quartz, kaolinite, and tempered clay dusts were used. The indices for the effects of the dusts studied were organ weights, numbers of bronchoalveolar cells, lung surfactant phospholipid concentrations including subfractions, and lung clearance. Exposure to the test samples was carried out according to the Essen inhalation model in two independent series. The results of the two series were similar: Compared with sham controls, exposure to SiC did not affect the indices studied. Even at a low dose (a quarter of the SiC dose) quartz gave pronounced deviations in all indices. In particular, an increase in granulocytes indicated toxic properties of the dust. The long term elimination of quartz from the lung was worse than that of SiC. The kaolinite and tempered clay dusts were intermediate between SiC and quartz based on several of the indices studied. It is concluded that SiC is deposited practically inert in the lung.

通过吸入实验研究了暴露于碳化硅(SiC)导致的肺损伤问题,以获得肺组织对测试物质(SiC)的定性反应信息。为了进行比较,使用了石英、高岭石和回火粘土粉尘。所研究的粉尘影响指标包括器官重量、支气管肺泡细胞数量、肺表面活性物质磷脂浓度(包括亚组分)和肺清除率。根据埃森吸入模型在两个独立的系列中对测试样品进行暴露。两个系列的结果是相似的:与假对照相比,暴露于SiC没有影响所研究的指标。即使在低剂量(SiC剂量的四分之一)下,石英在所有指标上都有明显的偏差。特别是,粒细胞的增加表明粉尘具有毒性。石英的肺部长期清除情况较碳化硅差。高岭石和回火粘土粉尘的各项指标介于碳化硅和石英之间。结果表明,碳化硅在肺中的沉积几乎是惰性的。
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引用次数: 31
Authors' reply 作者的回复
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.863-a
K. Kilburn, Daniel Powers, R. Warshaw
The experiments carried out MMVF10 (2) 30 mg/m3 232 f/ml Wagner PGS 2 5 to 3 MMVF1 1 (2) 30 mg/mr3 246 f/ml Wagner PGS 2 5 to 3 RCF (2) 30 mg/m3 187 f/ml Wagner PGS 4 Lung tumours 16 (13-0%) Mesothelioma 2 (1 6%) Aramid (3) Not stated 100 f/ml Fibrosis and cystic keratinising squamous tumours Chrysotile (2) 10 mg/m3 10 600 f/ml Wagner PGS 4 Lung tumours 13 (18%) Mesothelioma 1 (14%) The experiment that was never caried out Chrysotile 0 18 mg/m3 200 f/ml ?
实验进行MMVF10(2) 30毫克/立方米232 f /毫升瓦格纳后卫2 5 3 MMVF1 1(2) 30毫克/ mr3 246 f /毫升瓦格纳后卫2 5 3 RCF(2) 30毫克/立方米187 f /毫升瓦格纳后卫4肺肿瘤16(13 - 0%)间皮瘤2(1 6%)芳纶(3)不是说100 f /毫升纤维化和囊性keratinising鳞状上皮肿瘤温石棉(2)10 mg / m3 10 600 f /毫升瓦格纳后卫4肺肿瘤13例(18%)间皮瘤1(14%)实验,从未卡里温石棉0 18毫克/立方米200 f /毫升?
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引用次数: 0
Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. 1965. 伦敦地区暴露于石棉后的胸膜和腹膜间皮瘤。1965.
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.769-a
M. Newhouse, H. Thompson
A series of 83 patients from the London Hospital with a diagnosis of mesothelioma confirmed by necropsy or biopsy has been studied for possible exposure to asbestos. The series consisted of 41 men and 42 women; 27 of the patients had peritoneal and 56 pleural tumours. The earliest death recorded was in 1917, but only 10 of the series died before 1950 and 40 (48%) between 1960 and 1964. In 76 of the series full occupational and residential histories were obtained. Forty (52-6 %) gave a history of occupational or domestic (living in the same house as an asbestos worker) exposure to asbestos compared with nine (11-8.) out of 76 patients from the same hospital suffering from other diseases (p < 0-001). None of the 17 suspected cases of mesothelioma, rejected on pathological grounds, was found to have had any exposure to asbestos. There was also evidence that neighbourhood exposures may be important. Among those with no evidence of occupational or domestic exposures, 30-6% of the mesothelioma patients and 7-6% of the in-patients with other diseases lived within half a mile of an asbestos factory (p < 0'01). Out of the 31 patients with occupational exposures only 10 were in jobs scheduled under the Asbestos Regulations of 1931. The interval between first exposure and the development of the terminal illness of mesothelioma ranged between 16 and 55 years. In 47 patients in the mesothelioma series, lung tissue or sputum was available for examination. In 30 (62 5%), either asbestosis or asbestos bodies were present.
伦敦医院83例经尸检或活组织检查确诊为间皮瘤的患者对可能接触石棉的可能性进行了研究。该研究由41名男性和42名女性组成;27例患者有腹膜肿瘤,56例有胸膜肿瘤。最早的死亡记录是在1917年,但只有10只在1950年之前死亡,40只(48%)在1960年至1964年之间死亡。其中76例获得了完整的职业和居住史。40人(52.6%)有职业或家庭(与石棉工人同住)石棉暴露史,而同一医院76名患有其他疾病的患者中有9人(11.8%)有石棉暴露史(p < 0-001)。17例间皮瘤疑似病例经病理排除后,均未发现与石棉有任何接触。也有证据表明,邻里接触可能很重要。在没有职业或家庭接触证据的人群中,30-6%的间皮瘤患者和7-6%的其他疾病住院患者居住在石棉工厂半英里范围内(p < 0.01)。在31名职业性接触患者中,只有10名从事1931年石棉法规规定的工作。从首次接触间皮瘤到发展为晚期间皮瘤的时间间隔为16至55年。在47例间皮瘤系列患者中,肺组织或痰可用于检查。30例(62.5%)存在石棉沉滞或石棉体。
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引用次数: 46
Pulmonary effects of exposure to fine fibreglass: irregular opacities and small airways obstruction. 接触细玻璃纤维对肺部的影响:不规则混浊和小气道阻塞。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.863
K Mentzer
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引用次数: 1
The importance of lung function, non-malignant diseases associated with asbestos, and symptoms as predictors of ischaemic heart disease in shipyard workers exposed to asbestos. 暴露于石棉的船厂工人肺功能、与石棉相关的非恶性疾病和症状作为缺血性心脏病预测因素的重要性
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.785
A Sandén, B Järvholm, S Larsson

The mortality from ischaemic heart disease was studied in a prospective cohort of 1725 shipyard workers exposed to asbestos. The analyses were stratified for age and smoking habits and restricted to men. In agreement with other findings, men with impaired lung function had a significantly higher risk (relative risk (RR) = 3.5) of dying from ischaemic heart disease than men with normal lung function. Men with asbestosis or suspected asbestosis had a significantly higher risk (RR = 3.1) of dying from ischaemic heart disease than men without asbestosis. Thus asbestosis or suspected asbestosis also seemed to be a risk factor for ischaemic heart disease. This finding was independent of respiratory function. There was no increased risk for ischaemic heart disease in men with compared with men without pleural plaques. Men with production of phlegm or sputum and wheezing or whistling had no increased risk for ischaemic heart disease compared with men without these symptoms. In the group with normal lung function men with dyspnoea had a significantly higher risk of dying from ischaemic heart disease than men without dyspnoea. The findings for men with asbestosis or suspected asbestosis indicated a further risk factor besides impaired lung function, in persons exposed to asbestos. Perhaps this risk factor is due to lesions of the pericardium with consequences for heart function.

对1725名接触石棉的船厂工人进行了缺血性心脏病死亡率的前瞻性队列研究。这些分析根据年龄和吸烟习惯进行了分层,并且仅限于男性。与其他研究结果一致,肺功能受损的男性死于缺血性心脏病的风险(相对风险(RR) = 3.5)明显高于肺功能正常的男性。有石棉沉滞症或疑似石棉沉滞症的男性死于缺血性心脏病的风险(RR = 3.1)明显高于没有石棉沉滞症的男性。因此,石棉沉滞症或疑似石棉沉滞症似乎也是缺血性心脏病的危险因素。这一发现与呼吸功能无关。与没有胸膜斑块的男性相比,有胸膜斑块的男性患缺血性心脏病的风险没有增加。与没有这些症状的男性相比,有痰或痰、喘息或吹口哨的男性患缺血性心脏病的风险没有增加。在肺功能正常的一组中,有呼吸困难的男性死于缺血性心脏病的风险明显高于没有呼吸困难的男性。石棉沉滞症男性或疑似石棉沉滞症男性的研究结果表明,在接触石棉的人群中,除了肺功能受损外,还有一个进一步的危险因素。这一危险因素可能是由于心包损伤对心功能的影响。
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引用次数: 23
An analysis of the reliability of self reported work histories from a cohort of workers exposed to polychlorinated biphenyls. 一组接触多氯联苯的工人自我报告工作经历的可靠性分析。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.822
C R Rosenberg

An investigation was conducted to examine the reliability (reproducibility) of self reported occupational histories obtained from a cohort of 326 capacitor manufacturing workers who had participated in an epidemiological study relating health abnormalities to exposure to polychlorinated biphenyls (PCBs). For a subsample of the cohort (n = 164) in which occupational histories were obtained twice (in 1976 and 1979), reliability of cumulative exposure to PCBs ranged from 93.6% for the early PCB period (1947-70) to 95.7% for the late PCB period (1971-6). These respective reliabilities were lower, however, for workers who changed jobs often. Workers above the median value of a weighted job change index had early and late reliabilities of 89.9% and 83.6% respectively. Reliability is a relevant factor when calculating power or sample size during the planning stage of epidemiological studies, for interpretation or adjustment of estimates in the analysis stage, or for determination of study feasibility.

进行了一项调查,以检验326名电容器制造工人自我报告的职业史的可靠性(可重复性),这些工人参加了一项与接触多氯联苯(pcb)有关的健康异常的流行病学研究。对于该队列(n = 164)中两次获得职业史(1976年和1979年)的子样本,多氯联苯累积暴露的可靠性范围从早期多氯联苯时期(1947- 1970年)的93.6%到晚期多氯联苯时期(1971- 1976年)的95.7%。然而,对于经常换工作的人来说,这些各自的可靠性较低。在加权工作变动指数中位数以上的工人,其早期可靠性和后期可靠性分别为89.9%和83.6%。在流行病学研究的规划阶段计算能力或样本量时,在分析阶段解释或调整估计时,或在确定研究可行性时,可靠性是一个相关因素。
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引用次数: 13
Decrease in mercury concentration in blood after long term exposure: a kinetic study of chloralkali workers. 长期接触后血液中汞浓度的降低:氯碱工人的动力学研究。
G Sällsten, L Barregård, A Schütz

The elimination of mercury (Hg) in blood was investigated in 14 chloralkali workers exposed to metallic Hg vapour for 1-24 (median 10) years. Blood and urine samples were collected on several (median eight) occasions during a period of 17-26 days. The initial Hg concentrations were about 80 nmol/l in whole blood (B-Hg) and 17 nmol/mmol creatinine in urine (U-Hg). The decrease in Hg in whole blood, plasma (P) and erythrocytes (Ery) was best characterised by a two compartment model. In a model with a common half life for all subjects, the best fit for B-Hg was obtained with half lives of 3.8 days for a fast phase and 45 days for a slow phase. The half life of the fast phase was shorter for P-Hg than for Ery-Hg, whereas the opposite was the case for the slow phase. The half lives of the slow phases in whole blood and plasma were longer, and the relative fractions of the slow phases were higher (about 50%) after long term exposure than those (about 20%) reported after brief exposure. Slower elimination indicates higher accumulation of Hg in organs with long half lives, and possibly the presence of at least one additional, even slower compartment. The U-Hg fluctuated substantially during the sampling period, and average concentrations decreased only slightly.

对14名接触金属汞蒸气1 ~ 24年(中位10年)的氯碱工人血液中汞的消除情况进行了调查。在17-26天期间,多次(中位数为8次)采集血液和尿液样本。全血Hg (B-Hg)初始浓度约为80 nmol/l,尿肌酐(U-Hg)初始浓度约为17 nmol/mmol。全血、血浆(P)和红细胞(Ery)中汞的降低最好用双室模型来描述。在所有受试者具有共同半衰期的模型中,B-Hg的最佳拟合期为快半衰期3.8天,慢半衰期45天。P-Hg快相的半衰期比ry- hg短,而慢相的半衰期则相反。全血和血浆中慢相的半衰期较长,长期暴露后慢相的相对比例(约50%)高于短暂暴露后的(约20%)。较慢的消除表明汞在半衰期较长的器官中积累较高,并且可能存在至少一个额外的,甚至更慢的隔室。U-Hg在采样期间波动较大,平均浓度仅略有下降。
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引用次数: 0
Toxicological investigations on silicon carbide. 2. In vitro cell tests and long term injection tests. 碳化硅的毒理学研究。2. 体外细胞试验和长期注射试验。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.807
J Bruch, B Rehn, W Song, E Gono, W Malkusch

Silicon carbide (SiC) dust and other dusts for comparison were injected intratracheally at a high dose (50 mg) into rats and the response of the lungs and the lymph nodes was studied after an appropriate experimental period. The indices studied were: histological changes in the lung and lymph nodes, organ weights, the formation of collagenous fibres, and the appearance of quartz typical areas. According to several epidemiological investigations and previous experimental animal studies, SiC produces silicogenic (fibrogenic) effects. No changes in the tissues studied in terms of damaging fibrogenic effects could be found after eight months (first series) and three and 12 months (second series). In particular, the histological findings and the absence of quartz typical areas as well as the quantitative determination of collagen fibres show that SiC had no harmful effects on tissues. Based on these results, the extent to which other exposures during the production of SiC can be responsible for the established radiological alterations is discussed. Without doubt the following may be confounders: SiC fibres, crystalline SiO2 (quartz, cristobalite, tridymite), and possibly gaslike emissions (SO2). From the hygienic medical point of view the workplaces during SiC manufacture should be examined carefully. The substance SiC dust as such can be considered as inert from the experimental results based on qualitative and extremely sensitive procedures. A revision of the present threshold value for SiC in ther German MAK list is called for.

采用大鼠气管内注射高剂量(50 mg)碳化硅粉尘和其他粉尘作为对照,在适当的实验时间后观察肺和淋巴结的反应。研究的指标有:肺和淋巴结的组织学改变、器官重量、胶原纤维的形成和石英典型区域的出现。根据几项流行病学调查和先前的实验动物研究,SiC具有致硅(纤维)效应。在8个月(第一个系列)和3个月和12个月(第二个系列)后,所研究的组织在破坏性纤维化效应方面没有发现变化。特别是,组织学结果和石英典型区域的缺失以及胶原纤维的定量测定表明,SiC对组织没有有害影响。基于这些结果,讨论了在碳化硅生产过程中的其他暴露在多大程度上可能对已建立的放射性改变负责。毫无疑问,以下可能是混杂物:SiC纤维、结晶SiO2(石英、方石英、钇石),可能还有气体状排放物(SO2)。从卫生医学的角度来看,SiC生产过程中的工作场所应仔细检查。从基于定性和极其敏感的程序的实验结果来看,这种物质SiC粉尘可以被认为是惰性的。要求修订其德国MAK清单中SiC的现行阈值。
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引用次数: 27
Estimation of prevalence rate ratios for cross sectional data: an example in occupational epidemiology. 估算横断面数据的流行率比率:职业流行病学中的一个例子。
Pub Date : 1993-09-01 DOI: 10.1136/oem.50.9.861
J Lee, K S Chia
Sir,-A cross sectional or prevalence study is often used in an occupational setting to assess whether an association exists between exposure in the workplace and some physiological state where information on exposure and physiological state are obtained contemporaneously. If the physiological state is dichotomised as "normal" or "pathological" the data can either be analysed by stratification, standardisation,' or by multiple logistic regression.2 The last is an especially valuable statistical tool in that it allows statistical adjustment of several confounders as well as assessment of effect modification based on modest sample size. The drawback with logistic regression for cross sectional data is that the model estimates the prevalence odds ratio (POR) as effect measure. Under certain restricted conditions the POR approximates the incidence density ratio,34 which makes it (arguably) a useful effect measure for causal inference. Nevertheless, because prevalence data lack time dimension-they do not establish that cause antecedes effect5-the usefulness of POR as an indicator of aetiology may be illusory. In aetiological research, especially if the latent period (interval between exposure and occurrence of disease) is protracted and ill defined, a cross sectional study can only be used to
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引用次数: 174
期刊
British Journal of Industrial Medicine
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