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Maternal obesity and its association with neonatal morbidity 产妇肥胖及其与新生儿发病率的关系
Pub Date : 2018-07-18 DOI: 10.15406/jpnc.2018.08.00332
Sabrina C Burn, M. Burn, P. Burn
of class III obesity was 9.9%.2 More concerning is the finding that among women giving birth in 2014, 24.8% were reported as obese and 25.6% as overweight.3 This unfortunate trend is further illustrated by the Centers for Disease Control and Prevention (CDC) who reported that obesity among women of childbearing age (18-44 years) increased by almost 30% over the last decade, from 21.7% in 2006 to 27.5 % in 2016.4 Despite the fact that most recently the prevalence of obesity seems to have stabilized in the overall population, the prevalence of class II and class III obesity in reproductive aged women is still on the rise.5 In short, pre-pregnancy BMI outside the normal range are now at an all time high in reproductive aged women and raise considerable individual and public health concerns.
更令人担忧的是,在2014年分娩的女性中,24.8%被报告为肥胖,25.6%被报告为超重。3疾病控制和预防中心(CDC)报告称,在过去十年中,育龄女性(18-44岁)的肥胖增加了近30%,从2006年的21.7%上升到2016年的27.5%。4尽管最近肥胖的患病率在总体人口中似乎已经稳定下来,但育龄妇女的II类和III类肥胖患病率仍在上升。5简而言之,育龄妇女的孕前BMI在正常范围之外,目前处于历史最高水平,并引起了相当大的个人和公共健康问题。
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引用次数: 1
Management of intractable supraventricular tachycardia unresponsive to primary therapy with Verapamil in a neonatal case 难治性室上性心动过速对维拉帕米初步治疗无反应的新生儿病例的处理
Pub Date : 2018-07-17 DOI: 10.15406/JPNC.2018.08.00331
Yun Ju Lim
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引用次数: 1
Rescue therapy with betamethasone in preterm infants (day of life>14) at high risk for bronchopulmonary dysplasia to assist weaning from ventilator support: a case series 倍他米松对支气管肺发育不良高危早产儿(出生日bbbb14)辅助脱离呼吸机支持的抢救治疗:一个病例系列
Pub Date : 2018-07-16 DOI: 10.15406/jpnc.2018.08.00330
Holly Sims, Guillermo Godoy
Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease (CLD) that is a major sequel of respiratory distress syndrome (RDS) associated with significant neonatal mortality and long-term morbidity in survivors. The incidence is highest in babies born at less than 28 weeks of gestational who have severe respiratory distress at birth, particularly in those who require respiratory support with oxygen and positive-pressure ventilation for more than two weeks after birth.1 Despite the high prevalence of BPD among the increasingly immature population of infants surviving preterm birth, no drugs for prevention have been licensed.2 Persistent lung inflammation is the most likely mediator of lung injury contributing to the development of BPD.1 The role of corticosteroids as anti-inflammatory agents has been extensively studied and proven to be efficacious in the management of neonatal respiratory disorders, although use is associated with many short and long-term side effects.1 Research has proven that prenatal steroids are an inexpensive, safe and highly effective way of enhancing neonatal survival, reducing morbidity, decreasing the incidence and severity of RDS, and decreasing the incidence of intra ventricular hemorrhage and necrotizing enterocolit is in babies born prematurely.2 Although postnatal steroids are recognized to reduce rates of BPD, usage has been more controversial due to uncertainty regarding safety.2–7 In the late 1990s, reports on long-term outcomes showed early postnatal systemic dexamethasone treatment was associated with an increased risk of abnormal neurological
支气管肺发育不良(BPD)是一种慢性肺部疾病(CLD),是呼吸窘迫综合征(RDS)的主要后遗症,与新生儿死亡率和幸存者的长期发病率相关。妊娠少于28周出生的婴儿在出生时有严重呼吸窘迫,特别是在出生后两周以上需要氧气和正压通气呼吸支持的婴儿中,发病率最高尽管BPD在越来越多的早产儿中发病率很高,但目前还没有获得预防药物的许可持续的肺部炎症是促进bpd发展的最可能的肺损伤介质。皮质类固醇作为抗炎药物的作用已被广泛研究,并被证明在新生儿呼吸系统疾病的治疗中有效,尽管使用与许多短期和长期的副作用有关研究证明,产前类固醇是一种廉价、安全、高效的方法,可以提高新生儿存活率,降低发病率,降低RDS的发生率和严重程度,降低早产儿脑室内出血和坏死性小肠结肠炎的发生率虽然产后类固醇被认为可以降低BPD的发生率,但由于安全性的不确定性,使用类固醇的争议更大。2-7在20世纪90年代后期,关于长期预后的报告显示,产后早期全身性地塞米松治疗与神经系统异常的风险增加有关
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引用次数: 0
New methods of improving the quality of medical services 提高医疗服务质量的新方法
Pub Date : 2018-07-10 DOI: 10.15406/jpnc.2018.08.00329
Askerov Arsen Askerovich
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引用次数: 0
Rare congenital fistula connection between right subclavian artery and superior vena cava presenting in neonate with congestive cardiac failure 新生儿充血性心力衰竭的罕见先天性瘘管连接右锁骨下动脉与上腔静脉
Pub Date : 2018-06-28 DOI: 10.15406/jpnc.2018.08.00328
Awadh Salem Al-Majrafi, Naela Khalifa Al Kalbani, Farida Ambusaidi
Intra-thoracic arteriovenous malformations are uncommon. As the most reported localizations of AVM are the head (vein of Galen malformation), the abdomen (infantile hepatic hemangioma), the neck and extremities.1 Arterio venous malformation divided into congenital and acquired. The congenital forms are even more uncommon and patients present with variable symptoms that make the diagnosis more challenging.2,3 A congenital Aortocaval fistula from subclavian artery to the superior vena cava (SVC) may represent a subclass of this condition.
胸腔内动静脉畸形并不常见。AVM的报告最多的部位是头部(Galen畸形的静脉)、腹部(婴儿肝血管瘤)、颈部和四肢。1动静脉畸形分为先天性和获得性。先天性形式更为罕见,患者表现出的各种症状使诊断更具挑战性。2,3从锁骨下动脉到上腔静脉(SVC)的先天性主动脉腔瘘可能代表这种疾病的一个亚类。
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引用次数: 0
Laparoscopic management of nonpalpable testis: 5 years’ experience at Dhaka Shishu (Children) Hospital 腹腔镜治疗无法触及的睾丸:达卡Shishu(儿童)医院5年的经验
Pub Date : 2018-06-26 DOI: 10.15406/jpnc.2018.08.00327
K. M. N. Ferdous, Samiullah Hasan, K. Kabir, Abd Aziz, M. K. Islam
Cryptorchidism or undescended testis is one of the most common genitourinary disorders in young boys, where the testis can’t be reached at the bottom of the scrotum.1 3-5% of full termand1845%ofpre-termnewborn boys are born with either unilateral or bilateral undecided testes. The prevalence drops to1-2% by three months of age and 0.8% will still have cryptorchidism attend of 1 years.2-4 Smolko et al.,5 reported that 20% of undescended testes are clinicallynonpalpable.5 The non palpable testis can be non-present, atrophic, or have a failure to descend and be found in ahighscrotal, inguinal, orintra-abdominal location. Most of the literatures report that approximately 20–40%ofnon-palpabletestesareintraabdominalinlocation.6 Localization of the Nonpalpable testis is a significant problem in pediatric age group. The diagnostic methods are Ultra sonography, CT scan, MRI and laparoscopy have been used to locate non palpable testis.7 In a case with Nonpalpable testis, the classical approach was in guinal exploration, if testis found then orchiopexy. If testis cannot be found, then the procedure is preceded with open abdominal exploration.8 But, unplanned groin exploration may be detrimental to the outcome of surgery and sometime fruitless.9 Use of laparoscopy was firstly recommended by Cortesietal in1976 to locate non palpableundescended testes and laparoscopic orchidopexy was firstly performed by Jordan et al., in 1992.8 Nowadays, laparoscopic procedure is a gold standard in the management of patients with a Nonpalpable testis for localization and to plan subsequent surgical management in many centers.10 Wide screen behereour institutional experience with laparoscopic management of Nonpalpable testes in children over the last 5years.
隐睾或隐睾是年轻男孩最常见的泌尿生殖系统疾病之一,睾丸在阴囊底部无法到达。1 3-5%的足月和1845%的足月新生儿出生时有单侧或双侧未决定的睾丸。到三个月大时,发病率下降到12%,0.8%的人在一年后仍会有隐睾。2-4 Smolko等人5报道称,20%的未触及睾丸在临床上是无法触及的。5无法触及的睾丸可以是不存在的、萎缩的或下降失败的,见于阴囊、腹股沟或腹部。大多数文献报道,大约20-40%的不可触摸的睾丸位于腹部。6不可触摸睾丸的定位在儿童年龄组是一个重要问题。诊断方法包括超声、CT扫描、MRI和腹腔镜检查,用于定位无法触及的睾丸。7在睾丸不可触及的病例中,经典的方法是进行睾丸探查,如果发现睾丸,则进行睾丸切除术。如果找不到睾丸,则在手术前进行腹部开放探查。8但是,计划外的腹股沟探查可能会对手术结果不利,有时甚至毫无结果。9 Cortesietal于1976年首次建议使用腹腔镜定位未触诊的睾丸,Jordan等人于1992年首次进行腹腔镜睾丸固定术。8如今,腹腔镜手术是许多中心对睾丸不可切除患者进行定位和计划后续手术治疗的黄金标准。10过去5年来,我们在儿童睾丸不可移植腹腔镜治疗方面拥有丰富的机构经验。
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引用次数: 0
Cutaneous leishmaniasis in Moroccan children: about 12 cases 摩洛哥儿童皮肤利什曼病:约12例
Pub Date : 2018-06-08 DOI: 10.15406/JPNC.2018.08.00325
A. Nassiri
During the blood meal in the exposed areas of human body, female sand flies injects promastigotes in their infective stage into the skin; The parasites are captured by phagocytes in dermal tissue, initially by short-lived neutrophils (the first leukocyte recruited to the bite site that subsequently enter into apoptosis) and subsequently also by macrophages. In addition to phagocytized parasites, macrophages also phagocytize infected apoptotic neutrophils. Inside the macrophages, promastigotes establish an intracellular residence and transform into aflagellate amastigotes, where they multiply, and are released upon cell lysis, when too many amastigotes are present in the phagolysosome, resulting in reinfection of other cells. The cycle is completed when other sandfly ingest infected phagocytes during the blood meal. Inside the vectors, amastigotes are converted into promastigotes in hindgut/midgut. At this site, parasites proliferate and differentiate into infective promastigotes and migrate to the salivary glands of the sand fly and perpetuate its life cycle.
在人体暴露区域的血餐过程中,雌性沙蝇在感染阶段将前鞭毛虫注射到皮肤中;寄生虫被真皮组织中的吞噬细胞捕获,最初被短命的中性粒细胞(第一个被募集到叮咬部位的白细胞,随后进入细胞凋亡)捕获,随后也被巨噬细胞捕获。除了吞噬寄生虫外,巨噬细胞还吞噬受感染的凋亡中性粒细胞。在巨噬细胞内,前鞭毛体建立细胞内滞留,并转化为无鞭毛体,在那里繁殖,并在细胞裂解时释放,当吞噬溶酶体中存在过多无鞭毛时,导致其他细胞再次感染。当其他沙蝇在吸血过程中摄入受感染的吞噬细胞时,这个循环就完成了。在载体内,无鞭毛体在后肠/中肠转化为前鞭毛体。在这个部位,寄生虫增殖并分化为感染性前鞭毛虫,并迁移到沙蝇的唾液腺,使其生命周期延续下去。
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引用次数: 0
Haemophilus influenzae meningitis in Cuban children: a nineteen years follow up 古巴儿童流感嗜血杆菌脑膜炎19年随访
Pub Date : 2018-06-07 DOI: 10.15406/JPNC.2018.08.00324
J. R. García, Waldemar Baldomir, Misladys Rodriguez, F. Dickinson
Despite the advances in antibiotic therapy and vaccines as well as the availability of sophisticated intensive care reached in the past century and the ongoing, community acquired Bacterial Meningitis (CABM) remains a serious threat to global health due to its high rates of morbidity and mortality (especially in infants),1 the serious permanent sequels in survivors2 as well as the variability in causative bacteria.3 Three species, Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae (Hi) are responsible for most cases of CABM occurring beyond the neonatal period, causing more than 80% of cases worldwide.4 Haemophilus influenza (Hi)is an important human pathogen that causes severe infections including meningitis, sepsis, bacteremia, pneumonia, sinusitis, epiglottitis and otitis mostly affecting young children.5 In the pre-vaccine era, H. influenzaeserotype b(Hib) was a leading cause of CABM, epiglottitis, and pneumonia, primarily in children under 5 years.6 Hib conjugate vaccines were introduced initially in the late 1980s for children aged 12 months or older, and later in the early 1990s for infants younger than 6 months old. Near elimination of Hib disease in children has occurred in countries that implemented pediatric Hib immunization programs.7 In Cuba Hib vaccination was introduced in 1999, decreasing the overall incidence of Hib meningitis from 1.3/105 population in 1998 to 0.6/105 population in 1999 (53.4% reduction), with the greatest proportion in infants (70.5 %).8 After this intervention public health authorities decided to continue routine Hib vaccination through the National Immunization Program.9 The aim of this study was to describe the main features of Hi meningitis in infants and young children, as well as to analyze the effects of continuing and massive vaccination on infant’s morbidity and mortality in the Cuban context.
尽管在抗生素治疗和疫苗方面取得了进展,并且在过去的一个世纪和现在都有了先进的重症监护,但社区获得性细菌性脑膜炎(CABM)仍然是对全球健康的严重威胁,因为它的发病率和死亡率很高(特别是在婴儿中)1,幸存者的严重永久性后遗症2,以及致病细菌的可变性肺炎链球菌、脑膜炎奈瑟菌和流感嗜血杆菌(Hi)这三种细菌是导致新生儿期以后发生的大多数CABM病例的原因,占全世界病例的80%以上流感嗜血杆菌(Hi)是一种重要的人类病原体,可引起严重感染,包括脑膜炎、败血症、菌血症、肺炎、鼻窦炎、会咽炎和中耳炎,主要影响幼儿在未接种疫苗的时代,b型流感嗜血杆菌(Hib)是导致CABM、会厌炎和肺炎的主要原因,主要发生在5岁以下儿童中Hib结合疫苗最初于1980年代末用于12个月或以上的儿童,后来在1990年代初用于6个月以下的婴儿。在实施儿童Hib免疫规划的国家,儿童Hib疾病已接近消除古巴于1999年开始接种Hib疫苗,将Hib脑膜炎的总发病率从1998年的1.3/105人减少到1999年的0.6/105人(减少53.4%),其中婴儿的比例最大(70.5%)在这一干预措施之后,公共卫生当局决定通过国家免疫计划继续进行常规Hib疫苗接种。9本研究的目的是描述婴儿和幼儿中Hib脑膜炎的主要特征,并分析在古巴情况下持续和大规模接种疫苗对婴儿发病率和死亡率的影响。
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引用次数: 0
A case report of an infant with both left-sided gastroschisis and septo-optic dysplasia and literature review: possible shared etiology? 婴儿左侧胃裂合并中隔-视神经发育不良1例并文献复习:可能的共同病因?
Pub Date : 2018-06-05 DOI: 10.15406/JPNC.2018.08.00326
K. Sullivan, D. Croitoru, Samuel Casella, T. Hartman, W. Edwards
Gastroschisis is a congenital abdominal wall defect with extrusion of the abdominal contents through a defect typically just to the right of the umbilicus. Gastroschisis has been associated with multiple risk factors but its pathogenesis remains unknown. There are theories that it is due to a vascular insult, with known associations of young maternal age, cigarette smoking, and illicit drug use.1,2 The incidence of gastroschisis is ~5 per 10,000 live births, and may be increasing.3 Left-sided gastroschisis is even rarer with only 18 reports found in our review of the literature. Septo-optic dysplasia (SOD) is a heterogeneous clinical disorder characterized by a combination of optic nerve hypoplasia, pituitary hormone abnormalities and midline brain defects. The incidence of SOD is not certain, but reported to likely be ~1 per 10,000 livebirths.4 These two seemingly unrelated congenital anomalies have several features in common. While the incidence of most congenital anomalies is directly correlated with maternal age, both of these anomalies are more common in younger mothers.1,5–7 They are also both postulated to be related to an insult around the 6th week of gestation.1,5–7 Co-occurrence of gastroschisis and septo-optic dysplasia has been reported 4 times, with the gastroschisis on the left side in one case. We present a second case of both left-sided gastroschisis and septo-optic dysplasia occurring in an infant girl.
腹裂是一种先天性腹壁缺陷,腹部内容物通常通过脐右侧的缺陷而挤压。胃裂与多种危险因素有关,但其发病机制尚不清楚。有理论认为,这是由于血管损伤,已知与年轻母亲年龄,吸烟和非法药物使用有关。胃裂的发生率为每1万活产5例,并有可能增加左侧腹裂更为罕见,在我们的文献综述中仅发现18例报道。视中隔发育不良(SOD)是一种以视神经发育不全、垂体激素异常和脑中线缺陷为特征的异质性临床疾病。超氧化物歧化酶的发病率尚不确定,但据报道可能为1 / 10,000活产这两种看似无关的先天性畸形有几个共同的特征。虽然大多数先天性异常的发生率与母亲年龄直接相关,但这两种异常在年轻母亲中更为常见。1,5 - 7他们也都被认为与怀孕第6周左右的侮辱有关。1,5 - 7同时出现胃裂和视中隔发育不全的病例有4例,其中左侧胃裂1例。我们提出了第二个病例的左侧胃裂和隔视发育不良发生在一个女婴。
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引用次数: 2
The feasibility of telemedicine in pediatric cardiology 远程医疗在儿科心脏病学中的可行性
Pub Date : 2018-05-25 DOI: 10.15406/JPNC.2018.08.00322
J. Pick, Rachel Watson, Ian Lee, Brian Lee, A. Gearhart, A. Batra
Telemedicine is the delivery of health-related services and information via telecommunications technologies.1,2 The two primary modes of telemedicine practice are “store and forward” and “realtime” videoconferencing.3,4 In store-and-forward, tele health digital images, video, and audio recordings are captured and “stored” on the client computer or mobile device. At a later time, “stored” data is transmitted securely (“forwarded”) and studied by relevant specialists who then responds with their opinion and recommendations.1,4 Prior studies have demonstrated how this method increases patient access to tertiary care centers by overcoming geographical barriers.5 There are currently several applications of telemedicine within the field of pediatric cardiology focused on discriminating between pathologic and benign murmurs and arrhythmias in children.6,7 Studies have estimated that 80% of children will develop a murmur in their lifetime and less than 1% of these murmurs being pathologic.8 Several electronic stethoscopes can accurately detect the difference between a benign and pathologic murmur with great sensitivity and specificity (95%, 96%, respectively), but the feasibility of it in practice remains in question.8,9 However, it is unknown if general practitioners would be willing to use this new form of communication. In this feasibility study, we investigate the agreeability of general practitioners to use the technology as well as its convenience for the general practitioners.
远程医疗是通过电信技术提供与健康相关的服务和信息。1,2远程医疗实践的两种主要模式是“存储转发”和“实时”视频会议。3,4在存储转发中,远程医疗数字图像、视频和音频记录被捕获并“存储”在客户端计算机或移动设备上。稍后,“存储”的数据被安全地传输(“转发”),并由相关专家进行研究,然后由他们提出意见和建议。1,4先前的研究已经证明了这种方法如何通过克服地理障碍来增加患者进入三级护理中心的机会。5目前,远程医疗在儿科心脏病学领域有几种应用关于区分儿童的病理性和良性杂音以及心律失常。6,7研究估计,80%的儿童一生中会出现杂音,而这些杂音中只有不到1%是病理性的。8几种电子听诊器可以非常灵敏和特异地准确检测良性和病理性杂音之间的差异(分别为95%和96%),但是它在实践中的可行性仍然存在疑问。8,9然而,全科医生是否愿意使用这种新的交流形式还不得而知。在这项可行性研究中,我们调查了全科医生使用该技术的可行性及其对全科医生的便利性。
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引用次数: 2
期刊
Journal of pediatrics & neonatal care
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