Khalid EL-Ouardi, Othman Mouslim, Amine Lakmichi Mohamed, Z. Dahami, Said Moudouni Mohammed, I. Sarf
Background: For the majority of renal injuries, non-operative management is the standard of care with nephrectomy reserved for those with severe trauma. The aim of our study is to assess the characteristics of perinephric hematoma and other prognostic factors of surgical intervention for high-grade renal trauma independent of AAST OIS. Materials and methods: A total of 119 patients with high-grade renal trauma from January 2005 to September 2021 were identified for analysis. Hospital records and diagnostic imaging were reviewed to identify the need for surgical intervention, including total and partial nephrectomy. Factors examined include patient age, gender, ISS (Injury severity score), AAST-OIS, laceration location, length and number, perinephric hematoma characteristics, intravascular contrast extravasation, and devitalized segment status. Descriptive statistics and binary logistic regression were performed as appropriate. Results: The mean patient age was 31,39 and the mean ISS was 22,80. A total of 24 surgical interventions were required (20%) including partial and total nephrectomy. On univariate analysis, hypotension on admission, hematoma diameter, degree of devitalized fragment superior of 25%, and AAST OIS grade was associated with the need for surgical intervention. On multivariate analysis, only hypotension on admission (p: 0,029), hematoma diameter greater than 3,5 cm (p: 0,021), and AAST-OIS grade (p: 0,010 ) remained independently associated with surgical intervention. Conclusion: Perinephric hematoma size remains among prognostic factors for surgical intervention that allow better stratification of renal lesions and its study allows a better management of high-grade renal trauma.
{"title":"Predictors of nephrectomy in high-grade renal trauma patients treated primarily with conservative intent","authors":"Khalid EL-Ouardi, Othman Mouslim, Amine Lakmichi Mohamed, Z. Dahami, Said Moudouni Mohammed, I. Sarf","doi":"10.17352/aur.000047","DOIUrl":"https://doi.org/10.17352/aur.000047","url":null,"abstract":"Background: For the majority of renal injuries, non-operative management is the standard of care with nephrectomy reserved for those with severe trauma. The aim of our study is to assess the characteristics of perinephric hematoma and other prognostic factors of surgical intervention for high-grade renal trauma independent of AAST OIS. Materials and methods: A total of 119 patients with high-grade renal trauma from January 2005 to September 2021 were identified for analysis. Hospital records and diagnostic imaging were reviewed to identify the need for surgical intervention, including total and partial nephrectomy. Factors examined include patient age, gender, ISS (Injury severity score), AAST-OIS, laceration location, length and number, perinephric hematoma characteristics, intravascular contrast extravasation, and devitalized segment status. Descriptive statistics and binary logistic regression were performed as appropriate. Results: The mean patient age was 31,39 and the mean ISS was 22,80. A total of 24 surgical interventions were required (20%) including partial and total nephrectomy. On univariate analysis, hypotension on admission, hematoma diameter, degree of devitalized fragment superior of 25%, and AAST OIS grade was associated with the need for surgical intervention. On multivariate analysis, only hypotension on admission (p: 0,029), hematoma diameter greater than 3,5 cm (p: 0,021), and AAST-OIS grade (p: 0,010 ) remained independently associated with surgical intervention. Conclusion: Perinephric hematoma size remains among prognostic factors for surgical intervention that allow better stratification of renal lesions and its study allows a better management of high-grade renal trauma.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"53 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139964886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: A varicocele is a vascular lesion characterised by dilatation and tortuosity of the veins of the pampiniform plexus and is found in approximately one-fifth of the adult male population. It is the most common cause of treatable infertility. Physical examination may or may not show a varicocele which is mostly diagnosed only when patients present with infertility or adolescents during a physical examination, like testicular hypotrophy, impairment in spermatogenesis mainly in the form of low or absent count, decreased sperm motility, and abnormal sperm morphology. Treatment for varicocele includes medical therapies, radiological embolization, and surgical techniques. Medical therapy, including antioxidants and anti-inflammatory agents, has been utilized with variable success. Radiological embolization of varicocele is a new technique in the treatment of varicocele, but it is associated with high recurrences and high cost. Varicoceles are surgically treated either by open or laparoscopic approaches the principal aim being occlusion of the dilated veins of the pampiniform plexus. A definitive conclusion of indication of medical treatment cannot be drawn at present because most published studies have inadequate design and lack controls. Various studies in the past have concluded significant changes in sperm parameters (total count, motility, morphology) post-varicocele repair. However, few other studies suggest no improvement in sperm parameters following surgical varicocele repair and studies that conclude recommendations against repair of varicocele. Thus, conflicting opinions have opened the scope to establish this fact by this study. Aim: To evaluate changes in sperm morphology, sperm count, and sperm motility in a patient with varicocele after varicocele surgery. Materials and methods: The study was conducted in the Department of Surgery, North Delhi Municipal Corporation Medical College & Hindu Rao Hospital, Delhi, India from August 2019 to February 2021. The sample size was calculated to be 50 using Slovin’s formula with a confidence level of 95% with a margin error taken as 5% (p - value 0.05). Sperm morphology, sperm count, and sperm motility were the parameters studied before and after 3 months of surgery. Results: The majority of patients belonged to the age group of 18 to 25 years (42%) followed by 26 to 35 years (40%) (27.78 ± 6.547 years). Left-sided varicocele was more common (54%), followed by bilateral varicocele (42%). Varicocele grade II was most common (58%) followed by grade I (30%) and lastly grade III (12%). Total sperm count improved by 8.88 million per ml after varicocelectomy. Total sperm motility improved by 6.08% after the surgery. Total normal sperm forms improved by 6.44% after varicocele repair. Conclusion: Based on the findings it was concluded that Varicocelectomy results in significant improvement in total sperm count, total sperm motility, and total normal sperm morphology. The best improvement was seen
{"title":"Effect of varicocele surgery on sperm quality","authors":"Chandrakant Chaudhari Tejas, Sahai Rajiv Nandan","doi":"10.17352/aur.000046","DOIUrl":"https://doi.org/10.17352/aur.000046","url":null,"abstract":"Introduction: A varicocele is a vascular lesion characterised by dilatation and tortuosity of the veins of the pampiniform plexus and is found in approximately one-fifth of the adult male population. It is the most common cause of treatable infertility. Physical examination may or may not show a varicocele which is mostly diagnosed only when patients present with infertility or adolescents during a physical examination, like testicular hypotrophy, impairment in spermatogenesis mainly in the form of low or absent count, decreased sperm motility, and abnormal sperm morphology. Treatment for varicocele includes medical therapies, radiological embolization, and surgical techniques. Medical therapy, including antioxidants and anti-inflammatory agents, has been utilized with variable success. Radiological embolization of varicocele is a new technique in the treatment of varicocele, but it is associated with high recurrences and high cost. Varicoceles are surgically treated either by open or laparoscopic approaches the principal aim being occlusion of the dilated veins of the pampiniform plexus. A definitive conclusion of indication of medical treatment cannot be drawn at present because most published studies have inadequate design and lack controls. Various studies in the past have concluded significant changes in sperm parameters (total count, motility, morphology) post-varicocele repair. However, few other studies suggest no improvement in sperm parameters following surgical varicocele repair and studies that conclude recommendations against repair of varicocele. Thus, conflicting opinions have opened the scope to establish this fact by this study. Aim: To evaluate changes in sperm morphology, sperm count, and sperm motility in a patient with varicocele after varicocele surgery. Materials and methods: The study was conducted in the Department of Surgery, North Delhi Municipal Corporation Medical College & Hindu Rao Hospital, Delhi, India from August 2019 to February 2021. The sample size was calculated to be 50 using Slovin’s formula with a confidence level of 95% with a margin error taken as 5% (p - value 0.05). Sperm morphology, sperm count, and sperm motility were the parameters studied before and after 3 months of surgery. Results: The majority of patients belonged to the age group of 18 to 25 years (42%) followed by 26 to 35 years (40%) (27.78 ± 6.547 years). Left-sided varicocele was more common (54%), followed by bilateral varicocele (42%). Varicocele grade II was most common (58%) followed by grade I (30%) and lastly grade III (12%). Total sperm count improved by 8.88 million per ml after varicocelectomy. Total sperm motility improved by 6.08% after the surgery. Total normal sperm forms improved by 6.44% after varicocele repair. Conclusion: Based on the findings it was concluded that Varicocelectomy results in significant improvement in total sperm count, total sperm motility, and total normal sperm morphology. The best improvement was seen ","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"163 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Escherichia coli-induced urinary tract infections (E.coli-UTIs) are considered one of the most prevalent infections in Iran. One of the important factors of pathogenicity, particularly in its binding to epithelial cells, is the presence of iutA and papG virulence genes in Escherichia coli (E.coli). Lactobacilli, as a group of probiotics, play a vital role in the body and are useful in some cases due to their therapeutic effects. The aim of this study was to evaluate how the molecular activity of Lactobacillus casei PTCC1608 influences different strains of pathogenic E.coli isolated from urinary infections through PCR. In this study, the pathogenic strain of E.coli was isolated from the patients with Urinary Tract Infections (UTIs) and analyzed by the use of the PCR method. Then, the strains with positive genotypes were isolated and the antimicrobial effect of Lactobacillus casei was evaluated through the disc diffusion and dilution methods in liquid medium. The antimicrobial effect of Lactobacillus casei on E.coli bacteria isolated from urine samples from 40 patients with UTI was studied. In addition, the results of the antibiotic sensitivity test at 1:10 dilution showed a growth inhibition zone of 9 mm. The results indicated that the isolated bacterium was not resistant to the ampicillin and the antibiotic treatment was effective for this strain. Moreover, the probiotic also plays a therapeutic role and can improve urinary infections.
{"title":"Molecular investigation of effects of probiotic on papG and iutA genes in different strains of E.coli isolated from urinary tract infection","authors":"Rezaei Romina, Aliha Mona Mohammad, Andouhjerdi Roudabeh Behzadi, Ebrahimi Maryam Tajabadi","doi":"10.17352/aur.000045","DOIUrl":"https://doi.org/10.17352/aur.000045","url":null,"abstract":"Escherichia coli-induced urinary tract infections (E.coli-UTIs) are considered one of the most prevalent infections in Iran. One of the important factors of pathogenicity, particularly in its binding to epithelial cells, is the presence of iutA and papG virulence genes in Escherichia coli (E.coli). Lactobacilli, as a group of probiotics, play a vital role in the body and are useful in some cases due to their therapeutic effects. The aim of this study was to evaluate how the molecular activity of Lactobacillus casei PTCC1608 influences different strains of pathogenic E.coli isolated from urinary infections through PCR. In this study, the pathogenic strain of E.coli was isolated from the patients with Urinary Tract Infections (UTIs) and analyzed by the use of the PCR method. Then, the strains with positive genotypes were isolated and the antimicrobial effect of Lactobacillus casei was evaluated through the disc diffusion and dilution methods in liquid medium. The antimicrobial effect of Lactobacillus casei on E.coli bacteria isolated from urine samples from 40 patients with UTI was studied. In addition, the results of the antibiotic sensitivity test at 1:10 dilution showed a growth inhibition zone of 9 mm. The results indicated that the isolated bacterium was not resistant to the ampicillin and the antibiotic treatment was effective for this strain. Moreover, the probiotic also plays a therapeutic role and can improve urinary infections.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136379800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Kousalya, K. Rekha Rani, Patnaik Srinivas, P. Josthna
Folk medicine has been considered one of the novel remedies for treating cancers. Women's cancers are increasing worldwide, and disease recurrence has been a major threat all over the world. Our current study focused on the formation of silver nanoparticles (AgNPs) by organic methods and their chemo-preventive capacity against the breast (MCF-7) and ovarian cancer (PA-1) cell lines from humans by employing MTT, Flow cytometry, and migration assays. Plant extracts in organic nanoparticle production have become more common in recent years due to their benefits, including affordability, effectiveness, simplicity and briefness. Melia azedarach leaf and fruit methanolic extracts were used to successfully create silver nanoparticles simultaneously to evaluate the potency and efficacy of the extracts. Characterization studies were performed using synthesized M. azedarach silver nanoparticles (MA-AgNPs). A typical SPR peak was discovered ranging from 400 nm (leaf) and 427 nm (fruit) using absorption spectroscopy, with an average particle size of 92.5 nm (leaf) and 124.1 (fruit) nm. The zeta potential for Melia leaves and fruits was found to be -20.9 and -31.2 mV for the extracts. The relevant functional groups for the capping agent found in the extracts and silver nanoparticles formed as a result of the reduction of silver nitrate were identified using Fourier transform infrared spectroscopy (FTIR). Antimicrobial activity against Escherichia coli, Bacillus aureus, Staphylococcus aureus, and Klebsiella pneumonia would be useful in new antimicrobial medications being developed. MCF-7 and PA-1 cell lines were found to be more susceptible to the cytotoxic action of the biosynthesized nanoparticles. The silver nanoparticles that were synthesized exhibited extremely positive anti-cancer activity.
{"title":"Biogenesis of Melia Azedarach silver nanoparticles using leaves and fruits in breast and ovarian cancer cell lines","authors":"L. Kousalya, K. Rekha Rani, Patnaik Srinivas, P. Josthna","doi":"10.17352/aur.000044","DOIUrl":"https://doi.org/10.17352/aur.000044","url":null,"abstract":"Folk medicine has been considered one of the novel remedies for treating cancers. Women's cancers are increasing worldwide, and disease recurrence has been a major threat all over the world. Our current study focused on the formation of silver nanoparticles (AgNPs) by organic methods and their chemo-preventive capacity against the breast (MCF-7) and ovarian cancer (PA-1) cell lines from humans by employing MTT, Flow cytometry, and migration assays. Plant extracts in organic nanoparticle production have become more common in recent years due to their benefits, including affordability, effectiveness, simplicity and briefness. Melia azedarach leaf and fruit methanolic extracts were used to successfully create silver nanoparticles simultaneously to evaluate the potency and efficacy of the extracts. Characterization studies were performed using synthesized M. azedarach silver nanoparticles (MA-AgNPs). A typical SPR peak was discovered ranging from 400 nm (leaf) and 427 nm (fruit) using absorption spectroscopy, with an average particle size of 92.5 nm (leaf) and 124.1 (fruit) nm. The zeta potential for Melia leaves and fruits was found to be -20.9 and -31.2 mV for the extracts. The relevant functional groups for the capping agent found in the extracts and silver nanoparticles formed as a result of the reduction of silver nitrate were identified using Fourier transform infrared spectroscopy (FTIR). Antimicrobial activity against Escherichia coli, Bacillus aureus, Staphylococcus aureus, and Klebsiella pneumonia would be useful in new antimicrobial medications being developed. MCF-7 and PA-1 cell lines were found to be more susceptible to the cytotoxic action of the biosynthesized nanoparticles. The silver nanoparticles that were synthesized exhibited extremely positive anti-cancer activity.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82668892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Totaro, E. Scarciglia, M. Ragonese, A. Cretì, F.P. Bizzarri, M. Campetella, C. Gandi, G. Palermo, M. Racioppi, E. Sacco
Robotic-Assisted Laparoscopic Radical Prostatectomy (RARP) is the gold standard surgical treatment for localized clinically significant prostate cancer. In patients undergone previous abdominal or pelvic surgery, it can be difficult to perform and it is also contraindicated execution of radiotherapy. We have described step-by-step the first case of RARP performed with the robotic system HugoTM RAS in a patient previously subjected to proctocolectomy and ileal pouch-anal anastomosis packaging for ulcerative colitis. The procedure was found to be safe and feasible, with intra- and post-operative data overlapping those of the same procedure in the general population. Execution by an experienced surgeon is in any case recommended.
{"title":"Robotic assisted laparoscopic radical prostatectomy with the new surgical robot HugoTM RAS in a man with proctocolectomy and restorative ileal pouch-anal anastomosis. The first European urological step-by-step procedure","authors":"A. Totaro, E. Scarciglia, M. Ragonese, A. Cretì, F.P. Bizzarri, M. Campetella, C. Gandi, G. Palermo, M. Racioppi, E. Sacco","doi":"10.17352/aur.000043","DOIUrl":"https://doi.org/10.17352/aur.000043","url":null,"abstract":"Robotic-Assisted Laparoscopic Radical Prostatectomy (RARP) is the gold standard surgical treatment for localized clinically significant prostate cancer. In patients undergone previous abdominal or pelvic surgery, it can be difficult to perform and it is also contraindicated execution of radiotherapy. We have described step-by-step the first case of RARP performed with the robotic system HugoTM RAS in a patient previously subjected to proctocolectomy and ileal pouch-anal anastomosis packaging for ulcerative colitis. The procedure was found to be safe and feasible, with intra- and post-operative data overlapping those of the same procedure in the general population. Execution by an experienced surgeon is in any case recommended.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73440438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several lesions of the bladder are incidental findings and a few of them are seen against a background of bladder outlet obstruction. Tuberculosis of the bladder is associated with characteristic lesions and changes. Presented here is a never-seen-before bladder lesion in a patient presenting with symptoms of Bladder Outlet Obstruction due to an enlarged tuberculous prostate, and no evidence of tuberculous cystitis.
{"title":"A Band from the “Blue”","authors":"Vijayan Padmanabha","doi":"10.17352/aur.000042","DOIUrl":"https://doi.org/10.17352/aur.000042","url":null,"abstract":"Several lesions of the bladder are incidental findings and a few of them are seen against a background of bladder outlet obstruction. Tuberculosis of the bladder is associated with characteristic lesions and changes. Presented here is a never-seen-before bladder lesion in a patient presenting with symptoms of Bladder Outlet Obstruction due to an enlarged tuberculous prostate, and no evidence of tuberculous cystitis. ","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87426080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renal duplexing (also known as a duplicate collection system) occurs in about 1% of children and does not usually require medical attention. The condition results in two tubes rather than the normal single ureter tube for each kidney. Medical problems that warrant attention are obstruction of urine flow or the backflow of urine into the kidney (reflux). These double ureter tubes can join in a "y" shape before reaching the bladder (partial duplex) and combining their urine delivery. In other cases, each duplicate ureter empties into the bladder on its own (complete duplex). There is cause for concern when a duplex kidney is associated with urological conditions requiring treatment. Renal duplexing can cause urine to reflux into the kidney (vesicoureteral reflux) rather than going into the bladder and can cause subsequent Urinary Tract Infection (UTI). This can result in serious consequences like the loss of renal parenchyma (reflux nephropathy) and sometimes death in acute infections if not attended to in a timely manner. Weigert-Meyer postulated that rule i-e in a complete duplex system is mostly associated with reflux in lower moiety and obstruction in upper moiety with ectopic insertion and ureterocele. Ureteroceles may require simple management of symptoms or surgery, depending on the size of the ballooning, the functioning of the kidney and bladder and the degree of urine obstruction. An ectopic ureter is when the ureter opens and drains urine outside the bladder rather than inside.
{"title":"Unusual presentation of duplex kidney with poor functioning upper moiety in an adult patient a case report","authors":"Khalid Hina, Mahar Naveed Ahmed, Lal Murli","doi":"10.17352/aur.000041","DOIUrl":"https://doi.org/10.17352/aur.000041","url":null,"abstract":"Renal duplexing (also known as a duplicate collection system) occurs in about 1% of children and does not usually require medical attention. The condition results in two tubes rather than the normal single ureter tube for each kidney. Medical problems that warrant attention are obstruction of urine flow or the backflow of urine into the kidney (reflux). These double ureter tubes can join in a \"y\" shape before reaching the bladder (partial duplex) and combining their urine delivery. In other cases, each duplicate ureter empties into the bladder on its own (complete duplex). There is cause for concern when a duplex kidney is associated with urological conditions requiring treatment. Renal duplexing can cause urine to reflux into the kidney (vesicoureteral reflux) rather than going into the bladder and can cause subsequent Urinary Tract Infection (UTI). This can result in serious consequences like the loss of renal parenchyma (reflux nephropathy) and sometimes death in acute infections if not attended to in a timely manner. Weigert-Meyer postulated that rule i-e in a complete duplex system is mostly associated with reflux in lower moiety and obstruction in upper moiety with ectopic insertion and ureterocele. Ureteroceles may require simple management of symptoms or surgery, depending on the size of the ballooning, the functioning of the kidney and bladder and the degree of urine obstruction. An ectopic ureter is when the ureter opens and drains urine outside the bladder rather than inside.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85924365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Jinxing, Falagario Ugo, Winks Sarah G, Angell Kendal, Fulcher Ann S, Turner Mary A, Jones Sterling, Kankaria Rohan, Smith Steven C
Purpose: To compare accuracy in predicting final Gleason Grade Group (GGG) of Prostate Cancer (PCa) of US/MRI fusion guided target (fBx) vs. systematic Transrectal Ultrasound-Guided (TRUS) biopsy, using histopathologic analysis at prostatectomy as the gold standard. Materials and methods: After obtaining IRB approval, we retrospectively reviewed records of patients who underwent Radical Prostatectomy (RP) from January 2014 through May 2019 with prior US/MRI fusion guided target or TRUS biopsy. The rates of upgrading (RP GGG > BX GGG), downgrading (RP GGG < BX GGG), and concordance (RP GGG = BX GGG) were compared between the fBx and TRUS groups. Age, PSA, PSA density, and prostate volume were also noted for all patients. Statistical analysis was utilized to assess the data. Results: A total of 348 men with complete clinical data were included in this study. The rate of downgrading and upgrading in the fBx group was less than in the TRUS biopsy group (14% vs. 19.6%, and 13.2% vs. 19.6%, respectively). The concordance rate was higher in the US-MR fBx group (72.9% vs. 60.7%, p < 0.05)) across all GGG. Notably, lower rates of concordance were found for GGG 1 (24.1%) and GGG 4 (3.6%) in the TRUS Bx group. Patients who underwent US-MR fBx had higher average PSA (9.4 vs. 6.5 ng/ml), higher PSA density (0.3 vs. 0.2 ng/ml2), and lower prostate volume (31 vs. 42 cc). Additionally, biopsy results showed a lower rate of GGG 1 (3.1% vs. 13.2%) and a higher rate of GGG 5 (14.7% vs. 5.5%) in the US-MR fBx group. Conclusions: Target biopsy has a higher GGG concordance compared to TRUS biopsy (72.9% vs. 60.7%, p < 0.05). In addition, there was less downgrading or upgrading of final PCa GGG in the fBx groups compared to TRUS Bx (14% vs. 19.6%, 13.2% vs. 19.6%, respectively). This finding may have important implications for treatment decisions.
目的:比较US/MRI融合引导靶标(fBx)与系统经直肠超声引导(TRUS)活检预测前列腺癌(PCa)最终Gleason分级组(GGG)的准确性，以前列腺切除术时的组织病理学分析为金标准。材料和方法:在获得IRB批准后，我们回顾性回顾了2014年1月至2019年5月期间接受根治性前列腺切除术(RP)的患者记录，这些患者先前接受了US/MRI融合引导的靶活检或TRUS活检。比较fBx组和TRUS组的升级率(RP GGG > BX GGG)、降级率(RP GGG < BX GGG)和一致性(RP GGG = BX GGG)。所有患者的年龄、PSA、PSA密度和前列腺体积也被记录下来。采用统计学方法对资料进行评价。结果:本研究共纳入临床资料完整的男性348例。fBx组的降级和升级率低于TRUS活检组(分别为14%对19.6%，13.2%对19.6%)。在所有GGG中，US-MR fBx组的符合率更高(72.9%比60.7%，p < 0.05)。值得注意的是，TRUS Bx组ggg1(24.1%)和ggg4(3.6%)的一致性率较低。接受US-MR fBx检查的患者平均PSA较高(9.4 vs. 6.5 ng/ml)， PSA密度较高(0.3 vs. 0.2 ng/ml2)，前列腺体积较低(31 vs. 42 cc)。此外，活检结果显示，在US-MR fBx组，GGG 1的发生率较低(3.1%对13.2%)，GGG 5的发生率较高(14.7%对5.5%)。结论:靶活检与TRUS活检相比GGG一致性更高(72.9% vs. 60.7%， p < 0.05)。此外，与TRUS Bx组相比，fBx组最终PCa GGG的降级或升级较少(分别为14%对19.6%，13.2%对19.6%)。这一发现可能对治疗决策具有重要意义。
{"title":"Comparison of Gleason score of Prostate Cancer at Ultrasound/MRI Fusion Target Biopsy vs. Systematic Transrectal Ultrasound Guided Biopsy with Final Gleason score at Radical Prostatectomy","authors":"Yu Jinxing, Falagario Ugo, Winks Sarah G, Angell Kendal, Fulcher Ann S, Turner Mary A, Jones Sterling, Kankaria Rohan, Smith Steven C","doi":"10.17352/aur.000039","DOIUrl":"https://doi.org/10.17352/aur.000039","url":null,"abstract":"Purpose: To compare accuracy in predicting final Gleason Grade Group (GGG) of Prostate Cancer (PCa) of US/MRI fusion guided target (fBx) vs. systematic Transrectal Ultrasound-Guided (TRUS) biopsy, using histopathologic analysis at prostatectomy as the gold standard. Materials and methods: After obtaining IRB approval, we retrospectively reviewed records of patients who underwent Radical Prostatectomy (RP) from January 2014 through May 2019 with prior US/MRI fusion guided target or TRUS biopsy. The rates of upgrading (RP GGG > BX GGG), downgrading (RP GGG < BX GGG), and concordance (RP GGG = BX GGG) were compared between the fBx and TRUS groups. Age, PSA, PSA density, and prostate volume were also noted for all patients. Statistical analysis was utilized to assess the data. Results: A total of 348 men with complete clinical data were included in this study. The rate of downgrading and upgrading in the fBx group was less than in the TRUS biopsy group (14% vs. 19.6%, and 13.2% vs. 19.6%, respectively). The concordance rate was higher in the US-MR fBx group (72.9% vs. 60.7%, p < 0.05)) across all GGG. Notably, lower rates of concordance were found for GGG 1 (24.1%) and GGG 4 (3.6%) in the TRUS Bx group. Patients who underwent US-MR fBx had higher average PSA (9.4 vs. 6.5 ng/ml), higher PSA density (0.3 vs. 0.2 ng/ml2), and lower prostate volume (31 vs. 42 cc). Additionally, biopsy results showed a lower rate of GGG 1 (3.1% vs. 13.2%) and a higher rate of GGG 5 (14.7% vs. 5.5%) in the US-MR fBx group. Conclusions: Target biopsy has a higher GGG concordance compared to TRUS biopsy (72.9% vs. 60.7%, p < 0.05). In addition, there was less downgrading or upgrading of final PCa GGG in the fBx groups compared to TRUS Bx (14% vs. 19.6%, 13.2% vs. 19.6%, respectively). This finding may have important implications for treatment decisions.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84061231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bolgeo Tatiana, Matteo Roberta di, Gatti Denise, Cotroneo Salvatore, R. Pietro, Stasio Andrea Di, Serao Armando, Boccafoschi Carmelo, Maconi Antonio
Background: A prostatic biopsy is a diagnostic test used in cases of suspected prostate cancer. The patient expresses significant levels of anxiety from the very first outpatient visits; anxiety and pain management is essential for a successful outcome of the procedure. Lavender oil is one of the essential oils that is commonly used in aromatherapy to reduce anxiety and pain, its low toxicity and side effects have made it the preferred treatment in complementary medicine. Aim: To assess the 'effectiveness of lavender scent in decreasing the levels of anxiety and pain in patients undergoing a prostatic biopsy. Methods: An interventional non-pharmacological, randomized, two-arm, multi-center, nonprofit study. The SS Antonio e Biagio e Cesare Arrigo Hospital and the City of Alessandria Clinic, Monza Polyclinic of Alessandria, will enroll consecutively all adult patients undergoing outpatient prostatic biopsy from April 1, 2022, to October 1, 2022. The Numerical Rating Scale and Hamilton Anxiety Rating Scale will be used for assessments. Conclusion: Lavender oil aromatherapy could have a clinically significant effect on reducing pain and anxiety during prostatic biopsy procedures; its simple use, safety, and low cost provide a therapeutic option to be considered, complementary to other medical interventions in certain clinical settings.
背景:前列腺活组织检查是一种诊断前列腺癌的方法。患者从第一次门诊就诊开始就表现出显著的焦虑水平;焦虑和疼痛管理是手术成功的关键。薰衣草油是芳香疗法中常用的一种精油，用于减轻焦虑和疼痛，其低毒和副作用使其成为补充医学的首选治疗方法。目的:评估薰衣草香味在降低前列腺活检患者焦虑和疼痛水平方面的有效性。方法:一项非药物介入、随机、两组、多中心、非营利性研究。SS Antonio e Biagio e Cesare Arrigo医院和亚历山德里亚市蒙扎综合诊所将于2022年4月1日至2022年10月1日连续招募所有接受门诊前列腺活检的成年患者。将使用数字评定量表和汉密尔顿焦虑评定量表进行评估。结论:薰衣草精油芳香疗法对减轻前列腺活检过程中的疼痛和焦虑有显著的临床效果;它使用简单、安全、成本低，是一种值得考虑的治疗选择，在某些临床环境中可作为其他医疗干预措施的补充。
{"title":"A multicenter interventional study aimed to assess the effectiveness of Lavanda aroma in reducing anxiety and pain in patients undergoing PROstatic BIOpsy (LA-BIOPRO): Study protocol","authors":"Bolgeo Tatiana, Matteo Roberta di, Gatti Denise, Cotroneo Salvatore, R. Pietro, Stasio Andrea Di, Serao Armando, Boccafoschi Carmelo, Maconi Antonio","doi":"10.17352/aur.000038","DOIUrl":"https://doi.org/10.17352/aur.000038","url":null,"abstract":"Background: A prostatic biopsy is a diagnostic test used in cases of suspected prostate cancer. The patient expresses significant levels of anxiety from the very first outpatient visits; anxiety and pain management is essential for a successful outcome of the procedure. Lavender oil is one of the essential oils that is commonly used in aromatherapy to reduce anxiety and pain, its low toxicity and side effects have made it the preferred treatment in complementary medicine. Aim: To assess the 'effectiveness of lavender scent in decreasing the levels of anxiety and pain in patients undergoing a prostatic biopsy. Methods: An interventional non-pharmacological, randomized, two-arm, multi-center, nonprofit study. The SS Antonio e Biagio e Cesare Arrigo Hospital and the City of Alessandria Clinic, Monza Polyclinic of Alessandria, will enroll consecutively all adult patients undergoing outpatient prostatic biopsy from April 1, 2022, to October 1, 2022. The Numerical Rating Scale and Hamilton Anxiety Rating Scale will be used for assessments. Conclusion: Lavender oil aromatherapy could have a clinically significant effect on reducing pain and anxiety during prostatic biopsy procedures; its simple use, safety, and low cost provide a therapeutic option to be considered, complementary to other medical interventions in certain clinical settings.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83240829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Okorie, I. Sunday‐Adeoye, J. Obuna, A. Daniyan, K. Ekwedigwe, A. Oje, EN Yakubu, CJ Chukwu, Chukwu Uro, O. Omaka
Objectives: Complication of obstetric fistula is the formation of bladder stones which rarely occur in Vagina-Vesico Fistula (VVF) patients. In this study, the metal and organic characterization of bladder stones removed between 2010-2019 from vesicovaginal fistula patients managed at the National Obstetric Fistula Centre (NOFIC), Abakaliki, Ebonyi State, Nigeria were carried out. Methods: The solubility of the bladder stones in different solvents were investigated and metal compositions were determined using Inductively Coupled Plasma- Optical Emission Spectrometry (ICP-OESS). The qualitative chemical composition was determined following standard procedures while the structural chemical characterization and functional groups were determined using the Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform Infrared spectroscopy (FTIR). Results: Distilled water and aqueous solvent chloroform extract of W. lateritia demonstrated significant capacity to dissolve bladder stones in-vitro. Chemical compounds identified include uric acid, oxalate, cysteine, and phosphate from the bladder stones. The metals found in the bladder stones were: Ca, Na, Cu, Zn, Mg, B, Pb, and Al. Trace elements can influence the external morphology of growing crystals and may increase or decrease the speed of the crystallization process. The GC-MS revealed the presence of the following compounds: methyl 2-Hydroxyethyl sulfoxide; methylene chloride; mercaptamine;1,1diethoxy, dichloroactealdehyde; Cyclopentasiloxane; monoammonium salt; di-Allo-Cystathionine; dichloroacetaldehyde; 2-(2Furyl)-2,5-dimethyltetrahydrofuran; Methenamine; 1,1-Difluoro-1-sila-5-thiacyclooctane; Triacetonetriperoxde; 4-Aminosalicylic acid, 3-Trimethylsilyl (3TMS) derivative;Pentanethiol; and 2,5-Bis-(5-hexyl-[1,3,2]dioxaborinan-2-yloxy)-benzene. FTIR revealed the following: hydroxyl, carboxylic, ester, aromatic, and aliphatic groups, confirming the compounds identified. Conclusion: Metals (Mg, Ca, Pb, etc), organic metabolites (oxalate, cystine, uric acid, phosphate, methenamine, methylene chloride, 4-Aminosalicylic acid, 3-Trimethylsilyl, etc) were found in the bladder stones.
{"title":"Metal and organic characterization of bladder stones removed surgically from VesicoVaginal Fistula patients at the National Obstetric Fistula Centre, Abakaliki, Ebonyi State","authors":"U. Okorie, I. Sunday‐Adeoye, J. Obuna, A. Daniyan, K. Ekwedigwe, A. Oje, EN Yakubu, CJ Chukwu, Chukwu Uro, O. Omaka","doi":"10.17352/aur.000037","DOIUrl":"https://doi.org/10.17352/aur.000037","url":null,"abstract":"Objectives: Complication of obstetric fistula is the formation of bladder stones which rarely occur in Vagina-Vesico Fistula (VVF) patients. In this study, the metal and organic characterization of bladder stones removed between 2010-2019 from vesicovaginal fistula patients managed at the National Obstetric Fistula Centre (NOFIC), Abakaliki, Ebonyi State, Nigeria were carried out. Methods: The solubility of the bladder stones in different solvents were investigated and metal compositions were determined using Inductively Coupled Plasma- Optical Emission Spectrometry (ICP-OESS). The qualitative chemical composition was determined following standard procedures while the structural chemical characterization and functional groups were determined using the Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform Infrared spectroscopy (FTIR). Results: Distilled water and aqueous solvent chloroform extract of W. lateritia demonstrated significant capacity to dissolve bladder stones in-vitro. Chemical compounds identified include uric acid, oxalate, cysteine, and phosphate from the bladder stones. The metals found in the bladder stones were: Ca, Na, Cu, Zn, Mg, B, Pb, and Al. Trace elements can influence the external morphology of growing crystals and may increase or decrease the speed of the crystallization process. The GC-MS revealed the presence of the following compounds: methyl 2-Hydroxyethyl sulfoxide; methylene chloride; mercaptamine;1,1diethoxy, dichloroactealdehyde; Cyclopentasiloxane; monoammonium salt; di-Allo-Cystathionine; dichloroacetaldehyde; 2-(2Furyl)-2,5-dimethyltetrahydrofuran; Methenamine; 1,1-Difluoro-1-sila-5-thiacyclooctane; Triacetonetriperoxde; 4-Aminosalicylic acid, 3-Trimethylsilyl (3TMS) derivative;Pentanethiol; and 2,5-Bis-(5-hexyl-[1,3,2]dioxaborinan-2-yloxy)-benzene. FTIR revealed the following: hydroxyl, carboxylic, ester, aromatic, and aliphatic groups, confirming the compounds identified. Conclusion: Metals (Mg, Ca, Pb, etc), organic metabolites (oxalate, cystine, uric acid, phosphate, methenamine, methylene chloride, 4-Aminosalicylic acid, 3-Trimethylsilyl, etc) were found in the bladder stones.","PeriodicalId":92753,"journal":{"name":"Archive of urological research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74564531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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