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Dry eye, Contact lenses and Preservatives in Glaucoma Medication 青光眼药物中的干眼症、隐形眼镜和防腐剂
Pub Date : 2020-01-01 DOI: 10.29011/2689-7407.100040
Aristeidis Chandrinos, Dorotheos Dimitrios Tzamouranis
Current review focus on hidden links between glaucoma, contact lenses and Ocular Surface Disease (OSD), in glaucoma the most important treatment is the control of progression through targeted pharmaceutical protection, keeping low intraocular pressure, by prescribing ophthalmic medications. On the other hand, use of preservatives in glaucoma medications is a common practice in order to maintain their effectiveness for an extended period of time. Anti-glaucoma medications enclose preservatives and the 70% of them contain a very common preserving agent, the Benzalkonium chloride (BAK). In glaucoma medications BAK toxicity includes, loss of tear film stability, direct damages to the cornea and conjunctival epithelium, and possible immune allergic reactions. Other types of preservatives may exhibit less toxicity but are still irritating agents. Of course, concentration and duration of treatment determine the extent of side effects of the preservatives. High content hydrogel contact lenses absorb BAK molecules and release them slowly onto the corneal epithelium over time. So, patients that use contact lenses may wear those better 15 minutes after the medication. The prolonged exposure to BAK is well known to increase symptoms of ocular inflammation. A diminish of patient's life quality is observed and patient compliance to the specific anti-glaucoma medication, is also undermined. Conversely, there are more causes of dry eye in glaucoma patients, as the majority of the glaucomatous patients are elderly. Such factor is the decrease of tear production with increasing of age and numerous changes in the composition of the tear film. At the same time, elderly often suffer from other pathological diseases that encourage the development of dry eye and eye irritations. Adding the anti-glaucoma eye drops containing preservatives along with the constant use of contact lenses, we are led to a serious multifactorial dry eye condition. The last years several antiglaucoma agents have been marketed such as preservative-free or Benzalkonium chloride-free formulations in an attempt to reduce the side effects related to the preservatives.
目前的研究重点是青光眼、隐形眼镜与眼表疾病(OSD)之间的隐性联系,在青光眼中最重要的治疗是通过有针对性的药物保护、保持低眼压、处方眼科药物来控制进展。另一方面,在青光眼药物中使用防腐剂是一种常见的做法,以便在较长一段时间内保持其有效性。抗青光眼药物含有防腐剂,其中70%含有一种非常常见的防腐剂,即苯扎氯铵(BAK)。在青光眼药物中,BAK毒性包括泪膜稳定性的丧失,对角膜和结膜上皮的直接损伤,以及可能的免疫过敏反应。其他类型的防腐剂可能表现出较小的毒性,但仍然是刺激剂。当然,治疗的浓度和持续时间决定了防腐剂副作用的程度。高含量水凝胶隐形眼镜吸收BAK分子,并随时间缓慢释放到角膜上皮。因此,使用隐形眼镜的患者在服药15分钟后佩戴效果更好。众所周知,长期接触BAK会增加眼部炎症症状。观察到患者的生活质量下降,患者对特定抗青光眼药物的依从性也降低。相反,青光眼患者发生干眼的原因较多,青光眼患者以老年人居多。这一因素是随着年龄的增长,泪液产量减少,泪液膜的组成发生了许多变化。与此同时,老年人经常患有其他病理疾病,这些疾病助长了干眼和眼睛刺激的发展。加上含有防腐剂的抗青光眼滴眼液,加上经常使用隐形眼镜,我们会导致严重的多因素干眼症。在过去的几年里,一些抗青光眼药物已经上市,比如不含防腐剂或不含苯扎氯铵的配方,试图减少与防腐剂有关的副作用。
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引用次数: 2
Retinal Microvasculature Density Alteration in Type 2 Diabetes with and without Retinopathy using Optical Coherence Tomography Angiography 光学相干断层扫描血管造影检测伴有或不伴有视网膜病变的2型糖尿病视网膜微血管密度改变
Pub Date : 2020-01-01 DOI: 10.29011/2689-7407.100044
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引用次数: 0
Anatomical and Functional Response to Topical Carbonic Anhydrase Inhibitor in X-linked Juvenile Retinoschisis (XLJR) 外用碳酸酐酶抑制剂对x连锁幼年性视网膜裂(XLJR)的解剖和功能反应
Pub Date : 2018-12-30 DOI: 10.33425/2639-9482.1008
Tatianne Fernandes Duarte, Luciana Ferreira Brina, Jacques Ramos Houly, L. O. D. Carmo, Marcela Caetano Bastos, M. M. Gutierrez
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引用次数: 0
Bilateral Exophtalmy, Revealing a Lymphoma not Hodgkinien of the Coat Type 双侧眼外肿大,显示非霍奇金淋巴瘤
Pub Date : 2018-12-30 DOI: 10.33425/2639-9482.1006
Y. Mouzari, Ould Hamed Ma, R. Zerrouk, F. Elasri, K. Reda, A. Oubaaz
Introduction: The Non hodgkinien lymphma (NHL) orbital location is a rare tumor, difficult to diagnose. The mantle cell lymphoma represents 6% of cases of LNH B. We report a patient of 60 years with bilateral exophthalmia revealing a mantle cell lymphoma. Clinical Observation: A man of 60 years ran for ophthalmological emergencies in an array of orbital cellulitis of the right eye. This swelling was that day, painful, inflammatory, axile, irreducible, and non-pulsatile, with limited horizontal movement of the eyeball. In general terms, the patient has axillary lymph nodes and supraclavicular without splenomegaly. A biopsy of the orbital mass produced by trans-conjunctival, concluded in a non-Hodgkin lymphoma B type mantle (CD20 +, CD5 +, cyclin D1 +). The assessment of extension realized in the Hematology Clinic department shows that this is a mantle cell lymphoma NHL B stage (nodes above and below the diaphragm, bilateral eyelid damage, spinal cord and location). After 3 treatments Rituximab-CHOP and DHAP-Rituximab treatments 3, obtaining a complete remission. Discussion: The mantle cell lymphoma represents about 6% of NHL. Its incidence is estimated between 0.07 and three cases per 100 000 population per year. The geographical area and ethnicity shows a higher frequency in Caucasians than in African Americans. Ocular involvement in the NHL is a rare event, as evidenced by the limited number of cases reported in the literature. It may be opening that is the case of our patient, or alter the course of lymphoma known. Conclusion: The eye location of mantle cell lymphoma is a rare entity. The clinical picture of this location can be misleading, particularly that of orbital cellulitis. The tumor biopsy confirms the diagnosis. Despite the treatment regimens, the prognosis of this type of lymphoma is reserved.
非霍奇金淋巴瘤(NHL)是一种罕见的肿瘤,诊断困难。套细胞淋巴瘤占LNH b病例的6%。我们报告一位60岁的患者,双侧突出眼显示套细胞淋巴瘤。临床观察:一名60岁男子因右眼眼窝蜂窝织炎就诊。这天,这种肿胀是疼痛的、炎性的、轴状的、不可消除的、无搏动性的,眼球的水平运动受限。一般来说,患者有腋窝淋巴结和锁骨上淋巴结,但没有脾肿大。经结膜眶肿块活检,结论为非霍奇金淋巴瘤B型套膜(CD20 +, CD5 +, cyclin D1 +)。在血液科完成的延伸评估显示,这是一个套细胞淋巴瘤NHL B期(横膈膜上下淋巴结,双侧眼睑损伤,脊髓及位置)。经3次利妥昔单抗- chop和dhap -利妥昔单抗治疗,获得完全缓解。讨论:套细胞淋巴瘤约占NHL的6%。其发病率估计为每年每10万人0.07至3例。从地理区域和种族来看,白种人的发病率高于非裔美国人。NHL的眼部受累是一种罕见的事件,文献中报道的病例数量有限。它可能是开放的,这是我们的病例,或改变淋巴瘤的进程已知。结论:眼内发生套细胞淋巴瘤是一种罕见的疾病。这一部位的临床表现容易引起误解,尤其是眼眶蜂窝织炎。肿瘤活检证实了诊断。尽管治疗方案,这种类型的淋巴瘤的预后是保留的。
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引用次数: 0
ICL Implantation in A Long Standing and Challenging Pseudophakic Ametropia 长期假性屈光性屈光的ICL植入术
Pub Date : 2018-07-30 DOI: 10.15406/AOVS.2018.8.00310
C. Karaarslan
Pseudophakic ametropia may be a devastating problem in time after childhood cataract surgeries, which must be corrected.1 Spectacles are inconvenient options and contact lenses too.2,3 IOL exchange cannot be advised because of its serious complications.4 Corneal refractive surgery can be applied only in suitable corneas and diopters.5 In higher refractive situations, the posterior chamber implantable collamer lens (ICL V4c) is an advisable alternative option, even if corneal thickness is inadequate. The new central hole design in ICL V4c allows the flow of aqueous humor without additional a peripheral iridotomy.6 This research examines the correction of indecent refractive errors in pseudophakic ametropia using TICL V4c.
儿童白内障手术后假性屈光不正可能是一个毁灭性的问题,必须及时矫正眼镜和隐形眼镜都是不方便的选择。由于严重的并发症,不建议进行人工晶状体置换术角膜屈光手术只适用于合适的角膜和屈光度在高度屈光的情况下,即使角膜厚度不足,后房型人工晶状体(ICL V4c)也是一种可取的选择。ICL V4c的新中心孔设计允许房水流动,而无需额外的周围虹膜切开术本研究探讨了使用TICL V4c矫正假性屈光不正。
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引用次数: 0
Prevalence of Diabetic Retinopathy in Public Health Care Units of São José do Rio Preto-SP-Brazil 巴西Rio preto - sp州<s:1> jossore公共卫生保健单位糖尿病视网膜病变患病率
Pub Date : 2018-06-30 DOI: 10.33425/2639-9482.1004
Cury Jr C.E, Maniglia Jv, Abad L
Objective: To determine the prevalence of DR in public health care units of São José do Rio Preto-SP-Brazil. Material and Methods: Population-based cross-sectional study that included 710 diabetic patients. All patients underwent an eye examination by indirect ophthalmoscope to check for any signs of DR. Participants were also interviewed and examined to determine their demographic characteristics, medical conditions and the realization of previous fundoscopic eye examination. Statistical studies were done with t-Student test, Fisher test or chi-square test. Results: Among 710 screened patients, 112 had some degree of diabetic retinopathy, and the overall standardized prevalence of any retinopathy was 16,3%, including 90 (80,4%) with non-proliferative and (22) 19,6% with proliferative diabetic retinopathy. Conclusions: The prevalence of DR in São José do Rio Preto is 16,3%. The main risk factors associated with DR were time of disease and glicemic control. Type of DM and nephropathy were considered secondary risk factors. The presence of high blood pressure, in this study, was not a risk factor associated with DR.
目的:了解巴西里约普雷托州 jossore do Rio preto - sp公共卫生保健单位的DR患病率。材料和方法:以人群为基础的横断面研究,包括710名糖尿病患者。所有患者均通过间接检眼镜进行眼部检查,以检查dr的任何迹象。参与者还接受了访谈和检查,以确定他们的人口统计学特征、医疗状况和以前的眼底检查的实现情况。统计学研究采用t-Student检验、Fisher检验或卡方检验。结果:在710例筛查患者中,有112例存在不同程度的糖尿病视网膜病变,视网膜病变的总体标准化患病率为16.3%,其中非增生性糖尿病视网膜病变90例(80,4%),增生性糖尿病视网膜病变19.6%(22)。结论:在里约普雷图 jossore地区,DR患病率为16.3%。与DR相关的主要危险因素是发病时间和血糖控制。糖尿病类型和肾病被认为是次要危险因素。在这项研究中,高血压的存在并不是与DR相关的危险因素。
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引用次数: 0
Swept Source Optical Coherence Tomography (En-Face) Imaging in Conjunction with (Retinal flow) Optical Coherence Angiography Map “Marking Out” Deep Capillary Plexus Ischemia in Paracentral Acute Middle Maculopathy 扫描源光学相干断层扫描(En-Face)成像与(视网膜血流)光学相干血管造影图“标记”中央旁急性中黄斑病变的深毛细血管丛缺血
Pub Date : 2018-06-30 DOI: 10.33425/2639-9482.1003
Fawwaz Al-Mamoori, M. Harara, M. Abdullah
Introduction: PAMM, recently emerged retinal pathology involving preferentially deep retinal capillary system (ICP and DCP) where impaired blood flow occurs, and particularly anatomical and physiological watershed zone is affected (INL and OPL). Resultant ischemia is presented clinically with sudden drop of vision and manifested as band like hyperreflective lesions on SS OCT B scans. SS OCTA with Enface and Retinal flow maps have delineated ischemic lesions within middle retina and exhibited characteristic findings that may help in understanding the pathophysiology behind this entity. Purpose: To highlight PAMM diagnostic features on Optical Coherence Tomography Angiography and Enface, and to emphasize on their major role in detecting and assessing this condition. Methods: This is a retrospective study reviewing two clinical cases presented to our facility with sudden decrease in vision in one eye. DRI OCT Triton (Topcon Corporation, Tokyo, Japan) was employed. In addition to generating high quality conventional cross sectional B scan images, Enface C scans and three dimensional angiography images were obtained at different retinal levels. High-resolution color fundus imaging, Fluorescein Angiography (FA) and Fundus Auto fluorescence (FAF), and Enface in conjunction with OCTA were all used in the two cases. Detailed history, full comprehensive Eye exam was done, appropriate thorough systemic workup was performed; baseline blood tests (CBC, KFT, LFT, UA), coagulation profile (INR, APTT, D Dimer) with blood test for sickle cell (SC), and autoimmune profile. Results: In both cases, OCTA and Enface revealed multiple findings of PAMM during the acute phase of presentation. OCTA provided evidence of DCP ischemia by showing perfusion defects, or capillary dropout. Enface C scans visualized fern-like ischemic distribution at the level of DCP. Discussion: The use of OCTA in conjunction with Enface OCT has proved superior to other imaging modalities in identifying and diagnosing PAMM. It is anticipated that such imaging techniques may provide new insights for middle and deep retinal ischemic pathologies including PAMM which may have a constellation of imaging findings in the near future for its detection, diagnosis, classification, and perhaps management!
简介:PAMM,最近出现的视网膜病理,优先涉及视网膜深部毛细血管系统(ICP和DCP),血流受损,特别是受影响的解剖和生理分水岭(INL和OPL)。由此导致的缺血在临床上表现为视力突然下降,在SS OCT B扫描上表现为带状高反射病变。带有Enface和视网膜血流图的SS OCTA描绘了视网膜中部的缺血性病变,并展示了可能有助于理解该实体背后的病理生理学的特征性发现。目的:强调PAMM在光学相干断层血管造影和Enface中的诊断特点,并强调其在检测和评估该疾病中的主要作用。方法:回顾性分析两例单眼视力突然下降的临床病例。采用DRI OCT Triton (Topcon Corporation, Tokyo, Japan)。除了生成高质量的常规横断面B扫描图像外,还获得了不同视网膜水平的Enface C扫描和三维血管造影图像。高分辨率彩色眼底成像,荧光素血管造影(FA)和眼底自动荧光(FAF),以及Enface联合OCTA。详细的病史,全面的眼科检查,适当彻底的系统检查;基线血液检查(CBC、KFT、LFT、UA)、凝血特征(INR、APTT、D二聚体)、镰状细胞(SC)血液检查和自身免疫特征。结果:在这两例病例中,OCTA和Enface在急性期均显示多发性PAMM。OCTA通过显示灌注缺陷或毛细血管脱落提供DCP缺血的证据。Enface C扫描在DCP水平显示蕨类样缺血分布。讨论:OCTA联合Enface OCT在识别和诊断PAMM方面优于其他成像方式。预计这种成像技术可能为包括PAMM在内的中深部视网膜缺血性病变提供新的见解,这些病变在不久的将来可能会有一系列的影像学发现,用于其检测、诊断、分类和治疗!
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引用次数: 0
How to Deal with Posterior Lenticonus – Two Different Approaches 如何处理后晶状体-两种不同的方法
Pub Date : 2018-06-30 DOI: 10.33425/2639-9482.1001
H. Rolim, A. F. Belfort, M. Trigueiro, L. F. D. S. A. Carneiro
Introduction: Posterior lenticonus is a rare ectasia of the posterior capsule of the lens and has a prevalence of 1-4/100,000 and is associated with crystalline opacity in 14% of unilateral cases and 9% of bilateral cases. Depending on the degree of opacity and visual impairment, there is a risk of developing amblyopia but the effect on vision is extremely variable. We report two different treatment approaches to the disease. Case Report: The first case is a 10 months male patient with Down syndrome attended for evaluation of cataract with good fixation and no strabismus. Inicially a non surgical treatment was chosen but later he developed an agressive behavior and a posterior lenticone associated with posterior polar cataract was observed, which lead to the decision of a surgical treatment. The second case is a 7 years old patient with history of low visual acuity and posterior polar cataract in the left eye associated with posterior lenticonus discretely displaced superiorly. He was treated with tropicamide and oclusion of the right eye for thirty days. Discussion: The two cases shows how is it possible to manage posterior lenticonus with surgical ou clinical treatments. There is a tendency for patients who underwent cataract surgery to have a better visual acuity improvement compared with patients who did not have surgery, however this data was not statistically significant. Conclusion: The ophthalmologist should be able to recognise this finding during examn and decide wich treatment, surgical or clinical, will bring the best visual outcome for his pacients.
后晶状体圆锥是一种罕见的晶状体后囊扩张,发病率为1 / 4/100,000,单侧病例14%,双侧病例9%伴有晶状体混浊。视混浊程度和视力损害程度而定,有发展为弱视的风险,但对视力的影响是极不相同的。我们报告了两种不同的治疗方法。病例报告:第一例是一个10个月大的男性唐氏综合征患者,因白内障固定良好,无斜视而就诊。最初选择非手术治疗,但后来他出现了攻击性行为,并观察到与后极性白内障相关的后晶状体,这导致了手术治疗的决定。第二个病例是一名7岁的患者,患有低视力和左眼后极性白内障,并伴有后晶状体离散性上移位。他接受了tropicamide和右眼封闭治疗30天。讨论:这两个病例显示了如何通过手术或临床治疗来治疗后晶状体。与未接受白内障手术的患者相比,接受白内障手术的患者有更好的视力改善趋势,但这一数据没有统计学意义。结论:眼科医生应在检查时认识到这一发现,并决定手术或临床治疗哪种方法能给患者带来最佳的视力结果。
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引用次数: 1
Health Education of the Sickle Cell Disease Patient: Knowledge and Practical Attitudes of 186 Sickle Cell Patients Concerning Ophthalmologic Checking In Abidjan 镰状细胞病患者的健康教育:阿比让186例镰状细胞病患者眼科检查的知识和实践态度
Pub Date : 2018-06-30 DOI: 10.33425/2639-9482.1002
Cheucheu Nj, O. Y, Ouffouet Ygk, D. Z, Kouassi Fx, Sanogo I
of the Sickle Cell Disease Patient: Knowledge and Practical Attitudes of 186 Sickle Cell Patients Concerning Ophthalmologic Checking
186例镰状细胞病患者眼科检查的知识和实践态度
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引用次数: 1
Development of Novel Radial Relaxation Retinectomy Method on Retinal Detachment with Advanced Proliferative 进展性增殖性视网膜脱离的新型桡骨松弛视网膜切除术的进展
Pub Date : 2018-06-30 DOI: 10.33425/2639-9482.1005
Waldensius Girsang, S. Dcr, Srigutomo Wahyu, Sasongko Muhammad Bayu, T. D. Gondhowiardjo
Radial relaxation retinectomy followed by gas (C3F8 14%) tamponade usage has been applied to eyes experiencing retinal detachment accompanied by PVR of grade C1, C2, C3 and D1. In this method, geometrical boundaries of radial retinectomy are set up as to protect blood vessels, papil and macula. So far, out of totally 60 eyes who have received the treatment of this method, 2 eyes achieved 70% vision improvement, 4 eyes achieved 60%, 9 eyes achieved 50%, 16 eyes achived 40%, 14 eyes achieved 30%, 9 eyes achived 20%, and 6 eyes experienced 10% vision improvement. This new method provides an alternative relaxation retinectomy which is relatively fast and inexpensive and yields good results.
桡动脉松弛视网膜切除术后气体(C3F8 14%)填塞用于伴有C1、C2、C3和D1级PVR的视网膜脱离眼。该方法通过建立径向视网膜切除术的几何边界来保护血管、乳头和黄斑。到目前为止,在60只接受该方法治疗的眼睛中,2只眼睛视力改善70%,4只眼睛视力改善60%,9只眼睛视力改善50%,16只眼睛视力改善40%,14只眼睛视力改善30%,9只眼睛视力改善20%,6只眼睛视力改善10%。这种新方法提供了一种相对快速、廉价且效果良好的替代松弛性视网膜切除术。
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引用次数: 0
期刊
Ophthalmology research and reports
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